DOI record:
{
"DOI": "10.2174/1871529x21666211214153308",
"ISSN": [
"1871-529X"
],
"URL": "http://dx.doi.org/10.2174/1871529x21666211214153308",
"abstract": "<jats:sec>\n<jats:title>Aims:</jats:title>\n<jats:p> The study aimed to assess the inhibitory effect of Vitamin C on angiotensin-converting enzyme 2.\n</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Background:</jats:title>\n<jats:p>Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which uses angiotensin-converting enzyme 2 (ACE-II)\nas the first route to infect human cells. Accordingly, agents with potential inhibition of ACE-II receptors might be effective in the prevention and management of COVID-19.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Objective:</jats:title>\n<jats:p>The goal of this work was to assess the possible inhibitory effect of ACE-II on ascorbic\nacid using an ex vivo approach based on the inhibition of diminazene-induced vasorelaxation.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Material and Methods:</jats:title>\n<jats:p>In the present study, diminazene was used as a known specific inhibitor of\nACE-II. Then, the vasorelaxant effect of ascorbic acid on diminazene-induced relaxation was examined using isolated aortic rings. All experiments of this study were evaluated on isolated aortic\nrings precontracted by epinephrine.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Results:</jats:title>\n<jats:p>The results confirmed that diminazene-induced vasorelaxation in a dose-dependent manner. More interestingly, ascorbic acid inhibited diminazene-induced vasorelaxation in a dose-dependent manner.\n</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Conclusion:</jats:title>\n<jats:p> This investigation provides valuable experimental proof of the efficacy of ascorbic\nacid (Vitamin C) on inhibiting ex vivo vascular angiotensin-converting enzyme II, which is known\namong the pharmacological targets of anti-Covid-19 drugs.</jats:p>\n</jats:sec>",
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"name": "Department of Biology, Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 Errachidia, Morocco"
}
],
"family": "Amssayef",
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"affiliation": [
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"name": "Department of Biology, Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 Errachidia, Morocco"
}
],
"family": "Bouadid",
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{
"affiliation": [
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"name": "Department of Biology, Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 Errachidia, Morocco"
}
],
"family": "Eddouks",
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15
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"timestamp": 1639549691000
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"date-time": "2021-12-19T11:20:43Z",
"timestamp": 1639912843185
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14
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"language": "en",
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"publisher": "Bentham Science Publishers Ltd.",
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"source": "Crossref",
"subject": [
"Cardiology and Cardiovascular Medicine",
"Pharmacology",
"Hematology",
"Molecular Medicine",
"General Medicine"
],
"subtitle": [],
"title": [
"Vitamin C inhibits Angiotensin-Converting Enzyme-2 in Isolated Rat Aortic Ring"
],
"type": "journal-article",
"volume": "21"
}
