Conv. Plasma
Nigella Sativa

All antiandrogen studies
Meta analysis
study COVID-19 treatment researchAntiandrogenAntiandrogens (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men with prostate cancer

Gedeborg et al., Scandinavian Journal of Urology, doi:10.1080/21681805.2021.2019304
Dec 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality -25% Improvement Relative Risk Antiandrogens  Gedeborg et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 24,174 patients in Sweden Higher mortality with antiandrogens (not stat. sig., p=0.11) Gedeborg et al., Scandinavian J. Urology, Dec 2021 Favorsantiandrogen Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020
*, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments.
Case control study with 474 patients that died of COVID-19 in Sweden, showing higher risk with ADT, without statistical significance.
risk of death, 25.0% higher, OR 1.25, p = 0.11, treatment 271 of 474 (57.2%) cases, 5,181 of 23,700 (21.9%) controls, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gedeborg et al., 23 Dec 2021, retrospective, Sweden, peer-reviewed, 6 authors.
This PaperAntiandrogensAll
Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men with prostate cancer
Rolf Gedeborg, Lars Lindhagen, Stacy Loeb, Johan Styrke, Hans Garmo, Pär Stattin
Scandinavian Journal of Urology, doi:10.1080/21681805.2021.2019304
Background: Androgens facilitate entrance of the severe acute respiratory syndrome coronavirus 2 into respiratory epithelial cells, and male sex is associated with a higher risk of death from corona virus disease . Androgen deprivation therapy (ADT) could possibly improve COVID-19 outcomes. Methods: In a case-control study nested in the Prostate Cancer data Base Sweden (PCBaSe) RAPID 2019, we evaluated the association between ADT and COVID-19 as registered cause of death in men with prostate cancer. Each case was matched to 50 controls by region. We used conditional logistic regression to adjust for confounders and also evaluated potential impact of residual confounding. Results: We identified 474 men who died from COVID-19 in March-December 2020. In crude analyses, ADT exposure was associated with an increased risk of COVID-19 death (odds ratio [OR] 5.05, 95% CI: 4.18-6.10); however, the OR was substantially attenuated after adjustment for age, comorbidity, prostate cancer characteristics at diagnosis, recent healthcare use, and indicators of advanced cancer (adjusted OR 1.25, 95% CI: 0.95-1.65). If adjustment has accounted for at least 85% of confounding, then the true effect could be no more than a 5% reduction of the odds for COVID-19 death. Conclusions: The increased mortality from COVID-19 in men with prostate cancer treated with ADT was mainly related to high age, comorbidity, and more advanced prostate cancer. There was no evidence to support the hypothesis that ADT is associated with improved COVID-19 outcomes.
Consent to participate The requirement for informed consent was waived by the Ethical Review Authority. Disclosure statement Ethics approval Approved by the Swedish Ethical Review Authority: Dnr 2020-03889.
