Can Post-Exposure Prophylaxis for COVID-19 Be Considered as an Outbreak Response Strategy in Long-Term Care Hospitals?
et al., International Journal of Antimicrobial Agents, 2020, Apr 17, doi:10.1016/j.ijantimicag.2020.105988, Apr 2020
HCQ for COVID-19
1st treatment shown to reduce risk in
March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
Post exposure prophylaxis of 211 high-risk people after major exposure event in a long term care hospital, showing no positive cases after 14 days.
Lee et al., 17 Apr 2020, peer-reviewed, 3 authors.
Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.105988
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Declarations Funding: No funding. Competing Interests : There are no competing financial interests.
Ethical Approval: The study was approved and informed consent was waived by the Institutional Review Board of Pusan National University Hospital (H-2003-014-089).
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.ijantimicag.2020. 105988 .
References
Colson, Rolain, Lagier, Brouqui, Raoult, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, Int J Antimicrob Agents
Colson, Rolain, Raoult, Chloroquine for the 2019 novel coronavirus SARS-CoV-2, Int J Antimicrob Agents
Gao, Tian, Yang, Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci Trends
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents
Jie, He, Xi, Zhi, None
Savarino, Trani, Donatelli, Cauda, Cassone, New insights into the antiviral effects of chloroquine, Lancet Infect Dis
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquinone for the treatment of severe acute respiratory syndrome coronarvirus 2 (SARS-CoV-2), Clin Infect Dis, doi:10.1093/cid/ciaa237
Zhu, Zhang, Li, Yang, Song, A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med
DOI record:
{
"DOI": "10.1016/j.ijantimicag.2020.105988",
"ISSN": [
"0924-8579"
],
"URL": "http://dx.doi.org/10.1016/j.ijantimicag.2020.105988",
"alternative-id": [
"S092485792030145X"
],
"article-number": "105988",
"assertion": [
{
"label": "This article is maintained by",
"name": "publisher",
"value": "Elsevier"
},
{
"label": "Article Title",
"name": "articletitle",
"value": "Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?"
},
{
"label": "Journal Title",
"name": "journaltitle",
"value": "International Journal of Antimicrobial Agents"
},
{
"label": "CrossRef DOI link to publisher maintained version",
"name": "articlelink",
"value": "https://doi.org/10.1016/j.ijantimicag.2020.105988"
},
{
"label": "Content Type",
"name": "content_type",
"value": "article"
},
{
"label": "Copyright",
"name": "copyright",
"value": "© 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved."
}
],
"author": [
{
"affiliation": [],
"family": "Lee",
"given": "Sun Hee",
"sequence": "first"
},
{
"affiliation": [],
"family": "Son",
"given": "Hyunjin",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Peck",
"given": "Kyong Ran",
"sequence": "additional"
}
],
"container-title": "International Journal of Antimicrobial Agents",
"container-title-short": "International Journal of Antimicrobial Agents",
"content-domain": {
"crossmark-restriction": true,
"domain": [
"clinicalkey.jp",
"clinicalkey.com",
"clinicalkey.es",
"clinicalkey.com.au",
"clinicalkey.fr",
"elsevier.com",
"sciencedirect.com"
]
},
"created": {
"date-parts": [
[
2020,
4,
17
]
],
"date-time": "2020-04-17T01:34:12Z",
"timestamp": 1587087252000
},
"deposited": {
"date-parts": [
[
2020,
6,
23
]
],
"date-time": "2020-06-23T05:02:48Z",
"timestamp": 1592888568000
},
"indexed": {
"date-parts": [
[
2024,
5,
13
]
],
"date-time": "2024-05-13T17:15:44Z",
"timestamp": 1715620544322
},
"is-referenced-by-count": 51,
"issue": "6",
"issued": {
"date-parts": [
[
2020,
6
]
]
},
"journal-issue": {
"issue": "6",
"published-print": {
"date-parts": [
[
2020,
6
]
]
}
},
"language": "en",
"license": [
{
"URL": "https://www.elsevier.com/tdm/userlicense/1.0/",
"content-version": "tdm",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2020,
6,
1
]
],
"date-time": "2020-06-01T00:00:00Z",
"timestamp": 1590969600000
}
}
],
"link": [
{
