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Favipiravir-based treatment for outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Lan et al., Expert Review of Clinical Pharmacology, doi:10.1080/17512433.2022.2078701
May 2022  
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Systematic review and meta analysis of favipiravir RCTs, showing improved viral clearance and recovery, but no significant difference for mortality, ICU admission, or ventilation.
Currently there are 71 favipiravir studies and meta analysis shows:
OutcomeImprovement
Mortality11% lower [-5‑25%]
Ventilation10% higher [-23‑56%]
ICU admission31% higher [10‑56%]
Hospitalization4% higher [-13‑23%]
Lan et al., 17 May 2022, peer-reviewed, 6 authors.
This PaperFavipiravirAll
DOI record: { "DOI": "10.1080/17512433.2022.2078701", "ISSN": [ "1751-2433", "1751-2441" ], "URL": "http://dx.doi.org/10.1080/17512433.2022.2078701", "alternative-id": [ "10.1080/17512433.2022.2078701" ], "assertion": [ { "label": "Peer Review Statement", "name": "peerreview_statement", "order": 1, "value": "The publishing and review policy for this title is described in its Aims & Scope." }, { "URL": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierj20", "label": "Aim & Scope", "name": "aims_and_scope_url", "order": 2, "value": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierj20" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2022-01-15" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Revised", "name": "revised", "order": 1, "value": "2022-03-11" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2022-05-03" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2022-05-17" } ], "author": [ { "affiliation": [ { "name": "School of Pharmaceutical Sciences and Medical Technology, Putian University, Putian, 351100, China" } ], "family": "Lan", "given": "Shao-Huan", "sequence": "first" }, { "affiliation": [ { "name": "Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan" } ], "family": "Lai", "given": "Chih-Cheng", "sequence": "additional" }, { "affiliation": [ { "name": "Yijia Pharmacy, Tainan, 70846, Taiwan" } ], "family": "Chang", "given": "Shen-Peng", "sequence": "additional" }, { "affiliation": [ { "name": "School of Management, Putian University, Putian, 351100, China" } ], "family": "Lu", "given": "Li-Chin", "sequence": "additional" }, { "affiliation": [ { "name": "Division of Urology, Department of Surgery, Chi-Mei Hospital, Chia Li, Tainan, Taiwan" } ], "family": "Hung", "given": "Shun-Hsing", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Orthopedic, Chi Mei Medical Center, Tainan, 71004, Taiwan" } ], "family": "Lin", "given": "Wei-Ting", "sequence": "additional" } ], "container-title": "Expert Review of Clinical Pharmacology", "container-title-short": "Expert Review of Clinical Pharmacology", "content-domain": { "crossmark-restriction": true, "domain": [ "www.tandfonline.com" ] }, "created": { "date-parts": [ [ 2022, 5, 17 ] ], "date-time": "2022-05-17T08:53:10Z", "timestamp": 1652777590000 }, "deposited": { "date-parts": [ [ 2022, 5, 17 ] ], "date-time": "2022-05-17T08:53:24Z", "timestamp": 1652777604000 }, "indexed": { "date-parts": [ [ 2022, 5, 17 ] ], "date-time": "2022-05-17T09:13:44Z", "timestamp": 1652778824439 }, "is-referenced-by-count": 0, "issued": { 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