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All Studies   Meta Analysis    Recent:   

In COVID-19 patients, low 25-hydroxyvitamin D level in serum is associated with longer viral clearance time and higher risk of intensive care unit admission

Al-Salman et al., Nutrition & Food Science, doi:10.1108/NFS-05-2021-0143
Jul 2021  
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ICU admission 44% Improvement Relative Risk Vitamin D for COVID-19  Al-Salman et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 450 patients in Bahrain Lower ICU admission with higher vitamin D levels (p=0.03) c19early.org Al-Salman et al., Nutrition & Food Sci.., Jul 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
5,000+ studies for 104 treatments. c19early.org
Retrospective 450 hospitalized patients in Bahrain, showing increased risk of ICU admission and slower viral clearance with vitamin D deficiency.
This is the 82nd of 207 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 165,787,330 vigintillion).
risk of ICU admission, 44.4% lower, OR 0.56, p = 0.03, high D levels (≥50nmol/L) 113, low D levels (<50nmol/L) 337, inverted to make OR<1 favor high D levels (≥50nmol/L), multinomial regression, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Salman et al., 29 Jul 2021, retrospective, Bahrain, peer-reviewed, 5 authors.
This PaperVitamin DAll
{ 'indexed': {'date-parts': [[2022, 4, 26]], 'date-time': '2022-04-26T16:18:27Z', 'timestamp': 1650989907470}, 'reference-count': 64, 'publisher': 'Emerald', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2021, 7, 29]], 'date-time': '2021-07-29T00:00:00Z', 'timestamp': 1627516800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.emerald.com/insight/site-policies'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 2, 7]]}, 'abstract': '<jats:sec>\n' '<jats:title content-type="abstract-subheading">Purpose</jats:title>\n' '<jats:p>This study aims to investigate the association between vitamin D measured in serum 25 ' 'hydroxyvitamin D [25(OH)D] and outcomes of COVID-19 patients in Bahrain. This paper ' 'hypothesized that lower serum 25(OH)D concentration in COVID 19 patients is associated with ' 'longer viral clearance time (VCT) and higher risk of admission to the intensive care unit ' '(ICU).</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title content-type="abstract-subheading">Design/methodology/approach</jats:title>\n' '<jats:p>This study used a retrospective cohort design of patients admitted to Salmaniya ' 'Medical Complex, Manama, Kingdom of Bahrain, from February to June 2020. This study included ' 'patients with positive, confirmed COVID-19 diagnosis made using reverse ' 'transcription-polymerase chain reaction (RT-PCR), World Health Organization diagnosis manual ' 'and local diagnostic guidelines. Primary outcome measures were: VCT measured as the time in ' 'days between the first positive RT-PCR test result and the first of two consecutive negative ' 'RT-PCR results on recovery and admission need to ICU.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title content-type="abstract-subheading">Findings</jats:title>\n' '<jats:p>A total of 450 patients were analyzed; mean age was 46.4\u2009±\u200912.4\u2009years ' 'and 349 (78%) were men. Mean 25(OH)D concentration was 41.7\u2009±\u200923.7\u2009nmol/L for ' 'the entire sample. Severe vitamin D deficiency (&lt;25\u2009nmol/L) was present in 20%, ' 'mild-to-moderate deficiency (25–50\u2009nmol/L) in 55%, insufficiency (50 to &lt;75\u2009' 'nmol/L) in 18% and sufficiency (=75\u2009nmol/L) in 7%. The mean VCT was 12.9\u2009±\u2009' '8.2\u2009days. Multivariate linear regression analysis showed that severe vitamin D ' 'deficiency was associated with longer VCT, with an average of three extra days after ' 'correction for age and sex (<jats:italic>β</jats:italic>\u2009=\u20093.1; ' '<jats:italic>p</jats:italic>\u2009=\u20090.001). Multinomial regression analysis showed that ' 'vitamin D deficiency was associated with an 83% increased risk of admission to ICU after ' 'correction for age and sex (odds ratio\u2009=\u20091.8; <jats:italic>p</jats:italic>\u2009' '=\u20090.03).</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title content-type="abstract-subheading">Originality/value</jats:title>\n' '<jats:p>The results showed that severe vitamin D deficiency was associated with longer ' 'recovery time from COVID-19. Low serum 25(OH)D is associated with increased need for critical ' 'care in an ICU. Large-scale randomized controlled trials are necessary to further investigate ' 'the complex association between vitamin D and COVID-19 infection.