Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All andrographolide studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAndrographolideAndrographol.. (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial

Bhardwaj et al., Journal of Ayurveda and Integrative Medicine, doi:10.1016/j.jaim.2023.100778, CTRI/2021/05/033790
Nov 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Hospitalization time 13% Improvement Relative Risk Recovery, dsypnea 80% Recovery, fever -400% Recovery, cough 0% Recovery, headache 45% Recovery, sore throat 0% Time to viral- 12% Viral clearance, day 7 58% Viral clearance, day 5 27% Viral clearance, day 3 27% Andrographolide  Bhardwaj et al.  EARLY TREATMENT  DB RCT Is early treatment with andrographolide + multiple treatments beneficial for COVID-19? Double-blind RCT 150 patients in India (June - August 2021) Shorter hospitalization (p=0.046) and faster viral clearance (p=0.018) c19early.org Bhardwaj et al., J. Ayurveda and Integ.., Nov 2023 Favorsandrographolide Favorscontrol 0 0.5 1 1.5 2+
RCT 150 mild-moderate COVID-19 patients showing faster viral clearance and shorter hospitalization with NAOQ19, a polyherbal formulation containing 13 antiviral/antinflammatory compounds. NAOQ19 ingredients include curcumin, andrographis, and antiandrogen glycyrrhiza glabra.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Study covers andrographolide and curcumin.
hospitalization time, 12.8% lower, relative time 0.87, p = 0.046, treatment 75, control 75.
risk of no recovery, 80.0% lower, RR 0.20, p = 0.50, treatment 0 of 75 (0.0%), control 2 of 75 (2.7%), NNT 38, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 7, dsypnea.
risk of no recovery, 400.0% higher, RR 5.00, p = 0.50, treatment 2 of 75 (2.7%), control 0 of 75 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 7, fever.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 4 of 75 (5.3%), control 4 of 75 (5.3%), day 7, cough.
risk of no recovery, 45.5% lower, RR 0.55, p = 0.30, treatment 6 of 75 (8.0%), control 11 of 75 (14.7%), NNT 15, day 7, headache.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 3 of 75 (4.0%), control 3 of 75 (4.0%), day 7, sore throat.
time to viral-, 11.5% lower, relative time 0.88, p = 0.02, treatment 75, control 75.
risk of no viral clearance, 57.9% lower, RR 0.42, p = 0.03, treatment 8 of 75 (10.7%), control 19 of 75 (25.3%), NNT 6.8, day 7.
risk of no viral clearance, 27.3% lower, RR 0.73, p = 0.18, treatment 24 of 75 (32.0%), control 33 of 75 (44.0%), NNT 8.3, day 5.
risk of no viral clearance, 27.1% lower, RR 0.73, p = 0.048, treatment 35 of 75 (46.7%), control 48 of 75 (64.0%), NNT 5.8, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bhardwaj et al., 15 Nov 2023, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, 26 authors, study period 7 June, 2021 - 28 August, 2021, this trial uses multiple treatments in the treatment arm (combined with multiple treatments) - results of individual treatments may vary, trial CTRI/2021/05/033790. Contact: director.ssiar@artofliving.org.
This PaperAndrographol..All
Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric trial
Pankaj Bhardwaj, Kalaiselvan Ganapathy, Monika Pathania, K H Naveen, Jaykaran Charan, Siddhartha Dutta, Ravisekhar Gadepalli, Srikanth Srinivasan, Manoj Kumar Gupta, Akhil D Goel, Naresh Midha, Bharat Kumar, Meenakshi Sharma, Praveen Sharma, Mithu Banerjee, Prasenjit Mitra, Sanjeev Misra, Vinayagamoorthy V b Girija Subramaniant, Praveen R k Minakshi Dhar, Vartika Saxena, Puneet Dhamija, Archana Singh, Saumya Subramanian, Divya Kanchibhotla
Journal of Ayurveda and Integrative Medicine, doi:10.1016/j.jaim.2023.100778
Background: Medicines in indigenous systems such as Ayurveda have strong antimicrobial activity but doubleblind randomized control trials are infrequent in this system of medicine. The efficacy of a new ayurvedic formulation was evaluated during the pandemic. Methods: 150 mild-moderate COVID-19 patients were enrolled and randomized in 1:1 to NAOQ19 and placebo group. RT-PCR was done on Day 3, 5 and 7. CBC, CRP, LFT, and KFT were assessed at baseline and exit. Duration of hospital stay was noted and clinical assessment was also performed. Result: The results demonstrated more people turning RT-PCR negative in the NAOQ19 group compared to the placebo group on day 3 (p-value = 0.033). The mean time duration to turn RT-PCR negative was significantly lower in the NAOQ19 group (4.6 days) compared to placebo group (5.2 days) (p-value = 0.018). There was significant reduction in hospital stay among patients in the NAOQ19 arm who were discharged earlier (5.6 days) compared to placebo group (6.4 days) (p-value = 0.046). Patients in NAOQ19 arm did not show any adverse lifethreatening events. Conclusion: The ayurvedic preparation given along with standard of care therapy reduced the duration of hospital stay and there was earlier conversion to RT-PCR negative.The integrated approach can help to reduce patient workload in the hospitals as well as limit the transmission of the virus in the community.
Author contributions Conceptualization: Divya Kanchibhotla, Pankaj Bhardwaj; Data curation: Pankaj Bhardwaj, Kalaiselvan Ganapathy, Monika Pathania, K H Naveen, Jaykaran Charan, Siddhartha Dutta, Ravisekhar Gadepalli, Srikanth Srinivasan, Manoj Kumar Gupta, Akhil D Goel, Naresh Midha, Bharat Kumar, Meenakshi Sharma, Praveen Sharma, Mithu Banerjee, Prasenjit Mitra, Sanjeev Misra, Vinayagamoorthy V, Girija Subramaniant, Praveen R Puneet Dhamija, Archana Singh; Formal Analysis: Divya Kanchibhotla, Saumya Subramanian; Declaration of competing interest Besides providing the NAOQ19 intervention tablets, Sriveda Sattva Pvt. Ltd. was not involved in any aspect of this study. All the other authors have no conflicts of interest to declare. Ethical approval The study was approved by Institutional Ethics Committee with registration number as follows: AIIMS Jodhpur AIIMS/IEC/2021/3626; AIIMS Rishikesh AIIMS/IEC/21/306 and SMVMCH, Puducherry SMVMCH-ECO-AL/153/2021. The study was registered at Clinical Trial Registry, India bearing registration number CTRI/2021/05/033790.
References
Ahirwar, Kaim, Ahirwar, Jha, The second wave of COVID-19: effect on Indian health care system, Horm Mol Biol Clin Invest
Banerjee, Kar, Mukherjee, Haldar, Sharma et al., Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections-LC-MS/MS and network pharmacology analysis, Phytochem Anal
Chopra, Chavan-Gautam, Tillu, Saluja, Borse, Randomized, double blind, placebo controlled, clinical trial to study ashwagandha administration in participants vaccinated against COVID-19 on safety, immunogenicity, and protection with COVID-19 vaccine-a study protocol, Front Med
Cinatl, Morgenstern, Bauer, Chandra, Rabenau et al., Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus, Lancet
Das, Dash, Panda, Sadana, Kumar et al., The efficacy of a plant based formulation in the symptomatic management of mild COVID-19 cases: a double blind, randomized controlled trial, AMCRS
Devpura, Tomar, Nathiya, Sharma, Bhandari et al., Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients, Phytomedicine
Dutt, Ganatra, Suthar, Malek, Shukla, A randomized and comparative study to assess safety and efficacy of supplemental treatment of a herbal formulation-Aayudh Advance comprising essential oils in patients with corona virus 2019 (COVID-19), Contemp Clin Trials Commun
Ethirajan, Natarajan, Velayudham, Jayakumaran, Karnan, Clinicoepidemiological profile of COVID-19 patients with Omicron variant admitted in a tertiary care center, South India, Int J Gen Med
Gautam, Gautam, Chhetri, Bhattarai, Immunity against COVID-19: potential role of Ayush Kwath, J Ayurveda Integr Med, doi:10.1016/j.jaim.2020.08.003
Hoever, Baltina, Michaelis, Kondratenko, Baltina, Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus, J Med Chem
Jena, Munusami, Mm, Computationally approached inhibition potential of Tinospora cordifolia towards COVID-19 targets, Virus Disease
Joshi, Kamath, Nair, Thimmappa, Sriranjini, Modulation of neutrophil (dys) function by Ayurvedic herbs and its potential influence on SARS-CoV-2 infection, J Ayurveda Integr Med
Kanchibhotla, Harsora, Subramanian, Reddy, Venkatesh, Rate of recovery and symptomatic efficacy of a polyherbal AYUSH formulation in the treatment of SARS-CoV-2 disease: a single-arm trial, Alternative Ther Health Med
Kanchibhotla, Subramanian, Kumar, Hari, Pathania, An In-vitro evaluation of a polyherbal formulation, against SARS-CoV-2, J Ayurveda Integr Med
Khuntia, Sharma, Wadhawan, Chhabra, Kidambi et al., Antiviral potential of Indian medicinal plants against influenza and SARS-CoV: a systematic review, Nat Prod Commun
Mathieu, Ritchie, Ortiz-Ospina, Roser, Hasell, A global database of COVID-19 vaccinations, Nat Human Behav
Nealon, Cowling, Omicron severity: milder but not mild, Lancet
Nivetha, Bhuvaragavan, Kumar, Ramanathan, Janarthanan, Inhibition of multiple SARS-CoV-2 proteins by an antiviral biomolecule, seselin from Aegle marmelos deciphered using molecular docking analysis, J Biomol Struct Dyn
Pandkar, Sachdeva, Pathophysiology of Covid-19 and host centric approaches in Ayurveda, J Ayurveda Integr Med, doi:10.1016/j.jaim.2020.11.010
Qazi, Das, Khuntia, Sharma, Sharma, In silico molecular docking and molecular dynamic simulation analysis of phytochemicals from Indian foods as potential inhibitors of SARS-CoV-2 RdRp and 3CLpro, Nat Prod Commun
Rais, Negi, Yadav, Arya, Verma et al., A Randomized open label parallel group pilot study to evaluate efficacy of Ayurveda interventions in the management of asymptomatic and mild COVID-19 patients-experiences of a Lucknow based level 2 hospital of Uttar Pradesh, India, J Ayurveda Integr Med
Reddy, Gosavi, Yadav, Rai, Holay, AYUSH-64 as an add-on to standard care in asymptomatic and mild cases of COVID-19: a randomized controlled trial, Ayu
Rizvi, Tripathy, Sharma, Goswami, Srikanth, Effect of prophylactic use of intranasal oil formulations in the hamster model of COVID-19, Front Pharmacol
Sa-Ngiamsuntorn, Suksatu, Pewkliang, Thongsri, Kanjanasirirat, Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component Andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives, J Nat Prod
Shehu, Datta, THERAPEUTIC PROFILE OF Glycyrrhiza glabra: a ray of hope in treating COVID-19, Malays J Pharmaceut Sci
Shree, Mishra, Selvaraj, Singh, Chaube, Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants-Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)-a molecular docking study, J Biomol Struct Dyn
Singh, Goel, Bourgeade, Aleya, Tewari, Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19, Environ Sci Pollut Res
Singh, Goel, Bourgeade, Aleya, Tewari, Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19, Environ Sci Pollut Res
Singh, Verma, Lakshminarayan, India's efforts to achieve 1.5 billion COVID-19 vaccinations: a narrative review, Osong Pub Health Res Perspect
Soni, Mehta, Ratre, Tiwari, Amit, Curcumin, a traditional spice component, can hold the promise against COVID-19?, Eur J Pharmacol
Srivastava, Rengaraju, Srivastava, Narayan, Gupta et al., A double blinded placebo controlled comparative clinical trial to evaluate the effectiveness of Siddha medicines, Kaba Sura Kudineer (KSK) & Nilavembu Kudineer (NVK) along with standard Allopathy treatment in the management of symptomatic COVID 19 patients-a structured summary of a study protocol for a randomized controlled trial, Trials
Stravalaci, Pagani, Paraboschi, Pedotti, Doni, Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules, Nat Immunol
Subhrajyoti, Immunomodulatory herbs of Ayurveda and covid-19: a review article, J Ayurveda Integr Med
Tripathi, Singh, Sharma, Singh, Ethayathulla et al., Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor, J Biomol Struct Dyn
Umashankar, Deshpande, Hegde, Singh, Chattopadhyay, Phytochemical moieties from Indian traditional medicine for targeting dual hotspots on SARS-CoV-2 spike protein: an integrative in-silico approach, Front Med
Vallish, Dang, Dang, Nature and mechanism of immune boosting by Ayurvedic medicine: a systematic review of randomized controlled trials, World J Methodol
Vincent, Arokiyaraj, Saravanan, Dhanraj, Molecular docking studies on the anti-viral effects of compounds from kabasura kudineer on SARS-CoV-2 3CLpro, Front Mol Biosci
Wanjarkhedkar, Sarade, Purandare, Kelkar, A prospective clinical study of an Ayurveda regimen in COVID 19 patients, J Ayurveda Integr Med
Wolny, Dittrich, Knabbe, Birschmann, Immature platelets in COVID-19, Platelets, doi:10.1080/09537104.2023.2184183
Zahedipour, Hosseini, Sathyapalan, Majeed, Potential effects of curcumin in the treatment of COVID-19 infection, Phytother Res
Zuo, Meng, Wang, Tang, A review of the antiviral activities of glycyrrhizic acid, glycyrrhetinic acid and glycyrrhetinic acid monoglucuronide, Pharmaceuticals, doi:10.3390/ph16050641
{ 'indexed': { 'date-parts': [[2023, 11, 25]], 'date-time': '2023-11-25T21:42:23Z', 'timestamp': 1700948543185}, 'reference-count': 41, 'publisher': 'Elsevier BV', 'issue': '6', 'license': [ { 'start': { 'date-parts': [[2023, 11, 1]], 'date-time': '2023-11-01T00:00:00Z', 'timestamp': 1698796800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2023, 7, 8]], 'date-time': '2023-07-08T00:00:00Z', 'timestamp': 1688774400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.com.au', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2023, 11]]}, 'DOI': '10.1016/j.jaim.2023.100778', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 11, 15]], 'date-time': '2023-11-15T05:04:14Z', 'timestamp': 1700024654000}, 'page': '100778', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the treatment of ' 'mild-moderate COVID-19 patients: A double blind, randomized, placebo-controlled, multicentric ' 'trial', 'prefix': '10.1016', 'volume': '14', 'author': [ {'given': 'Pankaj', 'family': 'Bhardwaj', 'sequence': 'first', 'affiliation': []}, {'given': 'Kalaiselvan', 'family': 'Ganapathy', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3609-1162', 'authenticated-orcid': False, 'given': 'Monika', 'family': 'Pathania', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4261-5989', 'authenticated-orcid': False, 'given': 'K.H.', 'family': 'Naveen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jaykaran', 'family': 'Charan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Siddhartha', 'family': 'Dutta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ravisekhar', 'family': 'Gadepalli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Srikanth', 'family': 'Srinivasan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Manoj Kumar', 'family': 'Gupta', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-6156-7903', 'authenticated-orcid': False, 'given': 'Akhil D.', 'family': 'Goel', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-5673-890X', 'authenticated-orcid': False, 'given': 'Naresh', 'family': 'Midha', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0044-6825', 'authenticated-orcid': False, 'given': 'Bharat', 'family': 'Kumar', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8235-9644', 'authenticated-orcid': False, 'given': 'Meenakshi', 'family': 'Sharma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Praveen', 'family': 'Sharma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mithu', 'family': 'Banerjee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Prasenjit', 'family': 'Mitra', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanjeev', 'family': 'Misra', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vinayagamoorthy', 'family': 'V', 'sequence': 'additional', 'affiliation': []}, {'given': 'Girija', 'family': 'Subramaniant', 'sequence': 'additional', 'affiliation': []}, {'given': 'Praveen', 'family': 'R', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6336-5179', 'authenticated-orcid': False, 'given': 'Minakshi', 'family': 'Dhar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vartika', 'family': 'Saxena', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-2890-4939', 'authenticated-orcid': False, 'given': 'Puneet', 'family': 'Dhamija', 'sequence': 'additional', 'affiliation': []}, {'given': 'Archana', 'family': 'Singh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Saumya', 'family': 'Subramanian', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0760-630X', 'authenticated-orcid': False, 'given': 'Divya', 'family': 'Kanchibhotla', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '7', 'key': '10.1016/j.jaim.2023.100778_bib3', 'doi-asserted-by': 'crossref', 'first-page': '947', 'DOI': '10.1038/s41562-021-01122-8', 'article-title': 'A global database of COVID-19 vaccinations', 'volume': '5', 'author': 'Mathieu', 'year': '2021', 'journal-title': 'Nat Human Behav'}, { 'issue': '40', 'key': '10.1016/j.jaim.2023.100778_bib4', 'doi-asserted-by': 'crossref', 'first-page': '55925', 'DOI': '10.1007/s11356-021-16280-5', 'article-title': 'Ayurveda Rasayana as antivirals and immunomodulators: potential ' 'applications in COVID-19', 'volume': '28', 'author': 'Singh', 'year': '2021', 'journal-title': 'Environ Sci Pollut Res'}, { 'key': '10.1016/j.jaim.2023.100778_bib5', 'article-title': 'Modulation of neutrophil (dys) function by Ayurvedic herbs and its ' 'potential influence on SARS-CoV-2 infection', 'volume': '16', 'author': 'Joshi', 'year': '2021', 'journal-title': 'J Ayurveda Integr Med'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib6', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaim.2020.11.010', 'article-title': 'Pathophysiology of Covid-19 and host centric approaches in Ayurveda', 'volume': '13', 'author': 'Pandkar', 'year': '2022', 'journal-title': 'J Ayurveda Integr Med'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib7', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaim.2020.08.003', 'article-title': 'Immunity against COVID-19: potential role of Ayush Kwath', 'volume': '13', 'author': 'Gautam', 'year': '2022', 'journal-title': 'J Ayurveda Integr Med'}, { 'issue': '2', 'key': '10.1016/j.jaim.2023.100778_bib8', 'first-page': '203', 'article-title': 'Immunomodulatory herbs of Ayurveda and covid-19: a review article', 'volume': '5', 'author': 'Subhrajyoti', 'year': '2020', 'journal-title': 'J Ayurveda Integr Med'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib9', 'doi-asserted-by': 'crossref', 'first-page': '190', 'DOI': '10.1080/07391102.2020.1810778', 'article-title': 'Targeting COVID-19 (SARS-CoV-2) main protease through active ' 'phytochemicals of ayurvedic medicinal plants–Withania somnifera ' '(Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum ' '(Tulsi)–a molecular docking study', 'volume': '40', 'author': 'Shree', 'year': '2022', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '10.1016/j.jaim.2023.100778_bib10', 'first-page': '1', 'article-title': 'Identification of bioactive molecule from Withania somnifera ' '(Ashwagandha) as SARS-CoV-2 main protease inhibitor', 'author': 'Tripathi', 'year': '2020', 'journal-title': 'J Biomol Struct Dyn'}, { 'issue': '9', 'key': '10.1016/j.jaim.2023.100778_bib11', 'article-title': 'Randomized, double blind, placebo controlled, clinical trial to study ' 'ashwagandha administration in participants vaccinated against COVID-19 ' 'on safety, immunogenicity, and protection with COVID-19 vaccine–a study ' 'protocol', 'volume': '16', 'author': 'Chopra', 'year': '2022', 'journal-title': 'Front Med'}, { 'key': '10.1016/j.jaim.2023.100778_bib12', 'first-page': '1', 'article-title': 'Inhibition of multiple SARS-CoV-2 proteins by an antiviral biomolecule, ' 'seselin from Aegle marmelos deciphered using molecular docking analysis', 'volume': '12', 'author': 'Nivetha', 'year': '2021', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '10.1016/j.jaim.2023.100778_bib13', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2021.672629', 'article-title': 'Phytochemical moieties from Indian traditional medicine for targeting ' 'dual hotspots on SARS-CoV-2 spike protein: an integrative in-silico ' 'approach', 'volume': '8', 'author': 'Umashankar', 'year': '2021', 'journal-title': 'Front Med'}, { 'issue': '9', 'key': '10.1016/j.jaim.2023.100778_bib14', 'article-title': 'In silico molecular docking and molecular dynamic simulation analysis ' 'of phytochemicals from Indian foods as potential inhibitors of ' 'SARS-CoV-2 RdRp and 3CLpro', 'volume': '16', 'author': 'Qazi', 'year': '2021', 'journal-title': 'Nat Prod Commun'}, { 'issue': '5', 'key': '10.1016/j.jaim.2023.100778_bib15', 'doi-asserted-by': 'crossref', 'first-page': '641', 'DOI': '10.3390/ph16050641', 'article-title': 'A review of the antiviral activities of glycyrrhizic acid, ' 'glycyrrhetinic acid and glycyrrhetinic acid monoglucuronide', 'volume': '16', 'author': 'Zuo', 'year': '2023', 'journal-title': 'Pharmaceuticals'}, { 'issue': '7', 'key': '10.1016/j.jaim.2023.100778_bib16', 'first-page': '434', 'article-title': 'Molecular docking studies on the anti-viral effects of compounds from ' 'kabasura kudineer on SARS-CoV-2 3CLpro', 'volume': '23', 'author': 'Vincent', 'year': '2020', 'journal-title': 'Front Mol Biosci'}, { 'key': '10.1016/j.jaim.2023.100778_bib17', 'first-page': '12', 'article-title': 'Effect of prophylactic use of intranasal oil formulations in the ' 'hamster model of COVID-19', 'author': 'Rizvi', 'year': '2021', 'journal-title': 'Front Pharmacol'}, { 'issue': '3', 'key': '10.1016/j.jaim.2023.100778_bib18', 'article-title': 'Antiviral potential of Indian medicinal plants against influenza and ' 'SARS-CoV: a systematic review', 'volume': '17', 'author': 'Khuntia', 'year': '2022', 'journal-title': 'Nat Prod Commun'}, { 'issue': '4', 'key': '10.1016/j.jaim.2023.100778_bib19', 'doi-asserted-by': 'crossref', 'first-page': '1261', 'DOI': '10.1021/acs.jnatprod.0c01324', 'article-title': 'Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its ' 'major component Andrographolide in human lung epithelial cells and ' 'cytotoxicity evaluation in major organ cell representatives', 'volume': '84', 'author': 'Sa-Ngiamsuntorn', 'year': '2021', 'journal-title': 'J Nat Prod'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib20', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/09537104.2023.2184183', 'article-title': 'Immature platelets in COVID-19', 'volume': '34', 'author': 'Wolny', 'year': '2023', 'journal-title': 'Platelets'}, { 'issue': '4', 'key': '10.1016/j.jaim.2023.100778_bib21', 'doi-asserted-by': 'crossref', 'first-page': '629', 'DOI': '10.1002/pca.3011', 'article-title': 'Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis ' 'paniculata) against respiratory viral infections–LC–MS/MS and network ' 'pharmacology analysis', 'volume': '32', 'author': 'Banerjee', 'year': '2021', 'journal-title': 'Phytochem Anal'}, { 'issue': '11', 'key': '10.1016/j.jaim.2023.100778_bib22', 'doi-asserted-by': 'crossref', 'first-page': '2911', 'DOI': '10.1002/ptr.6738', 'article-title': 'Potential effects of curcumin in the treatment of COVID‐19 infection', 'volume': '34', 'author': 'Zahedipour', 'year': '2020', 'journal-title': 'Phytother Res'}, { 'key': '10.1016/j.jaim.2023.100778_bib23', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejphar.2020.173551', 'article-title': 'Curcumin, a traditional spice component, can hold the promise against ' 'COVID-19?', 'volume': '886', 'author': 'Soni', 'year': '2020', 'journal-title': 'Eur J Pharmacol'}, { 'issue': '2', 'key': '10.1016/j.jaim.2023.100778_bib24', 'doi-asserted-by': 'crossref', 'first-page': '107', 'DOI': '10.4103/ayu.ayu_14_21', 'article-title': 'AYUSH-64 as an add-on to standard care in asymptomatic and mild cases ' 'of COVID-19: a randomized controlled trial', 'volume': '41', 'author': 'Reddy', 'year': '2020', 'journal-title': 'Ayu'}, { 'issue': '2', 'key': '10.1016/j.jaim.2023.100778_bib25', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaim.2020.12.013', 'article-title': 'A Randomized open label parallel group pilot study to evaluate efficacy ' 'of Ayurveda interventions in the management of asymptomatic and mild ' 'COVID-19 patients-experiences of a Lucknow based level 2 