Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin A studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin AVitamin A (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Therapeutic effect of Vitamin A on severe COVID-19 patients

Al-Sumiadai et al., EurAsian Journal of Biosciences, 14:7347-7350
Dec 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 86% Improvement Relative Risk Vitamin A  Al-Sumiadai et al.  EARLY TREATMENT Is early treatment with vitamin A beneficial for COVID-19? Retrospective 140 patients in Iraq Lower mortality with vitamin A (p=0.0024) c19early.org Al-Sumiadai et al., EurAsian J. Biosci.., Dec 2020 Favorsvitamin A Favorscontrol 0 0.5 1 1.5 2+
Vitamin A for COVID-19
42nd treatment shown to reduce risk in June 2023, now with p = 0.021 from 14 studies.
Lower risk for recovery and cases.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 104 treatments. c19early.org
Retrospective 70 severe condition patients treated with vitamin A (200,000IU for two days), salbutamol, and budesonide, and 70 patients not treated with vitamin A, showing significantly lower mortality with the addition of vitamin A.
This study is excluded in the after exclusion results of meta analysis: minimal details of groups provided.
risk of death, 85.7% lower, RR 0.14, p = 0.002, treatment 2 of 70 (2.9%), control 14 of 70 (20.0%), NNT 5.8.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Sumiadai et al., 31 Dec 2020, retrospective, Iraq, peer-reviewed, 3 authors.
This PaperVitamin AAll
Therapeutic effect of Vitamin A on severe COVID-19 patients
Mahmood M Al-Sumiadai, Hazim Ghazzay, Wisam Zabin, Saleh Al-Dulaimy
Objective: To find the effect of administration of vitamin A on patients with severe COVID-19. Material and Methods: A cross-sectional and retrospective study was done on two groups of patients with severe COVID-19 in isolation centers in Anbar governorate. The first group was patients with severe COVID-19 given two doses of vitamin A (200,000 I.U.) for two days from the first day of admission and three doses per day of salbutamol and budesonide nebulizers.. Data about the respiratory rate and SPO2 were collected after 48 and 96 hours from the administration in addition to the death rate among those patients. In a second group, the data was collected from files of patients with severe COVID-19 previously admitted to isolated centers and not receiving vitamin A. Results: A significant improvement in SPO2 and respiratory rate among severe COVID-19 patients given vitamin A as compared to those not given vitamin A. A lower death rate was recorded among severe COVID-19 patients who received vitamin A from those not received. Conclusions; A great benefit of the using of vitamin A in patients with severe COVID-19. Adding vitamin A to the regime COVID-19 therapy is recommended.
References
Alabama, Mm F, Huang, Galea, Calderon et al., Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression, Clin. Infect. Dis
Cabezas-Wallscheid, Buettner, Sommerkamp, Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy, Cell, doi:10.1016/j.cell.2017.04.018
Chen, Yang, Yan, Chen, Yu, Influence of vitamin A status on the antiviral immunity of children with hand, foot, and mouth disease, Clin. Nutr
Ertesvag, Engedal, Naderi, Blomhoff, Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion, Journal of Immunology, doi:10.4049/Immunol.169.10.5555
Fisher, Heymann, Q&A: The novel coronavirus outbreak causing COVID-19, BMC Medicine, doi:10.1186/s12916-020-01533-w.PMC7047369
Fuchs, Green, Regulation of terminal differentiation of cultured human keratinocytes by vitamin A, Cell, doi:10.1016/0092-8674(81)90169-0
Gallegos, WHO Declares Public Health Emergency for Novel Coronavirus, Medscape Medical News
Ghazzay, Al-Ani, Therapeutic Effect of Vitamin A on COVID-19 Patients and Its Prophylactic Effect on Contacts, SRP, doi:10.31838/SRP.2021.1.33
Imai, District Clinician Manual. Hospital care for adolescents and adults
Johnson, Russell, Beta-Carotene
Liu, Fang, Deng, Liu, Wang et al., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province, Chinese Medical Journal
Makinde, Rotimi, Ikumawoyi, Adeyemo, Olayemi, Effect of vitamin A and vitamin C supplementation on oxidative stress in HIV and HIV-TB co-infection at Lagos University Teaching Hospital (LUTH) Nigeria, Afr. Health Sci
Mora, Iwata, Von Andrian, Vitamin effects on the immune system: vitamins A and D take center stage, Nature Reviews. Immunology, doi:10.1038/nri2378.PMC2906676
Mucida, Park, Kim, Turovskaya, Scott et al., Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid, Science, doi:10.1126/science.1145697
Olson, Vitamin, Present knowledge in nutrition
Ramzy, Mcneil, Declares Global Emergency as Wuhan Coronavirus Spreads, The New York Times
Ross, Encyclopedia of Dietary Supplements
Ross, Vitamin A and Carotenoids
Ross, Vitamin A and retinoic acid in T cell-related immunity, The American Journal of Clinical Nutrition, doi:10.3945/an.112.034637
Solomons, Vitamin A
Sun, Hall, Blank, Bouladoux, Oukka et al., Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid, The Journal of Experimental Medicine, doi:10.1084/jem.20070602.PMC2118682
Wang, Du, Zhu, Cao, An et al., Comorbidities and multi-organ injuries in the treatment of COVID-19, Lancet, doi:10.1016/s0140-6736(20)30558-4.PMC7270177
Who, The global prevalence of vitamin A deficiency in populations at risk 1995-2005
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit