Montelukast Drug May Improve COVID-19 Prognosis: A Review of Evidence
Jean Barré, Jean-Marc Sabatier, Cédric Annweiler
Frontiers in Pharmacology, doi:10.3389/fphar.2020.01344
With the lack of effective therapy, chemoprevention and vaccination, focusing on the immediate repurposing of existing drugs gives hope of curbing the pandemic. Interestingly, montelukast, a drug usually used in asthma, may be proposed as a potential adjuvant therapy in COVID-19. The aim of the present article was to review the properties of montelukast that could be beneficial in COVID-19. Ten experimentally supported properties were retrieved, either related to SARS-CoV-2 (antiviral properties, prevention of endotheliitis and of neurological disorders linked to SARS-CoV-2), and/or related to the host (improvement of atherogenic vascular inflammation, limitation of the ischemia/reperfusion phenomenon, improvement of respiratory symptoms), and/or related to serious COVID-19 outcomes (limitation of the cytokine storm, mitigation of acute respiratory distress syndrome), and/or related to tissue sequelae (antioxidant properties, anti-fibrosis effects). Based on gathered theoretical evidence, we argue that montelukast should be further tested to prevent and treat COVID-19 outcomes.
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Ahn, Shin, Kim, Lee, Kim et al., Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19), J. Microbiol. Biotechnol,
doi:10.4014/jmb.2003.03011Al-Amran, Hadi, Hashim, Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats, Eur. J. Cardiothorac. Surg,
doi:10.1093/ejcts/ezs312Allen, Dashwood, Chester, Tadjkarimi, Collins et al., Influence of Atherosclerosis on the Vascular Reactivity of Isolated Human Epicardial Coronary Arteries to Leukotriene C4, Cardioscience
Almerie, Kerrigan, The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast, Med. Hypotheses,
doi:10.1016/j.mehy.2020.109883Aquino-Junior, Brito, Rigonato-Oliveira, Damaceno-Rodrigues, Oliveira et al., Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Barre ´et al. Treatment of COVID-19 Human Neutrophil Activation, Arch. Bronconeumol,
doi:10.1016/j.arbres.2019.05.003Bilgic, Altun, Çakıcı, Gideroglu, Saka, The protective effect of Montelukast against skeletal muscle ischemia reperfusion injury: An experimental rat model, Ulus. Travma. Acil. Cerrahi. Derg,
doi:10.5505/tjtes.2017.22208Bourgonje, Abdulle, Timens, Hillebrands, Navis et al., Angiotensin-converting enzyme-2 (ACE2), SARS-CoV-2 and Pathophysiology of Coronavirus Disease 2019 (COVID-19), J. Pathol,
doi:10.1002/path.5471Brodlie, Gupta, Rodriguez-Martinez, Castro-Rodriguez, Ducharme et al., Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children, Cochr. Database. Syst. Rev,
doi:10.1002/14651858.CD008202.pub2Cardani, Boulton, Kim, Braciale, Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells, PLoS Pathog,
doi:10.1371/journal.ppat.1006140Chari, Lonial, Mark, Krishnan, Stockerl-Goldstein et al., Results of an early access treatment protocol of daratumumab in United States patients with relapsed or refractory multiple myeloma, Cancer,
doi:10.1002/cncr.31706Chen, Li, Wang, Zou, Montelukast, an Anti-asthmatic Drug, Inhibits Zika Virus Infection by Disrupting Viral Integrity, Front. Microbiol,
doi:10.3389/fmicb.2019.03079Debelleix, Siao-Him, Fa, Begueret, Berger et al., Montelukast Reverses Airway Remodeling in Actively Sensitized Young Mice, Pediatr. Pulmonol,
doi:10.1002/ppul.23980Deschildre, Exacerbations of Asthma: A Demonstration That Guidelines Are Insufficiently Followed, Rev. Mal. Respir,
doi:10.1016/j.rmr.2014.01.001Gelosa, Bonfanti, Castiglioni, Delgado-Garcia, Gruart et al., Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug, Pharmacol. Res,
doi:10.1016/j.phrs.2019.02.025Glockler-Lauf, Finkelstein, Zhu, Feldman, To, Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case-Control Study, J. Pediatr,
doi:10.1016/j.jpeds.2019.02.009Hamamoto, Ano, Allard, O'sullivan, Mcgovern et al., Montelukast reduces inhaled chlorine triggered airway hyperresponsiveness and airway inflammation in the mouse, Br. J. Pharmacol,
doi:10.1111/bph.13953Han, Jia, Takeda, Shiraishi, Okamoto et al., Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus, Am. J. Respir. Crit. Care Med,
doi:10.1164/rccm.200912-1811OCHareedy, Ahmed, Ali, Montelukast modifies simvastatin-induced myopathy and hepatotoxicity, Drug Dev. Res,
doi:10.1002/ddr.21581Hormati, Ahmadpour, Afkhami Ardekani, Khodadust, Refahi, Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice, J. Biochem. Mol. Toxicol,
doi:10.1002/jbt.22479Hoxha, Lewis-Mikhael, Bueno-Cavanillas, Potential role of leukotriene receptor antagonists in reducing cardiovascular and cerbrovascular risk: A systematic review of human, Biomed. Pharmacother,
doi:10.1016/j.biopha.2018.07.033Huynh, Wang, Luan, Bartosch, Ivanov, In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2's Main Protease, J. Phys. Chem. Lett,