Barlow, Westergren, Holmberg, The completeness of the Swedish cancer register: a sample survey for year 1998, Acta Oncol
Brooke, Talback, Hornblad, The Swedish cause of death register, Eur J Epidemiol
Caffo, Gasparro, Lorenzo, Incidence and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with metastatic castration-resistant prostate cancer, Eur J Cancer
Caffo, Zagonel, Baldessari, On the relationship between androgen-deprivation therapy for prostate cancer and risk of infection by SARS-CoV-2, Ann Oncol
Charlson, Pompei, Ales, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis
Cindolo, Francesco, Petragnani, Persistence and adherence to androgen deprivation therapy in men with prostate cancer: an administrative database study, Minerva Urol Nefrol
Damodaran, Lang, Jarrard, Targeting metastatic hormone sensitive prostate cancer: Chemohormonal therapy and new combinatorial approaches, J Urol
De Lusignan, Dorward, Correa, Risk factors for SARS-CoV-2 among patients in the oxford royal college of general practitioners research and surveillance centre primary care network: a cross-sectional study, Lancet Infect Dis
Galloway, Norton, Barker, A clinical risk score to identify patients with COVID-19 at high risk of critical care admission or death: an observational cohort study, J Infect
Gedeborg, Garmo, Robinson, Prescription-based prediction of baseline mortality risk among older men, PLoS One
Gedeborg, Styrke, Loeb, Androgen deprivation therapy and excess mortality in men with prostate cancer during the initial phase of the COVID-19 pandemic, PLoS One
Gedeborg, Sund, Lambe, An aggregated comorbidity measure based on the history of filled drug prescriptionsdevelopment and evaluation in two separate cohorts, Epidemiology
George, Garmo, Rudman, Long-term adherence to GnRH agonists in men with prostate cancer. A nation-wide population-based study in prostate cancer data base Sweden, Scand J Urol
Grasselli, Greco, Zanella, Network, Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy, JAMA Intern Med
Grundmark, Garmo, Zethelius, Anti-androgen prescribing patterns, patient treatment adherence and influencing factors; results from the nationwide PCBaSe Sweden, Eur J Clin Pharmacol
Gupta, Hayek, Wang, Investigators, Factors associated with death in critically ill patients with coronavirus disease 2019 in the US, JAMA Intern Med
Hagel, Garmo, Bill-Axelson, PCBaSe Sweden: a register-based resource for prostate cancer research, Scand J Urol Nephrol
Hoffmann, Kleine-Weber, Schroeder, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Klein, Li, Milinovich, Androgen deprivation therapy in men with prostate cancer does not affect risk of infection with SARS-CoV-2, J Urol
Koskinen, Carpen, Honkanen, Androgen deprivation and SARS-CoV-2 in men with prostate cancer, Ann Oncol
Lee, Cazier, Starkey, COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study, Lancet
Ludvigsson, Andersson, Ekbom, External review and validation of the Swedish national inpatient register, BMC Public Health
Lycken, Drevin, Garmo, Adherence to guidelines for androgen deprivation therapy after radical prostatectomy: Swedish population-based study, Scand J Urol
Meng, Lu, Guo, Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis, J Hematol Oncol
Montopoli, Zumerle, Vettor, Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N ¼ 4532), Ann Oncol
Paner, Stadler, Hansel, Updates in the eighth edition of the tumor-node-metastasis staging classification for urologic cancers, Eur Urol
Patanavanich, Glantz, Smoking is associated with COVID-19 progression: a Meta-analysis, Nicotine Tob Res
Patel, Zhong, Liaw, Does androgen deprivation therapy protect against severe complications from COVID-19?, Ann Oncol
Pranata, Lim, Yonas, Body mass index and outcome in patients with COVID-19: a dose-response Meta-analysis, Diabetes Metab
Quan, Sundararajan, Halfon, Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data, Med Care
Savitz, Bar On, Ae, Estimating and correcting for confounder misclassification, Am J Epidemiol
Scully, Haverfield, Ursin, Considering how biological sex impacts immune responses and COVID-19 outcomes, Nat Rev Immunol
Suttmann, Gleissner, Huebner, Adherence measures for patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate plus prednisone: results of a prospective, cluster-randomized trial, Cancers
