Meta analysis using the most serious outcome reported shows 7% [-138‑63%] lower risk, without reaching statistical significance. Early treatment is more effective than late treatment. Currently all studies are RCTs.
2 studies from 2 independent teams in 2 countries show significant benefit.
Control Peg.. Lambda
Currently there is limited data, with only 9 control events for the most serious outcome in trials to date.
The primary positive trial1 has major anomolies2. Results from
NCT04967430 (history) have not been reported and contact information was deleted in the registry.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Other treatments are more effective. All data and sources to reproduce this analysis are in the appendix.
