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Lactobacillus paragasseri SBT2055 Activates Plasmacytoid Dendritic Cells and Improves Subjective Symptoms of Common Cold in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Comparative Trial

Kobatake et al., Nutrients, doi:10.3390/nu15204458
Oct 2023  
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RCT showing benefits for the common cold with probiotic LG2055. This randomized, double-blind, placebo-controlled trial examined whether Lactobacillus paragasseri SBT2055 (LG2055) could suppress common cold symptoms by activating plasmacytoid dendritic cells (pDCs) in 200 healthy adults. In vitro experiments showed LG2055 upregulated pDC activation markers. In the clinical trial, the LG2055 group had significantly higher ratios of symptom-free days versus placebo for several common cold symptoms based on a daily questionnaire. Stratified analysis revealed LG2055 intake increased pDC activation markers at 12 weeks in participants with low salivary sIgA, suggesting activation of pDCs in immune-weakened individuals. In conclusion, LG2055 intake suppressed subjective common cold symptoms by activating pDCs and improving immunity, especially in immune-weakened adults.
The immune effects of probiotics are strain-specific.
Kobatake et al., 20 Oct 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Japan, peer-reviewed, 5 authors, study period October 2022 - May 2023. Contact: (corresponding author).
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Lactobacillus paragasseri SBT2055 Activates Plasmacytoid Dendritic Cells and Improves Subjective Symptoms of Common Cold in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Comparative Trial
Eiji Kobatake, Yoshitaka Iwama, Toshinobu Arai, Yuki Tsukisaka, Toshihide Kabuki
Nutrients, doi:10.3390/nu15204458
This study investigated whether Lactobacillus paragasseri SBT2055 (LG2055) activates plasmacytoid dendritic cells (pDCs) and suppresses common cold symptoms in healthy adults. Cell-based experiments showed that a LG2055 treatment upregulated CD86 and HLA-DR expression in pDCs, indicating that LG2055 activates pDCs in vitro. In a subsequent randomized, double-blind, placebocontrolled, parallel-group comparative trial, 200 participants were randomly divided into two groups and consumed three capsules with or without LG2055 once daily for 12 weeks. The primary outcome was the score on a daily physical health questionnaire survey of common cold symptoms. Three participants discontinued the trial and six participants were excluded from the analysis, thus 191 participants (95 in the LG2055 group and 96 in the placebo group) were analyzed. The LG2055 group showed a significantly higher ratio of "without symptoms" responses for runny nose, plugged nose, sneezing, sore throat, hoarseness, and chill than the placebo group. Furthermore, a stratified analysis revealed that LG2055 intake enhanced CD86 and HLA-DR expression in the pDCs of the participants with low secretion rates of salivary secretory immunoglobulin A. These data suggest that LG2055 suppresses the subjective symptoms of the common cold by activating pDCs and improving the host's immune system in healthy adults, especially in immune-weakened individuals (UMIN000049183).
Author Contributions: Conceptualization, E.K., Y.I., T.A., Y.T. and T.K.; Methodology, E.K. and T.K.; Formal analysis, E.K., Y.T. and T.K.; Investigation, E.K. and T.A.; Data curation, E.K., Y.T. and T.K.; Writing-original draft preparation, E.K.; Writing-review and editing, Y.I., T.A., Y.T. and T.K.; Visualization, E.K., Y.T. and T.K.; Supervision, Y.I.; Project administration, T.A. and T.K. All authors have read and agreed to the published version of the manuscript. Funding: This research received no external funding. Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Nihonbashi Cardiology Clinic (NJI-022-09-01, 28 September 2022). Informed Consent Statement: Informed consent was obtained from all participants involved in the study. Conflicts of Interest: Authors E.K., T.A. and T.K. were employed by MEGMILK SNOW BRAND Co., Ltd. Author Y.T. was employed by KSO Corporation. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
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