Abstract: Med. Forum, Vol. 36, No. 4
31
April, 2025
Original Article
Assessment of the Anticoagulant
Effect of Curcumin as Adjuvant Therapy to
Enoxaparinin Covid-19 Iraqi Patients
Anticoagulant
Effect of
Curcumin in
Covid-19
Maiss S. Baqer1, Saifan A Dushan1, Rafif Raad1, Rabab Mohammed Noori Hameed1,
Ayaashraf Ahmed1 and Basim Dhawi Dakhil2
ABSTRACT
Objective: To assess the anticoagulant effect of curcumin as adjuvant treatment to enoxaparin in COVID-19
patients.
Study Design: Randomized open-labelled controlled trial study.
Place and Duration of Study: This study was conducted at the College of Pharmacy, Al-Esraa University,
Baghdad, Iraq from 1st February 2020 to 31st July 2020.
Methods: Fifty-eight patients with confirmed Covid19 were enrolled into 2 groups: Group A; 29 patients were
given Enoxaparin prophylactic dose 4000 IU twice daily every 12 hrs. Group B; 29 patients were given Enoxaparin
prophylactic dose 4000 IU twice daily every 12 hrs + Curcumin 500 mg 3 times daily.
Results: A significantly higher level of improvement in the outcomes of D-dimer serum level in the group treated
with enoxaparin and curcumin in comparison with group A which was treated with enoxaparin alone (P<0.05).
Conclusion: The overall results of this clinical study showed a significant D-dimer reduction by curcumin
supplementation as well as reducing mortality and enhancing the overall clinical outcome of the treatment when
used as an adjunct to enoxaparin.
Key Words: Curcumin, D-dimer, Enoxaparin, COVID-19, Anticoagulant effect
Citation of article: Baqer MS, Dushan SA, Raad R, Hameed RMN, Ahmed A, Dakhil BD. Assessment of the
Anticoagulant Effect of Curcumin as Adjuvant Therapy to Enoxaparinin Covid-19 Iraqi Patients. Med
Forum 2025;36(4):31-34. doi:10.60110/medforum.360407.
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"abstract": "<jats:p>Objective: To assess the anticoagulant effect of curcumin as adjuvant treatment to enoxaparin in COVID-19 patients. Study Design: Randomized open-labelled controlled trial study. Place and Duration of Study: This study was conducted at the College of Pharmacy, Al-Esraa University, Baghdad, Iraq from 1st February 2020 to 31st July 2020. Methods: Fifty-eight patients with confirmed Covid19 were enrolled into 2 groups: Group A; 29 patients were given Enoxaparin prophylactic dose 4000 IU twice daily every 12 hrs. Group B; 29 patients were given Enoxaparin prophylactic dose 4000 IU twice daily every 12 hrs + Curcumin 500 mg 3 times daily. Results: A significantly higher level of improvement in the outcomes of D-dimer serum level in the group treated with enoxaparin and curcumin in comparison with group A which was treated with enoxaparin alone (P<0.05). Conclusion: The overall results of this clinical study showed a significant D-dimer reduction by curcumin supplementation as well as reducing mortality and enhancing the overall clinical outcome of the treatment when used as an adjunct to enoxaparin. </jats:p>",
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