Conv. Plasma
Nigella Sativa

All vitamin D studies
Meta analysis
study COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The association between micronutrient and hemogram values and prognostic factors in COVID-19 patients: A single-center experience from Turkey

Ersöz et al., International Journal of Clinical Practice, doi:10.1111/ijcp.14078
Feb 2021  
  Source   PDF   All Studies   Meta AnalysisMeta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 310 hospitalized COVID-19 patients in Turkey, showing patients that were admitted to the ICU, intubated, or died had lower vitamin D levels compared to those that were not (statistically significant for ICU admission).
Study covers vitamin B9 and vitamin D.
Ersöz et al., 8 Feb 2021, peer-reviewed, 2 authors.
This PaperVitamin DAll
The association between micronutrient and hemogram values and prognostic factors in COVID‐19 patients: A single‐center experience from Turkey
Ayşegül Ersöz, Tarık Eren Yılmaz
International Journal of Clinical Practice, doi:10.1111/ijcp.14078
Aim: The contribution of micronutrients to the immune system has been known for a long time. This study aimed to investigate the association between the micronutrient levels and hemogram values and prognostic factors of the disease in COVIDpatients in Ankara City Hospital. Materials and methods: Our study is a descriptive observational study based on a retrospective review of patient files. COVID-19 patients over 18 years of age who were admitted to our hospital between 14 March and 1 June 2020, and with a complete micronutrient profile were included in the study. Age, gender, chronic diseases, micronutrient concentrations in the last 6 months, hemogram data on the day of hospitalization, total length of stay in hospital, and hospitalization to Intensive Care Unit (ICU)-intubation-death status of the patients were obtained from the patient files. Results: A total of 310 patients whose parameters were thoroughly examined were included in our study; 51.9% of them were men and the mean age of all patients was 57.02 ± 18.28 years, and the most common comorbid disease was hypertension. The percentage of patients who were followed in the ICU, were intubated, and died was 34.5%, 13.9%, and 9.4%, respectively. The mean length of hospital stay was 15.87 ± 12.79 days. Low folate, iron, vitamin D, and hemoglobin levels of the patients and high vitamin B12 concentration were more related to poor prognostic factors. The number of white blood cells was significantly higher in patients with a worse prognosis, and the number of lymphocytes was lower in patients with ICU admission but higher in intubated and dead patients. Conclusion : Micronutrient and hemogram values, advanced age, being male, and having comorbid diseases were correlated with the poor prognosis of COVIDinfection. Deficiency of Iron, Folate, and vitamin D should be well-considered in COVID-19. Excessive vitamin B12 and multivitamin supplementation should be avoided by choosing supplement wisely. In addition, attention should be paid to leukocytosis, lymphocyte counts, and anemia during COVID-19 patient follow-up.
Ahn, Shin, Kim, Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19), J Microbiol Biotechnol
Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J
Bellmann-Weiler, Lanser, Barket, Prevalence and predictive value of anemia and dysregulated iron homeostasis in patients with COVID-19 infection, J Clin Med
Chen, Wu, Chen, Yang, Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study, BMJ
Dağcıoğlu, Hekimliğinde, Seçimler, Bütüncül Tıp Birinci Basamakta ve Aile Hekimliğinde Güncel Tanı ve Tedavi
Ghasemian, Shamshirian, Heydari, The role of vitamin D in the age of COVID-19: a systematic review and meta-analysis along with an ecological approach, medRxiv, doi:10.1101/2020.06.05.20123554
Gombart, Pierre, Maggini, A review of micronutrients and the immune system-working in harmony to reduce the risk of infection, Nutrients
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res
Im, Je, Baek, Chung, Kwon et al., Nutritional status of patients with COVID-19, Int J Infect Dis
Itelman, Wasserstrum, Segev, Clinical characterization of 162 COVID-19 patients in Israel: Preliminary Report from a Large Tertiary Center, Isr Med Assoc J
Jain, Chaurasia, Sengar, Singh, Mahor et al., Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Sci Rep
Jammal, Deneuville, Mario, Concentration plasmatique élevée de la vitamine B12: Un indicateur des maladies hépatiques ou tumorales, Rev Med Interne