Takahashi, Iwasaki, Sex differences in immune responses, Science
Van Hemelrijck, Garmo, Wigertz, Cohort profile update: the national prostate cancer register of Sweden and prostate cancer data base-a refined prostate cancer trajectory, Int J Epidemiol
Wallerstedt, Wettermark, Hoffmann, The first decade with the Swedish prescribed drug register -a systematic review of the output in the scientific literature, Basic Clin Pharmacol Toxicol
White, Royston, Wood, Multiple imputation using chained equations: issues and guidance for practice, Stat Med
{ 'indexed': {'date-parts': [[2022, 3, 30]], 'date-time': '2022-03-30T20:03:30Z', 'timestamp': 1648670610596}, 'reference-count': 38, 'publisher': 'Informa UK Limited', 'license': [ { 'start': { 'date-parts': [[2021, 12, 23]], 'date-time': '2021-12-23T00:00:00Z', 'timestamp': 1640217600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': ''}], 'funder': [ { 'DOI': '10.13039/501100004359', 'name': 'Swedish Research Council', 'doi-asserted-by': 'publisher', 'award': ['2020-05866']}], 'content-domain': {'domain': [''], 'crossmark-restriction': True}, 'short-container-title': ['Scandinavian Journal of Urology'], 'DOI': '10.1080/21681805.2021.2019304', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 12, 23]], 'date-time': '2021-12-23T12:46:16Z', 'timestamp': 1640263576000}, 'page': '1-8', 'update-policy': '', 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': [ 'Androgen deprivation therapy, comorbidity, cancer stage and mortality from COVID-19 in men ' 'with prostate cancer'], 'prefix': '10.1080', 'author': [ { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Rolf', 'family': 'Gedeborg', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Surgical Sciences, Uppsala University, Uppsala, ' 'Sweden'}]}, { 'given': 'Lars', 'family': 'Lindhagen', 'sequence': 'additional', 'affiliation': [{'name': 'Uppsala Clinical Research Center (UCR), Uppsala, Sweden'}]}, { 'given': 'Stacy', 'family': 'Loeb', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Urology and Population Health, New York University ' 'and Manhattan Veterans Affairs Medical Center, New York, NY, ' 'USA;'}]}, { 'given': 'Johan', 'family': 'Styrke', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Surgical and Perioperative Sciences, Urology and ' 'Andrology, Umeå University, Umeå, Sweden'}]}, { 'given': 'Hans', 'family': 'Garmo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Surgical Sciences, Uppsala University, Uppsala, ' 'Sweden'}, { 'name': "Translational Oncology and Urology Research (TOUR), King's " "College London, Guy's Hospital, London, UK"}]}, { 'given': 'Pär', 'family': 'Stattin', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Surgical Sciences, Uppsala University, Uppsala, ' 'Sweden'}]}], 'member': '301', 'published-online': {'date-parts': [[2021, 12, 23]]}, 'reference': [ {'key': 'CIT0001', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamainternmed.2020.3596'}, {'key': 'CIT0002', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamainternmed.2020.3539'}, {'key': 'CIT0003', 'author': 'Galloway JB', 'year': '2020', 'journal-title': 'J Infect'}, { 'key': 'CIT0004', 'doi-asserted-by': 'crossref', 'first-page': '1034', 'author': 'de Lusignan S', 'year': '2020', 'journal-title': 'Lancet Infect Dis', 'DOI': '10.1016/S1473-3099(20)30371-6'}, { 'issue': '6527', 'key': 'CIT0005', 'doi-asserted-by': 'crossref', 'first-page': '347', 'DOI': '10.1126/science.abe7199', 'volume': '371', 'author': 'Takahashi T', 'year': '2021', 'journal-title': 'Science'}, {'key': 'CIT0006', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41577-020-0348-8'}, {'key': 'CIT0007', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cell.2020.02.052'}, { 'issue': '5', 'key': 'CIT0008', 'doi-asserted-by': 'crossref', 'first-page': '876', 'DOI': '10.1097/JU.0000000000000117', 'volume': '201', 'author': 'Damodaran S', 'year': '2019', 'journal-title': 'J Urol'}, { 'key': 'CIT0009', 'doi-asserted-by': 'crossref', 'first-page': '1040', 'author': 'Montopoli M', 'year': '2020', 'journal-title': 'Ann Oncol', 'DOI': '10.1016/j.annonc.2020.04.479'}, { 'key': 'CIT0010', 'unstructured': ' The National Library of Medicine (NLM) at the ' 'National Institutes of Health (NIH); 2020. [29 November 2020].'