Nitric Oxide Accumulation in the Nonventilated Nasal Cavity
MD Jose Miguel Chatkin, MD Wei Qian, MSc Patricia A Mcclean, MD Noe Zamel, MD James Haight, MD Phillip Silkoff
Background: Nasal nitric oxide is present in high concentrations in the upper airway relative to the lower respiratory tract. Objective: To explore the rate of nitric oxide accumulation in the nonventilated nasal cavity. Methods: In 9 healthy subjects previously trained to close the soft palate, steady-state plateau nitric oxide levels were recorded while air was aspirated through the nasal airway in series at a constant flow rate. Nitric oxide was then allowed to accumulate in the nasal cavity by occluding both nares and keeping the velum closed. After varying occlusion times, peak nitric oxide levels and a second plateau were ascertained. Results: While the subjects aspirated air at a constant flow, there was a slow rise to a first nitric oxide plateau.
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