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Muscle strength is associated with COVID‐19 hospitalization in adults 50 years of age or older

Cheval et al., Journal of Cachexia, Sarcopenia and Muscle, doi:10.1002/jcsm.12738
Aug 2021  
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Hospitalization 36% per SD change Improvement Relative Risk Exercise for COVID-19  Cheval et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective study in multiple countries (June - September 2020) Lower hospitalization with higher activity levels (p=0.015) c19early.org Cheval et al., J. Cachexia, Sarcopenia.., Aug 2021 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 3,600 adults showing that higher grip strength was associated with a lower risk of COVID-19 hospitalization.
risk of hospitalization, 36.0% lower, OR 0.64, p = 0.01, RR approximated with OR, per standard deviation change.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cheval et al., 6 Aug 2021, multiple countries, peer-reviewed, survey, 8 authors, study period June 2020 - September 2020. Contact: cheval@unige.ch.
This PaperExerciseAll
Muscle strength is associated with COVID‐19 hospitalization in adults 50 years of age or older
Boris Cheval, Stefan Sieber, Silvio Maltagliati, Grégoire P Millet, Tomáš Formánek, Aïna Chalabaev, Stéphane Cullati, Matthieu P Boisgontier
Journal of Cachexia, Sarcopenia and Muscle, doi:10.1002/jcsm.12738
Background Weak muscle strength has been associated with a wide range of adverse health outcomes. Yet, whether individuals with weaker muscle strength are more at risk for hospitalization due to severe COVID-19 is still unclear. The objective of this study was to investigate the independent association between muscle strength and COVID-19 hospitalization. Methods Data from adults 50 years of age or older were analysed using logistic models adjusted for several chronic conditions, body-mass index, age, and sex. Hand-grip strength was repeatedly measured between 2004 and 2017 using a handheld dynamometer. COVID-19 hospitalization during the lockdown was self-reported in summer 2020 and was used as an indicator of COVID-19 severity. Results The study was based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 older adults (68.8 ± 8.8 years, 2044 female), among whom 316 were tested positive for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were hospitalized due to COVID-19. Results showed that higher grip strength was associated with a lower risk of COVID-19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard deviation in grip strength = 0.64, 95% confidence interval (95% CI) = 0.45-0.87, P = 0.015]. Results also showed that age (OR for a 10 -year period = 1.70, 95% CI = 1.32-2.20, P < 0.001) and obesity (OR = 2.01, 95% CI = 1.00-3.69, P = 0.025) were associated with higher risk of COVID-19 hospitalization. Sensitivity analyses using different measurements of grip strength as well as robustness analyses based on rare-events logistic regression and a different sample of participants (i.e. COVID-19 patients) were consistent with the main results. Conclusions Muscle strength is an independent risk factor for COVID-19 severity in adults 50 years of age or older.
Author contributions All the authors designed the study. S. S. cleaned the data. B. C. analysed the data. B. C. and M. P. B. drafted the manuscript. All authors critically appraised the manuscript, worked on its content, and approved its submitted version. Conflict of interest All authors declare that they have no conflict of interests. Ethical approval This study was part of the SHARE study, approved by the relevant research ethics committees in the participating countries. Informed consent All participants provided written informed consent. Online supplementary material Additional supporting information may be found online in the Supporting Information section at the end of the article. Table S1 . Cumulative proportion of COVID-19 cases. Table S2 . Results based on average muscle strength (2004-2017). Table S3 . Results based on muscle strength assessed in wave 7. Table S4 . Results adjusted for the country of residence. Table S5 . Results based on the rare events logistic regression with a tau of 84/100,00. Table S6 . Results in COVID-19 patients (N = 289).
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COVID‐19 hospitalization during ' 'the lockdown was self‐reported in summer 2020 and was used as an indicator of COVID‐19 ' 'severity.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The study was ' 'based on the Survey of Health, Ageing and Retirement in Europe (SHARE) and included 3600 ' 'older adults (68.8\xa0±\xa08.8\xa0years, 2044 female), among whom 316 were tested positive ' 'for the severe acute respiratory syndrome coronavirus 2 (8.8%), and 83 (2.3%) were ' 'hospitalized due to COVID‐19. Results showed that higher grip strength was associated with a ' 'lower risk of COVID‐19 hospitalization [adjusted odds ratio (OR) per increase of 1 standard ' 'deviation in grip strength\xa0=\xa00.64, 95% confidence interval (95% CI)\xa0=\xa00.45–0.87, ' '<jats:italic>P</jats:italic>\xa0=\xa00.015]. 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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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