Famotidine reduces COVID-19 risk: real-time meta analysis of 30 studies

Covid Analysis, Nov 2025
Famotidine for COVID-19
29th treatment shown to reduce risk in October 2021, now with p = 0.00028 from 30 studies, recognized in 2 countries.
No treatment is 100% effective. Protocols combine treatments.
6,200+ studies for 200+ treatments. c19early.org
Significantly lower risk is seen for mortality, hospitalization, recovery, and viral clearance. 15 studies from 15 independent teams in 7 countries show significant benefit.
Meta analysis using the most serious outcome reported shows 17% [8‑24%] lower risk. Results are similar for Randomized Controlled Trials, higher quality studies, and peer-reviewed studies. Early treatment is more effective than late treatment.
Control Famotidine
1 RCT with 528 patients has not reported results (2 years late)1.
No treatment is 100% effective. Protocols combine safe and effective options with individual risk/benefit analysis and monitoring. Other treatments are more effective. All data and sources to reproduce this analysis are in the appendix.
Covid Analysis et al., Nov 2025, preprint, 1 author.
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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