</jats:p>\n' '</jats:sec>', 'DOI': '10.1108/nfs-05-2021-0143', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 28]], 'date-time': '2021-07-28T12:08:32Z', 'timestamp': 1627474112000}, 'page': '240-254', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'In COVID-19 patients, low 25-hydroxyvitamin D level in serum is associated with longer viral ' 'clearance time and higher risk of intensive care unit admission', 'prefix': '10.1108', 'volume': '52', 'author': [ {'given': 'Jameela', 'family': 'Al-Salman', 'sequence': 'first', 'affiliation': []}, {'given': 'Sarah', 'family': 'Alghareeb', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eman', 'family': 'Alarab', 'sequence': 'additional', 'affiliation': []}, {'given': 'Haitham', 'family': 'Jahrami', 'sequence': 'additional', 'affiliation': []}, {'given': 'William 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Clinical ' 'medicine', 'volume': '20', 'year': '2020', 'journal-title': 'Journal of the Royal College of Physicians of London'}, { 'key': 'key2022020411225110900_ref056', 'article-title': 'COVID-19 diagnostic testing in the context of international travel: ' 'scientific brief', 'author': 'WHO', 'year': '2020'}, { 'issue': '2', 'key': 'key2022020411225110900_ref057', 'article-title': 'Isolation, quarantine, social distancing and community containment: ' 'pivotal role for old-style public health measures in the novel ' 'coronavirus (2019-nCoV) outbreak', 'volume': '27', 'year': '2020', 'journal-title': 'Journal of Travel Medicine'}, { 'key': 'key2022020411225110900_ref058', 'doi-asserted-by': 'crossref', 'first-page': '133', 'DOI': '10.1016/j.ijid.2020.03.042', 'article-title': 'Delivery of infection from asymptomatic carriers of COVID-19 in a ' 'familial cluster', 'volume': '94', 'year': '2020', 'journal-title': 'International Journal of Infectious Diseases'}, { 'key': 'key2022020411225110900_ref059', 'volume-title': 'COVID-19 Pathophysiology: A Review', 'year': '2020'}, { 'issue': '8', 'key': 'key2022020411225110900_ref060', 'doi-asserted-by': 'crossref', 'first-page': 'e029334', 'DOI': '10.1136/bmjopen-2019-029334', 'article-title': 'Vitamin D status among adults (18–65 years old) attending primary ' 'healthcare centres in Qatar: a cross-sectional analysis of the ' 'electronic medical records for the year 2017', 'volume': '9', 'year': '2019', 'journal-title': 'BMJ Open'}, { 'issue': '6', 'key': 'key2022020411225110900_ref061', 'doi-asserted-by': 'crossref', 'first-page': '1324', 'DOI': '10.1111/jth.14859', 'article-title': 'D‐dimer levels on admission to predict in‐hospital mortality in ' 'patients with covid‐19', 'volume': '18', 'year': '2020', 'journal-title': 'Journal of Thrombosis and Haemostasis'}, { 'issue': '10229', 'key': 'key2022020411225110900_ref062', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'year': '2020', 'journal-title': 'The Lancet'}, { 'issue': '12', 'key': 'key2022020411225110900_ref063', 'doi-asserted-by': 'crossref', 'first-page': '1177', 'DOI': '10.1056/NEJMc2001737', 'article-title': 'SARS-CoV-2 viral load in upper respiratory specimens of infected ' 'patients', 'volume': '382', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'issue': '6', 'key': 'key2022020411225110900_ref064', 'doi-asserted-by': 'crossref', 'first-page': '1155', 'DOI': '10.1515/cclm-2020-1567', 'article-title': 'Vitamin D levels and intensive care unit outcomes of a cohort of ' 'critically ill COVID-19 patients', 'volume': '59', 'year': '2021', 'journal-title': 'Clinical Chemistry and Laboratory Medicine (CCLM)'}], 'container-title': 'Nutrition &amp; Food Science', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.emerald.com/insight/content/doi/10.1108/NFS-05-2021-0143/full/xml', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.emerald.com/insight/content/doi/10.1108/NFS-05-2021-0143/full/html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 2, 4]], 'date-time': '2022-02-04T11:26:08Z', 'timestamp': 1643973968000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://www.emerald.com/insight/content/doi/10.1108/NFS-05-2021-0143/full/html'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 7, 29]]}, 'references-count': 64, 'journal-issue': { 'issue': '2', 'published-online': {'date-parts': [[2021, 7, 29]]}, 'published-print': {'date-parts': [[2022, 2, 7]]}}, 'alternative-id': ['10.1108/NFS-05-2021-0143'], 'URL': 'http://dx.doi.org/10.1108/NFS-05-2021-0143', 'relation': {}, 'ISSN': ['0034-6659', '0034-6659'], 'subject': ['Nutrition and Dietetics', 'Food Science'], 'container-title-short': 'NFS', 'published': {'date-parts': [[2021, 7, 29]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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