hospital of ' 'Uttar Pradesh, India', 'volume': '13', 'author': 'Rais', 'year': '2022', 'journal-title': 'J Ayurveda Integr Med'}, { 'key': '10.1016/j.jaim.2023.100778_bib26', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.phymed.2021.153494', 'article-title': 'Randomized placebo-controlled pilot clinical trial on the efficacy of ' 'ayurvedic treatment regime on COVID-19 positive patients', 'volume': '84', 'author': 'Devpura', 'year': '2021', 'journal-title': 'Phytomedicine'}, { 'issue': '3', 'key': '10.1016/j.jaim.2023.100778_bib27', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jaim.2022.100581', 'article-title': 'An In-vitro evaluation of a polyherbal formulation, against SARS-CoV-2', 'volume': '13', 'author': 'Kanchibhotla', 'year': '2022', 'journal-title': 'J Ayurveda Integr Med'}, { 'key': '10.1016/j.jaim.2023.100778_bib28', 'first-page': '5', 'article-title': 'The efficacy of a plant based formulation in the symptomatic management ' 'of mild COVID-19 cases: a double blind, randomized controlled trial', 'volume': '7', 'author': 'Kumar Das', 'year': '2023', 'journal-title': 'AMCRS'}, { 'issue': '4', 'key': '10.1016/j.jaim.2023.100778_bib29', 'first-page': '134', 'article-title': 'Rate of recovery and symptomatic efficacy of a polyherbal AYUSH ' 'formulation in the treatment of SARS-CoV-2 disease: a single-arm trial', 'volume': '29', 'author': 'Kanchibhotla', 'year': '2023', 'journal-title': 'Alternative Ther Health Med'}, { 'key': '10.1016/j.jaim.2023.100778_bib32', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.conctc.2021.100755', 'article-title': 'A randomized and comparative study to assess safety and efficacy of ' 'supplemental treatment of a herbal formulation-Aayudh Advance ' 'comprising essential oils in patients with corona virus 2019 (COVID-19)', 'volume': '22', 'author': 'Dutt', 'year': '2021', 'journal-title': 'Contemp Clin Trials Commun'}, { 'issue': '4', 'key': '10.1016/j.jaim.2023.100778_bib33', 'first-page': '343', 'article-title': 'The second wave of COVID-19: effect on Indian health care system', 'volume': '42', 'author': 'Ahirwar', 'year': '2021', 'journal-title': 'Horm Mol Biol Clin Invest'}, { 'key': '10.1016/j.jaim.2023.100778_bib34', 'doi-asserted-by': 'crossref', 'first-page': '185', 'DOI': '10.2147/IJGM.S365207', 'article-title': 'Clinico-epidemiological profile of COVID-19 patients with Omicron ' 'variant admitted in a tertiary care center, South India', 'author': 'Ethirajan', 'year': '2023', 'journal-title': 'Int J Gen Med'}, { 'issue': '40', 'key': '10.1016/j.jaim.2023.100778_bib35', 'doi-asserted-by': 'crossref', 'first-page': '55925', 'DOI': '10.1007/s11356-021-16280-5', 'article-title': 'Ayurveda Rasayana as antivirals and immunomodulators: potential ' 'applications in COVID-19', 'volume': '28', 'author': 'Singh', 'year': '2021', 'journal-title': 'Environ Sci Pollut Res'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib36', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s13063-020-04976-x', 'volume': '22', 'author': 'Srivastava', 'year': '2021', 'journal-title': 'Trials'}, { 'issue': '4', 'key': '10.1016/j.jaim.2023.100778_bib37', 'doi-asserted-by': 'crossref', 'first-page': '1256', 'DOI': '10.1021/jm0493008', 'article-title': 'Antiviral activity of glycyrrhizic acid derivatives against SARS− ' 'coronavirus', 'volume': '48', 'author': 'Hoever', 'year': '2005', 'journal-title': 'J Med Chem'}, { 'issue': '1', 'key': '10.1016/j.jaim.2023.100778_bib38', 'doi-asserted-by': 'crossref', 'first-page': '65', 'DOI': '10.1007/s13337-021-00666-7', 'article-title': 'Computationally approached inhibition potential of Tinospora cordifolia ' 'towards COVID-19 targets', 'volume': '32', 'author': 'Jena', 'year': '2021', 'journal-title': 'Virus Disease'}, { 'issue': '2', 'key': '10.1016/j.jaim.2023.100778_bib39', 'first-page': '147', 'article-title': 'THERAPEUTIC PROFILE OF Glycyrrhiza glabra: a ray of hope in treating ' 'COVID-19', 'volume': '20', 'author': 'Shehu', 'year': '2022', 'journal-title': 'Malays J Pharmaceut Sci'}, { 'issue': '9374', 'key': '10.1016/j.jaim.2023.100778_bib40', 'doi-asserted-by': 'crossref', 'first-page': '2045', 'DOI': '10.1016/S0140-6736(03)13615-X', 'article-title': 'Glycyrrhizin, an active component of liquorice roots, and replication ' 'of SARS-associated coronavirus', 'volume': '361', 'author': 'Cinatl', 'year': '2003', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.jaim.2023.100778_bib41', 'article-title': 'A prospective clinical study of an Ayurveda regimen in COVID 19 ' 'patients', 'author': 'Wanjarkhedkar', 'year': '2020', 'journal-title': 'J Ayurveda Integr Med'}, { 'issue': '5', 'key': '10.1016/j.jaim.2023.100778_bib42', 'doi-asserted-by': 'crossref', 'first-page': '316', 'DOI': '10.24171/j.phrp.2022.0104', 'article-title': "India's efforts to achieve 1.5 billion COVID-19 vaccinations: a " 'narrative review', 'volume': '13', 'author': 'Singh', 'year': '2022', 'journal-title': 'Osong Pub Health Res Perspect'}, { 'issue': '10323', 'key': '10.1016/j.jaim.2023.100778_bib44', 'doi-asserted-by': 'crossref', 'first-page': '412', 'DOI': '10.1016/S0140-6736(22)00056-3', 'article-title': 'Omicron severity: milder but not mild', 'volume': '399', 'author': 'Nealon', 'year': '2022', 'journal-title': 'Lancet'}, { 'issue': '2', 'key': '10.1016/j.jaim.2023.100778_bib45', 'doi-asserted-by': 'crossref', 'first-page': '275', 'DOI': '10.1038/s41590-021-01114-w', 'article-title': 'Recognition and inhibition of SARS-CoV-2 by humoral innate immunity ' 'pattern recognition molecules', 'volume': '23', 'author': 'Stravalaci', 'year': '2022', 'journal-title': 'Nat Immunol'}, { 'issue': '3', 'key': '10.1016/j.jaim.2023.100778_bib46', 'doi-asserted-by': 'crossref', 'first-page': '132', 'DOI': '10.5662/wjm.v12.i3.132', 'article-title': 'Nature and mechanism of immune boosting by Ayurvedic medicine: a ' 'systematic review of randomized controlled trials', 'volume': '12', 'author': 'Vallish', 'year': '2022', 'journal-title': 'World J Methodol'}], 'container-title': 'Journal of Ayurveda and Integrative Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0975947623000943?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0975947623000943?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2023, 11, 25]], 'date-time': '2023-11-25T21:21:11Z', 'timestamp': 1700947271000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0975947623000943'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 11]]}, 'references-count': 41, 'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2023, 11]]}}, 'alternative-id': ['S0975947623000943'], 'URL': 'http://dx.doi.org/10.1016/j.jaim.2023.100778', 'relation': {}, 'ISSN': ['0975-9476'], 'subject': ['Complementary and alternative medicine', 'Drug Discovery'], 'container-title-short': 'Journal of Ayurveda and Integrative Medicine', 'published': {'date-parts': [[2023, 11]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Effectiveness of ayurvedic formulation, NAOQ19 along with standard care in the ' 'treatment of mild-moderate COVID-19 patients: A double blind, randomized, ' 'placebo-controlled, multicentric trial', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Journal of Ayurveda and Integrative Medicine', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jaim.2023.100778', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2023 The Authors. Published by Elsevier B.V. on behalf of Institute of ' 'Transdisciplinary Health Sciences and Technology and World Ayurveda Foundation', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '100778'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit