Increasing Natural Killer Cell Activity of Mineral Nanomaterial ALP1018 in Healthy Adults: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

DOI record: { "DOI": "10.3390/nu16060850", "ISSN": [ "2072-6643" ], "URL": "http://dx.doi.org/10.3390/nu16060850", "abstract": "<jats:p>This randomized, double-blind, placebo comparative clinical trial aimed to determine the immune-enhancing effects and safety of a nanomaterial with iron and zinc (ALP1018) in healthy adults. Participants who met the inclusion criteria were recruited for this study (n = 80) and randomly assigned to either the test group (n = 40), which was given Alp1018 in capsule form, or the placebo group (n = 40), which was given crystal cellulose capsules of identical appearance, weight, and flavor for 8 weeks. Compared to baseline, natural killer (NK) cell activity (%) increased in the test group after 8 weeks, although there were no changes in the placebo group. Furthermore, in the subgroup analysis of Coronavirus disease 2019 (COVID-19) affected participants, significantly increased NK cell activity was observed in the test group at 4 (p &lt; 0.05) and 8 weeks (p &lt; 0.05). No significant differences were observed in cytokine levels between the two groups. ALP1018 supplementation appeared to enhance immune function by improving NK cell activity without adverse effects in healthy adults.</jats:p>", "alternative-id": [ "nu16060850" ], "author": [ { "affiliation": [ { "name": "Department of Pharmacology, School of Medicine, Eulji University, Daejeon 34824, Republic of Korea" } ], "family": "Kim", "given": "Soon-Ae", "sequence": "first" }, { "affiliation": [ { "name": "Department of Nanotech Research and Development, Ferramed Inc., Daejeon 34141, Republic of Korea" } ], "family": "Kim", "given": "Seyl", "sequence": "additional" }, { "affiliation": [ { "name": "Research Institute, MediCRO Co., Ltd., Anyang 14067, Republic of Korea" } ], "family": "Chai", "given": "Hyungyung", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Nanotech Research and Development, Ferramed Inc., Daejeon 34141, Republic of Korea" }, { "name": "School of Pharmacy, University of Sydny, Sydney 2000, Australia" } ], "family": "Cho", "given": "Junlae", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9573-8849", "affiliation": [ { "name": "Department of Family Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of Korea" } ], "authenticated-orcid": false, "family": "Paek", "given": "Yu-Jin", "sequence": "additional" } ], "container-title": "Nutrients", "container-title-short": "Nutrients", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2024, 3, 15 ] ], "date-time": "2024-03-15T18:05:25Z", "timestamp": 1710525925000 }, "deposited": { "date-parts": [ [ 2024, 3, 15 ] ], "date-time": "2024-03-15T18:24:10Z", "timestamp": 1710527050000 }, "funder": [ { "award": [ "S3035146" ], "name": "the Technology Development Program" }, { "name": "Eulji University" } ], "indexed": { "date-parts": [ [ 2024, 3, 16 ] ], "date-time": "2024-03-16T00:39:12Z", "timestamp": 1710549552160 }, "is-referenced-by-count": 0, "issue": "6", "issued": { "date-parts": [ [ 2024, 3, 15 ] ] }, "journal-issue": { "issue": "6", "published-online": { "date-parts": [ [ 2024, 3 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 15 ] ], "date-time": "2024-03-15T00:00:00Z", "timestamp": 1710460800000 } } ], "link": [ { "URL": "https://www.mdpi.com/2072-6643/16/6/850/pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1968", "original-title": [], "page": "850", "prefix": "10.3390", "published": { "date-parts": [ [ 2024, 3, 15 ] ] }, "published-online": { "date-parts": [ [ 2024, 3, 15 ] ] }, "publisher": "MDPI AG", "reference": [ { "DOI": "10.1111/j.0022-202X.2005.23856.x", "article-title": "Old Meets New: The Interaction Between Innate and Adaptive Immunity", "author": "Clark", "doi-asserted-by": "crossref", "first-page": "629", "journal-title": "J. 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