Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study

DOI record: { "DOI": "10.1186/s12967-022-03407-6", "ISSN": [ "1479-5876" ], "URL": "http://dx.doi.org/10.1186/s12967-022-03407-6", "abstract": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>The 2019 coronavirus disease pandemic (COVID-19) poses an enormous threat to public health worldwide, and the ensuing management of social isolation has greatly decreased opportunities for physical activity (PA) and increased opportunities for leisure sedentary behaviors (LSB). Given that both PA and LSB have been established as major influencing factors for obesity, diabetes and cardiometabolic syndrome, whether PA/LSB in turn affects the susceptibility to COVID-19 by disrupting metabolic homeostasis remains to be explored. In this study, we aimed to systematically evaluate the causal relationship between PA/LSB and COVID-19 susceptibility, hospitalization and severity using a Mendelian randomization study.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Data were obtained from a large-scale PA dataset (N = 377,000), LSB dataset (N = 422,218) and COVID-19 Host Genetics Initiative (N = 2,586,691). The causal effects were estimated with inverse variance weighted, MR-Egger, weighted median and MR-PRESSO. Sensitivity analyses were implemented with Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, leave-one-out analysis and the funnel plot. Risk factor analyses were further conducted to investigate the potential mediators.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Genetically predicted accelerometer-assessed PA decreased the risk for COVID-19 hospitalization (OR = 0.93, 95% CI 0.88–0.97; P = 0.002), while leisure television watching significantly increased the risk of COVID-19 hospitalization (OR = 1.55, 95% CI 1.29–1.88; P = 4.68 × 10<jats:sup>–6</jats:sup>) and disease severity (OR = 1.85, 95% CI 1.33–2.56; P = 0.0002) after Bonferroni correction. No causal effects of self-reported moderate to vigorous physical activity (MVPA), accelerometer fraction of accelerations &gt; 425 milligravities, computer use or driving on COVID-19 progression were observed. Risk factor analyses indicated that the above causal associations might be mediated by several metabolic risk factors, including smoking, high body mass index, elevated serum triglyceride levels, insulin resistance and the occurrence of type 2 diabetes.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusion</jats:title>\n <jats:p>Our findings supported a causal effect of accelerometer-assessed PA on the reduced risk of COVID-19 hospitalization as well as television watching on the increased risk of COVID-19 hospitalization and severity, which was potentially mediated by smoking, obesity and type 2 diabetes-related phenotypes. Particular attention should be given to reducing leisure sedentary behaviors and encouraging proper exercise during isolation and quarantine for COVID-19.</jats:p>\n </jats:sec>", "alternative-id": [ "3407" ], "article-number": "216", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "21 January 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "24 April 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "13 May 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "Not applicable." }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "The authors declare that they have no competing interests." } ], "author": [ { "affiliation": [], "family": "Chen", "given": "Xiong", "sequence": "first" }, { "affiliation": [], "family": "Hong", "given": "Xiaosi", "sequence": "additional" }, { "affiliation": [], "family": "Gao", "given": "Wenjing", "sequence": "additional" }, { "affiliation": [], "family": "Luo", "given": "Shulu", "sequence": "additional" }, { "affiliation": [], "family": "Cai", "given": "Jiahao", "sequence": "additional" }, { "affiliation": [], "family": "Liu", "given": "Guochang", "sequence": "additional" }, { "affiliation": [], "family": "Huang", "given": "Yinong", "sequence": "additional" } ], "container-title": "Journal of Translational Medicine", "container-title-short": "J Transl Med", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 5, 13 ] ], "date-time": "2022-05-13T11:09:48Z", "timestamp": 1652440188000 }, "deposited": { "date-parts": [ [ 2022, 5, 13 ] ], "date-time": "2022-05-13T12:09:17Z", "timestamp": 1652443757000 }, "funder": [ { "award": [ "KTa377a204193688" ], "name": "Research foundation of Guangzhou Women and Children’s Medical Center for Clinical Doctor" }, { "DOI": "10.13039/100018479", "award": [ "KT072c1204164651" ], "doi-asserted-by": "publisher", "name": "Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center" } ], "indexed": { "date-parts": [ [ 2022, 5, 13 ] ], "date-time": "2022-05-13T12:42:22Z", "timestamp": 1652445742937 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2022, 5, 13 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2022, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 5, 13 ] ], "date-time": "2022-05-13T00:00:00Z", "timestamp": 1652400000000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 5, 13 ] ], "date-time": "2022-05-13T00:00:00Z", "timestamp": 1652400000000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s12967-022-03407-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s12967-022-03407-6/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s12967-022-03407-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2022, 5, 13 ] ] }, "published-online": { "date-parts": [ [ 2022, 5, 13 ] ] }, "published-print": { "date-parts": [ [ 2022, 12 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.3949/ccjm.87a.20047", "author": "CC Bergmann", "doi-asserted-by": "publisher", "first-page": "321", "issue": "6", "journal-title": "Cleve Clin J Med", "key": "3407_CR1", "unstructured": "Bergmann CC, Silverman RH. 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