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Biochemical changes of electrolytes and trace elements among patient with coronavirus disease-19 (COVID-19) in Khartoum state

Ali et al., American Journal of Medical and Physical Education, 1:1
Jul 2023  
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Retrospective 50 COVID-19 patients and 50 healthy controls in Sudan, showing significantly lower zinc levels in COVID-19 patients, and an inverse correlation between zinc levels and COVID-19 severity.
Ali et al., 18 Jul 2023, retrospective, Sudan, peer-reviewed, 5 authors, study period December 2020 - April 2021.
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Abdallah Eltoum, Ahmed Jbril, Aldooma Sabil, Mohammed Abd Elfatah, Elamin Ali, Ahmed Ibn Edriss Mohammed, Salih A Elmahdi
Background: coronavirus disease 2019 COVID-19 is a pandemic caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) is respiratory and can be involved in multiorgan failure causes many biochemical changes in the human body, our study was designed to examine the serum level electrolytes and trace elements in COVID19 patients and associated with severity of the disease. Materials and methods: Cross-sectional study includes 50 COVID-19 patients conducted during the period from December 2020 to April 2021 and 50 healthy as control group. Blood samples were collected from the study group and measured electrolytes sodium and potassium by easy lite, calcium, phosphate, zinc, and copper by using calorimeter methods, statistical analysis was conducted using the SPSS version. Results: The study showed that in COVID-19 patients there was a significantly low level of sodium (132 ± 4.3), potassium (3.2 ± 0.4), and calcium (7.8 ± .98) in comparison to control, insignificant in level of phosphorus and magnesium when compared with control group respectively ( P.value = 0.15 , 0.8 .) . There is significant decrease in the mean level of zinc and increase in the mean level of copper in COVID-19 patients when were compared to control group (p value = 0.000) ,. However there was strong correlation between sodium (r=-.753, p= .000) , potassium (r= -.736, p=.000) , Zinc (r= -.819, p= .000) and Copper (r= .700, p= .000) with severity of disease. Conclusions: COVID-19 infection cause hypernatremia, hypokalemia, and hypocalcaemia. Low zinc and high copper levels, the level of parameters is correlated with the severity of the disease.
Allen, Perri, Mcclain, Kay, Alterations in human natural killer cell activity and monocyte cytotoxicity induced by zinc deficiency, J Lab Clin Med
Anuk, Polat, Akdas, Erol, Tanacan et al., The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy, Biol. Trace Elem. Res
Anuk, Polat, Akdas, The relation between trace element status (zinc, copper, magnesium) and clinical outcomes in COVID-19 infection during pregnancy, Biol Trace Elem Res, doi:10.1007/s12011-020-02496-y
Arrieta, Martinez-Vaello, Bengoa, Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition, Nutrition, doi:10.1016/j.nut.2021.111467
Ashikujaman, Coronavirus, A Mini-Review, Int. J. Curr. Res. Med. Sci
Belden, Deiuliis, Dobre, Rajagopalan, The role of the mineralocorticoid receptor in inflammation: focus on kidney and vasculature, American Journal of Nephrology
Berni, Malandrino, Parenti, Maggi, Poggesi et al., IL-6, and SARS-CoV-2 (COVID-19)
Besold, Culbertson, Culotta, The Yin and Yang of copper during infection, J Biol Inorg Chem
Bove-Fenderson, Mannstadt, Best Practice & Research, Clinical Endocrinology & Metabolism
Carlos, Cruz, Cao, Pasnick, Jamil, Novel Wuhan (2019-nCoV) coronavirus, Am J Respir Crit Care Med
Carlucci, Ahuja, Petrilli, Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients, J Med Microbiol, doi:10.1099/jmm.0.001250
Carvalho, Richard, Chouihedetal, Electrolyte imbalance in COVID-19 patients admitted to the emergency department: a case-control study, Internal and Emergency Medicine
Cernat, Mihaescu, Vornicu, Vione, Olariu et al., Serum trace metal and ceruloplasmin variability in individuals treated for pulmonary tuberculosis, Int J Tuberc Lung Dis
Chan, Yuan, Kok, To, Chu et al., a familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster, Lancet
Chen, Li, Hypokalemia and clinical implications in patients with coronavirus disease 2019 (COVID-19).WHO,( 18, 593 medRxiv
Chowdhuryandd, Lobo, Fluidsandgastrointestinal function, Clinical Nutrition and Metabolic Care
Corona, Giuliani, Parenti, Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis, PLoS One
Fan, Eddy, Byers, The human mineral -corticoid, Cytogenetic and Genome Research
Filippo, Lorenzo, Amico, COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalization: a posthoc analysis of a prospective cohort study, Clin Nutr, doi:10.1016/j.clnu.2020.10.043
Fuller, Young, Mechanisms of mineralocorticoid action, Hypertension
Gromova, Torshin, Kobalava, Deficit of Magnesium and States of Hypercoagulation: Intellectual Analysis of Data Obtained From a Sample of Patients Aged 18-50 years From Medical and Preventive Facilities in Russia, Kardiologiia
Guan, Ni, Hu, Clinical characteristics of coronavirus disease 2019 in China, The New England Journal of Medicine
Hct, Sudan-Coronavirus, COVID-19 Country preparedness and response plan [Internet]. (2020) Team TNCPERE. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China, Chin J Epidemiol
Holshue, Debolt, Lindquist, First Case of 2019 Novel Coronavirus in the United States
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, The Lancet
Hugo De, Richard, Chouihed, Goffinet, Bastard, Electrolyte imbalance in COVID-19 patients admitted to the Emergency Department: a case-control study, Internal and Emergency Medicine
Ilbäck, Frisk, Tallkvist, Gadhasson, Blomberg et al., Gastrointestinal uptake of trace elements are changed during a common human viral (Coxsackievirus B3) infection in mice, J Trace Elem Med Biol
In Wuhan, China: a Cross-sectional Study, J Nutr
Ishida, Antiviral activities of Cu2+ ions in viral prevention, replication, RNA degradation, and for antiviral efficacies of the lytic virus, ROS-mediated virus, copper chelation, World Sci News
Johnson, Djuh, Bruton, Williams, None, Clinical Chemistry
Kanellopoulou, George, Masutani, Cannons, Ravell et al., Mg2+ regulation of kinase signaling and immune function, J Exp Med
Kardos, Héja, Simon, Jablonkai, Kovács et al., Copper signaling: causes and consequences, CCS
Li, Zhang, Gong, Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China, Eur J Clin Nutr, doi:10.1038/s41430-0200642-3
Lippi, South, Henry, Annals express electrolyte imbalances in patients with severe coronavirus disease 2019(COVID-19), Ann Clin Biochem, doi:10.1177/0004563220922255
Lippi, South, Henry, Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19), Ann Clin Biochem
Lippi, South, Henry, Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19), Annals of Clinical Biochemistry
Liu, Cong, Wang, Risk of malnutrition is common in patients with Coronavirus Disease
Makarychev -Mikhailov, Shvarev, Eric Bakker New trend in iron selective electrode, Electrochemical Sensor, Biosensor and their applications
Maywald, Wessels, Rink, Zinc signals and immunity, Int J Mol Sci, doi:10.3390/ijms18102222
Muhammad, Kani, Iliya, Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: a cross-sectional comparative study in Jigawa, Northwestern Nigeria, SAGE Open Med
Pal, Ram, Zohmangaihi, Biswas, Suri et al., High Prevalence of Hypocalcemia in Non-severe COVID-19 Patients: A Retrospective Case-Control Study, Front. Med, doi:10.3389/fmed.2020.590805
Phan, Nguyen, Luong, Nguyen, Nguyen et al., Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam, N Engl J Med
Pourfridoni, Mahsa Abbasnia, Shafaei, Razaviyan, Heidarisoureshjani, Fluid and electrolyte disturbances in COVID-19 and Their Complications Hindawi BioMed Research International Volume
Rd, None
Rd, None
Rd, None
Rink, Gabriel, Zinc and the immune system, Proc Nutr Soc, doi:10.1017/S0029665100000781
Shechter, Merz, Rude, Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease, American heart journal
Sheu, Hsiao, Shen, Antithrombotic effects of magnesium sulfate in vivo experiments, Int J Hematol
Shrimanker, Bhattarai, Electrolytes, Treasure Island (FL): StatPearls Publishing; 2021 Jan
Sobczak, Phoenix, Pitt, Reduced Plasma Magnesium Levels in Type-1 Diabetes Associate with Prothrombotic Changes in Fibrin Clotting and Fibrinolysis, Thrombosis and haemostasis
Terry, the major electrolytes: sodium, potassium, and chloride, J Intraven Nurs
Tietz, Fundamentals of clinical chemistry
Vahidy, Pan, Ahnstedt, Munshi, Choi, TirunehY, et alSex differences in susceptibility, severity, and outcomes of coronavirus disease, PLoSONE journal. pone, doi:10.1371/journal.pone.0245556
Velthuis, Van Den Worm, Sims, Zn (2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture, PLoS Pathog, doi:10.1371/journal
Wang, Shi, Zhang, Field, Daszak et al., Review of bats and SARS, Emerg. Infect. Dis
Wei, Liu, Li, Zhang, Zhong et al., Evaluation of the nutritional status in patients with COVID-19, J Clin Biochem Nutr, doi:10.3164/jcbn.20-91
Wessels, Cousins, Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation, Am J Physiol Gastrointest Liver Physiol, doi:10.1152/ajpgi.00179.2015
Wessels, Maywald, Rink, Zinc as a gatekeeper of immune function, Nutrients, doi:10.3390/nu9121286
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention, J Am Med Assoc
Ye, Li, Xiao, Zheng, Serum magnesium and fractional exhaled nitric oxide about the severity in asthma chronic obstructive pulmonary disease overlap, Biol Trace Elem Res, doi:10.1007/s12011-020-02314-5
Yongkangdong, Dong, Novel Coronavirus Epidemic Prevention and Control Research Project of Shanxi Province, Grant/Award Numbers The Research Project of Shanxi Health Commission
Yu, Ye, Chen, Malnutrition prolongs the hospitalization of patients with COVID-19 infection: a clinical epidemiological analysis, J Nutr Health Aging, doi:10.1007/s12603-0201541-y
Zeng, Yang, Yuan, Wang, Cheng, Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID-19, FASEB J, doi:10.1096/fj.202002346RR
Zhang, Du, Li, correlation between hyponatremia and severity of coronavirus disease, Emerg Microbes Infect
Zhou, Ma, Liu, A correlation analysis between the nutritional status and prognosis of COVID-19 patients, J Nutr Health Aging, doi:10.1007/s12603-020-1457-6
Zimmer, Zink, Weißer, Hypernatremia-a manifestation of COVID-19: a case series, A&a Practice
Çiçek, Açıkgoz, Yayla, Magnesium as a predictor of acute stent thrombosis in patients with STsegment elevation myocardial infarction who underwent primary angioplasty, Coron Artery Dis
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