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0 0.5 1 1.5 2+ Case 8% Improvement Relative Risk Vitamin D  Blanch-Rubió et al.  Prophylaxis Does vitamin D reduce COVID-19 infections? Retrospective 2,102 patients in Spain No significant difference in cases Blanch-Rubió et al., Aging, October 2020 Favors vitamin D Favors control

Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions

Blanch-Rubió et al., Aging, doi:10.18632/aging.104117
Oct 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 118 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 2,102 rheumatology patients in Spain showing no significant difference in cases with vitamin D supplementation. Details of vitamin D supplementation are not providied - other patients may have also independently taken vitamin D.
This is the 5th of 118 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 30 sextillion). 29 studies are RCTs, which show efficacy with p=0.0000035.
risk of case, 8.0% lower, RR 0.92, p = 0.68, treatment 62 of 1,303 (4.8%), control 47 of 799 (5.9%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Blanch-Rubió et al., 20 Oct 2020, retrospective, Spain, peer-reviewed, mean age 66.4, 10 authors, dosage not specified.
This PaperVitamin DAll
Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions
Josep Blanch-Rubió, Natalia Soldevila-Domenech, Laura Tío, Jone Llorente-Onaindia, Manuel Ciria-Recasens, Luciano Polino, Alba Gurt, Rafael De La Torre, Rafael Maldonado, Jordi Monfort, Covidmar Study
INTRODUCTION Infections by SARS-CoV-2, a novel coronavirus that emerged in China in late 2019 [1], and the disease that it causes, COVID-19, became a global pandemic on March 11 th , 2020 [2]. By July19 th , 2020, COVID-19 had infected 14,348,475 people and caused 603,167 deaths worldwide [3].
Abbreviations ARBs: angiotensin II receptor blockers; ACE: angiotensin-converting-enzyme; CI: confidence interval; COVID-19: Coronavirus disease 19; CV: cardiovascular; NSAIDs: non-steroidal anti-inflammatory drugs; SERMs: selective estrogen receptor modulators; SSRIs: serotonin reuptake inhibitors. AUTHOR CONTRIBUTIONS J.B.R. was involved in conceptualizing the research idea, creating the research design, making the final interpretation of the statistical analyses, and writing the first draft and revision of the manuscript. N.S.D. participated in selection of statistical tests/analyses, performed the statistical analyses, computations and related computer work, and participated in writing the manuscript. L.T. was involved in conceptualizing the research idea, setting-up the research design, making the primary interpretation of the statistical analyses and participated in writing the manuscript. J.L.O. was involved in conceptualizing the research idea, setting-up the research design, making the primary interpretation of the statistical analyses and participated in writing the manuscript. M.C.R., L.P, and A.G. were responsible for patient cohort data collection. R.D.L.T. contributed to the statistical analyses and revised the manuscript. R.M. and J.M. were involved in conceptualizing the research idea, creating the research design, making the final interpretation of the statistical analysis, and writing the first draft and revision of the manuscript. CONFLICTS OF INTEREST..
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