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Outcomes and Laboratory and Clinical Findings of Asthma and Allergic Patients Admitted With Covid-19 in a Spanish University Hospital

García-Menaya et al., Frontiers in Pharmacology, doi:10.3389/fphar.2020.570721
Sep 2020  
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Mortality -228% Improvement Relative Risk ICU admission -392% PPIs for COVID-19  García-Menaya et al.  Prophylaxis Is prophylaxis with PPIs beneficial for COVID-19? Retrospective 113 patients in Spain (March - April 2020) Higher mortality (p=0.008) and ICU admission (p=0.017) c19early.org García-Menaya et al., Frontiers in Pha.., Sep 2020 FavorsPPI Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 109 treatments. c19early.org
Retrospective 113 hospitalized COVID-19 patients in Spain showing higher mortality and ICU admission with PPI use.
risk of death, 228.0% higher, RR 3.28, p = 0.008, treatment 15 of 54 (27.8%), control 5 of 59 (8.5%), adjusted per study, multivariable.
risk of ICU admission, 392.0% higher, RR 4.92, p = 0.02, treatment 9 of 54 (16.7%), control 2 of 59 (3.4%), adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
García-Menaya et al., 16 Sep 2020, retrospective, Spain, peer-reviewed, mean age 67.6, 5 authors, study period 16 March, 2020 - 24 April, 2020. Contact: jesusmiguelgarciamenaya@gmail.com.
This PaperPPIsAll
Outcomes and Laboratory and Clinical Findings of Asthma and Allergic Patients Admitted With Covid-19 in a Spanish University Hospital
Jesús Miguel García-Menaya, Concepción Cordobés-Durán, Juan Francisco Rangel-Mayoral, Elena García-Martín, José A G Agúndez
Frontiers in Pharmacology, doi:10.3389/fphar.2020.570721
conducted at Badajoz University Hospital Complex, which is the largest hospital in Extremadura, Spain. 1 World Health Organization (WHO). Naming the coronavirus disease (COVID-19) and the virus that causes it. Available from: https://www.who.int/emergencies/ diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirusdisease-(covid-2019)-and-the-virus-that-causes-it [
DATA AVAILABILITY STATEMENT All datasets presented in this study are included in the article/ Supplementary Material. ETHICS STATEMENT The studies involving human participants were reviewed and approved by The Research Ethics Committee of the Badajoz Health Area. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements because the data was collected as part of routine clinical care. AUTHOR CONTRIBUTIONS All authors contributed to the article and approved the submitted version. JG-M and CC-D wrote the first draft of the manuscript. EG-M and JA wrote sections of the manuscript and performed statistical analysis. JG-M acquired data. SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2020.570721/ full#supplementary-material Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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