Vitamin C inhibits Angiotensin-Converting Enzyme-2 in Isolated Rat Aortic Ring

{ 'indexed': { 'date-parts': [[2021, 12, 19]], 'date-time': '2021-12-19T11:20:43Z', 'timestamp': 1639912843185}, 'reference-count': 0, 'publisher': 'Bentham Science Publishers Ltd.', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': ['CHDDT'], 'published-print': {'date-parts': [[2021, 12, 14]]}, 'abstract': '<jats:sec>\n' '<jats:title>Aims:</jats:title>\n' '<jats:p> The study aimed to assess the inhibitory effect of Vitamin C on ' 'angiotensin-converting enzyme 2.\n' '</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Background:</jats:title>\n' '<jats:p>Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory ' 'syndrome coronavirus 2 (SARS-CoV-2), which uses angiotensin-converting enzyme 2 (ACE-II)\n' 'as the first route to infect human cells. Accordingly, agents with potential inhibition of ' 'ACE-II receptors might be effective in the prevention and management of COVID-19.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Objective:</jats:title>\n' '<jats:p>The goal of this work was to assess the possible inhibitory effect of ACE-II on ' 'ascorbic\n' 'acid using an ex vivo approach based on the inhibition of diminazene-induced ' 'vasorelaxation.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Material and Methods:</jats:title>\n' '<jats:p>In the present study, diminazene was used as a known specific inhibitor of\n' 'ACE-II. Then, the vasorelaxant effect of ascorbic acid on diminazene-induced relaxation was ' 'examined using isolated aortic rings. All experiments of this study were evaluated on ' 'isolated aortic\n' 'rings precontracted by epinephrine.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Results:</jats:title>\n' '<jats:p>The results confirmed that diminazene-induced vasorelaxation in a dose-dependent ' 'manner. More interestingly, ascorbic acid inhibited diminazene-induced vasorelaxation in a ' 'dose-dependent manner.\n' '</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Conclusion:</jats:title>\n' '<jats:p> This investigation provides valuable experimental proof of the efficacy of ascorbic\n' 'acid (Vitamin C) on inhibiting ex vivo vascular angiotensin-converting enzyme II, which is ' 'known\n' 'among the pharmacological targets of anti-Covid-19 drugs.</jats:p>\n' '</jats:sec>', 'DOI': '10.2174/1871529x21666211214153308', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 12, 15]], 'date-time': '2021-12-15T06:28:11Z', 'timestamp': 1639549691000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': ['Vitamin C inhibits Angiotensin-Converting Enzyme-2 in Isolated Rat Aortic Ring'], 'prefix': '10.2174', 'volume': '21', 'author': [ { 'given': 'Ayoub', 'family': 'Amssayef', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Biology, Team of Ethnopharmacology and ' 'Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, ' 'Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 ' 'Errachidia, Morocco'}]}, { 'given': 'Ismail', 'family': 'Bouadid', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biology, Team of Ethnopharmacology and ' 'Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, ' 'Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 ' 'Errachidia, Morocco'}]}, { 'given': 'Mohamed', 'family': 'Eddouks', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biology, Team of Ethnopharmacology and ' 'Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, ' 'Moulay Ismail, University of Meknes, BP 509, Boutalamine, 52000 ' 'Errachidia, Morocco'}]}], 'member': '965', 'container-title': ['Cardiovascular & Hematological Disorders-Drug Targets'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://eurekaselect.com/article/download/198905', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.eurekaselect.com/198905/article', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://eurekaselect.com/article/download/198905', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 12, 15]], 'date-time': '2021-12-15T06:28:15Z', 'timestamp': 1639549695000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 12, 14]]}, 'references-count': 0, 'alternative-id': ['LiveAll1'], 'URL': 'http://dx.doi.org/10.2174/1871529x21666211214153308', 'relation': {}, 'ISSN': ['1871-529X'], 'issn-type': [{'value': '1871-529X', 'type': 'print'}], 'subject': [ 'Cardiology and Cardiovascular Medicine', 'Pharmacology', 'Hematology', 'Molecular Medicine', 'General Medicine'], 'published': {'date-parts': [[2021, 12, 14]]}}