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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 18% Improvement Relative Risk Zinc for COVID-19  Citu et al.  Prophylaxis Is prophylaxis with zinc + calcium beneficial for COVID-19? Retrospective 135 patients in Romania (April 2020 - February 2022) Study underpowered to detect differences c19early.org Citu et al., Nutrients, March 2022 Favors zinc Favors control

Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection

Citu et al., Nutrients, doi:10.3390/nu14071445
Mar 2022  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 448 pregnant women with COVID-19. Patients with calcium, zinc, and magnesium supplementation, or magnesium only, had a significantly higher titer of SARS-CoV-2 anti-RBD antibodies. There was no statistically significant difference in severe cases based on supplementation.
risk of severe case, 17.6% lower, RR 0.82, p = 1.00, treatment 2 of 74 (2.7%), control 2 of 61 (3.3%), NNT 174, Ca+Mg+Zn vs. Mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Citu et al., 30 Mar 2022, retrospective, Romania, peer-reviewed, survey, 14 authors, study period 14 April, 2020 - 14 February, 2022, this trial uses multiple treatments in the treatment arm (combined with calcium) - results of individual treatments may vary. Contact: citu.ioan@umft.ro (corresponding author), citu.ioana@umft.ro, marganmm@gmail.com, crainamariuslucian@gmail.com, radu.neamtu@umft.ro, gorun.florin@umft.ro, oanabalan@hotmail.com, bogdanburlea@yahoo.com, felix.bratosin7@gmail.com, ovidiu.rosca@umft.ro, grigoras.mirela@umft.ro, amotoc@umft.ro, malita.daniel@umft.ro, dr.octavian.neagoe@gmail.com.
This PaperZincAll
Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection
Ioana Mihaela Citu, Cosmin Citu, Madalin-Marius Margan, Marius Craina, Radu Neamtu, Oana Maria Gorun, Bogdan Burlea, Felix Bratosin, Ovidiu Rosca, Mirela Loredana Grigoras, Andrei Motoc, Daniel Malita, Octavian Neagoe, Florin Gorun
Nutrients, doi:10.3390/nu14071445
Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production and other processes required for T and B cell activity. Considering magnesium as a recommended dietary supplement during pregnancy and the possible role of magnesium deficiency in COVID-19 and its complications, the current study sought to determine the effect of magnesium and magnesium-containing nutritional supplements on the immune response following SARS-CoV-2 infection in pregnant women, as well as to observe differences in pregnancy outcomes based on the supplements taken during pregnancy. The study followed a cross-sectional design, where patients with a history of SARS-CoV-2 infection during their pregnancy were surveyed for their preferences in nutritional supplementation and their profile compared with existing records from the institutional database. A cohort of 448 pregnant women with COVID-19 during 22 months of the pandemic was assembled, out of which 13.6% took a magnesiumonly supplement, and 16.5% supplemented their diet with a combination of calcium, magnesium, and zinc. Around 60% of patients in the no-supplementation group had the SARS-CoV-2 anti-RBD lower than 500 U/mL, compared with 50% in those who took magnesium-based supplements. A quantity of magnesium >450 mg in the taken supplements determined higher levels of antibody titers after COVID-19. Low magnesium dosage (<450 mg) was an independent risk factor for a weak immune response (OR-1.25, p-value = 0.003). The observed findings suggest supplementing the nutritional intake of pregnant women with magnesium-based supplements to determine higher levels of SARS-CoV-2 anti-RBD antibodies, although causality remains unclear.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: The authors declare no conflict of interest.
References
Acharya, Lee, Lee, Lee, Moon, Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes, Healthcare, doi:10.3390/healthcare8030338
Alejo, Mitchell, Chang, Chiang, Massie et al., Prevalence and Durability of SARS-CoV-2 Antibodies Among Unvaccinated US Adults by History of COVID-19, JAMA, doi:10.1001/jama.2022.1393
Alsaffar, Alwesaibi, Alhaddad, Alsenan, Alsheef et al., The Effectiveness of COVID-19 Vaccines in Improving the Outcomes of Hospitalized COVID-19 Patients, Cureus, doi:10.7759/cureus.21485
Bahat, Aldikactioglu Talmac, Bestel, Topbas Selcuki, Aydın et al., Micronutrients in COVID-19 Positive Pregnancies, Cureus, doi:10.7759/cureus.10609
Celewicz, Celewicz, Michalczyk, Woźniakowska-Gondek, Krejczy et al., Pregnancy as a Risk Factor of Severe COVID-19, J. Clin. Med, doi:10.3390/jcm10225458
Chaffee, King, Effect of zinc supplementation on pregnancy and infant outcomes: A systematic review, Paediatr. Perinat. Epidemiol, doi:10.1111/j.1365-3016.2012.01289.x
Chang, Lee, Lin, Lu, Hsu et al., The Effect of Azithromycin Plus Zinc Sulfate on ACE2 Expression through IκBα of Human Respiratory Cells in SARS-CoV-2: In Vitro Study, COVID, doi:10.3390/covid1010021
Citu, Citu, Gorun, Sas, Tomescu et al., Immunogenicity Following Administration of BNT162b2 and Ad26.COV2.S COVID-19 Vaccines in the Pregnant Population during the Third Trimester, Viruses, doi:10.3390/v14020307
Cruz Melguizo, De La Cruz Conty, Carmona Payán, Abascal-Saiz, Pintando Recarte et al., Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study, Viruses, doi:10.3390/v13050853
Dobrescu, Copaescu, Zmeu, Duta, Bedreag et al., Ghrelin levels and hunger sensation after laparoscopic sleeve gastrectomy compared with laparoscopic greater curvature plication in obese patients, Clin. Lab, doi:10.7754/Clin.Lab.2019.191012
Erol, Polat, Akdas, Ayral, Anuk et al., Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection, J. Med. Virol, doi:10.1002/jmv.27064
Fanni, Gerosa, Nurchi, Manchia, Saba et al., The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases, Biol. Trace Elem. Res, doi:10.1007/s12011-020-02513-0
Ghelani, Alesi, Mousa, Vitamin D and COVID-19: An Overview of Recent Evidence, Int. J. Mol. Sci, doi:10.3390/ijms221910559
Gorun, Motoi, Malita, Navolan, Nemescu et al., Cytomegalovirus seroprevalence in pregnant women in the western region of Romania: A large-scale study, Exp. Ther. Med, doi:10.3892/etm.2020.8945
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with COVID-19 in China: A nationwide analysis, Eur. Respir. J, doi:10.1183/13993003.00547-2020
Gupta, Khenduja, Pandey, Sati, Sofi et al., Dietary Intake of Minerals, Vitamins, and Trace Elements Among Geriatric Population in India, Biol. Trace Element Res, doi:10.1007/s12011-017-0972-8
Iddir, Brito, Dingeo, Fernandez Del Campo, Samouda et al., Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis, Nutrients, doi:10.3390/nu12061562
Junaid, Ejaz, Abdalla, Abosalif, Ullah et al., Effective Immune Functions of Micronutrients against SARS-CoV-2, Nutrients, doi:10.3390/nu12102992
Karmouty-Quintana, Thandavarayan, Keller, Sahay, Pandit et al., Emerging Mechanisms of Pulmonary Vasoconstriction in SARS-CoV-2-Induced Acute Respiratory Distress Syndrome (ARDS) and Potential Therapeutic Targets, Int. J. Mol. Sci, doi:10.3390/ijms21218081
Kawano, Matsuoka, Takishita, Omae, Effects of Magnesium Supplementation in Hypertensive Patients, Hypertension, doi:10.1161/01.HYP.32.2.260
Killilea, Maier, A connection between magnesium deficiency and aging: New insights from cellular studies, Magnes. Res
Kudlay, Kofiadi, Khaitov, Peculiarities of the T Cell Immune Response in COVID-19, Vaccines, doi:10.3390/vaccines10020242
Marcos, Editorial: A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, Nutrients, doi:10.3390/nu13114180
Mostafa, Kandeil, Shehata, El Shesheny, Samy et al., Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science, Microorganisms, doi:10.3390/microorganisms8070991
Nasser, Naffaa, Mashiach, Azzam, Braun, The association between serum magnesium levels and communityacquired pneumonia 30-day mortality, BMC Infect. Dis, doi:10.1186/s12879-018-3627-2
Nawsherwan, Khan, Zeb, Shoaib, Nabi et al., Selected Micronutrients: An Option to Boost Immunity against COVID-19 and Prevent Adverse Pregnancy Outcomes in Pregnant Women: A Narrative Review, Iran. J. Public Health, doi:10.18502/ijph.v49i11.4717
O'driscoll, Ribeiro Dos Santos, Wang, Cummings, Azman et al., Age-specific mortality and immunity patterns of SARS-CoV-2, Nature, doi:10.1038/s41586-020-2918-0
Ota, Mori, Middleton, Tobe-Gai, Mahomed et al., Zinc supplementation for improving pregnancy and infant outcome, Cochrane Database Syst. Rev, doi:10.1002/14651858.CD000230.pub5
Palaiodimos, Ali, Teo, Parthasarathy, Karamanis et al., Obesity, Inflammation, and Mortality in COVID-19: An Observational Study from the Public Health Care System of New York City, J. Clin. Med, doi:10.3390/jcm11030622
Propper, Smell/Taste alteration in COVID-19 may reflect zinc deficiency, J. Clin. Biochem. Nutr, doi:10.3164/jcbn.20-177
Rabaan, Al-Ahmed, Muhammad, Khan, Sule et al., Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm, Vaccines, doi:10.3390/vaccines9050436
Rude, Magnesium, Modern Nutrition in Health and Disease
Schwalfenberg, Genuis, The Importance of Magnesium in Clinical Healthcare, Scientifica, doi:10.1155/2017/4179326
Shittu, Afolami, Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives-A better synergy for future COVID-19 clinical trials, Infez. Med
Sinopoli, Isonne, Santoro, Baccolini, The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review, Rev. Med. Virol, doi:10.1002/rmv.2261
Skalny, Rink, Ajsuvakova, Aschner, Gritsenko et al., Zinc and respiratory tract infections: Perspectives for COVID-19 (Review), Int. J. Mol. Med, doi:10.3892/ijmm.2020.4575
Skirrow, Barnett, Bell, Riaposova, Mounier-Jack et al., Women's views on accepting COVID-19 vaccination during and after pregnancy, and for their babies: A multi-methods study in the UK, BMC Pregnancy Childbirth, doi:10.1186/s12884-021-04321-3
Stewart, Lambourne, Thorp-Jones, Thomas, Implementation of early management of iron deficiency in pregnancy during the SARS-CoV-2 pandemic, Eur. J. Obstet. Gynecol. Reprod. Biol, doi:10.1016/j.ejogrb.2020.12.055
Toprak, Kurt, Sarı, Şarkış, Us et al., Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study, Kidney Blood Press. Res, doi:10.1159/000468530
Trapani, Rosanoff, Baniasadi, Barbagallo, Castiglioni et al., The relevance of magnesium homeostasis in COVID-19, Eur. J. Nutr, doi:10.1007/s00394-021-02704-y
Uta, Neamtu, Bernad, Mocanu, Gluhovschi et al., The Influence of Nutritional Supplementation for Iron Deficiency Anemia on Pregnancies Associated with SARS-CoV-2 Infection, Nutrients, doi:10.3390/nu14040836
Vimercati, De Nola, Trerotoli, Metta, Cazzato et al., COVID-19 Infection in Pregnancy: Obstetrical Risk Factors and Neonatal Outcomes-A Monocentric, Single-Cohort Study, Vaccines, doi:10.3390/vaccines10020166
Wen, Chen, Tang, Wang, Zhou et al., Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: A meta-analysis, Ann. Med, doi:10.1080/07853890.2022.2034936
Wessels, Maywald, Rink, Zinc as a Gatekeeper of Immune Function, Nutrients, doi:10.3390/nu9121286
Zanza, Romenskaya, Manetti, Franceschi, La Russa et al., Cytokine Storm in COVID-19: Immunopathogenesis and Therapy, Medicina, doi:10.3390/medicina58020144
Álvarez Bartolomé, Abdallah Kassab, Cruz Melguizo, De La Cruz Conty, Forcen Acebal et al., Critical Care in SARS-CoV-2 Infected Pregnant Women: A Prospective Multicenter Study, Biomedicines, doi:10.3390/biomedicines10020475
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Med.', 'key': 'ref41', 'volume': '28', 'year': '2020'}, {'DOI': '10.3892/ijmm.2020.4575', 'doi-asserted-by': 'publisher', 'key': 'ref42'}, {'DOI': '10.3390/covid1010021', 'doi-asserted-by': 'publisher', 'key': 'ref43'}, {'DOI': '10.18502/ijph.v49i11.4717', 'doi-asserted-by': 'publisher', 'key': 'ref44'}, {'DOI': '10.1002/jmv.27064', 'doi-asserted-by': 'publisher', 'key': 'ref45'}, {'DOI': '10.1001/jama.2022.1393', 'doi-asserted-by': 'publisher', 'key': 'ref46'}], 'reference-count': 46, 'references-count': 46, 'relation': {}, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2072-6643/14/7/1445'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['Food Science', 'Nutrition and Dietetics'], 'subtitle': [], 'title': 'Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of ' 'Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection', 'type': 'journal-article', 'volume': '14'}
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