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All Studies   Meta Analysis    Recent:   

Adverse Effects of Aspirin, Acetaminophen, and Ibuprofen on Immune Function, Viral Shedding, and Clinical Status in Rhinovirus-Infected Volunteers

Graham et al., Journal of Infectious Diseases, doi:10.1093/infdis/162.6.1277
Dec 1990  
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Aspirin for COVID-19
19th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.000061 from 71 studies, recognized in 2 countries.
Lower risk for mortality and progression.
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RCT examining the effects of aspirin, acetaminophen, and ibuprofen on immune function, virus shedding, and clinical symptoms in 60 healthy volunteers experimentally infected with rhinovirus type 2. The study found that aspirin and acetaminophen use suppressed serum neutralizing antibody response and increased nasal obstruction compared to placebo, while ibuprofen had less noticeable effects. There were no significant differences in viral shedding, but a trend toward longer duration was seen with aspirin and acetaminophen. Their impact may be greater in vulnerable groups rather than the healthy patients studied here.
Study covers acetaminophen, aspirin, and ibuprofen.
Graham et al., 1 Dec 1990, Double Blind Randomized Controlled Trial, placebo-controlled, Australia, peer-reviewed, mean age 20.1, 5 authors.
This PaperAspirinAll
Adverse Effects of Aspirin, Acetaminophen, and Ibuprofen on Immune Function, Viral Shedding, and Clinical Status in Rhinovirus-Infected Volunteers
Dr Neil M H Graham, Christopher J Burrell, Robert M Douglas, Pamela Debelle, Lorraine Davies
A double-blind, placebo-controlled trial was conducted to study the effects of over-the-counter analgesic/antipyretic medications on virus shedding, immune response, and clinical status in the common cold. Sixty healthy volunteers were challenged intranasally with rhinovirus type 2 and randomized to one of four treatment arms: aspirin, acetaminophen, ibuprofen, or placebo. Fifty-six volunteers were successfully infected and shed virus on at least 4 days after challenge. Virus shedding, antibody levels, clinical symptoms and signs, and blood leukocyte levels were carefully monitored. Use of aspirin and acetaminophen was associated with suppression of serum neutralizing antibody response (P < .05 vs. placebo) and increased nasal symptoms and signs (P< .05 vs. placebo). A concomitant rise in circulating monocytes suggested that the suppression of antibody response may be mediated through drug effects on monocytes and/or mononuclear phagocytes, There were no significant differences in viral shedding among the four groups, but a trend toward longer duration of virus shedding was observed in the aspirin and acetaminophen groups. In 1975, Stanley et al. [1] reported that aspirin significantly increased virus shedding in rhinovirus-infected volunteers compared with those taking placebo. Because volunteers were started on aspirin before any symptoms had developed, this study did not replicate usual clinical practice but nonetheless suggested that aspirin might suppress the normal immune response to upper respiratory tract infection (URI). Mogabgab and Pollock [2] reported a subsequent experiment that found no differences in virus shedding between aspirin-and placebotreated volunteers. In that study, volunteers were not given medication until symptoms started, more closely reflecting the situation in community-acquired infections. Unfortunately, pharyngeal washings were used to detect virus shedding instead of the significantly more sensitive method of obtaining nasal or nasopharyngeal washings [3], yielding a very low infection rate. Thus, the evidence is equivocal, and the question of aspirin effects on virus shedding remains open. In addition to aspirin, acetaminophen and ibuprofen are
References
Ambrose, Symposium on in vitro studies of the immune response. 3. Biochemical agents affecting the inductive phase of the secondary antibody response initiated in vitro, Bacterio1 Rev
Bailey, Low, Pupillo, Reye's syndrome and aspirin use: a possible immunological relationship, Prostaglandins Leukot Essent Fatty Acids
Butler, Waldmanta, Rossen, Douglas, Jr et al., Changes in IgA and IgG concentrations in nasal secretions prior to the appearance of antibody during viral respiratory infection in man, J Immunol
Doran, Deangelis, Baumgardner, Mellits, Acetaminophen: more harm than good for chicken pox?, J Pediatr
Douglas, Cate, Gerone, Couch, Quantitative rhinovirus shedding patterns in volunteers, Am Rev Respir Dis
Lennette, Schmidt, Diagnostic procedures for viral, rickettsial and chlamydial infections
Meinert, Clinical trials. Design, conduct and analysis
Mestan, Digel, Mittnacht, Hillen, Blohm et al., Antiviral effects of recombinant tumor necrosis factor in vitro, Nature
Mogabgab, Pollack, Re: increased virus shedding with aspirin treatment of rhinovirus infection, JAMA
Naumann, On the defense mechanisms of the respiratory mucosa towards infection, Acta Otolaryngol (Stockh)
Nielsen, Webster, Inhibition of human polymorphonuclear leukocyte functions by ibuprofen, Immunopharmacology
Nossal, Current concepts: immunology. The basic components of the immune system, N Engl J Med
Panush, Anthony, Effects of acetylsalicylic acid on normal human peripheral blood lymphocytes. Inhibition of mitogen and antigen stimulated incorporation of tritiated thymidine, Clin Exp Immunol
Panush, Effects of certain antirheumatic drugs on normal human peripheral blood lymphocytes, Arthritis Rheum
Panush, Ossakow, Effects of acetaminophen on normal human peripheral blood lymphocytes: enhancement of mitogen and antigen stimulated incorporation of tritiated thymidine, Clin Exp Immunol
Pottathil, Chandrabose, Cuatrecasas, Lang, Establishment of the interferon mediated antiviral state: role of fatty acid cyclooxygenase, Proc Natl Acad Sci
Robert, Prill, Mann, Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus, J Exp Med
Root, Ryan, Humoral immunity and complement
Rossen, Butler, Waldman, Alford, Hornick et al., The proteins in nasal secretion. II. A longitudinal study of IgA and neutralizing antibody levels in nasal washings from men infected with influenza virus, JAMA
Rumore, Aron, Hiross, A review of mechanism of action of aspirin and its potential as an immunomodulating agent, Med Hypotheses
Skubitz, Hammerschmidt, Effects of ibuprofen on chemotactic peptide-receptor binding and granulocyte response, Biochem Phar-macoI
Smith, Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteriod anti-inflammatory agents and prostaglandins, J Pharmacol Exp Ther
Spagnuolo, Ellner, Salicylate blockade of granulocyte adherence and the inflammatory response to experimental peritonitis, Blood
Stanley, Jackson, Panusam, Rubenis, Dirda, Increased virus shedding with aspirin treatment of rhinovirus infection, JAMA
Starko, Ray, Lee, Stromberg, Woodall, Reye's syndrome and salicylate use, Pediatrics
Whittaker, Hughes, Khurshid, The effect of cytotoxic and anti-inflammatory drugs on the phagocytosis of neutrophilleucocytes, Br J Haematol
Wong, Goeddel, Tumor necrosis factors alpha and beta inhibit virus replication and synergize with interferons, Nature
Yousefi, Chiu, Carangdang, Archibeque, Vaziri et al., Effect of acetylsalicylic acid on production and action of leukocyte derived interferons, Antimicrob Agents Chemother
Zatz, Skotnicki, Bailey, Oliver, Goldstein, Mechanism of action of thymosin. 2. Effects of aspirin and thymosin on enhancement of IL-2 production, Immunopharmacology
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