Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection
Ali et al.
, Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection
, Asian Journal of Research in Biochemistry, doi:10.9734/ajrb/2022/v11i2214
Retrospective 50 hospitalized COVID-19 patients and 50 healthy controls, showing lower vitamin D levels in COVID-19 patients, and a negative correlation between vitamin D level and COVID-19 severity.
Ali et al., 8 Dec 2022, retrospective, Sudan, peer-reviewed, 5 authors, study period December 2021 - April 2022.
Abstract: Asian Journal of Research in Biochemistry
Volume 11, Issue 2, Page 29-38, 2022; Article no.AJRB.94190
Vitamin D, Calcium and Phosphorus
Status Involvement during COVID-19
Abdalla Eltoum Ali a,b*, Mohamed Fathy Seyyed Ahmed a,
Somia Mohammed Suliman b, Ibrahim Ahamed Ali Karti b
and Haidar Eltayeb Saleh c
Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Alzaeim
Program of Medicine & Medical Laboratory Science, Alofoug College of Science & Technology,
Clinical Research Laboratory Services, Sylvester Comprehensive Cancer Center (SCCC),
Miami University, Miami Fl33136, USA.
This work was carried out in collaboration among all authors. All authors read and approved the final
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Original Research Article
Background: COVID-19 is associated with a weak immune system in the human body. Vitamin D
plays a role in the body’s immune system and is known to enhance the function of immune cells. In
this case, vitamin D inhibits some of the inflammation that can make COVID-19 more severe. The is
study aims to determine the serum levels of vitamin D, calcium, and phosphorus in COVID-19
Methods: This was a cross sectional study conducted during the period from January 2021 to July
*Corresponding author: E-mail: firstname.lastname@example.org;
Asian J. Res. Biochem., vol. 11, no. 2, pp. 29-38, 2022
Ali et al.; Asian J. Res. Biochem., vol. 11, no. 2, pp. 29-38, 2022; Article no.AJRB.94190
2021. 50 COVID-19 patients as a case study and 50 healthy individuals as a control group were
included in this study. Blood samples were collected from the study group and measured for vitamin
D using Enzyme-linked immunosorbent assay (ELISA) technique. Calcium and phosphate were
measured by the Cobas 6000 fully automated analyzer (Roche, Germany).
Results: The study result showed that in COVID-19 patients, vitamin D (27 ± 5 ng/mL), p-value =
0.000, and calcium (10.2 ± 4 mg/dL), p-value = 0.000, in comparison with control. There was a
correlation between vitamin D (r = -.771; p =.000) and calcium (r = -.752; p =.000) and the severity
Conclusions: According to our research, vitamin D deficiency may increase the risk of developing
COVID-19 and the risk of developing severe illnesses.
Keywords: COVID -19; vitamin D; calcium; phosphate.
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