Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19

DOI record: { "DOI": "10.1007/s12011-022-03400-6", "ISSN": [ "0163-4984", "1559-0720" ], "URL": "http://dx.doi.org/10.1007/s12011-022-03400-6", "alternative-id": [ "3400" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "23 May 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "18 August 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "24 August 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Ethics Approval", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "This study was approved by the local ethics committee of Harran University and the Ministry of Health of Turkey (18/01/2020-HRU/210231)." }, { "group": { "label": "Consent to Participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "All patients signed an informed consent for inclusion of personal records in the local database and for use to scientifc research purposes." }, { "group": { "label": "Consent for Publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "Not applicable." }, { "group": { "label": "Conflict of Interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 5, "value": "The authors declare no competing interests." }, { "label": "Free to read", "name": "free", "value": "This content has been made available to all." } ], "author": [ { "ORCID": "http://orcid.org/0000-0002-5745-9678", "affiliation": [], "authenticated-orcid": false, "family": "Bayraktar", "given": "Nihayet", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-0352-0904", "affiliation": [], "authenticated-orcid": false, "family": "Bayraktar", "given": "Mustafa", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-2428-1831", "affiliation": [], "authenticated-orcid": false, "family": "Ozturk", "given": "Ali", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3086-0995", "affiliation": [], "authenticated-orcid": false, "family": "Ibrahim", "given": "Bashar", "sequence": "additional" } ], "container-title": "Biological Trace Element Research", "container-title-short": "Biol Trace Elem Res", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 8, 24 ] ], "date-time": "2022-08-24T07:10:28Z", "timestamp": 1661325028000 }, "deposited": { "date-parts": [ [ 2022, 8, 24 ] ], "date-time": "2022-08-24T09:51:38Z", "timestamp": 1661334698000 }, "indexed": { "date-parts": [ [ 2022, 8, 24 ] ], "date-time": "2022-08-24T10:17:22Z", "timestamp": 1661336242291 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 8, 24 ] ] }, "language": "en", "license": [ { "URL": "https://www.springer.com/tdm", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 8, 24 ] ], "date-time": "2022-08-24T00:00:00Z", "timestamp": 1661299200000 } }, { "URL": "https://www.springer.com/tdm", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 8, 24 ] ], "date-time": "2022-08-24T00:00:00Z", "timestamp": 1661299200000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1007/s12011-022-03400-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1007/s12011-022-03400-6/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1007/s12011-022-03400-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1007", "published": { "date-parts": [ [ 2022, 8, 24 ] ] }, "published-online": { "date-parts": [ [ 2022, 8, 24 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.7150/ijms.50039", "author": "Y Tu", "doi-asserted-by": "publisher", "first-page": "1198", "journal-title": "Int J Med Sci", "key": "3400_CR1", "unstructured": "Tu Y, Yang P, Zhou Y, Wen X, Li Q, Zhou J et al (2021) Risk factors for mortality of critically ill patients with covid-19 receiving invasive ventilation. Int J Med Sci 18:1198–1206. https://doi.org/10.7150/ijms.50039", "volume": "18", "year": "2021" }, { "DOI": "10.1177/2473974X20957975", "author": "TS Ibekwe", "doi-asserted-by": "publisher", "first-page": "1", "issue": "3", "journal-title": "OTO Open", "key": "3400_CR2", "unstructured": "Ibekwe TS, Fasunla AJ, Orimadegun AE (2020) Systematic review and meta-analysis of smell and taste disorders in COVID-19. OTO Open 4(3):1–13. https://doi.org/10.1177/2473974X20957975", "volume": "4", "year": "2020" }, { "DOI": "10.1016/j.meegid.2021.104773", "author": "B Bakhshandeh", "doi-asserted-by": "publisher", "first-page": "104773", "journal-title": "InInfect Genet Evol", "key": "3400_CR3", "unstructured": "Bakhshandeh B, Sorboni SG, Javanmard AR, Mottaghi SS, Mehrabi M, Sorouri F et al (2021) Variants in ACE2; potential influences on virus infection and COVID-19 severity. InInfect Genet Evol 90:104773. https://doi.org/10.1016/j.meegid.2021.104773", "volume": "90", "year": "2021" }, { "DOI": "10.1152/AJPLUNG.00259.2020", "author": "G Pathangey", "doi-asserted-by": "publisher", "first-page": "L301", "issue": "3", "journal-title": "Am J Physiol Lung Cell Mol Physiol", "key": "3400_CR4", "unstructured": "Pathangey G, Fadadu PP, Hospodar AR, Abbas AE (2021) Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies. Am J Physiol Lung Cell Mol Physiol 320(3):L301–L330. https://doi.org/10.1152/AJPLUNG.00259.2020", "volume": "320", "year": "2021" }, { "DOI": "10.1097/MRM.0000000000000217", "author": "A Ozturk", "doi-asserted-by": "publisher", "first-page": "234", "journal-title": "Rev Med Microbiol", "key": "3400_CR5", "unstructured": "Ozturk A, Abdulmajed O, Ibrahim B (2020) What is the novel coronavirus disease 2019 (COVID-19) that paralyze the world? Rev Med Microbiol 31:234–241. https://doi.org/10.1097/MRM.0000000000000217", "volume": "31", "year": "2020" }, { "DOI": "10.1016/j.jbior.2020.100741", "author": "G Schönrich", "doi-asserted-by": "publisher", "first-page": "100741", "journal-title": "Adv Biol Regul", "key": "3400_CR6", "unstructured": "Schönrich G, Raftery MJ, Samstag Y (2020) Devilishly radical NETwork in COVID-19: oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression. Adv Biol Regul 77:100741. https://doi.org/10.1016/j.jbior.2020.100741", "volume": "77", "year": "2020" }, { "DOI": "10.1111/jth.14859", "author": "L Zhang", "doi-asserted-by": "publisher", "first-page": "1324", "journal-title": "J Thromb Haemost", "key": "3400_CR7", "unstructured": "Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z et al (2020) D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost 18:1324–1329. https://doi.org/10.1111/jth.14859", "volume": "18", "year": "2020" }, { "DOI": "10.1007/s10930-020-09935-8", "author": "S Suhail", "doi-asserted-by": "publisher", "first-page": "644", "issue": "6", "journal-title": "Protein J", "key": "3400_CR8", "unstructured": "Suhail S, Zajac J, Fossum C, Lowater H, McCracken C, Severson N et al (2020) Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) ınfection: a review. Protein J 39(6):644–656. https://doi.org/10.1007/s10930-020-09935-8", "volume": "39", "year": "2020" }, { "DOI": "10.1097/MD.0000000000013087", "author": "Q Zhang", "doi-asserted-by": "publisher", "first-page": "e13087", "issue": "45", "journal-title": "Medicine (Baltimore)", "key": "3400_CR9", "unstructured": "Zhang Q, Ju Y, Ma Y, Wang T (2018) N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia. Medicine (Baltimore) 97(45):e13087. https://doi.org/10.1097/MD.0000000000013087", "volume": "97", "year": "2018" }, { "DOI": "10.1016/j.freeradbiomed.2021.06.018", "author": "N Saheb Sharif-Askari", "doi-asserted-by": "publisher", "first-page": "688", "journal-title": "Free Radical Biol Med", "key": "3400_CR10", "unstructured": "Saheb Sharif-Askari N, Saheb Sharif-Askari F, Mdkhana B, Hussain Alsayed HA, Alsafar H, Alrais ZF et al (2021) Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection. Free Radical Biol Med 172:688–698. https://doi.org/10.1016/j.freeradbiomed.2021.06.018", "volume": "172", "year": "2021" }, { "DOI": "10.3390/ijms18112255", "doi-asserted-by": "publisher", "key": "3400_CR11", "unstructured": "Roche JV, Törnroth-Horsefield S (2017) Aquaporin protein-protein interactions. Int J Mol 18:2255. https://doi.org/10.3390/ijms18112255" }, { "DOI": "10.3390/ijms17081229", "author": "M Wang", "doi-asserted-by": "publisher", "first-page": "1229", "issue": "8", "journal-title": "Int J Mol Sci", "key": "3400_CR12", "unstructured": "Wang M, Ding L, Gao L, Li Y, Shen Q, Guo S (2016) The interactions of aquaporins and mineral nutrients in higher plants. Int J Mol Sci 17(8):1229. https://doi.org/10.3390/ijms17081229", "volume": "17", "year": "2016" }, { "DOI": "10.1016/j.mehy.2020.110201", "author": "LF Mariajoseph-Antony", "doi-asserted-by": "publisher", "first-page": "110201", "journal-title": "Med Hypotheses", "key": "3400_CR13", "unstructured": "Mariajoseph-Antony LF, Kannan A, Panneerselvam A, Loganathan C, Anbarasu K, Prahalathan C (2020) Could aquaporin modulators be employed as prospective drugs for COVID-19 related pulmonary comorbidity? Med Hypotheses 143:110201. https://doi.org/10.1016/j.mehy.2020.110201", "volume": "143", "year": "2020" }, { "DOI": "10.1074/jbc.M205305200", "author": "HN Hunter", "doi-asserted-by": "publisher", "first-page": "37597", "journal-title": "J Biol Chem", "key": "3400_CR14", "unstructured": "Hunter HN, Bruce Fulton D, Ganz T, Vogel HJ (2002) The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 277:37597–37603. https://doi.org/10.1074/jbc.M205305200", "volume": "277", "year": "2002" }, { "DOI": "10.1182/blood-2002-10", "author": "E Nemeth", "doi-asserted-by": "publisher", "first-page": "2461", "issue": "7", "journal-title": "Blood", "key": "3400_CR15", "unstructured": "Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101(7):2461–3. https://doi.org/10.1182/blood-2002-10", "volume": "101", "year": "2003" }, { "DOI": "10.1371/journal.ppat.1004998", "author": "K Michels", "doi-asserted-by": "publisher", "first-page": "e1004998", "issue": "8", "journal-title": "PLoS Pathog", "key": "3400_CR16", "unstructured": "Michels K, Nemeth E, Ganz T, Mehrad B (2015) Hepcidin and host defense against ınfectious diseases. PLoS Pathog 11(8):e1004998. https://doi.org/10.1371/journal.ppat.1004998", "volume": "11", "year": "2015" }, { "DOI": "10.1152/ajplung.00484.2005.-Alveolar", "author": "NB Nguyen", "doi-asserted-by": "publisher", "first-page": "417", "journal-title": "Am J Physiol Lung Cell Mol Physiol", "key": "3400_CR17", "unstructured": "Nguyen NB, Callaghan KD, Ghio AJ, Haile DJ, Yang F, Hepcidin YF et al (2006) Expression and iron transport in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 291:417–425. https://doi.org/10.1152/ajplung.00484.2005.-Alveolar", "volume": "291", "year": "2006" }, { "DOI": "10.1186/s13062-020-00275-2", "doi-asserted-by": "publisher", "key": "3400_CR18", "unstructured": "Ehsani S (2020) COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein. Biol Direct 15(1):19. https://doi.org/10.1186/s13062-020-00275-2" }, { "DOI": "10.1039/d0mt00220h", "author": "JR de Jesus", "doi-asserted-by": "publisher", "first-page": "1912", "issue": "12", "journal-title": "Metallomics", "key": "3400_CR19", "unstructured": "de Jesus JR, de Araújo Andrade T (2020) Understanding the relationship between viral infections and trace elements from a metallomics perspective: ımplications for COVID-19. Metallomics 12(12):1912–1930. https://doi.org/10.1039/d0mt00220h", "volume": "12", "year": "2020" }, { "DOI": "10.1056/nejmra1804281", "author": "T Ganz", "doi-asserted-by": "publisher", "first-page": "1148", "journal-title": "N Engl J Med", "key": "3400_CR20", "unstructured": "Ganz T (2019) Anemia of ınflammation. N Engl J Med 381:1148–1157. https://doi.org/10.1056/nejmra1804281", "volume": "381", "year": "2019" }, { "DOI": "10.1016/j.jtemb.2017.06.008", "author": "M Wacewicz", "doi-asserted-by": "publisher", "first-page": "109", "journal-title": "J Trace Elem Med Biol", "key": "3400_CR21", "unstructured": "Wacewicz M, Socha K, Soroczyńska J, Niczyporuk M, Aleksiejczuk P, Ostrowska J et al (2017) Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: a case-control study. J Trace Elem Med Biol 44:109–114. https://doi.org/10.1016/j.jtemb.2017.06.008", "volume": "44", "year": "2017" }, { "DOI": "10.1042/BSR20130014", "author": "SL Stafford", "doi-asserted-by": "publisher", "first-page": "e00049", "issue": "4", "journal-title": "Biosci Rep", "key": "3400_CR22", "unstructured": "Stafford SL, Bokil NJ, Achard MES, Kapetanovic R, Schembri MA, Mcewan AG et al (2013) Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper. Biosci Rep 33(4):e00049. https://doi.org/10.1042/BSR20130014", "volume": "33", "year": "2013" }, { "DOI": "10.1016/j.nutres.2021.05.008", "author": "I Rani", "doi-asserted-by": "publisher", "first-page": "109", "journal-title": "Nutr Res", "key": "3400_CR23", "unstructured": "Rani I, Goyal A, Bhatnagar M, Manhas S, Goel P, Pal A et al (2021) Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19. Nutr Res 92:109–128. https://doi.org/10.1016/j.nutres.2021.05.008", "volume": "92", "year": "2021" }, { "DOI": "10.1093/ajcn/62.2.412", "author": "DS Kelley", "doi-asserted-by": "publisher", "first-page": "412", "issue": "2", "journal-title": "Am J Clin Nutr", "key": "3400_CR24", "unstructured": "Kelley DS, Daudu PA, Taylor PC, Mackey BE, Turniund JR (1995) Effects of low-copper diets on human immune response. Am J Clin Nutr 62(2):412–416. https://doi.org/10.1093/ajcn/62.2.412", "volume": "62", "year": "1995" }, { "DOI": "10.1016/j.mehy.2020.109814", "author": "S Raha", "doi-asserted-by": "publisher", "first-page": "109814", "journal-title": "Med Hypotheses", "key": "3400_CR25", "unstructured": "Raha S, Mallick R, Basak S, Duttaroy AK (2020) Is copper beneficial for COVID-19 patients? Med Hypotheses 142:109814. https://doi.org/10.1016/j.mehy.2020.109814", "volume": "142", "year": "2020" }, { "DOI": "10.1021/acs.chemrev.8b00074", "author": "SM Adam", "doi-asserted-by": "publisher", "first-page": "10840", "issue": "22", "journal-title": "Chem Rev", "key": "3400_CR26", "unstructured": "Adam SM, Wijeratne GB, Rogler PJ, Diaz DE, Quist DA, Liu JJ et al (2018) Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function. Chem Rev 118(22):10840–11022. https://doi.org/10.1021/acs.chemrev.8b00074", "volume": "118", "year": "2018" }, { "DOI": "10.1038/s41573-021-00233-1", "author": "HJ Forman", "doi-asserted-by": "publisher", "first-page": "689", "issue": "9", "journal-title": "Nat Rev Drug Discov", "key": "3400_CR27", "unstructured": "Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 20(9):689–709. https://doi.org/10.1038/s41573-021-00233-1", "volume": "20", "year": "2021" }, { "DOI": "10.1016/j.clinbiochem.2005.08.008", "author": "O Erel", "doi-asserted-by": "publisher", "first-page": "1103", "journal-title": "Clin Biochem", "key": "3400_CR28", "unstructured": "Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103–1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008", "volume": "38", "year": "2005" }, { "DOI": "10.3390/nu12103198", "author": "F Pecora", "doi-asserted-by": "publisher", "first-page": "3198", "issue": "10", "journal-title": "Nutrients", "key": "3400_CR29", "unstructured": "Pecora F, Persico F, Argentiero A, Neglia C, Esposito S (2020) The role of micronutrients in support of the immune response against viral infections. Nutrients 12(10):3198. https://doi.org/10.3390/nu12103198", "volume": "12", "year": "2020" }, { "DOI": "10.1093/clinchem/44.6.1309", "author": "G Cao", "doi-asserted-by": "publisher", "first-page": "1309", "issue": "6 Pt 1", "journal-title": "Clin Chem", "key": "3400_CR30", "unstructured": "Cao G, Prior RL (1998) Comparison of different analytical methods for assessing total antioxidant capacity of human serum Automation and Analytical Techniques. Clin Chem 44(6 Pt 1):1309–1315", "volume": "44", "year": "1998" }, { "DOI": "10.3390/antiox10060971", "author": "N Cárdenas-Rodríguez", "doi-asserted-by": "publisher", "first-page": "971", "issue": "6", "journal-title": "Antioxidants (Basel)", "key": "3400_CR31", "unstructured": "Cárdenas-Rodríguez N, Bandala C, Vanoye-Carlo A, Ignacio-Mejía I, Gómez-Manzo S, Hernández-Cruz EY et al (2021) Use of antioxidants for the neuro-therapeutic management of covid-19. Antioxidants (Basel) 10(6):971. https://doi.org/10.3390/antiox10060971", "volume": "10", "year": "2021" }, { "DOI": "10.1016/j.nut.2020.111016", "author": "D Fedele", "doi-asserted-by": "publisher", "first-page": "111016", "journal-title": "Nutrition", "key": "3400_CR32", "unstructured": "Fedele D, de Francesco A, Riso S, Collo A (2021) Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: an overview. Nutrition 81:111016. https://doi.org/10.1016/j.nut.2020.111016", "volume": "81", "year": "2021" }, { "DOI": "10.1002/ajh.26027", "author": "A Nai", "doi-asserted-by": "publisher", "first-page": "E32", "issue": "1", "journal-title": "Am J Hematol", "key": "3400_CR33", "unstructured": "Nai A, Lorè N, Pagani A, De Lorenzo R, Di Modica S, Saliu F et al (2021) Hepcidin levels predict Covid19 severity and mortality in a cohort of hospitalized Italian patients. Am J Hematol 96(1):E32–E35. https://doi.org/10.1002/ajh.26027", "volume": "96", "year": "2021" }, { "DOI": "10.1016/j.resp.2007.02.012", "author": "AS Verkman", "doi-asserted-by": "publisher", "first-page": "324", "journal-title": "Respir Physiol Neurobiol", "key": "3400_CR34", "unstructured": "Verkman AS (2007) Role of aquaporins in lung liquid physiology. Respir Physiol Neurobiol 159:324–330. https://doi.org/10.1016/j.resp.2007.02.012", "volume": "159", "year": "2007" }, { "DOI": "10.1007/s00424-018-2232-y", "doi-asserted-by": "publisher", "key": "3400_CR35", "unstructured": "Wittekindt OH, Dietl P (2019) Aquaporins in the lung, Pflugers Archiv European. Pflugers Arch 471(4):519–532. https://doi.org/10.1007/s00424-018-2232-y" }, { "DOI": "10.3390/metabo11040244", "author": "AV Skalny", "doi-asserted-by": "publisher", "first-page": "244", "journal-title": "Metabolites", "key": "3400_CR36", "unstructured": "Skalny AV, Timashev PS, Aschner M, Aaseth J, Chernova LN, Belyaev VE et al (2021) Serum zinc, copper, and other biometals are associated with COVID-19 severity markers. Metabolites 11:244. https://doi.org/10.3390/metabo11040244", "volume": "11", "year": "2021" } ], "reference-count": 36, "references-count": 36, "relation": {}, "resource": { "primary": { "URL": "https://link.springer.com/10.1007/s12011-022-03400-6" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Biochemistry (medical)", "Inorganic Chemistry", "Clinical Biochemistry", "General Medicine", "Biochemistry", "Endocrinology, Diabetes and Metabolism" ], "subtitle": [], "title": "Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy" }