Serum Vitamin D Concentrations in CoVID19 Patients
Azadeh et al., J. Mazandaran Univ. Med. Sci. 31:195
Azadeh et al., Serum Vitamin D Concentrations in CoVID19 Patients, J. Mazandaran Univ. Med. Sci. 31:195
Retrospective 80 COVID-19 patients in Iran and 70 healthy controls, showing significantly lower vitamin D levels in COVID-19 patients.
Azadeh et al., 30 Apr 2021, Iran, peer-reviewed, 6 authors.
Abstract: Serum Vitamin D Concentrations in CoVID19 Patients
1
Hossein Azadeh ,
2
Akbar Hedayatizadeh-Omran ,
3
Majid Saeedi ,
4
Laleh Vahedi-Larijani ,
5
Hossein Mehravaran ,
6
Keyvan Heydari
1
Assistant Professor, Department of Internal Medicine, Rheumatology Division, Mazandaran University of Medical Sciences, Sari, Iran
Associate Professor, Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of
Medical Sciences, Sari, Iran
3
Professor, Department of Pharmaceutics, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences,
Sari, Iran
4
Associate Professor, Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5
Assistant Professor, Department of Internal Medicine, Pulmonary and Critical Care Division, Faculty of Medicine, Mazandaran
University of Medical Sciences, Sari, Iran
6
Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2
(Received November 8, 2020 ; Accepted March 7, 2021)
Abstract
Background and purpose: Vitamin D deficiency is highly prevalent in Iran. Death toll due to
the Coronavirus Disease 2019 (COVID-19) is high in this country. The purpose of the present
investigation was to provide more information on the relationship between serum levels of vitamin D in
confirmed cases of COVID-19 in north of Iran.
Materials and methods: This cross-sectional descriptive study was performed in COVID-19
patients (n=80) attending Sari Imam Khomeini Hospital, Iran 2020, who were confirmed for COVID-19
infection with CT-Scan or RT-PCR. Seventy healthy individuals were also examined as the control group.
SPSS V19 was applied for data analysis.
Results: In this study, 80 patients with COVID-19 (mean age: 57.22 ± 17.44 years old) and 70
healthy individuals (mean age: 48.69 ± 12.99 years) were studied. There were 38 and 35 males in these
two groups, respectively. Serum Vitamin D levels were significantly lower in patients with COVID-19
than those in the control group (18.72 ± 12.53 vs. 30.86 ± 15.19 ng/ml, P< 0.001).
Conclusion: This study showed that serum levels of Vitamin D were lower in patients with
COVID-19 than healthy individuals and frequency of Vitamin D deficiency was higher in these patients.
Hence, further studies are needed to clarify the role of serum Vitamin D concentrations in patients with
COVID-19 infection.
Keywords: Vitamin D, COVID-19, SARS CoV-2, cholecalciferol
J Mazandaran Univ Med Sci 2021; 31 (195): 30-36 (Persian).
* Corresponding Author: Keyvan Heydari - Student Research Committee, Mazandaran University of Medical Sciences, Sari,
Iran (E-mail: K1heydari96@Gmail.com)
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ﭘﮋوﻫﺸﻲ
ﻣﺠــﻠــــﻪ داﻧـﺸــــﮕﺎه ﻋــﻠــــﻮم ﭘــﺰﺷــﻜـــــﻲ ﻣــﺎزﻧــــﺪران
دوره ﺳﻲ و ﻳﻜﻢ ﺷﻤﺎره 195ﻓﺮوردﻳﻦ ﺳﺎل (30-36) 1400
ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ Dدر ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ CoVID-19
ﺣﺴﻴﻦ آزاده
1
اﻛﺒﺮ ﻫﺪاﻳﺘﻲ زاده ﻋﻤﺮان
ﻣﺠﻴﺪ ﺳﻌﻴﺪي
2
3
ﻻﻟﻪ واﺣﺪي ﻻرﻳﺠﺎﻧﻲ
ﺣﺴﻴﻦ ﻣﻬﺮآوران
ﻛﻴﻮان ﺣﻴﺪري
4
5
6
ﭼﻜﻴﺪه
ﺳﺎﺑﻘﻪ و ﻫﺪف :ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺷﻴﻮع ﺑﺎﻻي ﻛﻤﺒﻮد وﻳﺘﺎﻣﻴﻦ Dدر ﻛﺸﻮر اﻳﺮان و ﻫﻤﭽﻨﻴﻦ ﻣﻴﺰان ﺑﺎﻻي ﻣﺮگ و ﻣﻴـﺮ ﻣـﺮﺗﺒﻂ ﺑـﺎ
ﻛﻮوﻳﺪ در ﺷﻤﺎل اﻳﺮان ،ﺑﺮرﺳﻲ ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ Dدر ﺑﻴﻤﺎران ﻣﺒـﺘﻼ ﺑـﻪ ﻛﻮوﻳـﺪ 19و ﻣﻘﺎﻳـﺴﻪ آن ﺑـﺎ اﻓـﺮاد ﺳـﺎﻟﻢ در اﻳـﻦ
ﻣﻄﺎﻟﻌﻪ اﻧﺠﺎم ﺷﺪ.
ﻣﻮاد و روشﻫﺎ :اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ -ﻣﻘﻄﻌﻲ در ﺳﺎل 1399و ﺑﺮ روي 80ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ ﻛﻮوﻳـﺪ 19ﻣﺮاﺟﻌـﻪﻛﻨﻨـﺪه ﺑـﻪ
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