The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918-1919 influenza pandemic in the United States
William B Grant, Sunlight, Edward Giovannucci
Deaths during the 1918-1919 influenza pandemic have been linked to both the influenza virus and secondary bacterial lung infections. Case fatality rates and percentage of influenza cases complicated by pneumonia were available from survey data for twelve United States locations in the 1918-1919 pandemic. This study analyzes case fatality rates and cases complicated by pneumonia with respect to estimated summertime and wintertime solar ultraviolet-B (UVB) doses as indicators of population mean vitamin D status. Substantial correlations were found for associations of July UVB dose with case fatality rates (r = -0.72, p = 0.009) and rates of pneumonia as a complication of influenza (r = -0.77, p = 0.005). Similar results were found for wintertime UVB. Vitamin D upregulates production of human cathelicidin, LL-37, which has both antimicrobial and antiendotoxin activities. Vitamin D also reduces the production of proinflammatory cytokines, which could also explain some of the benefit of vitamin D since H1N1 infection gives rise to a cytokine storm. The potential role of vitamin D status in reducing secondary bacterial infections and loss of life in pandemic influence requires further evaluation.
References
Adams, Hewison, Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity, Nat Clin Pract Endocrinol Metab
Aloia, Ng, Re: epidemic influenza and vitamin D, Epidemiol Infect
Ardizzone, Cassinotti, Trabattoni, Manzionna, Rainone et al., Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study, Int J Immunopathol Pharmacol
Bikle, Vitamin D and the immune system: role in protection against bacterial infection, Curr Opin Nephrol Hypertens
Britten, The incidence of epidemic influenza, 1918-19, Pub Health Rep
Brundage, Shanks, Deaths from bacterial pneumonia during 1918-19 influenza pandemic, Emerg Infect Dis
Cannell, Vieth, Umhau, Holick, Grant et al., Epidemic influenza and vitamin D, Epidemiol Infect
Cannell, Zasloff, Garland, Scragg, Giovannucci, On the epidemiology of influenza, Virol J
Cantorna, Mahon, D-hormone and the immune system, J Rheumatol Suppl
Chan, Cheung, Chui, Tsao, Nicholls et al., Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells, Respir Res
Cheung, Poon, Lau, Luk, Lau et al., Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?, Lancet
Cox, Brokstad, Haaheim, Pandemic influenza vaccine development: time is of the essence, Expert Rev Vaccines
Douglas, Strachan, Maxwell, Seasonality of tuberculosis: the reverse of other respiratory diseases in the UK, Thorax
Droebner, Reiling, Planz, Role of hypercytokinemia in NFkappaB p50-deficient mice after H5N1 influenza A virus infection, J Virol
Ferguson, Cummings, Fraser, Cajka, Cooley et al., Strategies for mitigating an influenza pandemic, Nature
Ginde, Mansbach, Camargo, Vitamin D, respiratory infections and asthma, Curr Allergy Asthma Rep
Grant, An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation, Cancer
Grant, Garland, The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates, Anticancer Res
Grant, Holick, Benefits and requirements of vitamin D for optimal health: a review, Altern Med Rev
Grant, Variations in vitamin D production could possibly explain the seasonality of childhood respiratory infections in Hawaii, Pediatr Infect Dis J
Gupta, George, Nguyen-Van-Tam, Bacterial pneumonia and pandemic influenza planning, Emerg Infect Dis
Halloran, Ferguson, Eubank, Longini, Jr et al., Modeling targeted layered containment of an influenza pandemic in the United States, Proc Natl Acad Sci
Hewison, Vitamin D and innate immunity, Curr Opin Investig Drugs
Holmøy, Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis, Med Hypotheses
Hsieh, Wu, Liu, Shao, Chang et al., Influenza pandemics: past, present and future, J Formos Med Assoc
Kash, Tumpey, Proll, Carter, Perwitasari et al., Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus, Nature
Leffell, Brash, Sunlight and skin cancer, Sci Am
Liu, Stenger, Li, Wenzel, Tan et al., Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response, Science
Liu, Stenger, Tang, Modlin, Cutting Edge: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin, J Immunol
Markel, Lipman, Navarro, Sloan, Michalsen et al., Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic, JAMA
Mccullers, Planning for an Influenza Pandemic: Thinking beyond the Virus, J Infect Dis
Mcdonald, Asian influenza in Great Britain 1957-58, Proc Roy Soc Med
Meyer, The role of immunity in susceptibility to respiratory infection in the aging lung, Respir Physiol
Mookherjee, Rehaume, Hancock, Cathelicidins and functional analogues as antisepsis molecules, Expert Opin Ther Targets
Morens, Taubenberger, Fauci, Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness, J Infect Dis
Muhe, Lulseged, Mason, Simoes, Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children, Lancet
Nichol, Nordin, Nelson, Mullooly, Hak, Effectiveness of influenza vaccine in the community-dwelling elderly, N Engl J Med
Nimmerjahn, Dudziak, Dirmeier, Hobom, Riedel et al., Active NFkappaB signalling is a prerequisite for influenza virus infection, J Gen Virol
Peterson, Heffernan, Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women, J Inflamm (Lond)
Richard, Sugaya, Simonsen, Miller, Viboud, A comparative study of the 1918-1920 influenza pandemic in Japan, USA and UK: mortality impact and implications for pandemic planning, Epidemiol Infect
Roth, Jones, Prosser, Robinson, Vohra, Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood, Eur J Clin Nutr
Salomon, Hoffmann, Webster, Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection, Proc Natl Acad Sci
Schleithoff, Zittermann, Tenderich, Berthold, Stehle et al., Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial, Am J Clin Nutr
Talmor, Bernheim, Klein, Green, Rashid, Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro, Eur J Clin Invest
Wayse, Yousafzai, Mogale, Filteau, Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5, Eur J Clin Nutr
White, Vitamin D signaling, infectious diseases and regulation of innate immunity, Infect Immun
White, Vitamin D signaling, infectious diseases, and regulation of innate immunity, Infect Immun
Yusuf, Piedimonte, Auais, Demmler, Krishnan et al., The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus, Epidemiol Infect
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