Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
M.D Bin Cao, M.D Yeming Wang, M.D Hongzhou Lu, M.D Chaolin Huang, M.D Yumei Yang, Ph.D Lianhan Shang, M.D Zhu Chen, M.D Rongmeng Jiang, M.D Yihe Liu, M.D Ling Lin, M.D Ping Peng, M.D Fuxiang Wang, M.D Fengyun Gong, M.D Honglin Hu, M.S Cong Cheng, M.D Xiangyang Yao, M.D Xianwei Ye, M.D Hourong Zhou, M.D Yinzhong Shen, M.D Chenfan Liu, M.D Chunying Wang, M.D Zhennan Yi, M.D Bijie Hu, M.D Jiuyang Xu, M.D Xiaoying Gu, Ph.D Jingshan Shen, Ph.D Yechun Xu, Ph.D Leike Zhang, Ph.D Jia Fan, M.D Renhong Tang, Ph.D Chen Wang
New England Journal of Medicine, doi:10.1056/nejmoa2301425
BACKGROUND Simnotrelvir is an oral 3-chymotrypsin-like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential efficacy in a phase 1B trial.
CONCLUSIONS Early administration of simnotrelvir plus ritonavir shortened the time to the resolution of symptoms among adult patients with Covid-19, without evident safety concerns.
Appendix
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'URL': 'http://dx.doi.org/10.1056/NEJMoa2301425',
'relation': {},
'ISSN': ['0028-4793', '1533-4406'],
'subject': ['General Medicine'],
'container-title-short': 'N Engl J Med',
'published': {'date-parts': [[2024, 1, 18]]}}
