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All Studies   Meta Analysis    Recent:   

Exercise for COVID-19: real-time meta analysis of 66 studies

Covid Analysis
Apr 2024  
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Exercise for COVID-19
9th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 66 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Statistically significant lower risk is seen for mortality, ventilation, ICU admission, hospitalization, progression, recovery, and cases. 51 studies from 51 independent teams in 24 countries show statistically significant improvements.
Meta analysis using the most serious outcome reported shows 39% [34‑44%] lower risk. Results are similar for higher quality and peer-reviewed studies.
Results are robust — in exclusion sensitivity analysis 54 of 66 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.
Results are consistent with the overall risk of all cause mortality based on cardiorespiratory fitness — Laukkanen show RR 0.55 [0.50-0.61] for the top vs. bottom tertiles.
Most studies analyze activity levels before infection, comparing regular/moderate exercise and lower/no exercise. Risk may increase with more extreme activity levels. Exercise may also be beneficial after infection. One study shows lower COVID-19 mortality with exercise during hospitalization Fernandez.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis.
All data to reproduce this paper and sources are in the appendix. Other meta analyses show significant improvements with exercise for mortality Ezzatvar, Halabchi, Liu, Rahmati, Sittichai, ICU admission Rahmati, hospitalization Ezzatvar, Halabchi, Li, Rahmati, severity Ezzatvar, Liu, Sittichai, and cases Ezzatvar.
6 meta analyses show significant improvements with exercise for mortality Ezzatvar, Halabchi, Liu, Rahmati, Sittichai, ICU admission Rahmati, hospitalization Ezzatvar, Halabchi, Li, Rahmati, severity Ezzatvar, Liu, Sittichai, and cases Ezzatvar.
Covid Analysis et al., Apr 2024, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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