Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Zinc  COVID-19 treatment studies for Zinc  C19 studies: Zinc  Zinc   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  

Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase

Herrera-Quintana et al., Research Square, doi:10.21203/ (Preprint)
Herrera-Quintana et al., Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and.., Research Square, doi:10.21203/ (Preprint)
Apr 2023   Source   PDF  
  All Studies   Meta
Prospective study of 86 critical COVID-19 patients in Spain reporting high prevalence of zinc deficiency. Zinc levels were predictive for severity.
Herrera-Quintana et al., 4 Apr 2023, prospective, Spain, preprint, 7 authors, study period 1 April, 2020 - 1 December, 2020.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperZincAll
Changes in trace elements and metallothioneins levels and their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 during the early ICU phase
Lourdes Herrera-Quintana, Héctor Vázquez-Lorente, Yenifer Gamarra-Morales, Jorge Molina-López, Vojtech Adam, Lukas Richtera, Elena Planells
Background The levels of trace elements and Metallothioneins (MTs) could play a key role in modulating the in ammatory reaction and pathogenesis of COVID-19. Their effects on clinical variables are of interest for the characterization and management of this disease. Thus, the present study aimed to investigate the association between circulating Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn), and MTs levels, as well as their relationship with clinical, biochemical, and in ammatory parameters in critical care patients with COVID-19 at early Intensive Care Unit (ICU) phase. Methods A total of 86 critically ill patients with COVID-19 were monitored from the rst day of admission to the ICU until the third day of stay. Clinical parameters were retrieved from the hospital database. Biochemical and in ammatory parameters were analyzed following enzymatic colorimetry and immunoassay procedures. Serum samples were used to assess mineral levels by inductively coupled plasma-mass spectrometry and MTs levels by differential pulse voltammetric. Results Levels of Cu and MTs decreased (all P ≤ 0.046) after 3 days of ICU stay, increasing the prevalence of Cu de cient values from 50-65.3% (P = 0.015) on the third day of ICU stay. Fe and Zn were shown to have a predictive value for mortality and severity. Changes in Fe were directly related to changes in Cu and Mn (all r ≥ 0.266; P ≤ 0.019). In contrast, changes in MTs were inversely related to changes in Mn and albumin (all r≥-0.255; P ≤ 0.039). Conclusions The present study indicated a risk of trace element de ciencies related to different biochemical and clinical parameters. We suggest monitoring the mineral status and performing nutritional interventions, when appropriate, that could help to improve the altered parameters, such as in ammatory conditions and, thus, the prognosis in critically ill patients with COVID-19.
Supplementary Files This is a list of supplementary les associated with this preprint. Click to download. SupplementaryMaterial.docx
Al-Saleh, Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity, BioMetals
Atrian, Capdevila, Metallothionein-protein interactions, Biomol. Concepts
Berger, ESPEN micronutrient guideline, Clin. Nutr
Calder, Nutrition, immunity and COVID-19, BMJ Nutr. Prev. Health
Camerlingo, Predictors of disease severity, clinical course, and therapeutic outcome in COVID-19 patients: our experience with 1,700 patients
Da Costa, Jalalizadeh, Yadollahvandmiandoab, Buosi, Reis, Effect of BCG on Respiratory Complications Caused by COVID-19: A Scoping Review, Int. J. Gen. Med
Engin, Engin, Engin, Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?, Environ. Toxicol. Pharmacol
Fath, Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients, J. Trace Elem. Med. Biol
Fernandes, Emerging COVID-19 variants and their on SARS-CoV-2 diagnosis, therapeutics and vaccines, Ann. Med
Gaetke, Chow, Copper toxicity, oxidative stress, and antioxidant nutrients, Toxicology
Hackler, Relation of Serum Copper Status to Survival in COVID-19, Nutrients
