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Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all

Arefin, M., Indian Journal of Otolaryngology and Head & Neck Surgery, doi:10.1007/s12070-021-02525-9
Apr 2021  
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PVP-I for COVID-19
12th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Report on clinical experience with prophylactic use of PVP-I for COVID-19 in a very high risk environment with no infections, review of the use of PVP-I for the prevention of respiratory infections, and recommendations for use with COVID-19.
Arefin et al., 8 Apr 2021, peer-reviewed, 1 author.
This PaperPovidone-Iod..All
Povidone Iodine (PVP-I) Oro-Nasal Spray: An Effective Shield for COVID-19 Protection for Health Care Worker (HCW), for all
Mostafa Kamal
Indian Journal of Otolaryngology and Head & Neck Surgery, doi:10.1007/s12070-021-02525-9
SARS-CoV-2 or novel coronavirus enters in human body through nose and mouth, stays there for a while. Then binds with ACE2 receptor, enters inside cell, multiply there and manifests. Again, Polyvinyl Pyrrolidone or Povidone Iodine (PVP-I) is a strong microbicidal agent having 99.99% virucidal efficacy in its only 0.23% concentration, irrespective of all known viruses, even in SARS-CoV-2 (in vitro). An oro-nasal spray is designed to apply the PVP-I in nose and oral cavity to gain a protective layer or coating over nasal and oral mucosa, so that SARS-CoV-2 can't bind with the ACE-2 receptor and prevent their entry inside. So, it will be effective for prevention of COVID-19. Moreover, as PVP-I has the ability for destruction of SARS-CoV-2, transmission of SARS-CoV-2 from patient will be reduced also. Thus PVP-I oro-nasal spray can act as an effective shield for COVID-19 protection for healthcare workers, for all.
Conflict of interest There is no competing interest. Ethical Approval Not applicable. Informed Consent All of the patients or their attendants gave written informed consent to participate in the study willingly without any prejudice.
References
Arefin, Arafat, Talukder, POLIDON' Approach-A Novel Solution for the ENT & Skull Base Surgeons in COVID-19 era, Indian J Otolaryngol Head Neck Surg, doi:10.1007/s12070-020-02201-4
Arefin, Islam, Shawrave, Rahman, The Role of Povidone Iodine Mouthwash & Nasal Spray or Drop or Inhalation for Protection (Prevention & Treatment) of Health Care Professionals as Well as Patients and Reduction of Cross Infection during Current COVID-19 Pandemic Situation
Arefin, Uddin, Haque, Azam, POLI-DON' approach-a novel approach of mastoidectomy in the COVID-19 pandemic, On J Otolaryngol & Rhinol
Arefin, Uddin, Islam, Arafat, Novel technique of tracheostomy in the era of novel coronavirus, IJISRT
Eggers, Koburger-Janssen, Eickmann, Zorn, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther
Gluck, Martin, Bosse, Reimer, Mueller, A clinical study on the tolerability of a Liposomal povidone-iodinenasal spray: Implications for further development, ORL, doi:10.1159/000097758
Kariwa, Fujii, Takashima, Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions, and chemical reagents, Jpn J Vet Res
Khalil, Alam, Arefin, Role of personal protective measures in prevention of COVID-19 spread among Physicians in Bangladesh: a multicenter cross-sectional comparative study, SN ComprClin Med, doi:10.1007/s42399-020-00471-1
Khan, Parab, Paranjape, Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic, Am J Otolaryngol
Kirk-Bayley, Challacombe, Sunkaraneni, Combes, The use of povidone iodine nasal spray and mouthwash during the current COVID-19 pandemic may reduce cross infection and protect healthcare workers
Mady, Kubik, Consideration of povidone-iodine as a public health intervention for COVID-19: utilization as personal protective equipment for frontline providers exposed in high-risk head and neck and skull base oncology care, Oral Oncol
Nagatake, Ahmed, Oishi, Prevention of respiratory infections by povidone-iodine gargle, Dermatology
Naqvi, Citardi, Cattano, Povidone-iodine solution as SARS-CoV-2 prophylaxis for procedures of the upper aerodigestive tract a theoretical framework, J of Otolaryngol-Head Neck Surg, doi:10.1186/s40463-020-00474-x
Satomura, Kitamura, Kawamura, Prevention of upper respiratory tract infections by gargling: a randomized trial, Am J Prev Med
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