Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All vitamin K studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin KVitamin K (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   All Outcomes    Recent:   

The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19

Linneberg et al., Nutrients, doi:10.3390/nu13061985
Jun 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Retrospective 138 hospitalized COVID-19 patients showing lower vitamin K status was associated with higher mortality, which remained significant after adjusting for age and sex, but not after further adjusting for comorbidities. Vitamin K status was assessed by measuring dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP) levels, with higher levels reflecting lower vitamin K status. Patients had significantly higher dp-ucMGP levels compared to matched population controls. The association between vitamin K status and mortality attenuated and became statistically insignificant after adjusting for age, sex, cardiovascular disease, diabetes, BMI, and kidney function
Linneberg et al., 9 Jun 2021, retrospective, Denmark, peer-reviewed, 9 authors, study period 10 March, 2020 - 23 April, 2020. Contact: allan.linneberg@regionh.dk (corresponding author), freja.bach.kampmann.02@regionh.dk, sanne.marie.thysen.01@regionh.dk, henrik.loevendahl.joergensen.01@regionh.dk, niklas.rye.joergensen@regionh.dk, thomas.lars.benfield@regionh.dk, simone.elisabeth.bastrup.israelsen.02@regionh.dk, liv.raboel.andersen@regionh.dk, haakon.sandholdt@regionh.dk.
This PaperVitamin KAll
The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19
Allan Linneberg, Freja Bach Kampmann, Simone Bastrup Israelsen, Liv Rabøl Andersen, Henrik Løvendahl Jørgensen, Håkon Sandholt, Niklas Rye Jørgensen, Sanne Marie Thysen, Thomas Benfield
Nutrients, doi:10.3390/nu13061985
It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low vitamin K status predicts mortality in COVID-19 patients. In a cohort of 138 COVID-19 patients and 138 population controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects the functional vitamin K status in peripheral tissue. Forty-three patients died within 90 days from admission. In patients, levels of dp-ucMGP differed significantly between survivors (mean 877; 95% CI: 778; 995) and non-survivors (mean 1445; 95% CI: 1148; 1820). Furthermore, levels of dp-ucMGP (pmol/L) were considerably higher in patients (mean 1022; 95% CI: 912; 1151) compared to controls (mean 509; 95% CI: 485; 540). Cox regression survival analysis showed that increasing levels of dp-ucMGP (reflecting low vitamin K status) were associated with higher mortality risk (sex-and age-adjusted hazard ratio per doubling of dp-ucMGP was 1.49, 95% CI: 1.03; 2.24). The association attenuated and became statistically insignificant after adjustment for co-morbidities (sex, age, CVD, diabetes, BMI, and eGFR adjusted hazard ratio per doubling of dp-ucMGP was 1.22, 95% CI: 0.82; 1.80). In conclusion, we found that low vitamin K status was associated with mortality in patients with COVID-19 in sex-and age-adjusted analyses, but not in analyses additionally adjusted for co-morbidities. Randomized clinical trials would be needed to clarify a potential role, if any, of vitamin K in the course of COVID-19.
Conflicts of Interest: Benfield reports grants from Novo Nordisk Foundation, grants from Simonsen Foundation, grants and personal fees from GSK, grants and personal fees from Pfizer, personal fees from Boehringer Ingelheim, grants and personal fees from Gilead, personal fees from MSD, grants from Lundbeck Foundation, grants from Kai Hansen Foundation, personal fees from Pentabase A/S, outside the submitted work. Kappa Bioscience AS (https://www.kappabio.com/; accessed on 6 June 2021) contributed with an unrestricted postdoc grant to vitamin K-related epidemiological research at the Center for Clinical Research and Prevention. All other authors have no relevant disclosures. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
References
Basalyga, Simionescu, Xiong, Baxter, Starcher et al., Elastin Degradation and Calcification in an Abdominal Aorta Injury Model: Role of Matrix Metalloproteinases, Circulation, doi:10.1161/01.CIR.0000148367.08413.E9
Burstyn-Cohen, Heeb, Lemke, Lack of Protein S in Mice Causes Embryonic Lethal Coagulopathy and Vascular Dysgenesis, J. Clin. Investig, doi:10.1172/JCI39325
Caluwé, Verbeke, De Vriese, Evaluation of Vitamin K Status and Rationale for Vitamin K Supplementation in Dialysis Patients, Nephrol. Dial. Transplant, doi:10.1093/ndt/gfy373
Cui, Chen, Li, Liu, Wang, Prevalence of Venous Thromboembolism in Patients with Severe Novel Coronavirus Pneumonia, J. Thromb. Haemost, doi:10.1111/jth.14830
Dastoli, Bennardo, Patruno, Nisticò, Are Erythema Multiforme and Urticaria Related to a Better Outcome of COVID-19?, Dermatol. Ther, doi:10.1111/dth.13681
Dattola, Silvestri, Bennardo, Passante, Scali et al., Role of Vitamins in Skin Health: A Systematic Review, Curr. Nutr. Rep, doi:10.1007/s13668-020-00322-4
Dofferhoff, Piscaer, Schurgers, Visser, Van Den Ouweland et al., Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe COVID-19, Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am, doi:10.1093/cid/ciaa1258
Fraser, Price, Lung, Heart, and Kidney Express High Levels of MRNA for the Vitamin K-Dependent Matrix Gla Protein. Implications for the Possible Functions of Matrix Gla Protein and for the Tissue Distribution of the γ-Carboxylase, J. Biol. Chem, doi:10.1016/S0021-9258(18)37912-2
Grambsch, Therneau, Proportional Hazards Tests and Diagnostics Based on Weighted Residuals, Biometrika, doi:10.1093/biomet/81.3.515
Israelsen, Kristiansen, Hindsberger, Ulrik, Andersen et al., Characteristics of Patients with COVID-19 Pneumonia at Hvidovre Hospital, Dan. Med. J
Janssen, Visser, Dofferhoff, Vermeer, Janssens et al., Vitamin K Metabolism as the Potential Missing Link between Lung Damage and Thromboembolism in Covid-19, Br. J. Nutr, doi:10.1017/S0007114520003979
Jespersen, Møllehave, Thuesen, Skaaby, Rossing et al., Uncarboxylated Matrix Gla-Protein: A Biomarker of Vitamin K Status and Cardiovascular Risk, Clin. Biochem, doi:10.1016/j.clinbiochem.2020.05.005
Leth-Møller, Skaaby, Linneberg, Allergic Rhinitis and Allergic Sensitisation Are Still Increasing among Danish Adults, Allergy, doi:10.1111/all.14046
Mazzeffi, Chow, Amoroso, Tanaka, Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?, Anesth. Analg, doi:10.1213/ANE.0000000000005059
Morales, Rojo Rello, Cristóbal, Fiz-López, Arribas et al., Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome, Biomedicines, doi:10.3390/biomedicines9040335
Petrilli, Jones, Yang, Rajagopalan, O'donnell et al., Factors Associated with Hospital Admission and Critical Illness among 5279 People with Coronavirus Disease 2019 in New York City: Prospective Cohort Study, BMJ, doi:10.1136/bmj.m1966
Piscaer, Van Den Ouweland, Vermeersch, Reynaert, Franssen et al., Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease, J. Clin. Med, doi:10.3390/jcm8081116
Piscaer, Wouters, Vermeer, Janssens, Franssen et al., Deficiency: The Linking Pin between COPD and Cardiovascular Diseases?, Respir. Res, doi:10.1186/s12931-017-0673-z
Poissy, Goutay, Caplan, Parmentier, Duburcq et al., Pulmonary Embolism in Patients with COVID-19: Awareness of an Increased Prevalence, Circulation, doi:10.1161/CIRCULATIONAHA.120.047430
Selistre, Rabilloud, Cochat, De Souza, Iwaz et al., Comparison of the Schwartz and CKD-EPI Equations for Estimating Glomerular Filtration Rate in Children, Adolescents, and Adults: A Retrospective Cross-Sectional Study, PLoS Med, doi:10.1371/journal.pmed.1001979
Tang, Li, Wang, Sun, Abnormal Coagulation Parameters Are Associated with Poor Prognosis in Patients with Novel Coronavirus Pneumonia, J. Thromb. Haemost, doi:10.1111/jth.14768
Theuwissen, Cranenburg, Knapen, Magdeleyns, Teunissen et al., Low-Dose Menaquinone-7 Supplementation Improved Extra-Hepatic Vitamin K Status, But Had No Effect on Thrombin Generation in Healthy Subjects, Br. J. Nutr, doi:10.1017/S0007114511007185
Theuwissen, Smit, Vermeer, The Role of Vitamin K in Soft-Tissue Calcification, Adv. Nutr, doi:10.3945/an.111.001628
Wiersinga, Rhodes, Cheng, Peacock, Prescott et al., Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review, JAMA J. Am. Med. Assoc, doi:10.1001/jama.2020.12839
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit