Serum Vitamin D Concentrations in CoVID19 Patients
Azadeh et al., J. Mazandaran Univ. Med. Sci. 31:195
Azadeh et al., Serum Vitamin D Concentrations in CoVID19 Patients, J. Mazandaran Univ. Med. Sci. 31:195
Retrospective 80 COVID-19 patients in Iran and 70 healthy controls, showing significantly lower vitamin D levels in COVID-19 patients.
Azadeh et al., 30 Apr 2021, Iran, peer-reviewed, 6 authors.
Abstract: Serum Vitamin D Concentrations in CoVID19 Patients
Hossein Azadeh ,
Akbar Hedayatizadeh-Omran ,
Majid Saeedi ,
Laleh Vahedi-Larijani ,
Hossein Mehravaran ,
Assistant Professor, Department of Internal Medicine, Rheumatology Division, Mazandaran University of Medical Sciences, Sari, Iran
Associate Professor, Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of
Medical Sciences, Sari, Iran
Professor, Department of Pharmaceutics, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences,
Associate Professor, Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Assistant Professor, Department of Internal Medicine, Pulmonary and Critical Care Division, Faculty of Medicine, Mazandaran
University of Medical Sciences, Sari, Iran
Medical Student, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
(Received November 8, 2020 ; Accepted March 7, 2021)
Background and purpose: Vitamin D deficiency is highly prevalent in Iran. Death toll due to
the Coronavirus Disease 2019 (COVID-19) is high in this country. The purpose of the present
investigation was to provide more information on the relationship between serum levels of vitamin D in
confirmed cases of COVID-19 in north of Iran.
Materials and methods: This cross-sectional descriptive study was performed in COVID-19
patients (n=80) attending Sari Imam Khomeini Hospital, Iran 2020, who were confirmed for COVID-19
infection with CT-Scan or RT-PCR. Seventy healthy individuals were also examined as the control group.
SPSS V19 was applied for data analysis.
Results: In this study, 80 patients with COVID-19 (mean age: 57.22 ± 17.44 years old) and 70
healthy individuals (mean age: 48.69 ± 12.99 years) were studied. There were 38 and 35 males in these
two groups, respectively. Serum Vitamin D levels were significantly lower in patients with COVID-19
than those in the control group (18.72 ± 12.53 vs. 30.86 ± 15.19 ng/ml, P< 0.001).
Conclusion: This study showed that serum levels of Vitamin D were lower in patients with
COVID-19 than healthy individuals and frequency of Vitamin D deficiency was higher in these patients.
Hence, further studies are needed to clarify the role of serum Vitamin D concentrations in patients with
Keywords: Vitamin D, COVID-19, SARS CoV-2, cholecalciferol
J Mazandaran Univ Med Sci 2021; 31 (195): 30-36 (Persian).
* Corresponding Author: Keyvan Heydari - Student Research Committee, Mazandaran University of Medical Sciences, Sari,
Iran (E-mail: K1heydari96@Gmail.com)
ﻣﺠــﻠــــﻪ داﻧـﺸــــﮕﺎه ﻋــﻠــــﻮم ﭘــﺰﺷــﻜـــــﻲ ﻣــﺎزﻧــــﺪران
دوره ﺳﻲ و ﻳﻜﻢ ﺷﻤﺎره 195ﻓﺮوردﻳﻦ ﺳﺎل (30-36) 1400
ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ Dدر ﺑﻴﻤﺎران ﻣﺒﺘﻼ ﺑﻪ CoVID-19
اﻛﺒﺮ ﻫﺪاﻳﺘﻲ زاده ﻋﻤﺮان
ﻻﻟﻪ واﺣﺪي ﻻرﻳﺠﺎﻧﻲ
ﺳﺎﺑﻘﻪ و ﻫﺪف :ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺷﻴﻮع ﺑﺎﻻي ﻛﻤﺒﻮد وﻳﺘﺎﻣﻴﻦ Dدر ﻛﺸﻮر اﻳﺮان و ﻫﻤﭽﻨﻴﻦ ﻣﻴﺰان ﺑﺎﻻي ﻣﺮگ و ﻣﻴـﺮ ﻣـﺮﺗﺒﻂ ﺑـﺎ
ﻛﻮوﻳﺪ در ﺷﻤﺎل اﻳﺮان ،ﺑﺮرﺳﻲ ﺳﻄﺢ ﺳﺮﻣﻲ وﻳﺘﺎﻣﻴﻦ Dدر ﺑﻴﻤﺎران ﻣﺒـﺘﻼ ﺑـﻪ ﻛﻮوﻳـﺪ 19و ﻣﻘﺎﻳـﺴﻪ آن ﺑـﺎ اﻓـﺮاد ﺳـﺎﻟﻢ در اﻳـﻦ
ﻣﻄﺎﻟﻌﻪ اﻧﺠﺎم ﺷﺪ.
ﻣﻮاد و روشﻫﺎ :اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ -ﻣﻘﻄﻌﻲ در ﺳﺎل 1399و ﺑﺮ روي 80ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ ﻛﻮوﻳـﺪ 19ﻣﺮاﺟﻌـﻪﻛﻨﻨـﺪه ﺑـﻪ
ﺑﻴﻤﺎرﺳﺘﺎن اﻣﺎم ﺧﻤﻴﻨﻲ)ره( ﺳﺎري ،ﻛﻪ ﺑﻴﻤﺎري اﻳﺸﺎن ﺗﻮﺳﻂ ..
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