Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchSunlightSunlight (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

On the anti-correlation between COVID-19 infection rate and natural UV light in the UK

Blum et al., medRxiv, doi:10.1101/2020.11.28.20240242
Nov 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Sunlight for COVID-19
32nd treatment shown to reduce risk in December 2021, now with p = 0.000052 from 5 studies.
Lower risk for mortality, hospitalization, recovery, and cases.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Analysis of COVID-19 cases in the UK, showing a correlation between increased UV radiation and lower COVID-19 cases.
Blum et al., 30 Nov 2020, United Kingdom, preprint, 4 authors, study period 23 March, 2020 - 10 March, 2021. Contact: o.lahav@ucl.ac.uk.
This PaperSunlightAll
On the anti-correlation between COVID-19 infection rate and natural UV light in the UK
Arnon Blum, Constantina Nicolaou, Ben Henghes, Ofer Lahav
doi:10.1101/2020.11.28.20240242
While it is well established that the rate of COVID-19 infections can be suppressed by social distancing, environmental effects may also affect it. We consider the hypothesis that natural Ultra-Violet (UV) light is reducing COVID-19 infections by enhancing human immunity through increasing levels of Vitamin-D and Nitric Oxide or by suppressing the virus itself. We focus on the United Kingdom (UK), by examining daily COVID-19 infections (F) and UV Index (UVI) data from 23 March 2020 to 10 March 2021. We find an intriguing empirical anti-correlation between log 10 (F) and log 10 (UVI) with a correlation coefficient of -0.934 from 11 May 2020 (when the first UK lockdown ended) to 10 March 2021. The anti-correlation may reflect causation with other factors which are correlated with the UVI. We advocate that UVI should be added as a parameter in modelling the pattern of COVID-19 infections and deaths. We started quantifying such correlations in other countries and regions.
Author contributions AB has proposed the idea of looking at correlations between the UVI and COVID-19 infections and has contributed to interpretation of results. CN and BH have performed the statistical analysis of this work. OL has proposed analysis tools and plots, has contributed to interpretation and has coordinated the team. Each of the four authors have written sections of the paper. Competing interests The authors declare no competing interests.
References
Adler, Suppression of Herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2), Journal Of Experimental Medicine
Akaike, Pathogenesis of influenza virus-induced pneumonia: Involvement of both nitric oxide and oxygen radicals, Proceedings Of The National Academy Of Sciences Of The United States Of America
Akerstrom, Gunalan, Keng, Tan, Mirazimi, Dual effect of nitric oxide on SARS-CoV replication: Viral RNA production and palmitoylation of the S protein are affected, Virology
Cherrie, Ultraviolet A Radiation and COVID-19 Deaths: A Multi Country Study
Coleman, Nitric oxide in immunity and inflammation, International Immunopharmacology
Dong, Du, Gardner, An interactive web-based dashboard to track COVID-19 in real time, Lancet Inf Dis
Efron, Bootstrap Methods: Another Look at the Jackknife, Ann. Statist, doi:10.1214/aos/1176344552
Hale, Webster, Petherick, Phillips, Kira, Oxford COVID-19 Government Response Tracker
Herrick, Vitamin D status in the United States, 2011-2014, American Journal Of Clinical Nutrition
Holick, Biological Effects of Sunlight, Ultraviolet Radiation, Visible Light, Infrared Radiation and Vitamin D for Health. English, Anticancer Research
Holliman, Lowe, Cohen, Felton, Raj, Ultraviolet Radiation-Induced Production of Nitric Oxide: A multi-cell and multi-donor analysis, Scientific Reports
Kuchel, Barnetson, Halliday, Nitric oxide appears to be a mediator of solarsimulated ultraviolet radiation-induced immunosuppression in humans, Journal Of Investigative Dermatology
Kunutsor, Apekey, Steur, Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants, European Journal Of Epidemiology
Lane, Paoletti, Buchmeier, Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus, Journal Of Virology
Lips, Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society, European Journal Of Endocrinology
Liu, UVA Irradiation of Human Skin Vasodilates Arterial Vasculature and Lowers Blood Pressure Independently of Nitric Oxide Synthase, Journal Of Investigative Dermatology
Mackay, UVA and Seasonal Patterning of 56 370 Myocardial Infarctions Across Scotland, 2000-2011, Journal Of The American Heart Association
Mauss, Jarczok, Hoffmann, Thomas, Fischer, Association of Vitamin D Levels with Type 2 Diabetes in Older Working Adults, International Journal Of Medical Sciences
Merow, Urban, Seasonality and uncertainty in global COVID-19 growth rates, Proceedings of the National Academy of Sciences
Nicastro, Modulation of COVID-19 Epidemiology by UV-B and -A Photons from the Sun
Oplaender, Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates, Circulation Research
Poljakovic, Karpman, Svanborg, Persson, Human renal epithelial cells express iNOS in response to cytokines but not bacteria, Kidney International
Pope, Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide, Journal Of Virology
Price, Graham, Ramalingam, Association between viral seasonality and meteorological factors, English. Scientific Reports
Saxena, Mathur, Srivastava, Induction of nitric oxide synthase during Japanese encephalitis virus infection: Evidence of protective role, Archives Of Biochemistry And Biophysics
Van Geffen, Van Weele, Allaart, Van Der, TEMIS UV index and UV dose operational data products
Weller, The health benefits of UV radiation exposure through vitamin D production or non-vitamin D pathways. Blood pressure and cardiovascular disease, Photochemical & Photobiological Sciences
Whittemore, COVID-19 fatalities, latitude, sunlight, and vitamin D, American Journal Of Infection Control
Xu, The Modest Impact of Weather and Air Pollution on COVID-19 Transmission
Yao, A meta-analysis of the relationship between vitamin D deficiency and obesity, International Journal Of Clinical And Experimental Medicine
Yao, No association of COVID-19 transmission with temperature or UV radiation in Chinese cities, European Respiratory Journal
Yudistira, Sumitro, Nahas, Riama, UV light influences covid-19 activity through big data: trade offs between northern subtropical, tropical, and southern subtropical countries
{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2022, 12, 3]], 'date-time': '2022-12-03T11:49:24Z', 'timestamp': 1670068164995}, 'posted': {'date-parts': [[2020, 11, 30]]}, 'group-title': 'Public and Global Health', 'reference-count': 32, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2022, 2, 21]]}, 'abstract': '<jats:p>While it is well established that the rate of COVID-19 infections can be suppressed ' 'by social distancing, environmental effects may also affect it. We consider the hypothesis ' 'that natural Ultra-Violet (UV) light is reducing COVID-19 infections by enhancing human ' 'immunity through increasing levels of Vitamin-D and Nitric Oxide or by suppressing the virus ' 'itself. We focus on the United Kingdom (UK), by examining daily COVID-19 infections (F) and ' 'UV Index (UVI) data from 23 March 2020 to 10 March 2021. We find an intriguing empirical ' 'anti-correlation between log<jats:sub>10</jats:sub>(F) and log<jats:sub>10</jats:sub>(UVI) ' 'with a correlation coefficient of −0.934 from 11 May 2020 (when the first UK lockdown ended) ' 'to 10 March 2021. The anti-correlation may reflect causation with other factors which are ' 'correlated with the UVI. We advocate that UVI should be added as a parameter in modelling the ' 'pattern of COVID-19 infections and deaths. We started quantifying such correlations in other ' 'countries and regions.</jats:p>', 'DOI': '10.1101/2020.11.28.20240242', 'type': 'posted-content', 'created': { 'date-parts': [[2020, 11, 30]], 'date-time': '2020-11-30T21:50:10Z', 'timestamp': 1606773010000}, 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': 'On the anti-correlation between COVID-19 infection rate and natural UV light in the UK', 'prefix': '10.1101', 'author': [ {'given': 'Arnon', 'family': 'Blum', 'sequence': 'first', 'affiliation': []}, {'given': 'Constantina', 'family': 'Nicolaou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ben', 'family': 'Henghes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ofer', 'family': 'Lahav', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2022022305400540000_2020.11.28.20240242v2.1', 'doi-asserted-by': 'crossref', 'unstructured': 'Yao, Y. et al. No association of COVID-19 transmission with temperature ' 'or UV radiation in Chinese cities. European Respiratory Journal 55. ' 'issn: 0903-1936. eprint: ' 'https://erj.ersjournals.com/content/55/5/2000517.full.pdf (2020).', 'DOI': '10.1183/13993003.00517-2020'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.2', 'unstructured': 'Xu, R. et al. The Modest Impact of Weather and Air Pollution on COVID-19 ' 'Transmission. medRxiv. eprint: ' 'https://www.medrxiv.org/content/early/2020/05/24/2020.05.05.20092627.full.pdf ' '(2020).'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.3', 'doi-asserted-by': 'crossref', 'unstructured': 'Yudistira, N. , Sumitro, S. B. , Nahas, A. & Riama, N. F. UV light ' 'influences covid-19 activity through big data: trade offs between ' 'northern subtropical, tropical, and southern subtropical countries. ' 'medRxiv. eprint: ' 'https://www.medrxiv.org/content/early/2020/05/22/2020.04.30.20086983.full.pdf ' '(2020).', 'DOI': '10.1101/2020.04.30.20086983'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.4', 'doi-asserted-by': 'crossref', 'unstructured': 'Merow, C. & Urban, M. C. Seasonality and uncertainty in global COVID-19 ' 'growth rates. Proceedings of the National Academy of Sciences. issn: ' '0027-8424 (2020).', 'DOI': '10.1101/2020.04.19.20071951'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.5', 'unstructured': 'Nicastro, F. et al. Modulation of COVID-19 Epidemiology by UV-B and -A ' 'Photons from the Sun. medRxiv. eprint: ' 'https://www.medrxiv.org/content/early/2020/07/28/2020.06.03.20121392.full.pdf ' '(2020).'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.6', 'unstructured': 'Cherrie, M. et al. Ultraviolet A Radiation and COVID-19 Deaths: A Multi ' 'Country Study. medRxiv. eprint: ' 'https://www.medrxiv.org/content/early/2020/08/01/2020.07.03.20145912.full.pdf ' '(2020).'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.7', 'doi-asserted-by': 'crossref', 'unstructured': 'Price, R. H. M. , Graham, C. & Ramalingam, S. Association between viral ' 'seasonality and meteorological factors. English. Scientific Reports 9. ' 'issn: 2045-2322 (2019).', 'DOI': '10.1038/s41598-018-37481-y'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.8', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s10654-013-9790-2'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.9', 'doi-asserted-by': 'crossref', 'first-page': '362', 'DOI': '10.7150/ijms.10540', 'article-title': 'Association of Vitamin D Levels with Type 2 Diabetes in Older Working ' 'Adults', 'volume': '12', 'year': '2015', 'journal-title': 'International Journal Of Medical Sciences', 'ISSN': 'http://id.crossref.org/issn/1449-1907', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.10', 'first-page': '14977', 'article-title': 'A meta-analysis of the relationship between vitamin D deficiency and ' 'obesity', 'volume': '8', 'year': '2015', 'journal-title': 'International Journal Of Clinical And Experimental Medicine', 'ISSN': 'http://id.crossref.org/issn/1940-5901', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.11', 'doi-asserted-by': 'crossref', 'first-page': '150', 'DOI': '10.1093/ajcn/nqz037', 'article-title': 'Vitamin D status in the United States, 2011-2014', 'volume': '110', 'year': '2019', 'journal-title': 'American Journal Of Clinical Nutrition', 'ISSN': 'http://id.crossref.org/issn/0002-9165', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.12', 'doi-asserted-by': 'publisher', 'DOI': '10.1530/EJE-18-0736'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.13', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ajic.2020.06.193'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.14', 'doi-asserted-by': 'crossref', 'unstructured': 'Mackay, D. F. et al. UVA and Seasonal Patterning of 56 370 Myocardial ' 'Infarctions Across Scotland, 2000-2011. Journal Of The American Heart ' 'Association 8. issn: 2047-9980 (2019).', 'DOI': '10.1161/JAHA.119.012551'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.15', 'first-page': '1345', 'article-title': 'Biological Effects of Sunlight, Ultraviolet Radiation, Visible Light, ' 'Infrared Radiation and Vitamin D for Health. English', 'volume': '36', 'year': '2016', 'journal-title': 'Anticancer Research', 'ISSN': 'http://id.crossref.org/issn/0250-7005', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.16', 'doi-asserted-by': 'crossref', 'first-page': '374', 'DOI': '10.1039/C6PP00336B', 'article-title': 'The health benefits of UV radiation exposure through vitamin D ' 'production or non-vitamin D pathways. Blood pressure and cardiovascular ' 'disease', 'volume': '16', 'year': '2017', 'journal-title': 'Photochemical & Photobiological Sciences', 'ISSN': 'http://id.crossref.org/issn/1474-905X', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.17', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/jid.2014.27'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.18', 'doi-asserted-by': 'publisher', 'DOI': '10.1161/CIRCRESAHA.109.207019'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.19', 'doi-asserted-by': 'publisher', 'DOI': '10.1128/JVI.72.9.7084-7090.1998'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.20', 'first-page': '1533', 'article-title': 'Suppression of Herpes simplex virus type 1 (HSV-1)-induced pneumonia in ' 'mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2)', 'volume': '1997', 'year': '1997', 'journal-title': 'Journal Of Experimental Medicine 185. AAAAI/AAI/CIS Joint Meeting, SAN ' 'FRANCISCO, CA, FEB 21-26', 'ISSN': 'http://id.crossref.org/issn/0022-1007', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.21', 'doi-asserted-by': 'crossref', 'first-page': '2202', 'DOI': '10.1128/jvi.71.3.2202-2210.1997', 'article-title': 'Disassociation between the in vitro and in vivo effects of nitric oxide ' 'on a neurotropic murine coronavirus', 'volume': '71', 'year': '1997', 'journal-title': 'Journal Of Virology', 'ISSN': 'http://id.crossref.org/issn/0022-538X', 'issn-type': 'print'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.22', 'doi-asserted-by': 'publisher', 'DOI': '10.1073/pnas.93.6.2448'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.23', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1567-5769(01)00086-8'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.24', 'doi-asserted-by': 'publisher', 'DOI': '10.1046/j.1523-1755.2002.00138.x'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.25', 'doi-asserted-by': 'publisher', 'DOI': '10.1006/abbi.2001.2360'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.26', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.virol.2009.09.007'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.27', 'doi-asserted-by': 'crossref', 'unstructured': 'Holliman, G. , Lowe, D. , Cohen, H. , Felton, S. & Raj, K. Ultraviolet ' 'Radiation-Induced Production of Nitric Oxide: A multi-cell and ' 'multi-donor analysis. Scientific Reports 7. issn: 2045-2322 (2017).', 'DOI': '10.1038/s41598-017-11567-5'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.28', 'doi-asserted-by': 'publisher', 'DOI': '10.1046/j.1523-1747.2003.12415.x'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.29', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1473-3099(20)30120-1'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.30', 'unstructured': 'Van Geffen, J. , Van Weele, M. , Allaart, M. & Van der A, R. TEMIS UV ' 'index and UV dose operational data products, version 2. Dataset. 2017.'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.31', 'unstructured': 'Hale, T. , Webster, S. , Petherick, A. , Phillips, T. & Kira, B. Oxford ' 'COVID-19 Government Response Tracker. (2020).'}, { 'key': '2022022305400540000_2020.11.28.20240242v2.32', 'first-page': '1', 'article-title': 'Bootstrap Methods: Another Look at the Jackknife', 'volume': '7', 'year': '1979', 'journal-title': 'Ann. Statist'}], 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://syndication.highwire.org/content/doi/10.1101/2020.11.28.20240242', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 2, 23]], 'date-time': '2022-02-23T13:41:03Z', 'timestamp': 1645623663000}, 'score': 1, 'resource': {'primary': {'URL': 'http://medrxiv.org/lookup/doi/10.1101/2020.11.28.20240242'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 11, 30]]}, 'references-count': 32, 'URL': 'http://dx.doi.org/10.1101/2020.11.28.20240242', 'relation': {}, 'published': {'date-parts': [[2020, 11, 30]]}, 'subtype': 'preprint'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit