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Scientific Opinion on the substantiation of health claims related to selenium and protection of DNA, proteins and lipids from oxidative damage (ID 277, 283, 286, 1289, 1290, 1291, 1293, 1751), function of the immune system (ID 278), thyroid function (ID 279, 282, 286, 1289, 1290, 1291, 1293), function of the heart and blood vessels (ID 280), prostate function (ID 284), cognitive function (ID 285) and spermatogenesis (ID 396) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

EFSA, EFSA Journal, doi:10.2903/j.efsa.2009.1220
Oct 2009  
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European Food Safety Administration review concluding that there is a causal relationship between the intake of selenium and immune system function.
EFSA et al., 1 Oct 2009, peer-reviewed, 18 authors.
This PaperSeleniumAll
Scientific Opinion on the substantiation of health claims related to selenium and protection of DNA, proteins and lipids from oxidative damage (ID 277, 283, 286, 1289, 1290, 1291, 1293, 1751), function of the immune system (ID 278), thyroid function (ID 2
Jean-Louis Bresson, Albert Flynn, Marina Heinonen, Karin Hulshof, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Hildegard Przyrembel, Seppo Salminen, J J ) Strain, Stephan Strobel, Inge Tetens, Henk Van Den Berg, Hendrik Van Loveren, Hans Verhagen
EFSA Journal, doi:10.2903/j.efsa.2009.1220
Nutrition and Allergies (NDA) 2 European Food Safety Authority (EFSA), Parma, Italy
INFORMATION AS PROVIDED IN THE CONSOLIDATED LIST The consolidated list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006 3 submitted by Member States contains main entry claims with corresponding conditions of use and literature from similar health claims. The information provided in the consolidated list for the health claims subject to this opinion is tabulated in appendix C. APPENDICES APPENDIX A BACKGROUND AND TERMS OF REFERENCE AS PROVIDED BY THE EUROPEAN COMMISSION The Regulation 1924/2006 on nutrition and health claims made on foods 6 (hereinafter "the Regulation") entered into force on 19 th January 2007. Article 13 of the Regulation foresees that the Commission shall adopt a Community list of permitted health claims other than those referring to the reduction of disease risk and to children's development and health. This Community list shall be adopted through the Regulatory Committee procedure and following consultation of the European Food Safety Authority (EFSA). Health claims are defined as "any claim that states, suggests or implies that a relationship exists between a food category, a food or one of its constituents and health". In accordance with Article 13 (1) health claims other than those referring to the reduction of disease risk and to children's development and health are health claims describing or referring to: a) the role of a nutrient or other substance in growth, development and the functions of the body;..
References
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Gupta, Prostate cancer chemoprevention: current status and future prospects, Toxicol. Appl. Pharmacol
Kryukov, Castellano, Novoselov, Lobanov, Zehtab et al., Characterization of Mammalian Selenoproteomes, Science
Kuiper, Kester, Peeters, Visser, Biochemical mechanisms of thyroid hormone deiodination, Thyroid
Lippman, Klein, Goodman, Lucia, Thompson et al., Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT), JAMA
Papp, Lu, Holmgren, Khanna, From selenium to selenoproteins: synthesis, identity, and their role in human health, Antioxid. Redox Signal
Peters, Foster, Chatterjee, Schatzkin, Reding et al., Serum selenium and risk of prostate cancer-a nested case-control study, Am. J. Clin. Nutr
Puppa, Savaskan, Brauer, Behne, Kyriakopoulos, The role of selenite on microglial migration, Ann. N.Y. Acad. Sci
Schweizer, Brauer, Kohrle, Nitsch, Savaskan, Selenium and brain function: a poorly recognized liaison, Brain Res. Rev
Thomson, Assessment of requirements for selenium and adequacy of selenium status: a review, Eur. J. Clin. Nutr
Xu, Wang, Gu, Yang, Song et al., Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease, Biomed. Environ. Sci
Yousuf, Atif, Ahmad, Hoda, Khan et al., Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus, Brain Res
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