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Effects of Nirmatrelvir/ritonavir (paxlovid) on the nervous system: analysis on adverse events released by FDA

Gao et al., Expert Opinion on Drug Safety, doi:10.1080/14740338.2025.2471509
Feb 2025  
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Adverse event disproportionality analysis for COVID-19 drugs showing significantly higher risk of neurological adverse events with paxlovid.
Gao et al., 26 Feb 2025, peer-reviewed, 5 authors.
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DOI record: { "DOI": "10.1080/14740338.2025.2471509", "ISSN": [ "1474-0338", "1744-764X" ], "URL": "http://dx.doi.org/10.1080/14740338.2025.2471509", "alternative-id": [ "10.1080/14740338.2025.2471509" ], "assertion": [ { "label": "Peer Review Statement", "name": "peerreview_statement", "order": 1, "value": "The publishing and review policy for this title is described in its Aims & Scope." }, { "URL": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ieds20", "label": "Aim & Scope", "name": "aims_and_scope_url", "order": 2, "value": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ieds20" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2024-07-05" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Revised", "name": "revised", "order": 1, "value": "2024-10-17" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2024-10-18" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2025-02-26" } ], "author": [ { "affiliation": [ { "name": "Chongqing Medical University", "place": [ "Chongqing, China" ] } ], "family": "Gao", "given": "Caixia", "sequence": "first" }, { "affiliation": [ { "name": "Chongqing Medical University", "place": [ "Chongqing, China" ] } ], "family": "Liu", "given": "Zhihui", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-1651-591X", "affiliation": [ { "name": "Chongqing Medical University", "place": [ "Chongqing, China" ] } ], "authenticated-orcid": false, "family": "Zou", "given": "Zhen", "sequence": "additional" }, { "affiliation": [ { "name": "Chongqing Medical University", "place": [ "Chongqing, China" ] } ], "family": "Mao", "given": "Lejiao", "sequence": "additional" }, { "affiliation": [ { "name": "Chongqing Medical University", "place": [ "Chongqing, China" ] } ], "family": "Zhang", "given": "Jun", "sequence": "additional" } ], "container-title": "Expert Opinion on Drug Safety", "container-title-short": "Expert Opinion on Drug Safety", "content-domain": { "crossmark-restriction": true, "domain": [ "www.tandfonline.com" ] }, "created": { "date-parts": [ [ 2025, 2, 27 ] ], "date-time": "2025-02-27T03:03:32Z", "timestamp": 1740625412000 }, "deposited": { "date-parts": [ [ 2025, 2, 27 ] ], "date-time": "2025-02-27T03:03:58Z", "timestamp": 1740625438000 }, "indexed": { "date-parts": [ [ 2025, 2, 27 ] ], "date-time": "2025-02-27T05:33:26Z", "timestamp": 1740634406437, "version": "3.38.0" }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2025, 2, 26 ] ] }, "language": "en", "link": [ { "URL": "https://www.tandfonline.com/doi/pdf/10.1080/14740338.2025.2471509", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "301", "original-title": [], "prefix": "10.1080", "published": { "date-parts": [ [ 2025, 2, 26 ] ] }, "published-online": { "date-parts": [ [ 2025, 2, 26 ] ] }, "publisher": "Informa UK Limited", "reference": [ { "DOI": "10.1056/NEJMoa2208822", "doi-asserted-by": "publisher", "key": "e_1_3_8_3_1" }, { "DOI": "10.1038/s41591-021-01283-z", "article-title": "Post-acute COVID-19 syndrome", "author": "Nalbandian A.", "doi-asserted-by": "crossref", "first-page": "601", "issue": "4", "journal-title": "Nat Med", "key": "e_1_3_8_4_1", "unstructured": "Nalbandian, A., et al., Post-acute COVID-19 syndrome. 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