Meta analysis using the most serious outcome reported shows 7% [-138‑63%] lower risk, without reaching statistical significance. Early treatment is more effective than late treatment. Currently all studies are RCTs.
2 studies from 2 independent teams in 2 countries show statistically significant improvements.
Currently there is limited data, with only 9 control events for the most serious outcome in trials to date.
The primary positive trial Reis has major anomolies Kelleni. Results from
NCT04967430 (history) have not been reported and contact information was deleted in the registry.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments are significantly more effective.
All data to reproduce this paper and sources are in the appendix.