Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All zinc studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchZincZinc (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19

Bayraktar et al., Biological Trace Element Research, doi:10.1007/s12011-022-03400-6
Aug 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Analysis of 45 COVID-19 ICU patients and 45 healthy controls, showing significantly lower zinc levels in COVID-19 patients.
Bayraktar et al., 24 Aug 2022, retrospective, Turkey, peer-reviewed, 4 authors. Contact: ali.81ozturk@gmail.com, nihayetmehmet@yahoo.com, m.bayraktar1993@gmail.com, basharibrahim@sdu.edu.tr.
This PaperZincAll
Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and Oxidative Stress in the Serum of Critically Ill Patients with COVID-19
Nihayet Bayraktar, Mustafa Bayraktar, Ali Ozturk, Bashar Ibrahim
Biological Trace Element Research, doi:10.1007/s12011-022-03400-6
Our study aims to determine the relationship between hepcidin, aquaporin (AQP-1), copper (Cu), zinc (Zn), iron (Fe) levels, and oxidative stress in the sera of seriously ill COVID-19 patients with invasive mechanical ventilation. Ninety persons with and without COVID-19 were taken up and separated into two groups. The first group included seriously COVID-19 inpatients having endotracheal intubation in the intensive care unit (n = 45). The second group included individuals who had negative PCR tests and had no chronic disease (the healthy control group n = 45). AQP-1, hepcidin, Zn, Cu, Fe, total antioxidant status (TAS), and total oxidant status (TOS) were studied in the sera of both groups, and the relations of these levels with oxidative stress were determined. When the COVID-19 patient and the control groups were compared, all studied parameters were found to be statistically significant (p < 0.01). Total oxidant status (TOS), oxidative stress index (OSI), and AQP-1, hepcidin, and Cu levels were increased in patients with COVID-19 compared to healthy people. Serum TAC, Zn, and Fe levels were found to be lower in the patient group than in the control group. Significant correlations were detected between the studied parameters in COVID-19 patients. Results indicated that oxidative stress may play an important role in viral infection due to SARS-CoV-2. We think that oxidative stress parameters as well as some trace elements at the onset of COVID-19 disease will provide a better triage in terms of disease severity.
Declarations Ethics Approval This study was approved by the local ethics committee of Harran University and the Ministry of Health of Turkey (18/01/2020-HRU/210231). Consent to Participate All patients signed an informed consent for inclusion of personal records in the local database and for use to scientifc research purposes. Consent for Publication Not applicable. Conflict of Interest The authors declare no competing interests.
References
Adam, Wijeratne, Rogler, Diaz, Quist et al., Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function, Chem Rev, doi:10.1021/acs.chemrev.8b00074
Bakhshandeh, Sorboni, Javanmard, Mottaghi, Mehrabi et al., Variants in ACE2; potential influences on virus infection and COVID-19 severity, InInfect Genet Evol, doi:10.1016/j.meegid.2021.104773
Cao, Prior, Comparison of different analytical methods for assessing total antioxidant capacity of human serum Automation and Analytical Techniques, Clin Chem
Cárdenas-Rodríguez, Bandala, Vanoye-Carlo, Mejía, Gómez-Manzo et al., Use of antioxidants for the neuro-therapeutic management of covid-19, Antioxidants, doi:10.3390/antiox10060971
De Jesus, De, Andrade, Understanding the relationship between viral infections and trace elements from a metallomics perspective: ımplications for COVID-19, Metallomics, doi:10.1039/d0mt00220h
Ehsani, COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein, Biol Direct, doi:10.1186/s13062-020-00275-2
Erel, A new automated colorimetric method for measuring total oxidant status, Clin Biochem, doi:10.1016/j.clinbiochem.2005.08.008
Fedele, De Francesco, Riso, Collo, Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: an overview, Nutrition, doi:10.1016/j.nut.2020.111016
Forman, Zhang, Targeting oxidative stress in disease: promise and limitations of antioxidant therapy, Nat Rev Drug Discov, doi:10.1038/s41573-021-00233-1
Ganz, Anemia of ınflammation, N Engl J Med, doi:10.1056/nejmra1804281
Hunter, Fulton, Ganz, Vogel, The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis, J Biol Chem, doi:10.1074/jbc.M205305200
Ibekwe, Fasunla, Orimadegun, Systematic review and meta-analysis of smell and taste disorders in COVID-19, OTO Open, doi:10.1177/2473974X20957975
Kelley, Daudu, Taylor, Mackey, Turniund, Effects of low-copper diets on human immune response, Am J Clin Nutr, doi:10.1093/ajcn/62.2.412
Mariajoseph-Antony, Kannan, Panneerselvam, Loganathan, Anbarasu et al., Could aquaporin modulators be employed as prospective drugs for COVID-19 related pulmonary comorbidity?, Med Hypotheses, doi:10.1016/j.mehy.2020.110201
Michels, Nemeth, Ganz, Mehrad, Hepcidin and host defense against ınfectious diseases, PLoS Pathog, doi:10.1371/journal.ppat.1004998
Nai, Lorè, Pagani, Lorenzo, Modica et al., Hepcidin levels predict Covid19 severity and mortality in a cohort of hospitalized Italian patients, Am J Hematol, doi:10.1002/ajh.26027
Nemeth, Valore, Territo, Schiller, Lichtenstein et al., Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein, Blood, doi:10.1182/blood-2002-10
Nguyen, Callaghan, Ghio, Haile, Yang et al., Expression and iron transport in alveolar macrophages, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/ajplung.00484.2005.-Alveolar
Ozturk, Abdulmajed, What is the novel coronavirus disease 2019 (COVID-19) that paralyze the world?, Rev Med Microbiol, doi:10.1097/MRM.0000000000000217
Pathangey, Fadadu, Hospodar, Abbas, Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies, Am J Physiol Lung Cell Mol Physiol, doi:10.1152/AJPLUNG.00259.2020
Pecora, Persico, Argentiero, Neglia, Esposito, The role of micronutrients in support of the immune response against viral infections, Nutrients, doi:10.3390/nu12103198
Raha, Mallick, Basak, Duttaroy, Is copper beneficial for COVID-19 patients?, Med Hypotheses, doi:10.1016/j.mehy.2020.109814
Rani, Goyal, Bhatnagar, Manhas, Goel et al., Potential molecular mechanisms of zinc-and coppermediated antiviral activity on COVID-19, Nutr Res, doi:10.1016/j.nutres.2021.05.008
Roche, Törnroth-Horsefield, Aquaporin protein-protein interactions, Int J Mol, doi:10.3390/ijms18112255
Schönrich, Raftery, Samstag, Devilishly radical NETwork in COVID-19: oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression, Adv Biol Regul, doi:10.1016/j.jbior.2020.100741
Sharif-Askari, Sharif-Askari, Mdkhana, Alsayed, Alsafar et al., Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection, Free Radical Biol Med, doi:10.1016/j.freeradbiomed.2021.06.018
Skalny, Timashev, Aschner, Aaseth, Chernova et al., Serum zinc, copper, and other biometals are associated with COVID-19 severity markers, Metabolites, doi:10.3390/metabo11040244
Stafford, Bokil, Achard, Kapetanovic, Schembri et al., Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper, Biosci Rep, doi:10.1042/BSR20130014
Suhail, Zajac, Fossum, Lowater, Mccracken et al., Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) ınfection: a review, Protein J, doi:10.1007/s10930-020-09935-8
Tu, Yang, Zhou, Wen, Li et al., Risk factors for mortality of critically ill patients with covid-19 receiving invasive ventilation, Int J Med Sci, doi:10.7150/ijms.50039
Verkman, Role of aquaporins in lung liquid physiology, Respir Physiol Neurobiol, doi:10.1016/j.resp.2007.02.012
Wacewicz, Socha, Soroczyńska, Niczyporuk, Aleksiejczuk et al., Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: a case-control study, J Trace Elem Med Biol, doi:10.1016/j.jtemb.2017.06.008
Wang, Ding, Gao, Li, Shen et al., The interactions of aquaporins and mineral nutrients in higher plants, Int J Mol Sci, doi:10.3390/ijms17081229
Wittekindt, Dietl, Aquaporins in the lung, Pflugers Archiv European, Pflugers Arch, doi:10.1007/s00424-018-2232-y
Zhang, Ju, Ma, Wang, N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia, Medicine (Baltimore), doi:10.1097/MD.0000000000013087
Zhang, Yan, Fan, Liu, Liu et al., D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19, J Thromb Haemost, doi:10.1111/jth.14859
{ 'DOI': '10.1007/s12011-022-03400-6', 'ISSN': ['0163-4984', '1559-0720'], 'URL': 'http://dx.doi.org/10.1007/s12011-022-03400-6', 'alternative-id': ['3400'], 'assertion': [ { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Received', 'name': 'received', 'order': 1, 'value': '23 May 2022'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'Accepted', 'name': 'accepted', 'order': 2, 'value': '18 August 2022'}, { 'group': {'label': 'Article History', 'name': 'ArticleHistory'}, 'label': 'First Online', 'name': 'first_online', 'order': 3, 'value': '24 August 2022'}, {'group': {'label': 'Declarations', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 1}, { 'group': {'label': 'Ethics Approval', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 2, 'value': 'This study was approved by the local ethics committee of Harran University and ' 'the Ministry of Health of Turkey (18/01/2020-HRU/210231).'}, { 'group': {'label': 'Consent to Participate', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 3, 'value': 'All patients signed an informed consent for inclusion of personal records in ' 'the local database and for use to scientifc research purposes.'}, { 'group': {'label': 'Consent for Publication', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 4, 'value': 'Not applicable.'}, { 'group': {'label': 'Conflict of Interest', 'name': 'EthicsHeading'}, 'name': 'Ethics', 'order': 5, 'value': 'The authors declare no competing interests.'}, { 'label': 'Free to read', 'name': 'free', 'value': 'This content has been made available to all.'}], 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-5745-9678', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Bayraktar', 'given': 'Nihayet', 'sequence': 'first'}, { 'ORCID': 'http://orcid.org/0000-0002-0352-0904', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Bayraktar', 'given': 'Mustafa', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0003-2428-1831', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Ozturk', 'given': 'Ali', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0003-3086-0995', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Ibrahim', 'given': 'Bashar', 'sequence': 'additional'}], 'container-title': 'Biological Trace Element Research', 'container-title-short': 'Biol Trace Elem Res', 'content-domain': {'crossmark-restriction': False, 'domain': ['link.springer.com']}, 'created': {'date-parts': [[2022, 8, 24]], 'date-time': '2022-08-24T07:10:28Z', 'timestamp': 1661325028000}, 'deposited': { 'date-parts': [[2022, 8, 24]], 'date-time': '2022-08-24T09:51:38Z', 'timestamp': 1661334698000}, 'indexed': {'date-parts': [[2022, 8, 24]], 'date-time': '2022-08-24T10:17:22Z', 'timestamp': 1661336242291}, 'is-referenced-by-count': 0, 'issued': {'date-parts': [[2022, 8, 24]]}, 'language': 'en', 'license': [ { 'URL': 'https://www.springer.com/tdm', 'content-version': 'tdm', 'delay-in-days': 0, 'start': { 'date-parts': [[2022, 8, 24]], 'date-time': '2022-08-24T00:00:00Z', 'timestamp': 1661299200000}}, { 'URL': 'https://www.springer.com/tdm', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2022, 8, 24]], 'date-time': '2022-08-24T00:00:00Z', 'timestamp': 1661299200000}}], 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-022-03400-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s12011-022-03400-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s12011-022-03400-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '297', 'original-title': [], 'prefix': '10.1007', 'published': {'date-parts': [[2022, 8, 24]]}, 'published-online': {'date-parts': [[2022, 8, 24]]}, 'publisher': 'Springer Science and Business Media LLC', 'reference': [ { 'DOI': '10.7150/ijms.50039', 'author': 'Y Tu', 'doi-asserted-by': 'publisher', 'first-page': '1198', 'journal-title': 'Int J Med Sci', 'key': '3400_CR1', 'unstructured': 'Tu Y, Yang P, Zhou Y, Wen X, Li Q, Zhou J et al (2021) Risk factors for ' 'mortality of critically ill patients with covid-19 receiving invasive ' 'ventilation. Int J Med Sci 18:1198–1206. ' 'https://doi.org/10.7150/ijms.50039', 'volume': '18', 'year': '2021'}, { 'DOI': '10.1177/2473974X20957975', 'author': 'TS Ibekwe', 'doi-asserted-by': 'publisher', 'first-page': '1', 'issue': '3', 'journal-title': 'OTO Open', 'key': '3400_CR2', 'unstructured': 'Ibekwe TS, Fasunla AJ, Orimadegun AE (2020) Systematic review and ' 'meta-analysis of smell and taste disorders in COVID-19. OTO Open ' '4(3):1–13. https://doi.org/10.1177/2473974X20957975', 'volume': '4', 'year': '2020'}, { 'DOI': '10.1016/j.meegid.2021.104773', 'author': 'B Bakhshandeh', 'doi-asserted-by': 'publisher', 'first-page': '104773', 'journal-title': 'InInfect Genet Evol', 'key': '3400_CR3', 'unstructured': 'Bakhshandeh B, Sorboni SG, Javanmard AR, Mottaghi SS, Mehrabi M, Sorouri ' 'F et al (2021) Variants in ACE2; potential influences on virus infection ' 'and COVID-19 severity. InInfect Genet Evol 90:104773. ' 'https://doi.org/10.1016/j.meegid.2021.104773', 'volume': '90', 'year': '2021'}, { 'DOI': '10.1152/AJPLUNG.00259.2020', 'author': 'G Pathangey', 'doi-asserted-by': 'publisher', 'first-page': 'L301', 'issue': '3', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol', 'key': '3400_CR4', 'unstructured': 'Pathangey G, Fadadu PP, Hospodar AR, Abbas AE (2021) ' 'Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, ' 'and therapies. Am J Physiol Lung Cell Mol Physiol 320(3):L301–L330. ' 'https://doi.org/10.1152/AJPLUNG.00259.2020', 'volume': '320', 'year': '2021'}, { 'DOI': '10.1097/MRM.0000000000000217', 'author': 'A Ozturk', 'doi-asserted-by': 'publisher', 'first-page': '234', 'journal-title': 'Rev Med Microbiol', 'key': '3400_CR5', 'unstructured': 'Ozturk A, Abdulmajed O, Ibrahim B (2020) What is the novel coronavirus ' 'disease 2019 (COVID-19) that paralyze the world? Rev Med Microbiol ' '31:234–241. https://doi.org/10.1097/MRM.0000000000000217', 'volume': '31', 'year': '2020'}, { 'DOI': '10.1016/j.jbior.2020.100741', 'author': 'G Schönrich', 'doi-asserted-by': 'publisher', 'first-page': '100741', 'journal-title': 'Adv Biol Regul', 'key': '3400_CR6', 'unstructured': 'Schönrich G, Raftery MJ, Samstag Y (2020) Devilishly radical NETwork in ' 'COVID-19: oxidative stress, neutrophil extracellular traps (NETs), and T ' 'cell suppression. Adv Biol Regul 77:100741. ' 'https://doi.org/10.1016/j.jbior.2020.100741', 'volume': '77', 'year': '2020'}, { 'DOI': '10.1111/jth.14859', 'author': 'L Zhang', 'doi-asserted-by': 'publisher', 'first-page': '1324', 'journal-title': 'J Thromb Haemost', 'key': '3400_CR7', 'unstructured': 'Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z et al (2020) D-dimer levels ' 'on admission to predict in-hospital mortality in patients with Covid-19. ' 'J Thromb Haemost 18:1324–1329. https://doi.org/10.1111/jth.14859', 'volume': '18', 'year': '2020'}, { 'DOI': '10.1007/s10930-020-09935-8', 'author': 'S Suhail', 'doi-asserted-by': 'publisher', 'first-page': '644', 'issue': '6', 'journal-title': 'Protein J', 'key': '3400_CR8', 'unstructured': 'Suhail S, Zajac J, Fossum C, Lowater H, McCracken C, Severson N et al ' '(2020) Role of oxidative stress on SARS-CoV (SARS) and SARS-CoV-2 ' '(COVID-19) ınfection: a review. Protein J 39(6):644–656. ' 'https://doi.org/10.1007/s10930-020-09935-8', 'volume': '39', 'year': '2020'}, { 'DOI': '10.1097/MD.0000000000013087', 'author': 'Q Zhang', 'doi-asserted-by': 'publisher', 'first-page': 'e13087', 'issue': '45', 'journal-title': 'Medicine (Baltimore)', 'key': '3400_CR9', 'unstructured': 'Zhang Q, Ju Y, Ma Y, Wang T (2018) N-acetylcysteine improves oxidative ' 'stress and inflammatory response in patients with community acquired ' 'pneumonia. Medicine (Baltimore) 97(45):e13087. ' 'https://doi.org/10.1097/MD.0000000000013087', 'volume': '97', 'year': '2018'}, { 'DOI': '10.1016/j.freeradbiomed.2021.06.018', 'author': 'N Saheb Sharif-Askari', 'doi-asserted-by': 'publisher', 'first-page': '688', 'journal-title': 'Free Radical Biol Med', 'key': '3400_CR10', 'unstructured': 'Saheb Sharif-Askari N, Saheb Sharif-Askari F, Mdkhana B, Hussain Alsayed ' 'HA, Alsafar H, Alrais ZF et al (2021) Upregulation of oxidative stress ' 'gene markers during SARS-COV-2 viral infection. Free Radical Biol Med ' '172:688–698. https://doi.org/10.1016/j.freeradbiomed.2021.06.018', 'volume': '172', 'year': '2021'}, { 'DOI': '10.3390/ijms18112255', 'doi-asserted-by': 'publisher', 'key': '3400_CR11', 'unstructured': 'Roche JV, Törnroth-Horsefield S (2017) Aquaporin protein-protein ' 'interactions. Int J Mol 18:2255. https://doi.org/10.3390/ijms18112255'}, { 'DOI': '10.3390/ijms17081229', 'author': 'M Wang', 'doi-asserted-by': 'publisher', 'first-page': '1229', 'issue': '8', 'journal-title': 'Int J Mol Sci', 'key': '3400_CR12', 'unstructured': 'Wang M, Ding L, Gao L, Li Y, Shen Q, Guo S (2016) The interactions of ' 'aquaporins and mineral nutrients in higher plants. Int J Mol Sci ' '17(8):1229. https://doi.org/10.3390/ijms17081229', 'volume': '17', 'year': '2016'}, { 'DOI': '10.1016/j.mehy.2020.110201', 'author': 'LF Mariajoseph-Antony', 'doi-asserted-by': 'publisher', 'first-page': '110201', 'journal-title': 'Med Hypotheses', 'key': '3400_CR13', 'unstructured': 'Mariajoseph-Antony LF, Kannan A, Panneerselvam A, Loganathan C, Anbarasu ' 'K, Prahalathan C (2020) Could aquaporin modulators be employed as ' 'prospective drugs for COVID-19 related pulmonary comorbidity? Med ' 'Hypotheses 143:110201. https://doi.org/10.1016/j.mehy.2020.110201', 'volume': '143', 'year': '2020'}, { 'DOI': '10.1074/jbc.M205305200', 'author': 'HN Hunter', 'doi-asserted-by': 'publisher', 'first-page': '37597', 'journal-title': 'J Biol Chem', 'key': '3400_CR14', 'unstructured': 'Hunter HN, Bruce Fulton D, Ganz T, Vogel HJ (2002) The solution ' 'structure of human hepcidin, a peptide hormone with antimicrobial ' 'activity that is involved in iron uptake and hereditary hemochromatosis. ' 'J Biol Chem 277:37597–37603. https://doi.org/10.1074/jbc.M205305200', 'volume': '277', 'year': '2002'}, { 'DOI': '10.1182/blood-2002-10', 'author': 'E Nemeth', 'doi-asserted-by': 'publisher', 'first-page': '2461', 'issue': '7', 'journal-title': 'Blood', 'key': '3400_CR15', 'unstructured': 'Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T ' '(2003) Hepcidin, a putative mediator of anemia of inflammation, is a ' 'type II acute-phase protein. Blood 101(7):2461–3. ' 'https://doi.org/10.1182/blood-2002-10', 'volume': '101', 'year': '2003'}, { 'DOI': '10.1371/journal.ppat.1004998', 'author': 'K Michels', 'doi-asserted-by': 'publisher', 'first-page': 'e1004998', 'issue': '8', 'journal-title': 'PLoS Pathog', 'key': '3400_CR16', 'unstructured': 'Michels K, Nemeth E, Ganz T, Mehrad B (2015) Hepcidin and host defense ' 'against ınfectious diseases. PLoS Pathog 11(8):e1004998. ' 'https://doi.org/10.1371/journal.ppat.1004998', 'volume': '11', 'year': '2015'}, { 'DOI': '10.1152/ajplung.00484.2005.-Alveolar', 'author': 'NB Nguyen', 'doi-asserted-by': 'publisher', 'first-page': '417', 'journal-title': 'Am J Physiol Lung Cell Mol Physiol', 'key': '3400_CR17', 'unstructured': 'Nguyen NB, Callaghan KD, Ghio AJ, Haile DJ, Yang F, Hepcidin YF et al ' '(2006) Expression and iron transport in alveolar macrophages. Am J ' 'Physiol Lung Cell Mol Physiol 291:417–425. ' 'https://doi.org/10.1152/ajplung.00484.2005.-Alveolar', 'volume': '291', 'year': '2006'}, { 'DOI': '10.1186/s13062-020-00275-2', 'doi-asserted-by': 'publisher', 'key': '3400_CR18', 'unstructured': 'Ehsani S (2020) COVID-19 and iron dysregulation: distant sequence ' 'similarity between hepcidin and the novel coronavirus spike ' 'glycoprotein. Biol Direct 15(1):19. ' 'https://doi.org/10.1186/s13062-020-00275-2'}, { 'DOI': '10.1039/d0mt00220h', 'author': 'JR de Jesus', 'doi-asserted-by': 'publisher', 'first-page': '1912', 'issue': '12', 'journal-title': 'Metallomics', 'key': '3400_CR19', 'unstructured': 'de Jesus JR, de Araújo Andrade T (2020) Understanding the relationship ' 'between viral infections and trace elements from a metallomics ' 'perspective: ımplications for COVID-19. Metallomics 12(12):1912–1930. ' 'https://doi.org/10.1039/d0mt00220h', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1056/nejmra1804281', 'author': 'T Ganz', 'doi-asserted-by': 'publisher', 'first-page': '1148', 'journal-title': 'N Engl J Med', 'key': '3400_CR20', 'unstructured': 'Ganz T (2019) Anemia of ınflammation. N Engl J Med 381:1148–1157. ' 'https://doi.org/10.1056/nejmra1804281', 'volume': '381', 'year': '2019'}, { 'DOI': '10.1016/j.jtemb.2017.06.008', 'author': 'M Wacewicz', 'doi-asserted-by': 'publisher', 'first-page': '109', 'journal-title': 'J Trace Elem Med Biol', 'key': '3400_CR21', 'unstructured': 'Wacewicz M, Socha K, Soroczyńska J, Niczyporuk M, Aleksiejczuk P, ' 'Ostrowska J et al (2017) Concentration of selenium, zinc, copper, Cu/Zn ' 'ratio, total antioxidant status and c-reactive protein in the serum of ' 'patients with psoriasis treated by narrow-band ultraviolet B ' 'phototherapy: a case-control study. J Trace Elem Med Biol 44:109–114. ' 'https://doi.org/10.1016/j.jtemb.2017.06.008', 'volume': '44', 'year': '2017'}, { 'DOI': '10.1042/BSR20130014', 'author': 'SL Stafford', 'doi-asserted-by': 'publisher', 'first-page': 'e00049', 'issue': '4', 'journal-title': 'Biosci Rep', 'key': '3400_CR22', 'unstructured': 'Stafford SL, Bokil NJ, Achard MES, Kapetanovic R, Schembri MA, Mcewan AG ' 'et al (2013) Metal ions in macrophage antimicrobial pathways: emerging ' 'roles for zinc and copper. Biosci Rep 33(4):e00049. ' 'https://doi.org/10.1042/BSR20130014', 'volume': '33', 'year': '2013'}, { 'DOI': '10.1016/j.nutres.2021.05.008', 'author': 'I Rani', 'doi-asserted-by': 'publisher', 'first-page': '109', 'journal-title': 'Nutr Res', 'key': '3400_CR23', 'unstructured': 'Rani I, Goyal A, Bhatnagar M, Manhas S, Goel P, Pal A et al (2021) ' 'Potential molecular mechanisms of zinc- and copper-mediated antiviral ' 'activity on COVID-19. Nutr Res 92:109–128. ' 'https://doi.org/10.1016/j.nutres.2021.05.008', 'volume': '92', 'year': '2021'}, { 'DOI': '10.1093/ajcn/62.2.412', 'author': 'DS Kelley', 'doi-asserted-by': 'publisher', 'first-page': '412', 'issue': '2', 'journal-title': 'Am J Clin Nutr', 'key': '3400_CR24', 'unstructured': 'Kelley DS, Daudu PA, Taylor PC, Mackey BE, Turniund JR (1995) Effects of ' 'low-copper diets on human immune response. Am J Clin Nutr 62(2):412–416. ' 'https://doi.org/10.1093/ajcn/62.2.412', 'volume': '62', 'year': '1995'}, { 'DOI': '10.1016/j.mehy.2020.109814', 'author': 'S Raha', 'doi-asserted-by': 'publisher', 'first-page': '109814', 'journal-title': 'Med Hypotheses', 'key': '3400_CR25', 'unstructured': 'Raha S, Mallick R, Basak S, Duttaroy AK (2020) Is copper beneficial for ' 'COVID-19 patients? Med Hypotheses 142:109814. ' 'https://doi.org/10.1016/j.mehy.2020.109814', 'volume': '142', 'year': '2020'}, { 'DOI': '10.1021/acs.chemrev.8b00074', 'author': 'SM Adam', 'doi-asserted-by': 'publisher', 'first-page': '10840', 'issue': '22', 'journal-title': 'Chem Rev', 'key': '3400_CR26', 'unstructured': 'Adam SM, Wijeratne GB, Rogler PJ, Diaz DE, Quist DA, Liu JJ et al (2018) ' 'Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase ' 'structure and function. Chem Rev 118(22):10840–11022. ' 'https://doi.org/10.1021/acs.chemrev.8b00074', 'volume': '118', 'year': '2018'}, { 'DOI': '10.1038/s41573-021-00233-1', 'author': 'HJ Forman', 'doi-asserted-by': 'publisher', 'first-page': '689', 'issue': '9', 'journal-title': 'Nat Rev Drug Discov', 'key': '3400_CR27', 'unstructured': 'Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise ' 'and limitations of antioxidant therapy. Nat Rev Drug Discov ' '20(9):689–709. https://doi.org/10.1038/s41573-021-00233-1', 'volume': '20', 'year': '2021'}, { 'DOI': '10.1016/j.clinbiochem.2005.08.008', 'author': 'O Erel', 'doi-asserted-by': 'publisher', 'first-page': '1103', 'journal-title': 'Clin Biochem', 'key': '3400_CR28', 'unstructured': 'Erel O (2005) A new automated colorimetric method for measuring total ' 'oxidant status. Clin Biochem 38:1103–1111. ' 'https://doi.org/10.1016/j.clinbiochem.2005.08.008', 'volume': '38', 'year': '2005'}, { 'DOI': '10.3390/nu12103198', 'author': 'F Pecora', 'doi-asserted-by': 'publisher', 'first-page': '3198', 'issue': '10', 'journal-title': 'Nutrients', 'key': '3400_CR29', 'unstructured': 'Pecora F, Persico F, Argentiero A, Neglia C, Esposito S (2020) The role ' 'of micronutrients in support of the immune response against viral ' 'infections. Nutrients 12(10):3198. https://doi.org/10.3390/nu12103198', 'volume': '12', 'year': '2020'}, { 'DOI': '10.1093/clinchem/44.6.1309', 'author': 'G Cao', 'doi-asserted-by': 'publisher', 'first-page': '1309', 'issue': '6 Pt 1', 'journal-title': 'Clin Chem', 'key': '3400_CR30', 'unstructured': 'Cao G, Prior RL (1998) Comparison of different analytical methods for ' 'assessing total antioxidant capacity of human serum Automation and ' 'Analytical Techniques. Clin Chem 44(6 Pt 1):1309–1315', 'volume': '44', 'year': '1998'}, { 'DOI': '10.3390/antiox10060971', 'author': 'N Cárdenas-Rodríguez', 'doi-asserted-by': 'publisher', 'first-page': '971', 'issue': '6', 'journal-title': 'Antioxidants (Basel)', 'key': '3400_CR31', 'unstructured': 'Cárdenas-Rodríguez N, Bandala C, Vanoye-Carlo A, Ignacio-Mejía I, ' 'Gómez-Manzo S, Hernández-Cruz EY et al (2021) Use of antioxidants for ' 'the neuro-therapeutic management of covid-19. Antioxidants (Basel) ' '10(6):971. https://doi.org/10.3390/antiox10060971', 'volume': '10', 'year': '2021'}, { 'DOI': '10.1016/j.nut.2020.111016', 'author': 'D Fedele', 'doi-asserted-by': 'publisher', 'first-page': '111016', 'journal-title': 'Nutrition', 'key': '3400_CR32', 'unstructured': 'Fedele D, de Francesco A, Riso S, Collo A (2021) Obesity, malnutrition, ' 'and trace element deficiency in the coronavirus disease (COVID-19) ' 'pandemic: an overview. Nutrition 81:111016. ' 'https://doi.org/10.1016/j.nut.2020.111016', 'volume': '81', 'year': '2021'}, { 'DOI': '10.1002/ajh.26027', 'author': 'A Nai', 'doi-asserted-by': 'publisher', 'first-page': 'E32', 'issue': '1', 'journal-title': 'Am J Hematol', 'key': '3400_CR33', 'unstructured': 'Nai A, Lorè N, Pagani A, De Lorenzo R, Di Modica S, Saliu F et al (2021) ' 'Hepcidin levels predict Covid19 severity and mortality in a cohort of ' 'hospitalized Italian patients. Am J Hematol 96(1):E32–E35. ' 'https://doi.org/10.1002/ajh.26027', 'volume': '96', 'year': '2021'}, { 'DOI': '10.1016/j.resp.2007.02.012', 'author': 'AS Verkman', 'doi-asserted-by': 'publisher', 'first-page': '324', 'journal-title': 'Respir Physiol Neurobiol', 'key': '3400_CR34', 'unstructured': 'Verkman AS (2007) Role of aquaporins in lung liquid physiology. Respir ' 'Physiol Neurobiol 159:324–330. ' 'https://doi.org/10.1016/j.resp.2007.02.012', 'volume': '159', 'year': '2007'}, { 'DOI': '10.1007/s00424-018-2232-y', 'doi-asserted-by': 'publisher', 'key': '3400_CR35', 'unstructured': 'Wittekindt OH, Dietl P (2019) Aquaporins in the lung, Pflugers Archiv ' 'European. Pflugers Arch 471(4):519–532. ' 'https://doi.org/10.1007/s00424-018-2232-y'}, { 'DOI': '10.3390/metabo11040244', 'author': 'AV Skalny', 'doi-asserted-by': 'publisher', 'first-page': '244', 'journal-title': 'Metabolites', 'key': '3400_CR36', 'unstructured': 'Skalny AV, Timashev PS, Aschner M, Aaseth J, Chernova LN, Belyaev VE et ' 'al (2021) Serum zinc, copper, and other biometals are associated with ' 'COVID-19 severity markers. Metabolites 11:244. ' 'https://doi.org/10.3390/metabo11040244', 'volume': '11', 'year': '2021'}], 'reference-count': 36, 'references-count': 36, 'relation': {}, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s12011-022-03400-6'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [ 'Biochemistry (medical)', 'Inorganic Chemistry', 'Clinical Biochemistry', 'General Medicine', 'Biochemistry', 'Endocrinology, Diabetes and Metabolism'], 'subtitle': [], 'title': 'Evaluation of the Relationship Between Aquaporin-1, Hepcidin, Zinc, Copper, and İron Levels and ' 'Oxidative Stress in the Serum of Critically Ill Patients with COVID-19', 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit