Prevalence and clinical features of COVID-19 in a large cohort of 199 patients with sarcoidosis
Anne-Claire Desbois, Cindy Marques, Leila Lefèvre, Serge Barmo, Camille Lorenzo, Mathilde Leclercq, Gaëlle Leroux, Chloé Comarmond, Catherine Chapelon, Fanny Domont, Mathieu Vautier, David Saadoun, Patrice Cacoub
doi:10.21203/rs.3.rs-41653/v1
Objective: To investigate the prevalence, clinical features and outcomes of coronavirus disease 2019 (COVID-19) among sarcoidosis patients.
Methods: We retrospectively collected features of COVID-19 in a cohort of patients with sarcoidosis followed in a single tertiary university hospital. Results: Among 199 sarcoidosis patients [mean age 58.8 (±14) years, 86 (43.2%) men], 26 (13%) were diagnosed with , probable (n=12) and possible (n=7) ]. Twenty-four out of 26 patients (92%) had at least one comorbidity, and 11/26 (42%) had two or more comorbidities. Demographic and clinical features of COVID-19 positive patients were similar to those of COVID-19 negative patients. The administration of hydroxychloroquine or immunosuppressant was not associated with the occurrence or the severity of COVID-19. Four out of 26 (15.4%) COVID-19 positive patients required admission to hospital and two of them died. Hospitalized patients [mean age of 61 (±11.5) years] were receiving higher doses of long term treatment with corticosteroids than nonhospitalized patients; 4/4 had pulmonary and 2/4 cardiac involvement of sarcoidosis, and all one or more comorbidity.
Conclusion: The prevalence of COVID-19 in sarcoidosis is slightly higher to that of the general population. Almost half of the COVID-19 positive patients have two or more comorbidities and about 15% present a severe course.
Declarations
Ethics approval and consent to participate: The study was approved by our institutional ethics review board "Ethics committee of research in Sorbonne University". All patients gave informed consent. Consent for publication: Not applicable.
Competing interests: The authors declare that they have no competing interests.
Authors' contributions: ACD contributed to the conception and design of the work. ACD and CM wrote the manuscript. ACD, CM, LL, SB, CL, ML, GL, CC, CCA, FD, MV and DS collected the data. CM have drafted the work PC supervised the findings of this work. All authors approved the final manuscript.
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' <jats:p><jats:bold>Objective: </jats:bold>To investigate the prevalence, clinical '
'features and outcomes of coronavirus disease 2019 (COVID-19) among sarcoidosis patients. '
'Methods: We retrospectively collected features of COVID-19 in a cohort of patients with '
'sarcoidosis followed in a single tertiary university hospital. '
'<jats:bold>Results:</jats:bold> Among 199 sarcoidosis patients [mean age 58.8 (±14) years, 86 '
'(43.2%) men], 26 (13%) were diagnosed with COVID-19 [definite (n=7), probable (n=12) and '
'possible (n=7)]. Twenty-four out of 26 patients (92%) had at least one comorbidity, and 11/26 '
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'patients were similar to those of COVID-19 negative patients. The administration of '
'hydroxychloroquine or immunosuppressant was not associated with the occurrence or the '
'severity of COVID-19. Four out of 26 (15.4%) COVID-19 positive patients required admission to '
'hospital and two of them died. Hospitalized patients [mean age of 61 (±11.5) years] were '
'receiving higher doses of long term treatment with corticosteroids than non-hospitalized '
'patients; 4/4 had pulmonary and 2/4 cardiac involvement of sarcoidosis, and all one or more '
'comorbidity. <jats:bold>Conclusion:</jats:bold> The prevalence of COVID-19 in sarcoidosis is '
'slightly higher to that of the general population. Almost half of the COVID-19 positive '
'patients have two or more comorbidities and about 15% present a severe course.</jats:p>',
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