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0 0.5 1 1.5 2+ Mortality 73% Improvement Relative Risk Progression 66% Vitamin D for COVID-19  Asgari et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective study in Iran (May - September 2020) Lower mortality (p=0.026) and progression (p=0.019) Asgari et al., Acta Medica Iranica, Nov 2021 Favors vitamin D Favors control

Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients With SARS Corona Virus-2 Infection

Asgari et al., Acta Medica Iranica, doi:10.18502/acta.v59i11.7779
Nov 2021  
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Retrospective 98 moderate/severe hospitalized COVID-19+ patients in Iran, showing significantly increased risk of mortality and severity with vitamin D deficiency. IR.AJAUMS.REC.1399.060.
This is the 106th of 185 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 115 vigintillion).
risk of death, 72.5% lower, OR 0.27, p = 0.03, cutoff 25ng/mL, adjusted per study, inverted to make OR<1 favor high D levels (≥25ng/mL), RR approximated with OR.
risk of progression, 65.6% lower, OR 0.34, p = 0.02, cutoff 25ng/mL, adjusted per study, inverted to make OR<1 favor high D levels (≥25ng/mL), RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Asgari et al., 21 Nov 2021, retrospective, Iran, peer-reviewed, 6 authors, study period 21 May, 2020 - 4 September, 2020.
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Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients With SARS Corona Virus-2 Infection
Sam Alahyari, Ali Asgari, Ebrahim Hazrati, Saeed Soleiman-Meigooni, Mohsen Rajaeinejad, Malihe Nasiri
The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus's severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests, as well as ROC curves, were used for data analysis. Ninety-eight patients with Corona virus-2 disease (COVID-19), which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU), were evaluated. The mean age in the general wards was lower than in ICU (60.96±14.86 compared to 67.94±16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng/mL compared to 20.57 ng/mL, P=0.003). Furthermore, vitamin D deficiency (25 (OH) D <25 ng/ml) significantly increased the risk of severe disease. (odds ratio=2.91, P=0.019) and mortality (odds ratio=3.64, P=0.026). Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19. Vitamin D levels of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.
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