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Increasing Natural Killer Cell Activity of Mineral Nanomaterial ALP1018 in Healthy Adults: A Randomized, Double-Blind, Placebo Comparative Clinical Trial

Kim et al., Nutrients, doi:10.3390/nu16060850
Mar 2024  
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RCT 80 healthy adults in Korea showing increased natural killer cell activity with ALP1018, a nanomineral supplement containing iron and zinc. The study found a statistically significant increase in NK cell activity at an E:T ratio of 50:1 in the ALP1018 group compared to placebo after 8 weeks. This effect was more pronounced in a subgroup of participants with a history of COVID-19 infection. No significant differences were observed in cytokine levels between the groups.
Kim et al., 15 Mar 2024, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 5 authors. Contact: (corresponding author),,,,
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Increasing Natural Killer Cell Activity of Mineral Nanomaterial ALP1018 in Healthy Adults: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
Soon-Ae Kim, Seyl Kim, Hyungyung Chai, Junlae Cho, Yu-Jin Paek
Nutrients, doi:10.3390/nu16060850
This randomized, double-blind, placebo comparative clinical trial aimed to determine the immune-enhancing effects and safety of a nanomaterial with iron and zinc (ALP1018) in healthy adults. Participants who met the inclusion criteria were recruited for this study (n = 80) and randomly assigned to either the test group (n = 40), which was given Alp1018 in capsule form, or the placebo group (n = 40), which was given crystal cellulose capsules of identical appearance, weight, and flavor for 8 weeks. Compared to baseline, natural killer (NK) cell activity (%) increased in the test group after 8 weeks, although there were no changes in the placebo group. Furthermore, in the subgroup analysis of Coronavirus disease 2019 (COVID-19) affected participants, significantly increased NK cell activity was observed in the test group at 4 (p < 0.05) and 8 weeks (p < 0.05). No significant differences were observed in cytokine levels between the two groups. ALP1018 supplementation appeared to enhance immune function by improving NK cell activity without adverse effects in healthy adults.
Conflicts of Interest: Author Seyl Kim and Junlae Cho was employed by the company Ferramed Inc. that manufactures ALP1018. Hyungyung Chai was employed by the company MediCRO Co. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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