doi:10.3390/v10080392Kimura, Yoshizumi, Ishii, Oishi, Ryo, Cytokine production and signaling pathways in respiratory virus infection, Front. Microbiol,
doi:10.3389/fmicb.2013.00276Kloepfer, Demore, Vrtis, Swenson, Gaworski et al., Effects of montelukast on patients with asthma after experimental inoculation with human rhinovirus 16, Ann. Allergy Asthma. Immunol,
doi:10.1016/j.anai.2010.11.021Klok, Kruip, Van Der Meer, Arbous, Gommers et al., Incidence of thrombotic complications in critically ill ICU patients with COVID-19, Thromb. Res,
doi:10.1016/j.thromres.2020.04.013Kotchetkov, Mclean, Nay, Gerard, Hopkins et al., Premedication with montelukast and rupatadine decreased rituximab infusion time, rate, severity of reactions and use of rescue medications, Int. J. Cancer,
doi:10.1002/ijc.32985Landeras-Bueno, Fernańdez, Falcoń, Oliveros, Ortıń, Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition, mBio,
doi:10.1128/mBio.00085-16Lenz, Arroyo, Temp, Poersch, Masson et al., Cysteinyl Leukotriene Receptor (CysLT) Antagonists Decrease Pentylenetetrazol-Induced Seizures and Blood-Brain Barrier Dysfunction, Neuroscience,
doi:10.1016/j.neuroscience.2014.07.058Mao, Jin, Wang, Hu, Chen et al., Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China, JAMA Neurol,
doi:10.1001/jamaneurol.2020.1127Marschallinger, Schäffner, Klein, Gelfert, Rivera et al., Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug, Nat. Commun,
doi:10.1038/ncomms9466Miwa, Nagano, Ohnishi, Nishiuma, Takenaka et al., An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids, Kobe. J. Med. Sci
Morita, Campos Alberto, Suzuki, Sato, Hoshioka et al., Pranlukast reduces asthma exacerbations during autumn especially in 1to 5-year-old boys, Asia. Pac. Allergy,
doi:10.5415/apallergy.2017.7.1.10Mueller, Becher, Zimmer, Wassmann, Keuler et al., Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1, Mol. Cell. Biochem,
doi:10.1007/s11010-009-0227-xOral, Odabasoglu, Halici, Keles, Unal et al., Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation, Fertil. Steril,
doi:10.1016/j.fertnstert.2010.08.017Peng, Zhou, Kuang, Xie, Tian et al., The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling, Biochem. Biophys. Res. Commun,
doi:10.1016/j.bbrc.2017.01.052Ruiz, Nevers, Hernańdez, Ahnou, Brillet et al., MK-571, a cysteinyl leukotriene receptor-1 antagonist, inhibits hepatitis C virus (HCV) replication, Antimicrob. Agents. Chemother,
doi:10.1128/AAC.02078-19Russell, Moss, George, Santaolalla, Cope et al., Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence, Ecancermedicalscience,
doi:10.3332/ecancer.2020.1022Sayin, Cimen, Cimen, Bostanci, Akbaba et al., Colonic anastomosis can be protected from ischemia reperfusion injury with intra-peritoneal Montelukast treatment, Asian. J. Surg,
doi:10.1016/j.asjsur.2019.01.022Shao, Lan, Duan, Liu, Min et al., Upregulation of mitochondrial gene expression in PBMC from convalescent SARS patients, J. Clin. Immunol,
doi:10.1007/s10875-006-9046-ySılay, Toklu, Özagȃrı, Aydın, Tetik et al., Montelukast prevents testes against ischemia-reperfusion injury through suppression of iNOS expression, Turk. J. Urol,
doi:10.5152/tud.2014.61587Topaloglu, Olgun Yıldızeli, Sȩner, Lacin, Sȩhirli et al., Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis, Turk. Gogus. Kalp. Damar. Cerrahisi. Derg,
doi:10.5606/tgkdc.dergisi.2019.15149Van Den Brand, Haagmans, Van Riel, Osterhaus, Kuiken, The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models, J. Comp. Pathol,
doi:10.1016/j.jcpa.2014.01.004Wang, Birring, Taylor, Fry, Hay et al., Montelukast for postinfectious cough in adults: a double-blind randomised placebo-controlled trial, Lancet Respir. Med,
doi:10.1016/S2213-2600(13)70245-5Wang, Cheng, Liu, Shi, Cheng, Montelukast promotes mitochondrial biogenesis via CREB/PGC-1a in human bronchial epithelial cells, Artif. Cells Nanomed. Biotechnol,
doi:10.1080/21691401.2019.1687502Wang, Tian, Liu, Suppressive Effect of Leukotriene Antagonists on Capsular Contracture in Patients Who Underwent Breast Surgery with Prosthesis: A Meta-Analysis, Plast. Reconstr. Surg,
doi:10.1097/PRS.0000000000006629Yeh, Yang, Wang, Hepatic Warm Ischemia-Reperfusion-Induced Increase in Pulmonary Capillary Filtration Is Ameliorated by Administration of a Multidrug Resistance-Associated Protein 1 Inhibitor and Leukotriene D4 Antagonist (MK-571) Through Reducing Neutrophil Infiltration and Pulmonary Inflammation and Oxidative Stress in Rats, Transplant. Proc,
doi:10.1016/j.transproceed.2014.10.061Zamani, Prabhakaran, Varshosaz, Mhaisalkar, Ramakrishna, Electrosprayed Montelukast/poly (lactic-co-glycolic acid) particle based coating: A new therapeutic approach towards the prevention of in-stent restenosis, Acta Biomater,
doi:10.1016/j.actbio.2016.07.007Zhou, Cai, Liu, Wu, Gao, Cysteinyl leukotriene receptor type 1 (CysLT1R) antagonist zafirlukast protects against TNF-ainduced endothelial inflammation, Biomed. Pharmacother,
doi:10.1016/j.biopha.2018.12.064Zhou, Sun, Shi, Liu, Luan et al., Cysteinyl leukotriene receptor type 1 antagonist montelukast protects against injury of blood-brain barrier, Inflammopharmacology,
doi:10.1007/s10787-019-00611-7{ 'indexed': {'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T09:56:42Z', 'timestamp': 1713866202285},
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'volume': '30',
'author': 'Ahn',
'year': '2020',
'journal-title': 'J. Microbiol. Biotechnol.'},
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'lung injury following haemorrhagic shock in rats',
'volume': '43',
'author': 'Al-Amran',
'year': '2013',
'journal-title': 'Eur. J. Cardiothorac. Surg.'},
{ 'key': 'B3',
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'article-title': 'Influence of Atherosclerosis on the Vascular Reactivity of Isolated '
'Human Epicardial Coronary Arteries to Leukotriene C4',
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'author': 'Allen',
'year': '1993',
'journal-title': 'Cardioscience'},
{ 'key': 'B4',
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'article-title': 'The association between obesity and poor outcome after COVID-19 '
'indicates a potential therapeutic role for montelukast',
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'Inflammation and Human Neutrophil Activation',
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'year': '2019',
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'reperfusion injury: An experimental rat model',
'volume': '24',
'author': 'Bilgiç',
'year': '2018',
'journal-title': 'Ulus. Travma. Acil. Cerrahi. Derg.'},
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'volume': '2015',
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'year': '2015',
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'author': 'Cardani',
'year': '2017',
'journal-title': 'PLoS Pathog.'},
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'author': 'Chari',
'year': '2018',
'journal-title': 'Cancer'},
{ 'key': 'B12',
'doi-asserted-by': 'publisher',
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'Disrupting Viral Integrity',
'volume': '10',
'author': 'Chen',
'year': '2020',
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'doi-asserted-by': 'publisher',
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'Mice',
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'author': 'Debelleix',
'year': '2018',
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'Insufficiently Followed',
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'author': 'Deschildre',
'year': '2014',
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'volume': '209',
'author': 'Glockler-Lauf',
'year': '2019',
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'volume': '174',
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'year': '2017',
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'volume': '182',
'author': 'Han',
'year': '2010',
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'in mice',
'volume': '34',
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'year': '2020',
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'Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease',
'volume': '11',
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'year': '2020',
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'year': '2013',
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'volume': '106',
'author': 'Kloepfer',
'year': '2011',
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'volume': '191',
'author': 'Klok',
'year': '2020',
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'volume': '25',
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'year': '2015',
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'infusion time, rate, severity of reactions and use of rescue '
'medications',
'volume': '147',
'author': 'Kotchetkov',
'year': '2020',
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'DOI': '10.1128/mBio.00085-16',
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'Response as a Cellular Target for Influenza Virus Inhibition',
'volume': '7',
'author': 'Landeras-Bueno',
'year': '2016',
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'author': 'Russell',
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'year': '2020',
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'DOI': '10.1007/s10875-006-9046-y',
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'year': '2006',
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'year': '2018',
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'year': '2014',
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'year': '2019',
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'volume': '145',
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'year': '2020',
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