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Outcomes and Laboratory and Clinical Findings of Asthma and Allergic Patients Admitted With Covid-19 in a Spanish University Hospital

García-Menaya et al., Frontiers in Pharmacology, doi:10.3389/fphar.2020.570721
Sep 2020  
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Mortality -228% Improvement Relative Risk ICU admission -392% Proton Pump Inhibitors  García-Menaya et al.  Prophylaxis Is prophylaxis with proton pump inhibitors beneficial for COVID-19? Retrospective 113 patients in Spain (March - April 2020) Higher mortality (p=0.008) and ICU admission (p=0.017) c19early.org García-Menaya et al., Frontiers in Pha.., Sep 2020 FavorsPPIs Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 112 treatments. c19early.org
Retrospective 113 hospitalized COVID-19 patients in Spain showing higher mortality and ICU admission with PPI use.
risk of death, 228.0% higher, RR 3.28, p = 0.008, treatment 15 of 54 (27.8%), control 5 of 59 (8.5%), adjusted per study, multivariable.
risk of ICU admission, 392.0% higher, RR 4.92, p = 0.02, treatment 9 of 54 (16.7%), control 2 of 59 (3.4%), adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
García-Menaya et al., 16 Sep 2020, retrospective, Spain, peer-reviewed, mean age 67.6, 5 authors, study period 16 March, 2020 - 24 April, 2020. Contact: jesusmiguelgarciamenaya@gmail.com.
This PaperPPIsAll
Outcomes and Laboratory and Clinical Findings of Asthma and Allergic Patients Admitted With Covid-19 in a Spanish University Hospital
Jesús Miguel García-Menaya, Concepción Cordobés-Durán, Juan Francisco Rangel-Mayoral, Elena García-Martín, José A G Agúndez
Frontiers in Pharmacology, doi:10.3389/fphar.2020.570721
conducted at Badajoz University Hospital Complex, which is the largest hospital in Extremadura, Spain. 1 World Health Organization (WHO). Naming the coronavirus disease (COVID-19) and the virus that causes it. Available from: https://www.who.int/emergencies/ diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirusdisease-(covid-2019)-and-the-virus-that-causes-it [
DATA AVAILABILITY STATEMENT All datasets presented in this study are included in the article/ Supplementary Material. ETHICS STATEMENT The studies involving human participants were reviewed and approved by The Research Ethics Committee of the Badajoz Health Area. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements because the data was collected as part of routine clinical care. AUTHOR CONTRIBUTIONS All authors contributed to the article and approved the submitted version. JG-M and CC-D wrote the first draft of the manuscript. EG-M and JA wrote sections of the manuscript and performed statistical analysis. JG-M acquired data. SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2020.570721/ full#supplementary-material Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Bradding, Richardson, Hinks, Howarth, Choy et al., ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2020.05.013
Ceylan, Estimation of COVID-19 prevalence in Italy, Spain, and France, Sci. Total Environ, doi:10.1016/j.scitotenv.2020.138817
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, doi:10.1016/S0140-6736(20)30211-7
Drosten, Günther, Preiser, Van Der Werf, Brodt et al., Identification of a novel coronavirus in patients with severe acute respiratory syndrome, N. Engl. J. Med, doi:10.1056/NEJMoa030747
Du, Liang, Yang, Wang, Cao et al., Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study, Eur. Respir. J, doi:10.1183/13993003.00524-2020
Du, Tu, Zhu, Mu, Wang et al., Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study, Am. J. Respir. Crit. Care Med, doi:10.1164/rccm.202003-0543OC
Gaig, Ferrer, Muñoz-Lejarazu, Lleonart, Garcıá-Abujeta et al., Prevalencia de alergia en la poblacioń adulta española, Alergol. Inmunol. Clin
Garg, Kim, Whitaker, O'halloran, Cummings et al., Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 -COVID-NET, 14 States, MMWR. Morb. Mortal. Wkly. Rep, doi:10.15585/mmwr.mm6915e3
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int. J. Antimicrob. Agents, doi:10.1016/j.ijantimicag.2020.105949
Goyal, Choi, Pinheiro, Schenck, Chen et al., Clinical Characteristics of Covid-19 in New York City, N. Engl. J. Med, doi:10.1056/NEJMc2010419
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis, Eur. Respir. J, doi:10.1183/13993003.00547-2020
Guan, Ni, Hu, Liang, Ou et al., Clinical Characteristics of Coronavirus Disease 2019 in China, N. Engl. J. Med, doi:10.1056/NEJMoa2002032
Guzik, Mohiddin, Dimarco, Patel, Savvatis et al., COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options, Cardiovasc. Res, doi:10.1093/cvr/cvaa106
Halpin, Faner, Sibila, Badia, Agusti, Do chronic respiratory diseases or their treatment affect the risk of SARS-CoV-2 infection?, Lancet Respir. Med, doi:10.1016/S2213-2600(20)30167-3
