Peginterferon Lambda for COVID-19: real-time meta-analysis of 5 studies (Version 8)

Meta-analysis using the most serious outcome reported shows 15% [-36‑107%] higher risk, without reaching statistical significance. Results are consistent with early treatment being more effective than late treatment. Currently all studies are RCTs.

Control Peg.. Lambda

Currently there is limited data, with only 9 control events for the most serious outcome in trials to date.

The primary positive trial1 has major anomolies2. Results from NCT04967430 (history) have not been reported and contact information was deleted in the registry.

All data and sources to reproduce this analysis are in the appendix.