Kang, Jung, Age-related morbidity and mortality among patients with COVID-19, Infect Chemother
Kerget, Kerget, Kızıltunç, Evaluation of the relationship of serum vitamin D levels in COVID-19 patients with clinical course and prognosis, Tuberkuloz ve toraks
Kernan, Carcillo, Hyperferritinemia and inflammation, Int Immunol
Koronavirüs, None
Li, Cao, Chen, Hematological features of persons with COVID-19, Leukemia
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Nandy, Salunke, Pathak, Coronavirus disease (COVID-19): a systematic review and meta-analysis to evaluate the impact of various comorbidities on serious events, Diabetes Metab Syndr
Panagiotou, Tee, Ihsan, Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clin Endocrinol
Schiffrin, Flack, Ito, Muntner, Webb, Hypertension and COVID-19, Am J Hypertens
Spagnolo, Manson, Joffe, Sex, and gender differences in health: what the COVID-19 pandemic can teach us, Ann Int Med
Starke, Petereit-Haack, Schubert, The age-related risk of severe outcomes due to covid-19 infection: a rapid review, meta-analysis, and meta-regression, Int J Environ Res Public Health
Tan, Wang, Zhang, Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study, Signal Transduct Target Ther
Tao, Xu, Chen, Anemia is associated with severe illness in COVID-19: a retrospective cohort study, J Med Virol
Wang, Hu, Hu, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA
Wessling-Resnick, Crossing the iron gate: why and how transferrin receptors mediate viral entry, Annu Rev Nutr
Yuan, Huang, Ye, Changes of hematological and immunological parameters in COVID-19 patients, Int J Hematol
Zaki, Alashwal, Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: a systematic review, Diabetes Metab Syndr
Şimşek, Kara, Baran-Aksakal, Contact tracing management of the COVID-19 pandemic. Turk Hij Den Biyol Derg
{ 'DOI': '10.1111/ijcp.14078', 'ISSN': ['1368-5031', '1742-1241'], 'URL': '', 'alternative-id': ['10.1111/ijcp.14078'], 'archive': ['Portico'], 'assertion': [ { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Received', 'name': 'received', 'order': 0, 'value': '2021-01-07'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Accepted', 'name': 'accepted', 'order': 1, 'value': '2021-02-03'}, { 'group': {'label': 'Publication History', 'name': 'publication_history'}, 'label': 'Published', 'name': 'published', 'order': 2, 'value': '2021-02-17'}], 'author': [ { 'affiliation': [ { 'name': 'Department of Family Medicine Ankara City Hospital, University ' 'of Health Sciences Ankara Turkey'}], 'family': 'Ersöz', 'given': 'Ayşegül', 'sequence': 'first'}, { 'ORCID': '', 'affiliation': [ { 'name': 'Department of Family Medicine Ankara City Hospital, University ' 'of Health Sciences Ankara Turkey'}], 'authenticated-orcid': False, 'family': 'Yılmaz', 'given': 'Tarık Eren', 'sequence': 'additional'}], 'container-title': ['International Journal of Clinical Practice'], 'content-domain': {'crossmark-restriction': True, 'domain': ['']}, 'created': {'date-parts': [[2021, 2, 8]], 'date-time': '2021-02-08T11:15:36Z', 'timestamp': 1612782936000}, 'deposited': { 'date-parts': [[2021, 10, 16]], 'date-time': '2021-10-16T02:10:13Z', 'timestamp': 1634350213000}, 'indexed': {'date-parts': [[2021, 12, 9]], 'date-time': '2021-12-09T01:36:11Z', 'timestamp': 1639013771578}, 'is-referenced-by-count': 3, 'issn-type': [{'type': 'print', 'value': '1368-5031'}, {'type': 'electronic', 'value': '1742-1241'}], 'issue': '6', 'issued': {'date-parts': [[2021, 2, 17]]}, 'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2021, 6]]}}, 'language': 'en', 'license': [ { 'URL': '', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 2, 17]], 'date-time': '2021-02-17T00:00:00Z', 'timestamp': 1613520000000}}, { 'URL': '', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2021, 2, 17]], 'date-time': '2021-02-17T00:00:00Z', 'timestamp': 1613520000000}}], 'link': [ { 'URL': '', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '311', 'original-title': [], 'prefix': '10.1111', 'published': {'date-parts': [[2021, 2, 17]]}, 'published-online': {'date-parts': [[2021, 2, 17]]}, 'published-print': {'date-parts': [[2021, 6]]}, 'publisher': 'Wiley', 'reference': [ {'DOI': '10.4014/jmb.2003.03011', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_2_1'}, {'DOI': '10.3390/nu12010236', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_3_1'}, { 'key': 'e_1_2_11_4_1', 'unstructured': 'Guidelines of COVID‐19 (SARS ‐ CoV ‐ 2 Infection) Adult Patient ' 'Management of The Ministry of Health of the Republic of ' 'Turkey[Internet].