A machine learning-based phenotype for long COVID in children: an EHR-based study from the RECOVER programhttps://www.medrxiv.org/content/10.1101/2022.12.22.22283791
Lorman et al.,
A machine learning-based phenotype for long COVID in children: an EHR-based study from the RECOVER..,
medRxiv, doi:10.1101/2022.12.22.22283791 (Preprint)
Retrospective 87,398 pediatric patients in the USA, reporting acetaminophen and aspirin associated with PASC, without specific details. Authors note that this could be related to use for MIS-C treatment.
Lorman et al., 26 Dec 2022, retrospective, USA, preprint, 18 authors, study period September 2021 - April 2022.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2022.12.22.22283791; this version posted December 26, 2022. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
A machine learning-based phenotype for long COVID in children: an EHR-based study from the
RECOVER program
Authors
Vitaly Lorman, PhD1, Hanieh Razzaghi, MPH1, Xing Song, PhD2, Keith Morse, MD, MBA3, Levon Utidjian,
MD1, Andrea J. Allen, MS1, Suchitra Rao, MBBS, MSCS4, Colin Rogerson, MD, MPH5, Tellen D. Bennett,
MD, MS6, Hiroki Morizono, PhD7, Daniel Eckrich, MLIS8, Ravi Jhaveri, MD9, Yungui Huang, PhD, MBA10,
Daksha Ranade, MPH, MBA11, Nathan Pajor, MD, MS12, Grace M. Lee, MD, MPH13, Christopher B. Forrest,
MD, PhD1, L. Charles Bailey, MD, PhD1
Affiliations:
1
Applied Clinical Research Center, Children’s Hospital of Philadelphia, Philadelphia, PA, United States
2
Department of Health Management and Informatics, University of Missouri School of Medicine,
Columbia, MO, United States
3
Division of Pediatric Hospital Medicine, Department of Pediatrics, Stanford University School of
Medicine, Stanford, California, United States
4
Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital of
Colorado, Aurora, CO, United States
5
Division of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis,
IN, United States
6
Departments of Biomedical Informatics and Pediatrics, University of Colorado School of Medicine and
Children’s Hospital Colorado, Aurora, CO, United States
7
Center for Genetic Medicine Research, Children's National Hospital, Washington DC, United States
8
Biomedical Research Informatics Center, Nemours Children’s Health, Wilmington, DE, United States
9
Division of Infectious Diseases, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, United
States
10
IT Research and Innovation, The Research Institute at Nationwide Children’s Hospital, Columbus, OH,
United States
11
Research Informatics Department, Seattle Children’s Hospital, Seattle, WA, United States
12
Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center and University of
Cincinnati College of Medicine, Cincinnati, OH, United States
13
Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine,
Stanford, CA, United States
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2022.12.22.22283791; this version posted December 26, 2022. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Abstract
Background
As clinical understanding of pediatric Post-Acute Sequelae of SARS CoV-2 (PASC) develops, and hence
the clinical definition evolves, it is desirable to have a method to reliably identify patients who are likely
to have post-acute sequelae of SARS CoV-2 (PASC) in health systems data.
Methods and Findings
In this study, we developed and validated a machine learning algorithm to classify which patients have
PASC (distinguishing between Multisystem..
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