Correlation of vitamin D levels with serum parameters in Covid-19 patients
Masoud Beheshti, Niloofar Neisi, Mehdi Parsanahad, Mojtaba Rasti, Roohangiz Nashibi, Bahman Cheraghian
Clinical Nutrition ESPEN, doi:10.1016/j.clnesp.2023.04.012
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Author contributions All authors agreed with the content and gave explicit consent to submit, and obtained consent from the responsible authorities at the institute/organization where the work has been carried out before the submission. The conception and design of the study were carried out by N.N, M.R, and R.N. Data acquisition was done by N.N and M.B. Measurement was done by M.B, N.N, and M.P. The data were analyzed by M.B and B.C and interpreted by N.N, R.N., and M.B. All authors drafted the work or revised it critically for important intellectual content; approved the version to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved based on ICMJE authorship criteria.
Financial disclosure This study was issued from the M.Sc thesis of Masoud Beheshti and financially supported by the Infectious and Tropical Diseases Research Center (Grant no. OG-9964), Health Research Institute, Ahvaz Jundishapur University of Medical Sciences.
Ethical approvement The study was approved by the Iranian National Committee for Ethics in Biomedical Research (IR.AJUMS.REC.1399.948).
Declaration of competing interest
References
Alguwaihes, Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study, Cardiovascular diabetology
Alguwaihes, Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective case-control study in an Arab Gulf country, Aging clinical and experimental research
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, Journal of infection and public health
Allen, A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers, Mult Scler
Amer, Evaluation of 34 Cytokines and Vitamin D Status Reveal A Sexually-Dimorphic Active Immune Response to SARS-CoV-2, Healthcare
Cannell, Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic, Annals of Otology, Rhinology & Laryngology
Cannell, Epidemic influenza and vitamin D, Epidemiology & Infection
De Smet, Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality, American Journal of Clinical Pathology
Demopoulos, Antonopoulou, Theoharides, COVID-19, microthromboses, inflammation, and platelet activating factor, Biofactors
Desvignes, STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection, The Journal of clinical investigation
Detopoulou, Demopoulos, Antonopoulou, Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism, Nutrients
El-Kurdi, Mortality from coronavirus disease 2019 increases with unsaturated fat and may be reduced by early calcium and albumin supplementation, Gastroenterology
Ferreira, Polonini, Dijkers, Postulated Adjuvant Therapeutic Strategies for COVID-19, J Pers Med
Frisoni, Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α, Forensic science, medicine, and pathology
Ginde, Mansbach, Camargo, Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey, Archives of internal medicine
Gombart, Borregaard, Koeffler, Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3, The FASEB journal
Gozalbo-Rovira, SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients, Journal of Clinical Virology
Grant, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Greenhalgh, Ten scientific reasons in support of airborne transmission of SARS-CoV-2, The lancet
Hastie, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes & Metabolic Syndrome
Henry, Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis, Clinical Chemistry and Laboratory Medicine (CCLM
Hernández, Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection, The Journal of Clinical Endocrinology & Metabolism
Herold, Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19, Journal of Allergy and Clinical Immunology
Hogan, Rao, Dissecting ICRAC, a store-operated calcium current, Trends in biochemical sciences
Hogan, Transcriptional regulation by calcium, calcineurin, and NFAT, Genes & development
Inc, Vit, Direct AccuBind ELISA Kits
J O U R N A L P R E, -p r o o f
Jain, Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers, Scientific Reports
Jain, Parsanathan, Can vitamin D and L-cysteine co-supplementation reduce 25 (OH)-vitamin D deficiency and the mortality associated with COVID-19 in African Americans?, Journal of the American College of Nutrition
Jovic, Could Vitamins Help in the Fight Against COVID-19?, Nutrients
Katz, Yue, Xue, Increased risk for COVID-19 in patients with vitamin D deficiency, Nutrition
Kokkotis, Systematic review with meta-analysis: COVID-19 outcomes in patients receiving anti-TNF treatments, Alimentary Pharmacology & Therapeutics
Lei, Mechanisms of action of vitamin D as supplemental therapy for Pneumocystis pneumonia, Antimicrobial agents and chemotherapy
Lewis, The molecular choreography of a store-operated calcium channel, Nature
Mehta, COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet
Mehta, Retrospective case-control study to evaluate hypocalcaemia as a distinguishing feature of COVID-19 compared with other infective pneumonias and its association with disease severity, BMJ open
Meltzer, Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA network open
Mohammad, Mishra, Ashraf, Emerging role of vitamin D and its associated molecules in pathways related to pathogenesis of thrombosis, Biomolecules
Moutchia, Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis, PloS one
Moutchia, Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis, PloS one
Narahara, Miyakawa, Johnston, The inhibitory effect of 1, 25-dihydroxyvitamin D3 on the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages, The Journal of Clinical Endocrinology & Metabolism
Pereira, Vitamin D deficiency aggravates COVID-19: systematic review and metaanalysis, Critical reviews in food science and nutrition
Petrilli, Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study, BMJ
Pisoschi, Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy, European Journal of Medicinal Chemistry
Ruan, Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China, Intensive care medicine
Sabico, Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial, Nutrients
Shi, Chronic vitamin D deficiency induces lung fibrosis through activation of the reninangiotensin system, Scientific reports
Soares, Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure, British Journal of Nutrition
Sun, Cytokine storm intervention in the early stages of COVID-19 pneumonia, Cytokine Growth Factor Rev
Sun, Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease, Aging
Sun, Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease, Aging
Tanacan, The Association of Serum Electrolytes with Disease Severity and Obstetric Complications in Pregnant Women with COVID-19: a Prospective Cohort Study from a Tertiary Reference Center, Geburtshilfe Frauenheilkd
Tsujino, Pulmonary activation of vitamin D3 and preventive effect against interstitial pneumonia, Journal of clinical biochemistry and nutrition
Wang, Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin β2 innate immune pathway defective in Crohn disease, Journal of Biological Chemistry
Wessels, Rolles, Rink, The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis, Frontiers in immunology
Yavarian, First Cases of SARS-CoV-2 in Iran, 2020: Case Series Report, Iran J Public Health
Zhou, Luo, Qin, The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies, Medicine
Zhu, A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med
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