Retrospective 171 primary biliary cholangitis (PBC) patients taking ursodeoxycholic acid (UDCA) and 128 family members, showing no reduction in SARS-CoV-2 infection rates but milder symptoms in PBC patients. All PBC patients and family members were infected with SARS-CoV-2. PBC patients reported significantly milder symptoms for nasal congestion, chest pain, sneezing, and taste abnormalities compared to family members.
Jia et al., 25 Jul 2024, retrospective, China, peer-reviewed, 8 authors.
Effect of ursodeoxycholic acid on symptoms after severe acute respiratory syndrome coronavirus 2 infection in patients with primary biliary cholangitis and their family members
Gui ， Jia, Chunmei ， Yang, Xiufang ， Wang, Juan ， Deng, Ruiqing ， Sun, Linhua ， Zheng, Yulong ， Shang, Ying Han
doi:10.12449/JCH240714
摘要： 目的 探究熊去氧胆酸(UDCA)对原发性胆汁性胆管炎(PBC)患者及其家属严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染症状的影响。方法 通过问卷收集 2023 年 3 月 22 日之前就诊于空军军医大学第一附属医院的 PBC 患者(n=
References
Albillos A, Lario, Cirrhosis-associated im• mune dysfunction: Distinctive features and clinical relevance[J], J Hepatol,
doi:10.1016/j.jhep.2014.08.010Cm, Xf, Effect of ursodeoxycholic acid on symptoms after severe acute respiratory syndrome coronavirus 2 infection in patients with primary biliary cholangitis and their family members[J], J Clin Hepatol
Dennis A, Wamil, Alberts, Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: A prospective, community-based study, BMJ Open,
doi:10.1136/bmjopen-2020-048391Gaziano, Giambartolomei, Pereira Ac, Actionable druggable genome-wide Mendelian randomization identifies repur• posing opportunities for COVID-19, J]. Nat Med,
doi:10.1038/s41591-021-01310-zIoannou Gn, Green, Risk factors for hospitaliza• tion, mechanical ventilation, or death among 10 131 US veterans with SARS-CoV-2 infection[J], JAMA Netw Open,
doi:10.1001/jamanetworkopen.2020.22310Khandker Ss, Godman, Mi, A systematic review on COVID-19 vaccine strategies, their effectiveness, and issues, J]. Vaccines,
doi:10.3390/vaccines9121387Shahrani, Sooi, Hilmi, Autoimmune hepatitis (AIH) following coronavirus (COVID-19) vaccine-No longer exclusive to mRNA vaccine?, Liver Int,
doi:10.1111/liv.15350Study, Liver, EASL Clinical Prac• tice Guidelines: The diagnosis and management of patients with pri• mary biliary cholangitis[J], J Hepatol,
doi:10.1016/j.jhep.2017.03.022Tian Dd, Yh, Xu Hh, The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant [J], J Med Virol,
doi:10.1002/jmv.27643贾桂, 王秀芳, 熊去氧胆酸对原发性胆汁性胆管炎患 者及家属新型冠状病毒感染症状的影响