}, {'key': 'CIT0011', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.annonc.2020.06.005'}, { 'issue': '10', 'key': 'CIT0012', 'doi-asserted-by': 'crossref', 'first-page': '1417', 'DOI': '10.1016/j.annonc.2020.06.015', 'volume': '31', 'author': 'Koskinen M', 'year': '2020', 'journal-title': 'Ann Oncol'}, {'key': 'CIT0013', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0255966'}, {'key': 'CIT0014', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/ije/dyv305'}, {'key': 'CIT0015', 'doi-asserted-by': 'publisher', 'DOI': '10.3109/00365590903024577'}, {'key': 'CIT0016', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/02841860802247664'}, {'key': 'CIT0017', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s10654-017-0316-1'}, {'key': 'CIT0018', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/bcpt.12613'}, {'key': 'CIT0019', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/1471-2458-11-450'}, {'key': 'CIT0020', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/21681805.2019.1702093'}, {'key': 'CIT0021', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00228-012-1290-x'}, { 'issue': '5', 'key': 'CIT0022', 'doi-asserted-by': 'crossref', 'first-page': '615', 'DOI': '10.23736/S0393-2249.19.03595-1', 'volume': '72', 'author': 'Cindolo L', 'year': '2020', 'journal-title': 'Minerva Urol Nefrol'}, {'key': 'CIT0023', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/21681805.2020.1750475'}, { 'issue': '9', 'key': 'CIT0024', 'doi-asserted-by': 'crossref', 'first-page': '2550', 'DOI': '10.3390/cancers12092550', 'volume': '12', 'author': 'Suttmann H', 'year': '2020', 'journal-title': 'Cancers (Basel)'}, {'key': 'CIT0025', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eururo.2017.12.018'}, { 'key': 'CIT0026', 'doi-asserted-by': 'publisher', 'DOI': '10.1097/01.mlr.0000182534.19832.83'}, {'key': 'CIT0027', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/0021-9681(87)90171-8'}, {'key': 'CIT0028', 'doi-asserted-by': 'publisher', 'DOI': '10.1097/EDE.0000000000001358'}, {'key': 'CIT0029', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0241439'}, {'key': 'CIT0030', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/sim.4067'}, { 'issue': '5', 'key': 'CIT0031', 'doi-asserted-by': 'crossref', 'first-page': '1062', 'DOI': '10.1093/oxfordjournals.aje.a115210', 'volume': '129', 'author': 'Savitz DA', 'year': '1989', 'journal-title': 'Am J Epidemiol'}, {'key': 'CIT0032', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.annonc.2020.06.023'}, { 'key': 'CIT0033', 'doi-asserted-by': 'crossref', 'first-page': '140', 'DOI': '10.1016/j.ejca.2020.09.018', 'volume': '140', 'author': 'Caffo O', 'year': '2020', 'journal-title': 'Eur J Cancer'}, { 'issue': '2', 'key': 'CIT0034', 'doi-asserted-by': 'crossref', 'first-page': '441', 'DOI': '10.1097/JU.0000000000001338', 'volume': '205', 'author': 'Klein EA', 'journal-title': 'J Urol'}, {'key': 'CIT0035', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s13045-020-00907-0'}, {'key': 'CIT0036', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)31173-9'}, {'key': 'CIT0037', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.diabet.2020.07.005'}, {'key': 'CIT0038', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/ntr/ntaa082'}], 'container-title': ['Scandinavian Journal of Urology'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 12, 23]], 'date-time': '2021-12-23T12:46:25Z', 'timestamp': 1640263585000}, 'score': 1, 'resource': {'primary': {'URL': ''}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 12, 23]]}, 'references-count': 38, 'alternative-id': ['10.1080/21681805.2021.2019304'], 'URL': '', 'relation': {}, 'ISSN': ['2168-1805', '2168-1813'], 'issn-type': [{'value': '2168-1805', 'type': 'print'}, {'value': '2168-1813', 'type': 'electronic'}], 'subject': ['Urology', 'Nephrology'], 'published': {'date-parts': [[2021, 12, 23]]}, 'assertion': [ { 'value': 'The publishing and review policy for this title is described in its Aims & ' 'Scope.', 'order': 1, 'name': 'peerreview_statement', 'label': 'Peer Review Statement'}, { 'value': '', 'URL': '', 'order': 2, 'name': 'aims_and_scope_url', 'label': 'Aim & Scope'}, { 'value': '2021-10-05', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-11-30', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-12-23', 'order': 3, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop