Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All curcumin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchCurcuminCurcumin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Indian food habit & food ingredients may have a role in lowering the severity & high death rate from COVID-19 in Indians

Barh et al., Indian Journal of Medical Research, doi:10.4103/ijmr.ijmr_1701_22
Apr 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Curcumin for COVID-19
14th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000046 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Nutrigenomics study of blood transcriptomes from Indian and western COVID-19 patients, showing Indian dietary habits and food ingredients including higher zinc, iron, curcumin, fiber, catechins, and EGCG may be associated with reduced severity and lower death rates from COVID-19. Western diets higher in red meat, processed food, dairy products, coffee, and alcohol were associated with activation of pathways related to COVID-19 severity.
Study covers zinc, curcumin, and diet.
Barh et al., 13 Apr 2023, India, peer-reviewed, 19 authors.
This PaperCurcuminAll
Indian food habit & food ingredients may have a role in lowering the severity & high death rate from COVID-19 in Indians
Debmalya Barh, Flávia Figueira Aburjaile, Thais Silva Tavares, Miguel Etcheverria Da Silva, Gabriel Pissolati Mattos Bretz, Igor Fernando Martins Rocha, Annesha Dey, Renan Pedra De Souza, Aristóteles Góes-Neto, Sérvio Pontes Ribeiro, Khalid J Alzahrani, Ahmad A Alghamdi, Fuad M Alzahrani, Ibrahim Faisal Halawani, Sandeep Tiwari, Alaa A A Aljabali, Kenneth Lundstrom, Vasco Azevedo, Nirmal Kumar Ganguly
Indian Journal of Medical Research, doi:10.4103/ijmr.ijmr_1701_22
Background & objectives: During the COVID-19 pandemic, the death rate was reportedly 5-8 fold lower in India which is densely populated as compared to less populated western countries. The aim of this study was to investigate whether dietary habits were associated with the variations in COVID-19 severity and deaths between western and Indian population at the nutrigenomics level. Methods: In this study nutrigenomics approach was applied. Blood transcriptome of severe COVID-19 patients from three western countries (showing high fatality) and two datasets from Indian patients were used. Gene set enrichment analyses were performed for pathways, metabolites, nutrients, etc., and compared for western and Indian samples to identify the food-and nutrient-related factors, which may be associated with COVID-19 severity. Data on the daily consumption of twelve key food components
Supplementary Figure. Differences between Indian and western food and spices. The figure is developed based on Supplementary Table 1 , several web portals, following literature [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] . IIG Supplementary Table
References
Barh, Aljabali, Tambuwala, Tiwari, Serrano-Aroca et al., Predicting COVID-19-comorbidity pathway crosstalk-based targets and drugs: Towards personalized COVID-19 management, Biomedicines
Barh, Tiwari, Andrade, Weener, Góes-Neto et al., A novel multi-omics-based highly accurate prediction of symptoms, comorbid conditions, and possible long-term complications of COVID-19, Mol Omics
Barh, Tiwari, Weener, Azevedo, Góes-Neto et al., Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19, Comput Biol Med
Board, Executive summary of study on domestic consumption of tea in India
Branchi, Fiorenza, Torri, Muzio, Berra et al., Atorvastatin increases HDL cholesterol in hypercholesterolemic patients. Evidence of a relationship with baseline HDL cholesterol, Nutr Metab Cardiovasc Dis
Butler, Barrientos, The impact of nutrition on COVID-19 susceptibility and long-term consequences, Brain Behav Immun
Carnauba, Baptistella, Paschoal, Hübscher, Diet-induced low-grade metabolic acidosis and clinical outcomes: A review, Nutrients
Chen, Wu, Wang, Yu, Sun, The impact of COVID-19 on blood glucose: A systematic review and meta-analysis, Front Endocrinol
Cho, Choi, Gwon, Atorvastatin reduces the severity of COVID-19: A nationwide, total population-based, casecontrol study, COVID
Crouse, Grundy, Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man, J Lipid Res
De Almeida, Perassolo, Camargo, Bragagnolo, Gross, Fatty acid composition and cholesterol content of beef and chicken cuts from southern Brazil, Br J Pharml Sci
De Faria Coelho-Ravagnani, Corgosinho, Sanches, Prado, Laviano et al., Dietary recommendations during the COVID-19 pandemic, Nutr Rev
Debmalya, None
Devarajan, Mohanmarugaraja, A comprehensive review on rasam: A South Indian traditional functional food, Pharmacogn Rev
Dieter, Brondani, Leitão, Gerchman, Lemos et al., Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis, PLoS One
Dubé, Fatemi, Lu, Hertzer, The healthier the tastier? USA-India comparison studies on consumer perception of a nutritious agricultural product at different food processing levels, Front Public Health
Fan, Pedersen, Gut microbiota in human metabolic health and disease, Nat Rev Microbiol
Fathi, Vakili, Sayehmiri, Mohamadkhani, Hajiesmaeili et al., The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study, PLoS One
Ferrucci, Daniel, Kapur, Chadha, Shetty et al., Measurement of spices and seasonings in India: Opportunities for cancer epidemiology and prevention, Asian Pac J Cancer Prev
Fu, Chen, Guan, Yan, Lin et al., Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR 2 signaling pathway, Oncotarget
Fuloria, Mehta, Chandel, Sekar, Rani et al., A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent curcumin, Front Pharmacol
García-Casal, Peña-Rosas, Malavé, Sauces, spices, and condiments: definitions, potential benefits, consumption patterns, and global markets, Ann N Y Acad Sci
Ghanei, Baghani, Moravvej, Talebi, Bahmanjahromi et al., Low serum levels of zinc and 25-hydroxyvitmain D as potential risk factors for COVID-19 susceptibility: A pilot case-control study, Eur J Clin Nutr
Ghosh, Chattopadhyay, Preparation of idli batter, its properties and nutritional improvement during fermentation, J Food Sci Technol
Godfray, Aveyard, Garnett, Hall, Key et al., Meat consumption, health, and the environment, Science
Green, Milner, Joy, Agrawal, Dangour, Dietary patterns in India: A systematic review, Br J Nutr
Guha, Banerjee, Mitra, Das, The demographic diversity of food intake and prevalence of kidney stone diseases in the Indian continent, Foods
Hunter, Hegele, Functional foods and dietary supplements for the management of dyslipidaemia, Nat Rev Endocrinol
Jalili, Chemical composition and sensory characteristics of Feta cheese fortified with iron and ascorbic acid, Dairy Sci Technol
Jan, Rather, Sofi, Wani, Sheikh et al., Characterization of common bean (Phaseolus vulgaris L.) germplasm for morphological and seed nutrient traits from Western Himalayas, Legum Sci
Joshi, Jadeja, Zhou, Molecular mechanisms of palmitic acid augmentation in COVID-19 pathologies, Int J Mol Sci
Joshi-Barve, Barve, Amancherla, Gobejishvili, Hill et al., Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes, Hepatology
Jothimani, Kailasam, Danielraj, Nallathambi, Ramachandran et al., COVID-19: Poor outcomes in patients with zinc deficiency, Int J Infect Dis
Kaur, Singh, Kaur, Verma, Pandey et al., Upregulation of cytokine signalling in platelets increases risk of thrombophilia in severe COVID-19 patients, Blood Cells Mol Dis
Khan, Goliwas, Deshane, Sphingolipids in lung pathology in the coronavirus disease era: A review of sphingolipid involvement in the pathogenesis of lung damage, Front Physiol
Khoury, Julien, Inverse association between the Mediterranean diet and COVID-19 risk in Lebanon: A casecontrol study, Front Nutr
Kim, Rebholz, Hegde, Lafiura, Raghavan et al., Plant-based diets, pescatarian diets and COVID-19 severity: A population-based case-control study in six countries, BMJ Nutr Prev Health
Kong, Ye, Cao, Cai, Lin et al., Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/ NF-κB and P2X7R signaling in PMA-induced macrophages, Front Pharmacol
Korbecki, Bajdak-Rusinek, The effect of palmitic acid on inflammatory response in macrophages: An overview of molecular mechanisms, Inflamm Res
Kumar, Seven spices of India from kitchen to clinic, J Ethn Foods
Lamminpaa, Vilska, Acid-base balance in alcohol users seen in an emergency room, Vet Hum Toxicol
Law, Chen, Shi, Smyth, voom: Precision weights unlock linear model analysis tools for RNA-seq read counts, Genome Biol
Lee, Im, Jung, Kim, Park et al., Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells, Biochem Biophys Res Commun
Liu, Bodnar, Meng, Khan, Wang et al., Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor, Cell Biosci
Liu, Ying, The inhibitory effect of curcumin on virusinduced cytokine storm and its potential use in the associated severe pneumonia, Front Cell Dev Biol
Mallik, Sharangi, Sarkar, Phytochemicals of coriander, cumin, fenugreek, fennel and black cumin: A preliminary study, Natl Acad Sci Lett
Manik, Singh, Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19, J Med Virol
Manne, Denorme, Middleton, Portier, Rowley et al., Platelet gene expression and function in patients with COVID-19, Blood
Martín-Hernández, Reglero, Ordovás, Dávalos, NutriGenomeDB: A nutrigenomics exploratory and analytical platform, Database
Masana, Correig, Ibarretxe, Anoro, Arroyo et al., Low HDL and high triglycerides predict COVID-19 severity, Sci Rep
Mascitelli, Pezzetta, Sullivan, Inhibition of iron absorption by coffee and the reduced risk of type 2 diabetes mellitus, Arch Intern Med
Mcgowan, Haddadi, Nassif, Lin, Targeting the SphK-S1P-SIPR pathway as a potential therapeutic approach for COVID-19, Int J Mol Sci
Meini, Giani, Tascini, Intussusceptive angiogenesis in Covid-19: Hypothesis on the significance and focus on the possible role of FGF2, Mol Biol Rep
Miller, Reedy, Cudhea, Zhang, Shi et al., Global, regional, and national consumption of animal-source foods between 1990 and 2018: Findings from the Global Dietary Database, Lancet Planet Health
Mukherjea, Underwood, Stewart, Ivey, Kanaya, Asian Indian views on diet and health in the United States: Importance of understanding cultural and social factors to address disparities, Fam Community Health
Murru, Manca, Carta, Banni, Impact of dietary palmitic acid on lipid metabolism, Front Nutr
Nag, Banerjee, Paul, Kundu, Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) omicron, an in silico study, Comput Biol Med
Ohgitani, Shin-Ya, Ichitani, Kobayashi, Takihara et al., Significant inactivation of SARS-CoV-2 in vitro by a green tea catechin, a catechin-derivative, and black tea galloylated theaflavins, Molecules
Oliveira, Faria, Silva, Bezerra, Carvalho et al., Fatty acid profile of milk and cheese from dairy cows supplemented a diet with palm kernel cake, Molecules
Ordak, Bulska, Jablonka-Salach, Luciuk, Maj-Żurawska et al., Effect of disturbances of zinc and copper on the physical and mental health status of patients with alcohol dependence, Biol Trace Elem Res
Pal, Squitti, Picozza, Pawar, Rongioletti et al., Zinc and COVID-19: Basis of current clinical trials, Biol Trace Elem Res
Pandit, Joshi, Dalal, Patole, Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract, BMC Complement Altern Med
Pawar, Mastud, Pawar, Pawar, Bhoite et al., Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial, Front Pharmacol
Prasad, Reddy, Francis, Nayak, Kishore et al., an Indian dish prevents the development of dimethyl hydrazine-induced colon cancer: A preclinical study, Pharmacogn Mag
Rattis, Ramos, Celes, Curcumin as a potential treatment for COVID-19, Front Pharmacol
Reddy, Sathe, Pierson, Salunkhe, Idli, an Indian fermented food: A review, J Food Qual
Reyes, Cornelis, Caffeine in the diet: Country-level consumption and guidelines, Nutrients
Rossowska, Nakamoto, Caffeine decreases zinc and metallothionein levels in heart of newborn and adult rats, Pediatr Res
Saavedra-Romero, Paz, Litell, Weinkauf, Benson et al., Treatment of severe hypercapnic respiratory failure caused by SARS-CoV-2 lung injury with ECCO 2 R using the hemolung respiratory assist system, Case Rep Crit Care
Safarian, Parizadeh, Saberi-Karimain, Darroudi, Javandoost et al., The effect of curcumin on serum copper and zinc and Zn/Cu ratio in individuals with metabolic syndrome: A double-blind clinical trial, J Diet
Senanayake, Green tea extract: Chemistry, antioxidant properties and food applications -A review, J Funct Food
Shanmugarajan, Prabitha, Kumar, Suresh, Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: Computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets, RSC Adv
Sharma, Kishore, Roy, Joshi, A comparison of the Indian diet with the EAT-Lancet reference diet, BMC Public Health
Shen, Oesterling, Stromberg, Toborek, Macdonald et al., Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling, J Am Coll Nutr
Steele, Baraldi, Louzada, Moubarac, Mozaffarian et al., Ultra-processed foods and added sugars in the US diet: Evidence from a nationally representative cross-sectional study, BMJ Open
Thair, He, Hasin-Brumshtein, Sakaram, Pandya et al., Transcriptomic similarities and differences in host response between SARS-CoV-2 and other viral infections, iScience
Utrero-Rico, González-Cuadrado, Chivite-Lacaba, Cabrera-Marante, Laguna-Goya et al., Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery, Biomedicines
Varun, Kerutagi, Kunnal, Basavaraja, Ashalatha et al., Consumption pattern of coffee and tea in Karnataka, Karnataka J Agric Sci
Vesper, Schmelz, Nikolova-Karakashian, Dillehay, Lynch et al., Sphingolipids in food and the emerging importance of sphingolipids to nutrition, J Nutr
Wallace, Murray, Zelman, The nutritional value and health benefits of chickpeas and hummus, Nutrients
Wang, Li, Wen, Chen, Na et al., Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kAPPAB and JNK pathway, Biomed Environ Sci
Wargodsky, Cruz, Lafleur, Yamane, Kim et al., RNA sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections, PLoS One
Williams, Section 2: Key nutrients delivered by red meat in the diet, Nutr Dietet
Xie, Bailey, Kuleshov, Clarke, Evangelista et al., Gene set knowledge discovery with enrichr, Curr Protoc
Ye, Said, Lin, Manickavasagam, Hughes et al., Caffeinated coffee blunts the myocardial protective effects of statins against ischemia-reperfusion injury in the rat, Cardiovasc Drugs Ther
Yu, Fan, Ye, Li, Feng et al., Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models, Am J Med Sci
Zhao, Huang, Dai, Feng, Liu et al., Serum iron level as a potential predictor of coronavirus disease 2019 severity and mortality: A retrospective study, Open Forum Infect Dis
{ 'DOI': '10.4103/ijmr.ijmr_1701_22', 'ISSN': ['0971-5916'], 'URL': 'http://dx.doi.org/10.4103/ijmr.ijmr_1701_22', 'author': [ {'affiliation': [], 'family': 'Barh', 'given': 'Debmalya', 'sequence': 'first'}, { 'affiliation': [], 'family': 'Figueira Aburjaile', 'given': 'Flávia', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Tavares', 'given': 'Thais Silva', 'sequence': 'additional'}, { 'affiliation': [], 'family': 'Silva', 'given': 'Miguel Etcheverria da', 'sequence': 'additional'}, { 'affiliation': [], 'family': 'Bretz', 'given': 'Gabriel Pissolati Mattos', 'sequence': 'additional'}, { 'affiliation': [], 'family': 'Rocha', 'given': 'Igor Fernando Martins', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Dey', 'given': 'Annesha', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Souza', 'given': 'Renan Pedra de', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Góes-Neto', 'given': 'Aristóteles', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ribeiro', 'given': 'Sérvio Pontes', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alzahrani', 'given': 'Khalid J.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alghamdi', 'given': 'Ahmad A.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alzahrani', 'given': 'Fuad M.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Halawani', 'given': 'Ibrahim Faisal', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Tiwari', 'given': 'Sandeep', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Aljabali', 'given': 'Alaa A. A.', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Lundstrom', 'given': 'Kenneth', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Azevedo', 'given': 'Vasco', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ganguly', 'given': 'Nirmal Kumar', 'sequence': 'additional'}], 'container-title': 'Indian Journal of Medical Research', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2023, 4, 28]], 'date-time': '2023-04-28T05:56:14Z', 'timestamp': 1682661374000}, 'deposited': { 'date-parts': [[2024, 4, 18]], 'date-time': '2024-04-18T16:35:11Z', 'timestamp': 1713458111000}, 'indexed': {'date-parts': [[2024, 4, 19]], 'date-time': '2024-04-19T00:53:07Z', 'timestamp': 1713487987117}, 'is-referenced-by-count': 0, 'issued': {'date-parts': [[2023, 4, 13]]}, 'language': 'en', 'link': [ { 'URL': 'https://journals.lww.com/10.4103/ijmr.ijmr_1701_22', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '10894', 'original-title': [], 'prefix': '10.25259', 'published': {'date-parts': [[2023, 4, 13]]}, 'published-print': {'date-parts': [[2023, 4, 13]]}, 'publisher': 'Scientific Scholar', 'reference-count': 0, 'references-count': 0, 'relation': {}, 'resource': {'primary': {'URL': 'https://journals.lww.com/10.4103/ijmr.ijmr_1701_22'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': ['General Biochemistry, Genetics and Molecular Biology', 'General Medicine'], 'subtitle': ['findings from the first nutrigenomic analysis'], 'title': 'Indian food habit & food ingredients may have a role in lowering the severity & high ' 'death rate from COVID-19 in Indians', 'type': 'journal-article', 'volume': 'Publish Ahead of Print'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit