NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 infected patients: impact of melatonin as a medicinal supplement

{ 'indexed': {'date-parts': [[2024, 5, 9]], 'date-time': '2024-05-09T09:45:51Z', 'timestamp': 1715247951841}, 'reference-count': 32, 'publisher': 'Walter de Gruyter GmbH', 'issue': '1-2', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 1, 27]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>The inflammasome as a multiprotein complex has a role in activating ' 'ASC and caspase-1 resulting in activating IL-1β in various infections and diseases like ' 'corona virus infection in various tissues. It was shown that these tissues are affected by ' 'COVID-19 patients. According to the current evidence, melatonin is not veridical while ' 'possessing a high safety profile, however, it possesses indirect anti-viral actions owing to ' 'its anti-oxidation, anti-inflammation, and immune improving properties. This study aims to ' 'assess the impacts of melatonin as the complementary treatments on oxidative stress agents ' 'and inflammasome activation in patients with COVID-19. Melatonin supplement (9\xa0mg daily, ' 'orally) was provided for the patients hospitalized with a COVID-19 analysis for 14\xa0days. ' 'For measuring IL-10, IL-1β, and TNF-α cytokines and malondialdehyde (MDA), nitric oxide (NO), ' 'and superoxide dismutase (SOD) level and the expression of <jats:italic>CASP1</jats:italic> ' 'and <jats:italic>ASC</jats:italic> genes, blood samples were gathered from the individuals at ' 'the start and termination of the therapy. Our findings indicated that melatonin is used as a ' 'complementary treatment to reduce the levels of TNF-α and IL-1β cytokines, MDA, and NO levels ' 'in COVID-19 patients and significantly increase SOD level, however, the levels of IL-10 ' 'cytokine possesses no considerable changes. The findings revealed that genes of ' '<jats:italic>CASP1</jats:italic> and <jats:italic>ASC</jats:italic> were dysregulated by ' 'melatonin regulating the inflammasome complex. Based on the findings of the current study, it ' 'is found that melatonin can be effective as a medicinal supplement in decreasing the ' 'inflammasome multiprotein complex and oxidative stress along with beneficial impacts on lung ' 'cytokine storm of COVID-19 patients.</jats:p>', 'DOI': '10.1515/znc-2021-0101', 'type': 'journal-article', 'created': {'date-parts': [[2021, 8, 6]], 'date-time': '2021-08-06T03:35:18Z', 'timestamp': 1628220918000}, 'page': '37-42', 'source': 'Crossref', 'is-referenced-by-count': 11, 'title': 'NLRP3 inflammasome activation and oxidative stress status in the mild and moderate SARS-CoV-2 ' 'infected patients: impact of melatonin as a\xa0medicinal supplement', 'prefix': '10.1515', 'volume': '77', 'author': [ { 'given': 'Hadi', 'family': 'Esmaeili Gouvarchin Ghaleh', 'sequence': 'first', 'affiliation': [ { 'name': 'Applied Virology Research Center, Baqiyatallah University of ' 'Medical Sciences , Tehran , Iran'}]}, { 'given': 'Abdolkarim', 'family': 'Hosseini', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Animal Sciences and Biotechnology, Faculty of Life ' 'Sciences and Biotechnology , Shahid Beheshti University , Tehran ' ', Iran'}]}, { 'given': 'Hossein', 'family': 'Aghamollaei', 'sequence': 'additional', 'affiliation': [ { 'name': 'Chemical Injuries Research Center, Systems Biology and ' 'Poisonings Institute, Baqiyatallah University of Medical ' 'Sciences , Tehran , Iran'}]}, { 'given': 'Mahdi', 'family': 'Fasihi-Ramandi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Molecular Biology Research Center, Systems Biology and ' 'Poisonings Institute, Baqiyatallah University of Medical ' 'Sciences , Tehran , Iran'}]}, { 'given': 'Gholamhossein', 'family': 'Alishiri', 'sequence': 'additional', 'affiliation': [ { 'name': 'Chemical Injuries Research Center, Systems Biology and ' 'Poisonings Institute, Baqiyatallah University of Medical ' 'Sciences , Tehran , Iran'}]}, { 'given': 'Ali', 'family': 'Saeedi-Boroujeni', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Immunology, Faculty of Medicine , Ahvaz ' 'Jundishapur University of Medical Sciences , Ahvaz , Iran'}, {'name': 'Abadan University of Medical Sciences , Abadan , Iran'}]}, { 'given': 'Kazem', 'family': 'Hassanpour', 'sequence': 'additional', 'affiliation': [ { 'name': 'Sabzevar University of Medical Sciences, School of Medicine , ' 'Sabzevar , Iran'}]}, { 'given': 'Mohammad-Reza', 'family': 'Mahmoudian-Sani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Thalassemia and Hemoglobinopathy Research Center, Health ' 'Research Institute, Ahvaz Jundishapur University of Medical ' 'Sciences , Ahvaz , Iran'}]}, { 'given': 'Gholamreza', 'family': 'Farnoosh', 'sequence': 'additional', 'affiliation': [ { 'name': 'Applied Biotechnology Research Center, Baqiyatallah University ' 'of Medical Sciences , Tehran , Iran'}]}], 'member': '374', 'published-online': {'date-parts': [[2021, 8, 6]]}, 'reference': [ { 'key': '2023040103062794722_j_znc-2021-0101_ref_001', 'doi-asserted-by': 'crossref', 'unstructured': 'Patel, S, Rahmani, B, Gandhi, J, Seyam, O, Joshi, G, Reid, I, et al.. 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