‐66926/eriskin‐hasta‐tedavisi.html. ' 'Accessed January 1 2021.'}, {'DOI': '10.1093/ajh/hpaa057', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_5_1'}, {'DOI': '10.1016/j.dsx.2020.07.005', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_6_1'}, {'DOI': '10.1016/j.dsx.2020.06.064', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_7_1'}, {'DOI': '10.7326/M20-1941', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_8_1'}, { 'article-title': 'Clinical characteristics of 113 deceased patients with coronavirus ' 'disease 2019: retrospective study', 'author': 'Chen T', 'first-page': '1', 'issue': '1091', 'journal-title': 'BMJ', 'key': 'e_1_2_11_9_1', 'volume': '368', 'year': '2020'}, {'DOI': '10.3947/ic.2020.52.2.154', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_10_1'}, { 'article-title': 'The age‐related risk of severe outcomes due to covid‐19 infection: a ' 'rapid review, meta‐analysis, and meta‐regression', 'author': 'Starke KR', 'first-page': '1', 'journal-title': 'Int J Environ Res Public Health', 'key': 'e_1_2_11_11_1', 'volume': '17', 'year': '2020'}, { 'key': 'e_1_2_11_12_1', 'unstructured': 'Genel Koronavirüs Tablosu ' '[Internet].‐66935/genel‐koronavirus‐tablosu.html#. ' 'Accessed January 1 2021.'}, { 'DOI': '10.5505/TurkHijyen.2020.80688', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_13_1'}, { 'article-title': 'Vitamin D supplementation to prevent acute respiratory tract ' 'infections: systematic review and meta‐analysis of individual ' 'participant data', 'author': 'Martineau AR', 'first-page': '1', 'issue': '6583', 'journal-title': 'BMJ', 'key': 'e_1_2_11_14_1', 'volume': '356', 'year': '2017'}, { 'article-title': 'Vitamin D status and outcomes for hospitalised older patients with ' 'COVID‐19', 'author': 'Baktash V', 'first-page': '1', 'journal-title': 'Postgrad Med J', 'key': 'e_1_2_11_15_1', 'year': '2020'}, { 'DOI': '10.1007/s40520-020-01570-8', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_16_1'}, { 'article-title': 'The role of vitamin D in the age of COVID‐19: a systematic review and ' 'meta‐analysis along with an ecological approach', 'author': 'Ghasemian R', 'first-page': '1', 'journal-title': 'medRxiv', 'key': 'e_1_2_11_17_1', 'year': '2020'}, {'DOI': '10.5578/tt.70027', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_18_1'}, { 'DOI': '10.1038/s41598-020-77093-z', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_19_1'}, {'DOI': '10.1111/cen.14276', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_20_1'}, { 'DOI': '10.1146/annurev-nutr-082117-051749', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_21_1'}, {'DOI': '10.1093/intimm/dxx031', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_22_1'}, {'DOI': '10.3390/jcm9082429', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_23_1'}, {'DOI': '10.1002/jmv.26444', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_24_1'}, { 'DOI': '10.1007/s12185-020-02930-w', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_25_1'}, { 'article-title': 'Clinical characterization of 162 COVID‐19 patients in Israel: ' 'Preliminary Report from a Large Tertiary Center', 'author': 'Itelman E', 'first-page': '271', 'journal-title': 'Isr Med Assoc J', 'key': 'e_1_2_11_26_1', 'volume': '22', 'year': '2020'}, { 'DOI': '10.1016/j.revmed.2012.10.006', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_27_1'}, { 'DOI': '10.1016/j.ijid.2020.08.018', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_28_1'}, { 'article-title': 'Aile Hekimliğinde Akıllı Seçimler', 'author': 'Dağcıoğlu BF', 'first-page': '153', 'journal-title': 'Bütüncül Tıp Birinci Basamakta ve Aile Hekimliğinde Güncel Tanı ve ' 'Tedavi', 'key': 'e_1_2_11_29_1', 'volume': '1', 'year': '2020'}, {'DOI': '10.1038/s41392-020-0148-4', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_30_1'}, {'DOI': '10.1001/jama.2020.1585', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_31_1'}, { 'DOI': '10.1038/s41375-020-0910-1', 'doi-asserted-by': 'publisher', 'key': 'e_1_2_11_32_1'}], 'reference-count': 31, 'references-count': 31, 'relation': {}, 'score': 1, 'short-container-title': ['Int J Clin Pract'], 'short-title': [], 'source': 'Crossref', 'subject': ['General Medicine'], 'subtitle': [], 'title': [ 'The association between micronutrient and hemogram values and prognostic factors in COVID‐19 ' 'patients: A single‐center experience from Turkey'], 'type': 'journal-article', 'update-policy': '', 'volume': '75'}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop