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Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

Gerayeli et al., medRxiv, doi:10.1101/2024.02.26.24302674
Feb 2024  
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Single-cell RNA sequencing study of airway cells from patients with persistent respiratory symptoms due to COVID-19 infection (pulmonary long COVID) over 1 year after initial infection. Authors found increased neutrophils and neutrophil activation signatures in pulmonary long COVID airway cells compared to controls. Ingenuity pathway analysis predicted that budesonide could potentially revert the airway cell gene expression signature of pulmonary long COVID patients to resemble that of controls.
Gerayeli et al., 28 Feb 2024, preprint, 18 authors. Contact:
Ex Vivo studies are an important part of preclinical research, however results may be very different in vivo.
This PaperBudesonideAll
Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID
Firoozeh V.Gerayeli, Hye Yun Park, Stephen Milne, Xuan Li, Chen Xi Yang, Josie Tuong, Rachel L Eddy, Elizabeth Guinto, Chung Y Cheung, Julia Shun-Wei Yang, Cassie Gilchrist, Dina Yehia, Tara Stach, Tawimas Shaipanich, Jonathon Leipsic, Graeme Koelwyn, Janice M Leung, M.D. Don D Sin
Single cell profiling shows the infiltration of neutrophils with upregulation of mucin genes in the airway mucosa of patients with pulmonary long COVID, indicating persistent small airway inflammation in pulmonary long COVID.
Author Contributions: FVG, XL,CXY ran the analysis and co-wrote the method section. JT and GK analyzed the IPA analysis and contributed to the method section & discussion section. FVG, HYP, SM,XL,CXY,CYC,JT ,GK and DDS were involved in interpretation of the results. FVG,SM,CYC,EG,RLD,CG,JSWY,TS, DA,TS,JML contributed to the experiment and data acquisition. FVG, HYP and DDS prepared the first draft of the manuscript. All authors contributed to revise the manuscript and approved the final draft of the manuscript. Supplemental Figures: Supplemental Figure S1A-C
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