COVID-19 mortality is associated with low Vitamin D levels in patients with risk factors and/or advanced age
et al., Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2021.11.025, Nov 2021
Vitamin D for COVID-19
8th treatment shown to reduce risk in
October 2020, now with p < 0.00000000001 from 126 studies, recognized in 18 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
Retrospective 257 hospitalized patients in Hungary, showing mortality associated with lower vitamin D levels for all patients, for patients >60, and for age-matched patients with risk factors or age >60. The non-age-matched analyses are confounded by age, with elderly patients more likely to have lower vitamin D levels.
Jenei et al., 24 Nov 2021, peer-reviewed, 10 authors.
COVID-19 mortality is associated with low vitamin D levels in patients with risk factors and/or advanced age
Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2021.11.025
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Conflict of interest statement The authors do not declare any conflicts of interest
Author contributions
References
Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., None
Jolliffe, Camargo, Sluyter, Aglipay, Aloia et al., Vitamin D supplementation to prevent acute respiratory infections: a systematic review and metaanalysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol
Jolliffe, Stefanidis, Wang, Kermani, Dimitrov et al., Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med
Merzon, Tworowski, Gorohovski, Vinker, Cohen et al., Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study, FEBS J
Patchen, Clark, Gaddis, Hancock, Cassano, Genetically predicted serum vitamin D and COVID-19: a Mendelian randomisation study, BMJ Nutr Prev Health
Pereira, Damascena, Azevedo, De Almeida Oliveira, Da et al., Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis, Crit Rev Food Sci Nutr
Szeto, Zucker, Lasota, Rubin, Walker et al., Vitamin D Status and COVID-19 Clinical Outcomes in Hospitalized Patients, Endocr Res
Vimaleswaran, Forouhi, Khunti, Vitamin D and covid-19, BMJ
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