Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of Early COVID-19 and Treated at Home Within 3 Days or After 3 Days of Symptom Onset with Prescribed and Non-Prescribed Treatments Between November 2020 and August 2021
Fazio et al.,
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of..,
Medical Science Monitor, doi:10.12659/MSM.935379
Retrospective 158 COVID-19 patients in Italy treated with hesperidin, quercetin, indomethacin, aspirin, omeprazole, azithromycin, LMWH, and betamethasone (treatment specific for each patient), showing significantly lower hospitalization and faster recovery with early treatment. Severity at baseline was similar in both groups.
Fazio et al., 8 Dec 2021, retrospective, Italy, peer-reviewed, 6 authors, study period November 2020 - August 2021.
Contact:
serafazio50@gmail.com, paolo.bellavite@gmail.com.
Abstract: CLINICAL RESEARCH
e-ISSN 1643-3750
© Med Sci Monit, 2021; 27: e935379
DOI: 10.12659/MSM.935379
Received:
Accepted:
Available online:
Published:
Retrospective Study of Outcomes and
Hospitalization Rates of Patients in Italy with
a Confirmed Diagnosis of Early COVID-19 and
Treated at Home Within 3 Days or After 3 Days
of Symptom Onset with Prescribed and NonPrescribed Treatments Between November 2020
and August 2021
2021.11.05
2021.11.25
2021.12.08
2021.12.30
Authors’ Contribution:
Study Design A
Data Collection B
Statistical Analysis C
Data Interpretation D
Manuscript Preparation E
Literature Search F
Funds Collection G
ABDEF 1
AE 2
CD 3
DE 4
AD 5
ABF 6
Serafino Fazio
Paolo Bellavite
Elisabetta Zanolin
Peter A. McCullough
Sergio Pandolfi
Flora Affuso
1 Retired Professor of Internal Medicine, Medical School University Federico II,
Naples, Italy
2 Physiopathology Chair, Homeopathic Medical School of Verona, Verona, Italy
3 Unit of Epidemiology and Medical Statistics, Department of Diagnostics and
Public Health, University of Verona, Verona, Italy
4 Department of Cardiology, Truth for Health Foundation, Tucson, AZ, USA
5 Department of Neurosurgery, Villa Mafalda Clinics, Rome, Italy
6 Independent Researcher, Gallipoli, Italy
Corresponding Authors:
Financial support:
Conflict of interest:
Serafino Fazio, e-mail: serafazio50@gmail.com, Paolo Bellavite, e-mail: paolo.bellavite@gmail.com
None declared
Paolo Bellavite has a consultancy agreement with Vanda s.r.l. (Frascati, Rome), but he had no role in the treatments. Other authors have no competing interests to declare
Background:
This retrospective study aimed to investigate outcomes and hospitalization rates in patients with a confirmed
diagnosis of early COVID-19 treated at home with prescribed and non-prescribed treatments.
The medical records of a cohort of 158 Italian patients with early COVID-19 treated at home were analyzed.
Treatments consisted of indomethacin, low-dose aspirin, omeprazole, and a flavonoid-based food supplement,
plus azithromycin, low-molecular-weight heparin, and betamethasone as needed. The association of treatment
timeliness and of clinical variables with the duration of symptoms and with the risk of hospitalization was evaluated by logistic regression.
Patients were divided into 2 groups: group 1 (n=85) was treated at the earliest possible time (<72 h from onset of symptoms), and group 2 (n=73) was treated >72 h after the onset of symptoms. Clinical severity at the
beginning of treatment was similar in the 2 groups. In group 1, symptom duration was shorter than in group
2 (median 6.0 days vs 13.0 days, P<0.001) and no hospitalizations occurred, compared with 19.18% hospitalizations in group 2. One patient in group 1 developed chest X-ray alterations and 2 patients experienced an
increase in D-dimer levels, compared with 30 and 22 patients, respectively, in group 2. The main factor determining the duration of symptoms and the risk of hospitalization was the delay in starting therapy (P<0.001).
This real-world study of patients in the community showed that early diagnosis and early supportive patient
management reduced the severity of COVID-19 and reduced the rate of hospitalization.
Material/Methods:
Results:
Conclusions:
Keywords:
Full-text PDF:
Anti-Inflammatory Agents, Non-Steroidal • COVID-19 • Drug Therapy, Combination • Flavonoids •
Hospitalization • Indomethacin
https://www.medscimonit.com/abstract/index/idArt/935379
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