Conv. Plasma
Nigella Sativa
Peg.. Lambda

All nigella sativa studies
Meta analysis
Home COVID-19 treatment researchNigella SativaNigella Sativa (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Case 49% Improvement Relative Risk Case (b) 87% Case (c) 74% Nigella Sativa  Chandra et al.  Prophylaxis  RCT Does nigella sativa + combined treatments reduce COVID-19 infections? RCT 105 patients in India (September 2020 - May 2021) Fewer cases with nigella sativa + combined treatments (not stat. sig., p=0.36) Chandra et al., Phytotherapy Research, Jul 2022 Favors nigella sativa Favors control

Efficacy of polyherbal formulations for prevention of COVID-19 infection in high-risk subjects: A randomized open-label controlled clinical trial

Chandra et al., Phytotherapy Research, doi:10.1002/ptr.7531, CTRI/2020/08/027222
Jul 2022  
  Source   PDF   All Studies   Meta AnalysisMeta
RCT 251 high-risk individuals in India, mostly with direct contact with COVID-19 positive patients, testing polyherbal formulations Infuza, which includes nigella sativa, and Kulzam. Both formulations showed lower risk, without statisical significance, while the best results were from the combination of both.
risk of case, 49.0% lower, RR 0.51, p = 0.36, treatment 4 of 52 (7.7%), control 8 of 53 (15.1%), NNT 14, Infuza.
risk of case, 87.0% lower, RR 0.13, p = 0.03, treatment 1 of 51 (2.0%), control 8 of 53 (15.1%), NNT 7.6, Infuza and Kulzam.
risk of case, 74.0% lower, RR 0.26, p = 0.09, treatment 2 of 51 (3.9%), control 8 of 53 (15.1%), NNT 9.0, Kulzam.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chandra et al., 5 Jul 2022, Randomized Controlled Trial, India, peer-reviewed, 12 authors, study period 18 September, 2020 - 21 May, 2021, this trial uses multiple treatments in the treatment arm (combined with Infuza polyherbal formulation) - results of individual treatments may vary, trial CTRI/2020/08/027222.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperNigella SativaAll
Efficacy of polyherbal formulations for prevention of COVID ‐19 infection in high‐risk subjects: A randomized open‐label controlled clinical trial
Kailash Chandra, Ayan Kumar Das, Sumeera Banday, Naushad Ali Rana, Mohini Arora, Sonal Jain, Farzana Islam, Shashank Agarwal, Varun Kashyap, Santosh Joshi, Asad Mueed, Mridu Dudeja
Phytotherapy Research, doi:10.1002/ptr.7531
COVID-19 is arguably the biggest health crisis the world has faced in the 21st century. Therefore, two of the polyherbal formulations, Infuza and Kulzam were assessed for the prevention of COVID-19 infection as a repurposed medication. Four hundred seven high-risk subjects were recruited in the present open-label randomized controlled clinical trial for eligibility. After assessment for eligibility, remaining 251 subjects were randomized to the test and control groups. Further, 52 high-risk subjects in Infuza, 51 in Kulzam, 51 in Infuza & Kulzam and 53 in control group completed the 14 days of intervention/assessment. The phenotyping of lymphocytes at baseline (0 day) and after 14 days of treatment was carried out by flow cytometry assays. A total of 15.09% high-risk subjects in control group turned positive as compared to only 7.69% in Infuza, 3.92% in Kulzam and 1.96% in Infuza & Kulzam groups. The rate of conversion to COVID-19 infection in Infuza & Kulzam group was minimal and statistically significant as compared to control group (p0.017). No significant changes in phenotype of lymphocytes (T, B, NK cells), absolute lymphocyte count and cytokine levels were found in study groups. However, there was a decreasing trend of hs-CRP level in high-risk subjects after intervention of polyherbal formulations for 14 days. The combination of Infuza and Kulzam may synergistically prevent COVID-19 infection in high-risk subjects of COVID-19.
AUTHOR CONTRIBUTIONS Conceptualization: Mridu Dudeja, Kailash Chandra, Ayan Kumar Das, Naushad Ali Rana, Santosh Joshi, Asad Mueed; Data curation: Sumeera Banday, Mohini Arora, Shashank Agarwal, Santosh Joshi, Kailash Chandra; Formal analysis: Kailash Chandra, Varun Kashyap, Ayan Kumar Das, Sumeera Banday; Investigation: Mohini Arora, Santosh Joshi, Kailash Chandra, Ayan Kumar Das; Methodology: Ayan Kumar Das, Kailash Chandra, Varun Kashyap, Sonal Jain, Shashank CONFLICT OF INTEREST We confirm that there is no conflict of interest associated with this publication. The medications were provided by M/S Hamdard Laboratories (Medicine Division), India. Clinical trial was conducted at Hamdard Institute of Medical Sciences and Research and associated HAHC Hospital, New Delhi. M/S Hamdard Laboratories is not involved in any aspect of clinical trial reported in the study. SUPPORTING INFORMATION Additional supporting information can be found online in the Supporting Information section at the end of this article. How to cite this article: Chandra, K., Das, A. K., Banday, S., Rana, N. A., Arora, M., Jain, S., Islam, F., Agarwal, S., Kashyap, V., Joshi, S., Mueed, A., & Dudeja, M. (2022) .
Alabboud, Javadmanesh, In silico study of various antiviral drugs, vitamins, and natural substances as potential binding compounds with SARS-CoV-2 main protease, DYSONA -Life Science, doi:10.30493/DLS.2020.225404
Andrade, De Rangel, Santos, Freitas, De Soares et al., Repurposing approved drugs for guiding COVID-19 prophylaxis: A systematic review, Frontiers in Pharmacology, doi:10.3389/fphar.2020.590598
Basu, Sarkar, Maulik, Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2, Scientific Reports, doi:10.1038/s41598-020-74715-4
Calder, Carr, Gombart, Eggersdorfer, Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections, Nutrients, doi:10.3390/nu12041181
Chandra, Jain, Azhar, Khan, Alam et al., Effect of augmented glycation in mobilization of plasma free fatty acids in type 2 diabetes mellitus, Diabetes and Metabolic Syndrome, doi:10.1016/j.dsx.2020.07.028
Chandra, Khan, Jetley, Ahmad, Jain, Antidiabetic, toxicological, and metabolomic profiling of aqueous extract of Cichorium intybus seeds, Pharmacognosy Magazine, doi:10.4103/pm.pm_583_17
Cohen, Hydroxychloroquine for the prevention of Covid-19 -Searching for evidence, New England Journal of Medicine, doi:10.1056/nejme2020388
Fiore, Eisenhut, Krausse, Ragazzi, Pellati et al., Antiviral effects of Glycyrrhiza species, Phytotherapy Research, doi:10.1002/PTR.2295
Forman, Shah, Jeurissen, Jit, Mossialos, COVID-19 vaccine challenges: What have we learned so far and what remains to be done?, Health Policy, doi:10.1016/j.healthpol.2021.03.013
Han, Xu, Cheng, Zhong, Yuan et al., Descriptive, retrospective study of the clinical characteristics of asymptomatic COVID-19 patients, MSphere, doi:10.1128/msphere.00922-20
Hasan, Ara, Mondal, Kabir, Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra, Heliyon, doi:10.1016/J.HELIYON.2021.E07240
Jorge, Hydroxychloroquine in the prevention of COVID-19 mortality, The Lancet Rheumatology, doi:10.1016/S2665-9913(20)30390-8
Khanna, Kohli, Kaur, Bhardwaj, Bhardwaj et al., Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle, Phytomedicine, doi:10.1016/j.phymed.2020.153361
Koshak, Koshak, Nigella sativa L as a potential phytotherapy for coronavirus disease 2019: A mini review of in silico studies, Current Therapeutic Research, doi:10.1016/j.curtheres.2020.100602
Ma, Chen, Guo, Liu, Chen et al., Prevention and treatment of infectious diseases by traditional Chinese medicine: A commentary, APMIS, doi:10.1111/apm.12928
Maurya, Sharma, Evaluation of traditional ayurvedic Kadha for prevention and management of the novel coronavirus (SARS-CoV-2) using in silico approach, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2020.1852119
Mohammadi, Shaghaghi, Inhibitory effect of eight secondary metabolites from conventional medicinal plants on COVID-19 virus protease by molecular docking analysis, ChemRxiv, doi:10.26434/CHEMRXIV.11987475.V1
Mukherjee, Mao, Mohfw, Ramos ; Tovar, Muriel, Compendium of antiviral medicinal plants of north East India, doi:10.1016/B978-0-12-814466-4.00009-4
Najmul, Rampuri, None, Khazain ul Advia
References Akram, Tahir, Shah, Mahmood, Altaf et al., Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review, Phytotherapy Research, doi:10.1002/PTR.6024
Richman, COVID-19 vaccines: Implementation, limitations and opportunities, Global Health & Medicine, doi:10.35772/ghm.2021.01010
Saboo, Immunomodulator in traditional healthcare system, doi:10.5772/INTECHOPEN.94965
Salvi, Patankar, Emerging pharmacotherapies for COVID-19, Biomedicine & Pharmacotherapy, doi:10.1016/J.BIOPHA.2020.110267
Shah, Rasul, Yousaf, Haris, Faheem et al., Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID-19, Phytotherapy Research, doi:10.1002/PTR.7228
Sharanya, Sabu, Haridas, Potent phytochemicals against COVID-19 infection from phyto-materials used as antivirals in complementary medicines: A review, Future Journal of Pharmaceutical Sciences, doi:10.1186/S43094-021-00259-7
Sharma, Kaur, Bioactive molecules from eucalyptus essential oil as potential inhibitors of COVID-19 corona virus infection by molecular docking studies, Kragujevac Journal of Science
Wang, C-reactive protein levels in the early stage of COVID-19, Médecine et Maladies Infectieuses, doi:10.1016/j.medmal.2020.03.007
Yeh, Chih Wang, Chai Chiang, Shieh, Hong Yen et al., Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines, Journal of Ethnopharmacology, doi:10.1016/j.jep.2013.04.040
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop