Abstract: a consensus on sampling, methodologies for clinical measurement, and cutoff
values to guide the treatment of severe
COVID-19 patients with endothelialstabilizing agents, such as statins, glucocorticoids, and anticoagulants. Moreover,
endothelial function measurement is a
possible alternative method for the early
detection of cardiovascular sequelae.
Notes
Ming Tong,1,2 Fang Chen,2 Qing Zheng,3 and Yimin Zhu2
1
Department of Infectious Diseases, The First-affiliated
Hospital of Hunan Normal University (Hunan Provincial
People’s Hospital), Changsha, Hunan, China, 2Institute of
Emergency Medicine, Hunan Provincial Key Laboratory
of Emergency and Critical Care Metabonomics, The Firstaffiliated Hospital of Hunan Normal University (Hunan
Provincial People’s Hospital), Changsha, Hunan, China,
3
Department of Geriatrics, The First-affiliated Hospital
of Hunan Normal University (Hunan Provincial People’s
Hospital), Changsha, Hunan, China
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Received 28 December 2020; editorial decision 20 January
2021; accepted 28 January 2021; published online January
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Correspondence: Yimin Zhu, MD, PhD, Institute of
Emergency Medicine, Hunan Provincial Key Laboratory
of Emergency and Critical Care Metabonomics, The FirstAffiliated Hospital of Hunan Normal University (Hunan
Provincial People’s Hospital), Changsha, Hunan 410005, P. R.
China (cszhuyimin@163.com).
2021;223:1499–500
The Journal of Infectious Diseases®
© The Author(s) 2021. Published by Oxford University Press for
the Infectious Diseases Society of America. All rights reserved.
For permissions, e-mail: journals.permissions@oup.com.
DOI: 10.1093/infdis/jiab041
UVB Radiation Alone May Not
Explain Sunlight Inactivation of
SARS-CoV-2
To the Editor—Recently, RatnesarShumate et al [1] reported rapid
1500 • jid 2021:223 (15 April) • CORRESPONDENCE
sunlight inactivation of severe acute
respiratory syndrome coronavirus 2
(SARS-CoV-2) in simulated saliva and
in complete growth medium (gMEM).
Independently and essentially simultaneously, Sagripanti and Lytle [2] introduced a theory for sunlight inactivation
of SARS-CoV-2, building on their earlier
work with similar viruses [3]. To the
best of our knowledge, these data and
theory had not been compared. When
establishing this comparison, the experimentally reported sunlight inactivation
in Ratnesar-Shumate et al [1] is several
times faster than predicted by theory,
suggesting that additional experiments
and hypotheses may be needed to fully
elucidate the mechanism of SARS-CoV-2
sunlight inactivation.
Briefly, the theory of Sagripanti and
Lytle [2, 3] considers direct photochemical damage to viral RNA, which is maximal for UVC (wavelengths between
200 and 280 nm). The effectiveness of
UVC is expressed as the exposure that
produces one e-fold reduction..
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