"URL": "https://api.elsevier.com/content/article/PII:S092485792030145X?httpAccept=text/xml",
"content-type": "text/xml",
"content-version": "vor",
"intended-application": "text-mining"
},
{
"URL": "https://api.elsevier.com/content/article/PII:S092485792030145X?httpAccept=text/plain",
"content-type": "text/plain",
"content-version": "vor",
"intended-application": "text-mining"
}
],
"member": "78",
"original-title": [],
"page": "105988",
"prefix": "10.1016",
"published": {
"date-parts": [
[
2020,
6
]
]
},
"published-print": {
"date-parts": [
[
2020,
6
]
]
},
"publisher": "Elsevier BV",
"reference": [
{
"DOI": "10.1056/NEJMoa2001017",
"article-title": "A novel coronavirus from patients with pneumonia in China, 2019",
"author": "Zhu",
"doi-asserted-by": "crossref",
"first-page": "727",
"journal-title": "N Engl J Med",
"key": "10.1016/j.ijantimicag.2020.105988_bib0001",
"volume": "382",
"year": "2020"
},
{
"DOI": "10.3346/jkms.2020.35.e112",
"article-title": "Report on the epidemiological features of coronavirus disease 2019 (COVID-19) outbreak in the Republic of Korea from January 19 to March 2, 2020",
"doi-asserted-by": "crossref",
"first-page": "e112",
"journal-title": "J Korean Med Sci",
"key": "10.1016/j.ijantimicag.2020.105988_bib0002",
"volume": "35",
"year": "2020"
},
{
"DOI": "10.1016/S1473-3099(06)70361-9",
"article-title": "New insights into the antiviral effects of chloroquine",
"author": "Savarino",
"doi-asserted-by": "crossref",
"first-page": "67",
"journal-title": "Lancet Infect Dis",
"key": "10.1016/j.ijantimicag.2020.105988_bib0003",
"volume": "6",
"year": "2006"
},
{
"DOI": "10.1038/s41422-020-0282-0",
"article-title": "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro",
"author": "Wang",
"doi-asserted-by": "crossref",
"first-page": "269",
"journal-title": "Cell Res",
"key": "10.1016/j.ijantimicag.2020.105988_bib0004",
"volume": "30",
"year": "2020"
},
{
"DOI": "10.1093/cid/ciaa237",
"article-title": "In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquinone for the treatment of severe acute respiratory syndrome coronarvirus 2 (SARS-CoV-2)",
"author": "Yao",
"doi-asserted-by": "crossref",
"journal-title": "Clin Infect Dis",
"key": "10.1016/j.ijantimicag.2020.105988_bib0005",
"year": "2020"
},
{
"DOI": "10.1016/j.ijantimicag.2020.105923",
"article-title": "Chloroquine for the 2019 novel coronavirus SARS-CoV-2",
"author": "Colson",
"doi-asserted-by": "crossref",
"journal-title": "Int J Antimicrob Agents",
"key": "10.1016/j.ijantimicag.2020.105988_bib0006",
"year": "2020"
},
{
"DOI": "10.1016/j.ijantimicag.2020.105932",
"article-title": "Chloroquine and hydroxychloroquine as available weapons to fight COVID-19",
"author": "Colson",
"doi-asserted-by": "crossref",
"journal-title": "Int J Antimicrob Agents",
"key": "10.1016/j.ijantimicag.2020.105988_bib0007",
"year": "2020"
},
{
"DOI": "10.5582/bst.2020.01047",
"article-title": "Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies",
"author": "Gao",
"doi-asserted-by": "crossref",
"first-page": "72",
"journal-title": "Biosci Trends",
"key": "10.1016/j.ijantimicag.2020.105988_bib0008",
"volume": "14",
"year": "2020"
},
{
"article-title": "[Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]",
"first-page": "E019",
"journal-title": "Zhonghua Jie He He Hu Xi Za Zhi",
"key": "10.1016/j.ijantimicag.2020.105988_bib0009",
"volume": "43",
"year": "2020"
},
{
"DOI": "10.1016/j.ijantimicag.2020.105949",
"article-title": "Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial",
"author": "Gautret",
"doi-asserted-by": "crossref",
"journal-title": "Int J Antimicrob Agents",
"key": "10.1016/j.ijantimicag.2020.105988_bib0010",
"year": "2020"
}
],
"reference-count": 10,
"references-count": 10,
"relation": {},
"resource": {
"primary": {
"URL": "https://linkinghub.elsevier.com/retrieve/pii/S092485792030145X"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [],
"subtitle": [],
"title": "Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals?",
"type": "journal-article",
"update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
"volume": "55"
}