Halpin, Singh, Hadfield, Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective, Eur. Respir. J, doi:10.1183/13993003.01009-2020
Hegde, Does asthma make COVID-19 worse?, Nat. Rev. Immunol, doi:10.1038/s41577-020-0324-3
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Jackson, Busse, Bacharier, Kattan, O'connor et al., Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2020.04.009
Johnston, Asthma and COVID-19: Is asthma a risk factor for severe outcomes?, Allergy, doi:10.1111/all.14348
Lechien, Chiesa-Estomba, Place, Van Laethem, Cabaraux et al., Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019, J. Intern. Med, doi:10.1111/joim.13089
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2020.04.006
Lindsley, Schwartz, Rothenberg, Eosinophil responses during COVID-19 infections and coronavirus vaccination, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2020.04.021
Liu, Li, Zhou, Guan, Xiang, Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?, J. Autoimmun, doi:10.1016/j.jaut.2020.102452
Liu, Xu, Zhang, Xuan, Yan et al., Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression, Int. J. Infect. Dis, doi:10.1016/j.ijid.2020.03.013
Lu, Zhao, Li, Niu, Yang et al., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Lancet, doi:10.1016/S0140-6736(20)30251-8
Maes, Bracke, Brusselle, COVID-19, Asthma, and Inhaled Corticosteroids: Another Beneficial Effect of Inhaled Corticosteroids?, Am. J. Respir. Crit. Care Med, doi:10.1164/rccm.202005-1651ED
Mahdavinia, Foster, Jauregui, Moore, Adnan et al., Asthma prolongs intubation in COVID-19, J. Allergy Clin. Immunol. Pract, doi:10.1016/j.jaip.2020.05.006
Mehra, Desai, Ruschitzka, Patel, Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet, doi:10.1016/S0140-6736(20)31180-6
Mehra, Ruschitzka, Patel, Retraction-Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet, doi:10.1016/S0140-6736(20)31324-6
Moorthy, Dubey, Samanta, Adebajo, Aggarwal et al., COVID-19 and ethnicity: Spotlight on the global rheumatology issues in developing and developed countries, Int. J. Rheumatol. Dis, doi:10.1111/1756-185X.13883
Niedzwiedz, O'donnell, Jani, Demou, Ho et al., Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank, BMC Med, doi:10.1186/s12916-020-01640-8
Pennington, Asthma increases risk of severity of COVID-19, Cleve. Clin. J. Med, doi:10.3949/ccjm.87a.ccc002
Peters, Sajuthi, Deford, Christenson, Rios et al., COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids, Am. J. Respir. Crit. Care Med, doi:10.1164/rccm.202003-0821OC
Phua, Weng, Ling, Egi, Lim et al., Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations, Lancet Respir. Med, doi:10.1016/S2213-2600(20)30161-2
Quirce, Plaza, Picado, Vennera, Casafont, Prevalence of uncontrolled severe persistent asthma in pneumology and allergy hospital units in Spain, J. Investig. Allergol. Clin. Immunol
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area, JAMA, doi:10.1001/jama.2020.6775
Ruan, Yang, Wang, Jiang, Song, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive Care Med, doi:10.1007/s00134-020-05991-x
Sajuthi, Deford, Jackson, Montgomery, Everman et al., Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium, bioRxiv preprint Server Biol, doi:10.1101/2020.04.09.034454
Solaimanzadeh, Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19, Cureus, doi:10.7759/cureus.8069
Sotgiu, Gerli, Centanni, Miozzo, Canonica et al., Advanced forecasting of SARS-CoV-2-related deaths in Italy, Germany, Spain, and New York State, Allergy, doi:10.1111/all.14327
Spiteri, Fielding, Diercke, Campese, Enouf et al., First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24, Euro Surveill, doi:10.2807/1560-7917.ES.2020.25.9.2000178
Tan, Zhao, Ma, Wang, Niu et al., A novel coronavirus genome identified in a cluster of pneumonia cases-Wuhan, China 2019-2020, China CDC Wkly, doi:10.46234/ccdcw2020.017
Wang, Hu, Hu, Zhu, Liu et al., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China, JAMA, doi:10.1001/jama.2020.1585
Wang, Yin, Hu, Liu, Zhang et al., Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China, Crit. Care, doi:10.1186/s13054-020-02895-6
Zaki, Van Boheemen, Bestebroer, Osterhaus, Fouchier, Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia, N. Engl. J. Med, doi:10.1056/NEJMoa1211721
Zhang, Dong, Cao, Yuan, Yang et al., Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China, Allergy, doi:10.1111/all.14238
Zhao, Xu, Yin, Hu, Xiong et al., Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study, BMC Infect. Dis, doi:10.1186/s12879-020-05010-w
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, doi:10.1016/S0140-6736(20)30566-3
Zhu, Zhang, Wang, Li, Yang et al., A Novel Coronavirus from Patients with Pneumonia in China 2019, N. Engl. J. Med, doi:10.1056/NEJMoa2001017
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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