Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All montelukast studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchMontelukastMontelukast (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Montelukast Drug May Improve COVID-19 Prognosis: A Review of Evidence

Barré et al., Frontiers in Pharmacology, doi:10.3389/fphar.2020.01344
Sep 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
28th treatment shown to reduce risk in November 2021
 
*, now with p = 0.0045 from 8 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Review of evidence that montelukast may improve COVID-19 prognosis. Authors note ten experimentally supported properties of montelukast that could be beneficial, including antiviral effects, prevention of SARS-CoV-2-induced endotheliitis and neurological disorders, improvement of atherogenic vascular inflammation and respiratory symptoms, limitation of the cytokine storm and acute respiratory distress syndrome, and antioxidant and anti-fibrosis effects. The drug antagonizes the inflammatory cascade induced by angiotensin II and may protect the blood-brain barrier. It has shown anti-atheromatous properties and may alleviate ischemia/reperfusion injury. Montelukast is effective against asthmatic cough and may help control the inflammatory cytokine reaction in COVID-19. Authors argue montelukast should be further tested to prevent and treat COVID-19.
Barré et al., 4 Sep 2020, France, peer-reviewed, 3 authors. Contact: cedric.annweiler@chu-angers.fr.
This PaperMontelukastAll
Montelukast Drug May Improve COVID-19 Prognosis: A Review of Evidence
Jean Barré, Jean-Marc Sabatier, Cédric Annweiler
Frontiers in Pharmacology, doi:10.3389/fphar.2020.01344
With the lack of effective therapy, chemoprevention and vaccination, focusing on the immediate repurposing of existing drugs gives hope of curbing the pandemic. Interestingly, montelukast, a drug usually used in asthma, may be proposed as a potential adjuvant therapy in COVID-19. The aim of the present article was to review the properties of montelukast that could be beneficial in COVID-19. Ten experimentally supported properties were retrieved, either related to SARS-CoV-2 (antiviral properties, prevention of endotheliitis and of neurological disorders linked to SARS-CoV-2), and/or related to the host (improvement of atherogenic vascular inflammation, limitation of the ischemia/reperfusion phenomenon, improvement of respiratory symptoms), and/or related to serious COVID-19 outcomes (limitation of the cytokine storm, mitigation of acute respiratory distress syndrome), and/or related to tissue sequelae (antioxidant properties, anti-fibrosis effects). Based on gathered theoretical evidence, we argue that montelukast should be further tested to prevent and treat COVID-19 outcomes.
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Ahn, Shin, Kim, Lee, Kim et al., Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19), J. Microbiol. Biotechnol, doi:10.4014/jmb.2003.03011
Al-Amran, Hadi, Hashim, Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats, Eur. J. Cardiothorac. Surg, doi:10.1093/ejcts/ezs312
Allen, Dashwood, Chester, Tadjkarimi, Collins et al., Influence of Atherosclerosis on the Vascular Reactivity of Isolated Human Epicardial Coronary Arteries to Leukotriene C4, Cardioscience
Almerie, Kerrigan, The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast, Med. Hypotheses, doi:10.1016/j.mehy.2020.109883
Aquino-Junior, Brito, Rigonato-Oliveira, Damaceno-Rodrigues, Oliveira et al., Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Barre ´et al. Treatment of COVID-19 Human Neutrophil Activation, Arch. Bronconeumol, doi:10.1016/j.arbres.2019.05.003
Bilgic, Altun, Çakıcı, Gideroglu, Saka, The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model, Ulus. Travma. Acil. Cerrahi. Derg, doi:10.5505/tjtes.2017.22208
Bourgonje, Abdulle, Timens, Hillebrands, Navis et al., Angiotensin-converting enzyme-2 (ACE2), SARS-CoV-2 and Pathophysiology of Coronavirus Disease 2019 (COVID-19), J. Pathol, doi:10.1002/path.5471
Bozek, Winterstein, Montelukast's ability to fight COVID-19 infection, J. Asthma, doi:10.1080/02770903.2020.1786112
Brodlie, Gupta, Rodriguez-Martinez, Castro-Rodriguez, Ducharme et al., Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children, Cochr. Database. Syst. Rev, doi:10.1002/14651858.CD008202.pub2
Cardani, Boulton, Kim, Braciale, Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells, PLoS Pathog, doi:10.1371/journal.ppat.1006140
Chari, Lonial, Mark, Krishnan, Stockerl-Goldstein et al., Results of an early access treatment protocol of daratumumab in United States patients with relapsed or refractory multiple myeloma, Cancer, doi:10.1002/cncr.31706
Chen, Li, Wang, Zou, Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity, Front. Microbiol, doi:10.3389/fmicb.2019.03079
Debelleix, Siao-Him, Fa, Begueret, Berger et al., Montelukast Reverses Airway Remodeling in Actively Sensitized Young Mice, Pediatr. Pulmonol, doi:10.1002/ppul.23980
Deschildre, Exacerbations of Asthma: A Demonstration That Guidelines Are Insufficiently Followed, Rev. Mal. Respir, doi:10.1016/j.rmr.2014.01.001
Fan, Brodie, Slutsky, Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment, JAMA, doi:10.1001/jama.2017.21907
Fidan, Aydogdu, As a Potential Treatment of COVID-19: Montelukast, Med. Hypotheses, doi:10.1016/j.mehy.2020.109828
Gelosa, Bonfanti, Castiglioni, Delgado-Garcia, Gruart et al., Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug, Pharmacol. Res, doi:10.1016/j.phrs.2019.02.025
Glockler-Lauf, Finkelstein, Zhu, Feldman, To, Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case-Control Study, J. Pediatr, doi:10.1016/j.jpeds.2019.02.009
Hamamoto, Ano, Allard, O'sullivan, Mcgovern et al., Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse, Br. J. Pharmacol, doi:10.1111/bph.13953
Han, Jia, Takeda, Shiraishi, Okamoto et al., Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus, Am. J. Respir. Crit. Care Med, doi:10.1164/rccm.200912-1811OC
Hareedy, Ahmed, Ali, Montelukast modifies simvastatin-induced myopathy and hepatotoxicity, Drug Dev. Res, doi:10.1002/ddr.21581
Hormati, Ahmadpour, Afkhami Ardekani, Khodadust, Refahi, Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice, J. Biochem. Mol. Toxicol, doi:10.1002/jbt.22479
Hoxha, Lewis-Mikhael, Bueno-Cavanillas, Potential role of leukotriene receptor antagonists in reducing cardiovascular and cerbrovascular risk: A systematic review of human, Biomed. Pharmacother, doi:10.1016/j.biopha.2018.07.033
Huynh, Wang, Luan, Bartosch, Ivanov, In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2's Main Protease, J. Phys. Chem. Lett, doi:10.3390/v10080392
Kimura, Yoshizumi, Ishii, Oishi, Ryo, Cytokine production and signaling pathways in respiratory virus infection, Front. Microbiol, doi:10.3389/fmicb.2013.00276
Kloepfer, Demore, Vrtis, Swenson, Gaworski et al., Effects of montelukast on patients with asthma after experimental inoculation with human rhinovirus 16, Ann. Allergy Asthma. Immunol, doi:10.1016/j.anai.2010.11.021
Klok, Kruip, Van Der Meer, Arbous, Gommers et al., Incidence of thrombotic complications in critically ill ICU patients with COVID-19, Thromb. Res, doi:10.1016/j.thromres.2020.04.013
Korkmaz, Gedik, Budak, Yener, Kaya et al., Effect of Montelukast on Spinal Cord Ischemia-Reperfusion Injury, Turk. Neurosurg, doi:10.5137/1019-5149.JTN.11499-14.2
Kotchetkov, Mclean, Nay, Gerard, Hopkins et al., Premedication with montelukast and rupatadine decreased rituximab infusion time, rate, severity of reactions and use of rescue medications, Int. J. Cancer, doi:10.1002/ijc.32985
Landeras-Bueno, Fernańdez, Falcoń, Oliveros, Ortıń, Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition, mBio, doi:10.1128/mBio.00085-16
Lenz, Arroyo, Temp, Poersch, Masson et al., Cysteinyl Leukotriene Receptor (CysLT) Antagonists Decrease Pentylenetetrazol-Induced Seizures and Blood-Brain Barrier Dysfunction, Neuroscience, doi:10.1016/j.neuroscience.2014.07.058
Mao, Jin, Wang, Hu, Chen et al., Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China, JAMA Neurol, doi:10.1001/jamaneurol.2020.1127
Marschallinger, Schäffner, Klein, Gelfert, Rivera et al., Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug, Nat. Commun, doi:10.1038/ncomms9466
Miwa, Nagano, Ohnishi, Nishiuma, Takenaka et al., An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids, Kobe. J. Med. Sci
Morita, Campos Alberto, Suzuki, Sato, Hoshioka et al., Pranlukast reduces asthma exacerbations during autumn especially in 1to 5-year-old boys, Asia. Pac. Allergy, doi:10.5415/apallergy.2017.7.1.10
Mueller, Becher, Zimmer, Wassmann, Keuler et al., Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1, Mol. Cell. Biochem, doi:10.1007/s11010-009-0227-x
Oral, Odabasoglu, Halici, Keles, Unal et al., Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation, Fertil. Steril, doi:10.1016/j.fertnstert.2010.08.017
Peng, Zhou, Kuang, Xie, Tian et al., The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling, Biochem. Biophys. Res. Commun, doi:10.1016/j.bbrc.2017.01.052
Ruiz, Nevers, Hernańdez, Ahnou, Brillet et al., MK-571, a cysteinyl leukotriene receptor-1 antagonist, inhibits hepatitis C virus (HCV) replication, Antimicrob. Agents. Chemother, doi:10.1128/AAC.02078-19
Russell, Moss, George, Santaolalla, Cope et al., Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence, Ecancermedicalscience, doi:10.3332/ecancer.2020.1022
Sayin, Cimen, Cimen, Bostanci, Akbaba et al., Colonic anastomosis can be protected from ischemia reperfusion injury with intra-peritoneal Montelukast treatment, Asian. J. Surg, doi:10.1016/j.asjsur.2019.01.022
Shao, Lan, Duan, Liu, Min et al., Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients, J. Clin. Immunol, doi:10.1007/s10875-006-9046-y
Sılay, Toklu, Özagȃrı, Aydın, Tetik et al., Montelukast prevents testes against ischemia-reperfusion injury through suppression of iNOS expression, Turk. J. Urol, doi:10.5152/tud.2014.61587
Topaloglu, Olgun Yıldızeli, Sȩner, Lacin, Sȩhirli et al., Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis, Turk. Gogus. Kalp. Damar. Cerrahisi. Derg, doi:10.5606/tgkdc.dergisi.2019.15149
Van Den Brand, Haagmans, Van Riel, Osterhaus, Kuiken, The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models, J. Comp. Pathol, doi:10.1016/j.jcpa.2014.01.004
Varga, Flammer, Steiger, Haberecker, Andermatt et al., Endothelial cell infection and endotheliitis in COVID-19, Lancet, doi:10.1016/S0140-6736(20)30937-5
Wang, Birring, Taylor, Fry, Hay et al., Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial, Lancet Respir. Med, doi:10.1016/S2213-2600(13)70245-5
Wang, Cheng, Liu, Shi, Cheng, Montelukast promotes mitochondrial biogenesis via CREB/PGC-1a in human bronchial epithelial cells, Artif. Cells Nanomed. Biotechnol, doi:10.1080/21691401.2019.1687502
Wang, Tian, Liu, Suppressive Effect of Leukotriene Antagonists on Capsular Contracture in Patients Who Underwent Breast Surgery with Prosthesis: A Meta-Analysis, Plast. Reconstr. Surg, doi:10.1097/PRS.0000000000006629
Wu, Chik, Chan, Li, Tsang et al., Antiinflammatory effects of high-dose montelukast in an animal model of acute asthma, Clin. Exp. Allergy, doi:10.1046/j.1365-2222.2003.01615.x
Yeh, Yang, Wang, Hepatic Warm Ischemia-Reperfusion-Induced Increase in Pulmonary Capillary Filtration Is Ameliorated by Administration of a Multidrug Resistance-Associated Protein 1 Inhibitor and Leukotriene D4 Antagonist (MK-571) Through Reducing Neutrophil Infiltration and Pulmonary Inflammation and Oxidative Stress in Rats, Transplant. Proc, doi:10.1016/j.transproceed.2014.10.061
Zamani, Prabhakaran, Varshosaz, Mhaisalkar, Ramakrishna, Electrosprayed Montelukast/poly (lactic-co-glycolic acid) particle based coating: A new therapeutic approach towards the prevention of in-stent restenosis, Acta Biomater, doi:10.1016/j.actbio.2016.07.007
Zhang, Tan, Ling, Lu, Liu et al., Viral and host factors related to the clinical outcome of COVID-19, Nature, doi:10.1038/s41586-020-2355-0
Zhou, Cai, Liu, Wu, Gao, Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast protects against TNF-ainduced endothelial inflammation, Biomed. Pharmacother, doi:10.1016/j.biopha.2018.12.064