Hadi, Investigation of Serum Ferritin for the Prediction of COVID-19 Severity and Mortality: A Cross-Sectional Study, Cureus
Ivanova, Evaluation of zinc, copper, and Cu:Zn ratio in serum, and their implications in the course of COVID-19, J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS
Kernan, Carcillo, Hyperferritinemia and in ammation, Int. Immunol
Knaus, Draper, Wagner, Zimmerman, APACHE II: a severity of disease classi cation system, Crit. Care Med
Kocak, Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity, Biol. Trace Elem. Res
Krizkova, Electrophoretic ngerprint metallothionein analysis as a potential prostate cancer biomarker, Electrophoresis
Lindner, Lucchini, Broberg, Genetics and Epigenetics of Manganese Toxicity, Curr. Environ. Health Rep
Liu, Li, COVID-19: Attacks the 1-beta Chain of Hemoglobin to Disrupt Respiratory Function and Escape Immunity, doi:10.26434/chemrxiv-2021-dtpv3-v11
Maares, Free Zinc as a Predictive Marker for COVID-19 Mortality Risk, Nutrients
Maret, Inhibitory zinc sites in enzymes, BioMetals
Maret, The Metals in the Biological Periodic System of the Elements: Concepts and Conjectures, Int. J. Mol. Sci
Medical, World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects, JAMA
Milnerowicz, Jablonowska, Bizon, Change of Zinc, Copper, and Metallothionein Concentrations and the Copper-Zinc Superoxide Dismutase Activity in Patients With Pancreatitis, Pancreas
Nakazato, Determination of the serum metallothionein (MT)1/2 concentration in patients with Wilson's disease and Menkes disease, J. Trace Elem. Med. Biol
Notz, Clinical Signi cance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS, Nutrients
Oladipo, Ayo, Ambali, Mohammed, Evaluation of hepatorenal impairments in Wistar rats coexposed to lowdose lead, cadmium and manganese: insights into oxidative stress mechanism, Toxicol. Mech. Methods
Orihuela, Ferritin and metallothionein: dangerous liaisons, Chem. Commun. Camb. Engl
Osamor, Ikeakanam, Bishung, Abiodun, Ekpo, COVID-19 Vaccines: Computational tools and Development, Inform. Med. Unlocked, doi:10.1016/j.imu.2023.101164
Palmiter, The elusive function of metallothioneins, Proc. Natl. Acad. Sci. U. S. A
Parasher, COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment, Postgrad. Med. J
Polyzogopoulou, Amoiridou, Abraham, Ventoulis, Acute liver injury in COVID-19 patients hospitalized in the intensive care unit: Narrative review, World J. Gastroenterol
Sun, Kang, Prior Increase in Metallothionein Levels is Required to Prevent Doxorubicin Cardiotoxicity1, Exp. Biol. Med
Thirumoorthy, Manisenthil Kumar, Shyam Sundar, Panayappan, Chatterjee, Metallothionein: an overview, World J. Gastroenterol
Torreggiani, Structural Lesions of Proteins Connected to Lipid Membrane Damages Caused by Radical Stress: Assessment by Biomimetic Systems and Raman Spectroscopy, Biomolecules
Tsuchiya, Gustatory and Saliva Secretory Dysfunctions in COVID-19 Patients with Zinc De ciency, Life Basel Switz
Uddin, Hossain, Rahman, Uddin, Bhuiyan, Elemental Zinc Is Inversely Associated with C-Reactive Protein and Oxidative Stress in Chronic Liver Disease, Biol. Trace Elem. Res
Vincent, The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine, Intensive Care Med
Vázquez-Lorente, Effectiveness of eight-week zinc supplementation on vitamin D3 status and leptin levels in a population of postmenopausal women: A double-blind randomized trial, J. Trace Elem. Med. Biol, doi:10.1016/j.jtemb.2021.126730
Wellinghausen, Martin, Rink, Zinc inhibits interleukin-1-dependent T cell stimulation, Eur. J. Immunol
Wenzhong, Hualan, COVID-19: captures iron and generates reactive oxygen species to damage the human immune system, Autoimmunity
Yasmeen, Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators, Biochem. Pharmacol
Zeng, Yang, Yuan, Wang, Cheng, Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol
Zeng, Zhang, Wang, Yang, Cheng, Urinary trace elements in association with disease severity and outcome in patients with COVID-19, Environ. Res
Zhao, Yan, Qu, Interpretations of 'Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7), Chin. Med. J. (Engl.)
Zhou, Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19, Int. J. Clin. Pract
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop