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All Studies   Meta Analysis    Recent:   

Antihistamine H1RAs for COVID-19: real-time meta analysis of 15 studies

Covid Analysis
Oct 2024  
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10th treatment shown to reduce risk in December 2020
 
*, now with p = 0.00006 from 15 studies.
Lower risk for mortality, recovery, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
5,000+ studies for 104 treatments. c19early.org
Statistically significant lower risk is seen for mortality, recovery, and cases. 8 studies from 7 independent teams in 4 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 39% [23‑52%] lower risk. Results are similar for peer-reviewed studies and better for Randomized Controlled Trials. Early treatment is more effective than late treatment.
Results are very robust — in exclusion sensitivity analysis 8 of 15 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective.
All data to reproduce this paper and sources are in the appendix.
Covid Analysis et al., Oct 2024, preprint, 1 author.
This PaperH1RAsAll
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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