Proton Pump Inhibitor Use Is Not Strongly Associated With SARS-CoV-2 Related Outcomes: A Nationwide Study and Meta-analysis
Simone Bastrup Israelsen, Martin Thomsen Ernst, Andreas Lundh, Lene Fogt Lundbo, Håkon Sandholdt, Jesper Hallas, Thomas Benfield
Clinical Gastroenterology and Hepatology, doi:10.1016/j.cgh.2021.05.011
PPI use does not impact SARS-CoV-2 related outcomes No difference -Risk of infection -Severe outcomes
Supplementary Material Note: To access the supplementary material accompanying this article, visit the online version of Clinical Gastroenterology and Hepatology at www.cghjournal.org, and at https://doi.org/10.1016/j.cgh.2021.05.011.
Conflicts of interest This author discloses the following: Thomas Benfield reports grants from Novo Nordisk Foundation, grants from Simonsen Foundation, grants and personal fees from GSK, grants and personal fees from Pfizer, personal fees from Boehringer Ingelheim, grants and personal fees from Gilead, personal fees from MSD, grants from Lundbeck Foundation, grants from Kai Hansen Foundation, and personal fees from Pentabase A/S, with no relation to the work reported in this article. The remaining authors disclose no conflicts. Adjusted for age, sex, comorbidities (peptic ulcer, asthma, chronic obstructive pulmonary disease, cirrhosis, ischemic heart disease, diabetes, renal failure, heart failure, stroke, alcohol-related diagnoses, smoking-related diagnoses, major psychiatric disorders), other current medication use (systemic and inhaled corticosteroids, bronchodilators, H2-receptor antagonists, nonsteroidal anti-inflammatory drugs, anticholinergic agents, immunosuppressants, antipsychotic agents, antibiotics, alcohol abstinence treatment, smoking cessation treatment, blood pressure lowering drugs, lipid lowering drugs, glucose lowering drugs, antiplatelets, anticoagulants), Charlson Comorbidity Index (0, 1-2, 3þ), and number of hospital..
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Benfield, None, Conceptualization: Equal; Funding acquisition: Equal; Investigation: Equal; Methodology: Equal; Supervision: Lead; Writingreview & editing: Equal) Crude Death
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Thomsen, Formal analysis: Lead; Investigation: Equal; Methodology: Equal; Writingreview & editing: Supporting) Andreas Lundh (Formal analysis: Supporting; Investigation: Equal; Methodology: Equal; Writingreview & editing: Equal) Lene Fogt Lundbo (Conceptualization: Equal; Investigation: Equal; Methodology: Equal; Writingreview & editing: Equal) Håkon Sandholdt (Formal analysis: Supporting; Investigation: Equal; Methodology: Equal; Writingreview & editing: Supporting) Jesper Hallas (Investigation: Equal; Methodology: Equal; Supervision: Supporting; Writingreview & editing: Equal
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Zhou, Wang, Lee, Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity scorematched territory-wide study, Gut
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