Influence of mediterranean diet on survival from covid-19 disease
Retrospective 89 COVID-19 patients in Spain, showing lower mortality with adherence to the Mediterranean diet.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
risk of death, 53.0% lower, HR 0.47, p = 0.049, higher quality diet 58, lower quality diet 31.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Magaña et al., 31 Dec 2021, retrospective, Spain, peer-reviewed, 6 authors.
Clinical Nutrition ESPEN 46 (2021) 544e786
~ a, L. Rey Ferna
ndez, I. Cacace, B. Tortajada Goitia, V.
M. Miranda Magan
s Osinaga*. Pharmacy and Nutrition Department,
Faus Felipe, J. Abile
Hospital Costa del Sol, Marbella, Spain
the radius. In radio only 2 patients had z-score under -1 where in tibia were
9, and from those 3 had z-score lower than -2.
There was a correlation between amenorrhea duration and disease duration. No signiﬁcant associations were found between with bone strength.
Conclusion: Longer time on amenorrhea has an negative impact on bone
Prusky, M., Shear, M., & Attia, E. (2017). Anorexia Nervosa and Bulimia
Nervosa in Children and Adolescents. Handbook of DSM-5 Disorders in Children and Adolescents, 333e352.
Misra, M., & Klibanski, A. (2016). Anorexia Nervosa and Its Associated
Endocrinopathy in Young People. Hormone Research in Paediatrics, 85(3),
Misra, M., & Klibanski, A. (2014). Endocrine consequences of anorexia
nervosa. The Lancet Diabetes & Endocrinology, 2(7), 581e592.
Chou, S. H., & Mantzoros, C. (2018). Bone metabolism in anorexia nervosa
and hypothalamic amenorrhea. Metabolism, 80, 91e104.
Disclosure of Interest: None declared.
Rationale: Evaluate the effects of the Mediterranean Diet (MD) on mortality from COVID-19 disease in hospitalized patients with severe disease.
Methods: Retrospective descriptive study that included all patients with
diagnosis of COVID-19 who were nutritionally assessed during the period
from January to March 2021.The data included clinical and demographic
eligibility,Charlson index,HDL,LDL,Cholesterol,IL6,Ferritin and D-dimer).
Adherence to MD was evaluated using the Predimed questionnaire. Patients were followed after discharge for one month. Bivariate analysis was
performed to evaluate differences according to MD adherence using nonparametric statistical tests. Statistical analyses were performed by Cox
regression; hazard ratios (HRs) for associations of MD adherence with
mortality were estimated. BMI, sex and age were included in the Cox
model as potential confounders. Level of signiﬁcance was regarded as p
value< 0.05.The data were analyzed with the SPSS program.
Results: 89 patients were recruited.Median (SD) age was 72,4(22.3)years,
29.7% were woman. 58 patients (65.2%)had adequate adherence to MD
(PREDIMED score 8). Mortality of patients was 48.4% in non-adherent
MD, and 25.9% in MD-adherent.There was no statistically signiﬁcant difference in the basal characteristics and nutritional biomarkers between
both cohorts,except for HDL.MD-adherence was signiﬁcantly associated
with a reduced overall mortality HR[95%CI]:0.47[0.22-0.99].These results
remained statistically signiﬁcant after adjustment for age, sex, and BMI.
Conclusion: MD-adherent patients had a signiﬁcant higher survival
compared to non-adherent. Our study has a small sample size and
observational design,so causal relationship between lower mortality and
MD cannot be concluded,but the hypothesis of its protective effect deserves to be studied in more detail.
lez MA, Corella D, et al. Effects of a Medi1- Estruch R, Martínez-Gonza
terranean-style diet on 2- Detopoulou P, Demopoulos CA, Antonopoulou S.
Micronutrients, Phytochemicals and Mediterranean Diet: A Potential
Protective Role against COVID-19 through Modulation of PAF Actions and
Metabolism. Nutrients. 2021;13(2):462.
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