Zhou, Sun, Shi, Liu, Luan et al., Cysteinyl leukotriene receptor type 1 antagonist montelukast protects against injury of blood-brain barrier, Inflammopharmacology, doi:10.1007/s10787-019-00611-7
{ 'indexed': {'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T09:56:42Z', 'timestamp': 1713866202285}, 'reference-count': 56, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2020, 9, 4]], 'date-time': '2020-09-04T00:00:00Z', 'timestamp': 1599177600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'DOI': '10.3389/fphar.2020.01344', 'type': 'journal-article', 'created': {'date-parts': [[2020, 9, 4]], 'date-time': '2020-09-04T15:00:35Z', 'timestamp': 1599231635000}, 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 31, 'title': 'Montelukast Drug May Improve COVID-19 Prognosis: A Review of Evidence', 'prefix': '10.3389', 'volume': '11', 'author': [ {'given': 'Jean', 'family': 'Barré', 'sequence': 'first', 'affiliation': []}, {'given': 'Jean-Marc', 'family': 'Sabatier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cédric', 'family': 'Annweiler', 'sequence': 'additional', 'affiliation': []}], 'member': '1965', 'published-online': {'date-parts': [[2020, 9, 4]]}, 'reference': [ { 'key': 'B1', 'doi-asserted-by': 'publisher', 'first-page': '313', 'DOI': '10.4014/jmb.2003.03011', 'article-title': 'Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines ' 'for Novel Coronavirus Disease 2019 (COVID-19)', 'volume': '30', 'author': 'Ahn', 'year': '2020', 'journal-title': 'J. Microbiol. Biotechnol.'}, { 'key': 'B2', 'doi-asserted-by': 'publisher', 'first-page': '421', 'DOI': '10.1093/ejcts/ezs312', 'article-title': 'Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute ' 'lung injury following haemorrhagic shock in rats', 'volume': '43', 'author': 'Al-Amran', 'year': '2013', 'journal-title': 'Eur. J. Cardiothorac. Surg.'}, { 'key': 'B3', 'first-page': '47', 'article-title': 'Influence of Atherosclerosis on the Vascular Reactivity of Isolated ' 'Human Epicardial Coronary Arteries to Leukotriene C4', 'volume': '4', 'author': 'Allen', 'year': '1993', 'journal-title': 'Cardioscience'}, { 'key': 'B4', 'doi-asserted-by': 'publisher', 'first-page': '109883', 'DOI': '10.1016/j.mehy.2020.109883', 'article-title': 'The association between obesity and poor outcome after COVID-19 ' 'indicates a potential therapeutic role for montelukast', 'volume': '143', 'author': 'Almerie', 'year': '2020', 'journal-title': 'Med. Hypotheses'}, { 'key': 'B5', 'doi-asserted-by': 'publisher', 'first-page': '573', 'DOI': '10.1016/j.arbres.2019.05.003', 'article-title': 'Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung ' 'Inflammation and Human Neutrophil Activation', 'volume': '55', 'author': 'Aquino-Junior', 'year': '2019', 'journal-title': 'Arch. Bronconeumol.'}, { 'key': 'B6', 'doi-asserted-by': 'publisher', 'first-page': '185', 'DOI': '10.5505/tjtes.2017.22208', 'article-title': 'The protective effect of Montelukast against skeletal muscle ischemia ' 'reperfusion injury: An experimental rat model', 'volume': '24', 'author': 'Bilgiç', 'year': '2018', 'journal-title': 'Ulus. Travma. Acil. Cerrahi. Derg.'}, { 'key': 'B7', 'doi-asserted-by': 'publisher', 'first-page': '228', 'DOI': '10.1002/path.5471', 'article-title': 'Angiotensin-converting enzyme-2 (ACE2), SARS-CoV-2 and Pathophysiology ' 'of Coronavirus Disease 2019 (COVID-19)', 'volume': '251', 'author': 'Bourgonje', 'year': '2020', 'journal-title': 'J. Pathol'}, { 'key': 'B8', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1080/02770903.2020.1786112', 'article-title': 'Montelukast’s ability to fight COVID-19 infection', 'author': 'Bozek', 'year': '2020', 'journal-title': 'J. Asthma.'}, { 'key': 'B9', 'doi-asserted-by': 'publisher', 'first-page': 'CD008202', 'DOI': '10.1002/14651858.CD008202.pub2', 'article-title': 'Leukotriene receptor antagonists as maintenance and intermittent ' 'therapy for episodic viral wheeze in children', 'volume': '2015', 'author': 'Brodlie', 'year': '2015', 'journal-title': 'Cochr. Database. Syst. Rev.'}, { 'key': 'B10', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.ppat.1006140', 'article-title': 'Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting ' 'Infection Of Type-1 Alveolar Epithelial Cells', 'volume': '13', 'author': 'Cardani', 'year': '2017', 'journal-title': 'PLoS Pathog.'}, { 'key': 'B11', 'doi-asserted-by': 'publisher', 'first-page': '4342', 'DOI': '10.1002/cncr.31706', 'article-title': 'Results of an early access treatment protocol of daratumumab in United ' 'States patients with relapsed or refractory multiple myeloma', 'volume': '124', 'author': 'Chari', 'year': '2018', 'journal-title': 'Cancer'}, { 'key': 'B12', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fmicb.2019.03079', 'article-title': 'Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by ' 'Disrupting Viral Integrity', 'volume': '10', 'author': 'Chen', 'year': '2020', 'journal-title': 'Front. Microbiol.'}, { 'key': 'B13', 'doi-asserted-by': 'publisher', 'first-page': '701', 'DOI': '10.1002/ppul.23980', 'article-title': 'Montelukast Reverses Airway Remodeling in Actively Sensitized Young ' 'Mice', 'volume': '53', 'author': 'Debelleix', 'year': '2018', 'journal-title': 'Pediatr. Pulmonol.'}, { 'key': 'B14', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1016/j.rmr.2014.01.001', 'article-title': 'Exacerbations of Asthma: A Demonstration That Guidelines Are ' 'Insufficiently Followed', 'volume': '31', 'author': 'Deschildre', 'year': '2014', 'journal-title': 'Rev. Mal. Respir.'}, { 'key': 'B15', 'doi-asserted-by': 'publisher', 'first-page': '698', 'DOI': '10.1001/jama.2017.21907', 'article-title': 'Acute Respiratory Distress Syndrome: Advances in Diagnosis and ' 'Treatment', 'volume': '319', 'author': 'Fan', 'year': '2018', 'journal-title': 'JAMA'}, { 'key': 'B16', 'doi-asserted-by': 'publisher', 'first-page': '109828', 'DOI': '10.1016/j.mehy.2020.109828', 'article-title': 'As a Potential Treatment of COVID-19: Montelukast', 'volume': '142', 'author': 'Fidan', 'year': '2020', 'journal-title': 'Med. Hypotheses'}, { 'key': 'B17', 'doi-asserted-by': 'publisher', 'first-page': '223', 'DOI': '10.1016/j.phrs.2019.02.025', 'article-title': 'Improvement of fiber connectivity and functional recovery after stroke ' 'by montelukast, an available and safe anti-asthmatic drug', 'volume': '142', 'author': 'Gelosa', 'year': '2019', 'journal-title': 'Pharmacol. Res.'}, { 'key': 'B18', 'doi-asserted-by': 'publisher', 'first-page': '176', 'DOI': '10.1016/j.jpeds.2019.02.009', 'article-title': 'Montelukast and Neuropsychiatric Events in Children with Asthma: A ' 'Nested Case-Control Study', 'volume': '209', 'author': 'Glockler-Lauf', 'year': '2019', 'journal-title': 'J. Pediatr'}, { 'key': 'B19', 'doi-asserted-by': 'publisher', 'first-page': '3346', 'DOI': '10.1111/bph.13953', 'article-title': 'Montelukast reduces inhaled chlorine triggered airway ' 'hyperresponsiveness and airway inflammation in the mouse', 'volume': '174', 'author': 'Hamamoto', 'year': '2017', 'journal-title': 'Br. J. Pharmacol.'}, { 'key': 'B20', 'doi-asserted-by': 'publisher', 'first-page': '455', 'DOI': '10.1164/rccm.200912-1811OC', 'article-title': 'Montelukast during primary infection prevents airway ' 'hyperresponsiveness and inflammation after reinfection with respiratory ' 'syncytial virus', 'volume': '182', 'author': 'Han', 'year': '2010', 'journal-title': 'Am. J. Respir. Crit. Care Med.'}, { 'key': 'B21', 'doi-asserted-by': 'publisher', 'first-page': '1000', 'DOI': '10.1002/ddr.21581', 'article-title': 'Montelukast modifies simvastatin-induced myopathy and hepatotoxicity', 'volume': '80', 'author': 'Hareedy', 'year': '2019', 'journal-title': 'Drug Dev. Res.'}, { 'key': 'B22', 'doi-asserted-by': 'publisher', 'first-page': 'e22479', 'DOI': '10.1002/jbt.22479', 'article-title': 'Radioprotective effects of montelukast, a selective leukotriene CysLT1 ' 'receptor antagonist, against nephrotoxicity induced by gamma radiation ' 'in mice', 'volume': '34', 'author': 'Hormati', 'year': '2020', 'journal-title': 'J. Biochem. Mol. Toxicol.'}, { 'key': 'B23', 'doi-asserted-by': 'publisher', 'first-page': '956', 'DOI': '10.1016/j.biopha.2018.07.033', 'article-title': 'Potential role of leukotriene receptor antagonists in reducing ' 'cardiovascular and cerbrovascular risk: A systematic review of human', 'volume': '106', 'author': 'Hoxha', 'year': '2018', 'journal-title': 'Biomed. Pharmacother.'}, { 'key': 'B24', 'doi-asserted-by': 'publisher', 'first-page': '4413', 'DOI': '10.1021/acs.jpclett.0c00994', 'article-title': 'In Silico Exploration of the Molecular Mechanism of Clinically Oriented ' 'Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease', 'volume': '11', 'author': 'Huynh', 'year': '2020', 'journal-title': 'J. Phys. Chem. Lett.'}, { 'key': 'B25', 'doi-asserted-by': 'publisher', 'first-page': '392', 'DOI': '10.3390/v10080392', 'article-title': 'Redox Biology of Respiratory Viral Infections', 'volume': '10', 'author': 'Khomich', 'year': '2018', 'journal-title': 'Viruses'}, { 'key': 'B26', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fmicb.2013.00276', 'article-title': 'Cytokine production and signaling pathways in respiratory virus ' 'infection', 'volume': '4', 'author': 'Kimura', 'year': '2013', 'journal-title': 'Front. Microbiol.'}, { 'key': 'B27', 'doi-asserted-by': 'publisher', 'first-page': '252', 'DOI': '10.1016/j.anai.2010.11.021', 'article-title': 'Effects of montelukast on patients with asthma after experimental ' 'inoculation with human rhinovirus 16', 'volume': '106', 'author': 'Kloepfer', 'year': '2011', 'journal-title': 'Ann. Allergy Asthma. Immunol.'}, { 'key': 'B28', 'doi-asserted-by': 'publisher', 'first-page': '145', 'DOI': '10.1016/j.thromres.2020.04.013', 'article-title': 'Incidence of thrombotic complications in critically ill ICU patients ' 'with COVID-19', 'volume': '191', 'author': 'Klok', 'year': '2020', 'journal-title': 'Thromb. Res.'}, { 'key': 'B29', 'doi-asserted-by': 'publisher', 'first-page': '757', 'DOI': '10.5137/1019-5149.JTN.11499-14.2', 'article-title': 'Effect of Montelukast on Spinal Cord Ischemia- Reperfusion Injury', 'volume': '25', 'author': 'Korkmaz', 'year': '2015', 'journal-title': 'Turk. Neurosurg.'}, { 'key': 'B30', 'doi-asserted-by': 'publisher', 'first-page': '1979', 'DOI': '10.1002/ijc.32985', 'article-title': 'Premedication with montelukast and rupatadine decreased rituximab ' 'infusion time, rate, severity of reactions and use of rescue ' 'medications', 'volume': '147', 'author': 'Kotchetkov', 'year': '2020', 'journal-title': 'Int. J. Cancer'}, { 'key': 'B31', 'doi-asserted-by': 'publisher', 'first-page': 'e00085', 'DOI': '10.1128/mBio.00085-16', 'article-title': 'Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress ' 'Response as a Cellular Target for Influenza Virus Inhibition', 'volume': '7', 'author': 'Landeras-Bueno', 'year': '2016', 'journal-title': 'mBio'}, { 'key': 'B32', 'doi-asserted-by': 'publisher', 'first-page': '859', 'DOI': '10.1016/j.neuroscience.2014.07.058', 'article-title': 'Cysteinyl Leukotriene Receptor (CysLT) Antagonists Decrease ' 'Pentylenetetrazol-Induced Seizures and Blood-Brain Barrier Dysfunction', 'volume': '277', 'author': 'Lenz', 'year': '2014', 'journal-title': 'Neuroscience'}, { 'key': 'B33', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1001/jamaneurol.2020.1127', 'article-title': 'Neurologic Manifestations of Hospitalized Patients With Coronavirus ' 'Disease 2019 in Wuhan, China', 'volume': '77', 'author': 'Mao', 'year': '2020', 'journal-title': 'JAMA Neurol.'}, { 'key': 'B34', 'doi-asserted-by': 'publisher', 'first-page': '8466', 'DOI': '10.1038/ncomms9466', 'article-title': 'Structural and functional rejuvenation of the aged brain by an approved ' 'anti-asthmatic drug', 'volume': '6', 'author': 'Marschallinger', 'year': '2015', 'journal-title': 'Nat. Commun.'}, { 'key': 'B35', 'first-page': 'E134', 'article-title': 'An Open-Label, Multi-Institutional, Randomized Study to Evaluate the ' 'Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in ' 'Patients with Cough-Variant Asthma Being Treated with Inhaled ' 'Corticosteroids', 'volume': '64', 'author': 'Miwa', 'year': '2018', 'journal-title': 'Kobe. J. Med. Sci.'}, { 'key': 'B36', 'doi-asserted-by': 'publisher', 'first-page': '10', 'DOI': '10.5415/apallergy.2017.7.1.10', 'article-title': 'Pranlukast reduces asthma exacerbations during autumn especially in 1- ' 'to 5-year-old boys', 'volume': '7', 'author': 'Morita', 'year': '2017', 'journal-title': 'Asia. Pac. Allergy'}, { 'key': 'B37', 'doi-asserted-by': 'publisher', 'first-page': '261', 'DOI': '10.1007/s11010-009-0227-x', 'article-title': 'Angiotensin II triggers release of leukotriene C4 in vascular smooth ' 'muscle cells via the multidrug resistance-related protein 1', 'volume': '333', 'author': 'Mueller', 'year': '2010', 'journal-title': 'Mol. Cell. Biochem.'}, { 'key': 'B38', 'doi-asserted-by': 'publisher', 'first-page': '1360', 'DOI': '10.1016/j.fertnstert.2010.08.017', 'article-title': 'Protective effects of montelukast on ischemia-reperfusion injury in rat ' 'ovaries subjected to torsion and detorsion: biochemical and ' 'histopathologic evaluation', 'volume': '95', 'author': 'Oral', 'year': '2011', 'journal-title': 'Fertil. Steril.'}, { 'key': 'B39', 'doi-asserted-by': 'publisher', 'first-page': '474', 'DOI': '10.1016/j.bbrc.2017.01.052', 'article-title': 'The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist ' 'montelukast regulates extracellular matrix remodeling', 'volume': '484', 'author': 'Peng', 'year': '2017', 'journal-title': 'Biochem. Biophys. Res. Commun.'}, { 'key': 'B40', 'doi-asserted-by': 'publisher', 'first-page': 'e02078', 'DOI': '10.1128/AAC.02078-19', 'article-title': 'MK-571, a cysteinyl leukotriene receptor-1 antagonist, inhibits ' 'hepatitis C virus (HCV) replication', 'volume': '64', 'author': 'Ruiz', 'year': '2020', 'journal-title': 'Antimicrob. Agents. Chemother.'}, { 'key': 'B41', 'doi-asserted-by': 'publisher', 'first-page': '1022', 'DOI': '10.3332/ecancer.2020.1022', 'article-title': 'Associations between immune-suppressive and stimulating drugs and novel ' 'COVID-19-a systematic review of current evidence', 'volume': '14', 'author': 'Russell', 'year': '2020', 'journal-title': 'Ecancermedicalscience'}, { 'key': 'B42', 'doi-asserted-by': 'publisher', 'first-page': '130', 'DOI': '10.1016/j.asjsur.2019.01.022', 'article-title': 'Colonic anastomosis can be protected from ischemia reperfusion injury ' 'with intra-peritoneal Montelukast treatment', 'volume': '43', 'author': 'Sayin', 'year': '2020', 'journal-title': 'Asian. J. Surg.'}, { 'key': 'B43', 'doi-asserted-by': 'publisher', 'first-page': '546', 'DOI': '10.1007/s10875-006-9046-y', 'article-title': 'Upregulation of mitochondrial gene expression in PBMC from convalescent ' 'SARS patients', 'volume': '26', 'author': 'Shao', 'year': '2006', 'journal-title': 'J. Clin. Immunol.'}, { 'key': 'B44', 'doi-asserted-by': 'publisher', 'first-page': '221', 'DOI': '10.5152/tud.2014.61587', 'article-title': 'Montelukast prevents testes against ischemia-reperfusion injury through ' 'suppression of iNOS expression', 'volume': '40', 'author': 'Sılay', 'year': '2014', 'journal-title': 'Turk. J. Urol.'}, { 'key': 'B45', 'doi-asserted-by': 'publisher', 'first-page': '588', 'DOI': '10.5606/tgkdc.dergisi.2019.15149', 'article-title': 'Protective effect of cysteinyl leukotriene receptor antagonist ' 'montelukast in bleomycin-induced pulmonary fibrosis', 'volume': '26', 'author': 'Topaloğlu', 'year': '2018', 'journal-title': 'Turk. Gogus. Kalp. Damar. Cerrahisi. Derg.'}, { 'key': 'B46', 'doi-asserted-by': 'publisher', 'first-page': '83', 'DOI': '10.1016/j.jcpa.2014.01.004', 'article-title': 'The pathology and pathogenesis of experimental severe acute respiratory ' 'syndrome and influenza in animal models', 'volume': '151', 'author': 'van den Brand', 'year': '2014', 'journal-title': 'J. Comp. Pathol.'}, { 'key': 'B47', 'doi-asserted-by': 'publisher', 'first-page': '1417', 'DOI': '10.1016/S0140-6736(20)30937-5', 'article-title': 'Endothelial cell infection and endotheliitis in COVID-19', 'volume': '395', 'author': 'Varga', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': 'B48', 'doi-asserted-by': 'publisher', 'first-page': '35', 'DOI': '10.1016/S2213-2600(13)70245-5', 'article-title': 'Montelukast for postinfectious cough in adults: a double-blind ' 'randomised placebo-controlled trial', 'volume': '2', 'author': 'Wang', 'year': '2014', 'journal-title': 'Lancet Respir. Med.'}, { 'key': 'B49', 'doi-asserted-by': 'publisher', 'first-page': '4234', 'DOI': '10.1080/21691401.2019.1687502', 'article-title': 'Montelukast promotes mitochondrial biogenesis via CREB/PGC-1α in human ' 'bronchial epithelial cells', 'volume': '47', 'author': 'Wang', 'year': '2019', 'journal-title': 'Artif. Cells Nanomed. Biotechnol.'}, { 'key': 'B50', 'doi-asserted-by': 'publisher', 'first-page': '901', 'DOI': '10.1097/PRS.0000000000006629', 'article-title': 'Suppressive Effect of Leukotriene Antagonists on Capsular Contracture ' 'in Patients Who Underwent Breast Surgery with Prosthesis: A ' 'Meta-Analysis', 'volume': '145', 'author': 'Wang', 'year': '2020', 'journal-title': 'Plast. Reconstr. Surg.'}, { 'key': 'B51', 'doi-asserted-by': 'publisher', 'first-page': '359', 'DOI': '10.1046/j.1365-2222.2003.01615.x', 'article-title': 'Anti-inflammatory effects of high-dose montelukast in an animal model ' 'of acute asthma', 'volume': '33', 'author': 'Wu', 'year': '2003', 'journal-title': 'Clin. Exp. Allergy'}, { 'key': 'B52', 'doi-asserted-by': 'publisher', 'first-page': '1087', 'DOI': '10.1016/j.transproceed.2014.10.061', 'article-title': 'Hepatic Warm Ischemia-Reperfusion-Induced Increase in Pulmonary ' 'Capillary Filtration Is Ameliorated by Administration of a Multidrug ' 'Resistance-Associated Protein 1 Inhibitor and Leukotriene D4 Antagonist ' '(MK-571) Through Reducing Neutrophil Infiltration and Pulmonary ' 'Inflammation and Oxidative Stress in Rats', 'volume': '47', 'author': 'Yeh', 'year': '2015', 'journal-title': 'Transplant. Proc.'}, { 'key': 'B53', 'doi-asserted-by': 'publisher', 'first-page': '316', 'DOI': '10.1016/j.actbio.2016.07.007', 'article-title': 'Electrosprayed Montelukast/poly (lactic-co-glycolic acid) particle ' 'based coating: A new therapeutic approach towards the prevention of ' 'in-stent restenosis', 'volume': '42', 'author': 'Zamani', 'year': '2016', 'journal-title': 'Acta Biomater.'}, { 'key': 'B54', 'doi-asserted-by': 'publisher', 'first-page': '437', 'DOI': '10.1038/s41586-020-2355-0', 'article-title': 'Viral and host factors related to the clinical outcome of COVID-19', 'volume': '583', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Nature'}, { 'key': 'B55', 'doi-asserted-by': 'publisher', 'first-page': '452', 'DOI': '10.1016/j.biopha.2018.12.064', 'article-title': 'Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast ' 'protects against TNF-α-induced endothelial inflammation', 'volume': '111', 'author': 'Zhou', 'year': '2019', 'journal-title': 'Biomed. Pharmacother.'}, { 'key': 'B56', 'doi-asserted-by': 'publisher', 'first-page': '933', 'DOI': '10.1007/s10787-019-00611-7', 'article-title': 'Cysteinyl leukotriene receptor type 1 antagonist montelukast protects ' 'against injury of blood-brain barrier', 'volume': '27', 'author': 'Zhou', 'year': '2019', 'journal-title': 'Inflammopharmacology'}], 'container-title': 'Frontiers in Pharmacology', 'original-title': [], 'link': [ { 'URL': 'https://www.frontiersin.org/article/10.3389/fphar.2020.01344/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2020, 9, 4]], 'date-time': '2020-09-04T15:00:38Z', 'timestamp': 1599231638000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.frontiersin.org/article/10.3389/fphar.2020.01344/full'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 9, 4]]}, 'references-count': 56, 'alternative-id': ['10.3389/fphar.2020.01344'], 'URL': 'http://dx.doi.org/10.3389/fphar.2020.01344', 'relation': {}, 'ISSN': ['1663-9812'], 'subject': [], 'container-title-short': 'Front. Pharmacol.', 'published': {'date-parts': [[2020, 9, 4]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit