Abstract: Serum Vitamin D Concentrations in CoVID19 Patients 1 Hossein Azadeh , 2 Akbar Hedayatizadeh-Omran , 3 Majid Saeedi , 4 Laleh Vahedi-Larijani , 5 Hossein Mehravaran , 6 Keyvan Heydari 1 Assistant Professor, Department of Internal Medicine, Rheumatology Division, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran 3 Professor, Department of Pharmaceutics, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran 4 Associate Professor, Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 5 Assistant Professor, Department of Internal Medicine, Pulmonary and Critical Care Division, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 6 Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 2 (Received November 8, 2020 ; Accepted March 7, 2021) Abstract Background and purpose: Vitamin D deficiency is highly prevalent in Iran. Death toll due to the Coronavirus Disease 2019 (COVID-19) is high in this country. The purpose of the present investigation was to provide more information on the relationship between serum levels of vitamin D in confirmed cases of COVID-19 in north of Iran. Materials and methods: This cross-sectional descriptive study was performed in COVID-19 patients (n=80) attending Sari Imam Khomeini Hospital, Iran 2020, who were confirmed for COVID-19 infection with CT-Scan or RT-PCR. Seventy healthy individuals were also examined as the control group. SPSS V19 was applied for data analysis. Results: In this study, 80 patients with COVID-19 (mean age: 57.22 ± 17.44 years old) and 70 healthy individuals (mean age: 48.69 ± 12.99 years) were studied. There were 38 and 35 males in these two groups, respectively. Serum Vitamin D levels were significantly lower in patients with COVID-19 than those in the control group (18.72 ± 12.53 vs. 30.86 ± 15.19 ng/ml, P< 0.001). Conclusion: This study showed that serum levels of Vitamin D were lower in patients with COVID-19 than healthy individuals and frequency of Vitamin D deficiency was higher in these patients. Hence, further studies are needed to clarify the role of serum Vitamin D concentrations in patients with COVID-19 infection. Keywords: Vitamin D, COVID-19, SARS CoV-2, cholecalciferol J Mazandaran Univ Med Sci 2021; 31 (195): 30-36 (Persian). * Corresponding Author: Keyvan Heydari - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran (E-mail: K1heydari96@Gmail.com) 30 ‫ﭘﮋوﻫﺸﻲ‬ ‫ﻣﺠــﻠــــﻪ داﻧـﺸــــﮕﺎه ﻋــﻠــــﻮم ﭘــﺰﺷــﻜـــــﻲ ﻣــﺎزﻧــــﺪران‬ ‫دوره ﺳﻲ و ﻳﻜﻢ ﺷﻤﺎره ‪ 195‬ﻓﺮوردﻳﻦ ﺳﺎل ‪(30-36) 1400‬‬ ‫ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ ‪ D‬در ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ‪CoVID-19‬‬ ‫ﺣﺴﻴﻦ آزاده‬ ‫‪1‬‬ ‫اﻛﺒﺮ ﻫﺪاﻳﺘﻲ زاده ﻋﻤﺮان‬ ‫ﻣﺠﻴﺪ ﺳﻌﻴﺪي‬ ‫‪2‬‬ ‫‪3‬‬ ‫ﻻﻟﻪ واﺣﺪي ﻻرﻳﺠﺎﻧﻲ‬ ‫ﺣﺴﻴﻦ ﻣﻬﺮآوران‬ ‫ﻛﻴﻮان ﺣﻴﺪري‬ ‫‪4‬‬ ‫‪5‬‬ ‫‪6‬‬ ‫ﭼﻜﻴﺪه‬ ‫ﺳﺎﺑﻘﻪ و ﻫﺪف‪ :‬ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺷﻴﻮع ﺑﺎﻻي ﻛﻤﺒﻮد وﻳﺘﺎﻣﻴﻦ ‪ D‬در ﻛﺸﻮر اﻳﺮان و ﻫﻤﭽﻨﻴﻦ ﻣﻴﺰان ﺑﺎﻻي ﻣﺮگ و ﻣﻴـﺮ ﻣـﺮﺗﺒﻂ ﺑـﺎ‬ ‫ﻛﻮوﻳﺪ در ﺷﻤﺎل اﻳﺮان‪ ،‬ﺑﺮرﺳﻲ ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ ‪ D‬در ﺑﻴﻤﺎران ﻣﺒـﺘﻼ ﺑـﻪ ﻛﻮوﻳـﺪ ‪ 19‬و ﻣﻘﺎﻳـﺴﻪ آن ﺑـﺎ اﻓـﺮاد ﺳـﺎﻟﻢ در اﻳـﻦ‬ ‫ﻣﻄﺎﻟﻌﻪ اﻧﺠﺎم ﺷﺪ‪.‬‬ ‫ﻣﻮاد و روشﻫﺎ‪ :‬اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ‪ -‬ﻣﻘﻄﻌﻲ در ﺳﺎل ‪ 1399‬و ﺑﺮ روي ‪ 80‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ ﻛﻮوﻳـﺪ ‪ 19‬ﻣﺮاﺟﻌـﻪﻛﻨﻨـﺪه ﺑـﻪ‬ ‫ﺑﻴﻤﺎرﺳﺘﺎن اﻣﺎم ﺧﻤﻴﻨﻲ)ره( ﺳﺎري‪ ،‬ﻛﻪ ﺑﻴﻤﺎري اﻳﺸﺎن ﺗﻮﺳﻂ ‪..