Clinical Trial of Black Seeds Against COVID -19 in Kirkuk City/ Iraq
Kadhim Ali, Abbas Al-Haidari, Tunjainamiq Faiq, Ozdanakram Akram Ghareeb
In order to cope with Coronavirus Disease 2019 (COVID-19) pandemic, there is an urgent need for effective prevention and control measures. This study aims to explore the positive action of black seeds (BS) against COVID-19 in patients involved in the trail. It is a descriptive, comparative, and open-label study. In our study, (419) participants were divided into two groups.The studied participants included patients which received standard care treatment as a control group (CON) , while the (BS) group were patients received black seeds at a 40 mg/kg dose orally, once daily for 14 days plus standard protocol of treatment. The evidence of BS efficacy was obvious in the severity and outcome of infection with covid-19. A significantly higher severity of infection among control group 44 (17.0%) than the black seed group were noticed; the control group also showed 14 deaths (5.4%), while there were no deaths in black seeds group (0.0%). Thus, we can conclude that black seed is very effective in reducing the severity of covid-19 and preventing death in infected patients.
Conflict of Interest: The authors have declared no conflict of interest
References
Abate, Mantefardo, Basu, Postoperative mortality among surgical patients with COVID-19: a systematic review and meta-analysis. Patient safety in surgery
Ahmed, Khan, Azim, Saeed, Mesaik et al., Effect of natural honey on human platelets and blood coagulation proteins, Pakistan journal of pharmaceutical sciences
Alattas, Fat'heya, Mz, Turkistany, Nigella sativa and its active constituent thymoquinone in oral health, Saudi medical journal
Anwar, Soliman, Darwish, Mechanistic Similarity of Immuno-modulatory and Antiviral Effects of Chloroquine and Quercetin (The Naturally Occurring Flavonoid), ClinImmunol Res
Asadi-Pooya, Simani, Central nervous system manifestations of COVID-19: a systematic review, J Neurol Sci
Ashraf, Ashraf, Ashraf, Imran, Kalsoom et al., ): A multi-center placebo-controlled randomized clinical trial
Ashwak, Yashap, Jane, Studies on Antifungal Properties of Some Plant Extracts (Garlic, Fenugreek, Ginger) Against of Clinical Isolate Candida Species, International Journal of Scientific Engineering and Technology Research
Cianciosi, Forbes-Hernández, Afrin, Gasparrini, Reboredo-Rodriguez et al., Phenolic compounds in honey and their associated health benefits: A review
Elbarbry, Ragheb, Marfleet, Shoker, Modulation of hepatic drug metabolizing enzymes by dietary doses of thymoquinone in female New Zealand white rabbits, Phytother Res
Elbarbry, Ung, Abdelkawy, Studying the inhibitory effect of quercetin and thymoquinone on human cytochrome P450 enzyme activities, Pharmacognosy magazine
Emanuel, Persad, Upshur, Thome, Parker et al., Fair allocation of scarce medical resources in the time of Covid-19, N Engl J Med
Grasselli, Pesenti, Cecconi, Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response, JAMA
Hasan, Ali, Huq, Outcome of COVID-19 with co-existing surgical emergencies in children: our initial experiences and recommendations
Kakodkar, Kaka, Baig, A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19), Cureus
Kamarajah, Markar, Singh, Griffiths, The influence of the SARSCoV-2 pandemic on esophagogastric cancer services: an international survey of esophagogastric surgeons, Dis esophagus Off J IntSoc Dis Esophagus
Kooti, Hasanzadeh-Noohi, Sharafi-Ahvazi, Asadi-Samani, Ashtary-Larky, Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa), Chin J Nat Med
Kulyar, Li, Mehmood, Waqas, Li et al., Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic, Phytomedicine
Kumar, Arora, Sharma, Anikhindi, Bansal et al., Gastrointestinal and hepatic manifestations of Corona virus Disease-19 and their relationship to severe clinical course: a systematic review and metaanalysis, Indian J Gastroenterol
Lechien, Chiesa-Estomba, Siati, Horoi, Bon et al., Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study, Eur Arch Otorhinolaryngol
Mahboubi, Natural therapeutic approach of Nigella sativa (Black seed) fixed oil in management of Sinusitis, Integrative medicine research
Mohtashami, Entezari, Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials, J Res Med Sci
Mollazadeh, Afshari, Hosseinzadeh, Review on the potential therapeutic roles of nigella sativa in the treatment of patients with cancer: Involvement of apoptosis:-black cumin and cancer, J Pharmacopuncture
Oba, Stoop, Löhr, Hackert, Zyromski et al., Global survey on pancreatic surgery during the COVID-19 pandemic, Ann Surg
Pal, Shukla, Herbal medicine: current status and the future. Asian pacific journal of cancer prevention
Reichert, Sartelli, Weigand, Doppstadt, Hecker et al., Impact of the SARS-CoV-2 pandemic on emergency surgery services-a multi-national survey among WSES members, World Journal of Emergency Surgery
Sanders, Monogue, Jodlowski, Cutrell, Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review, Jama
Sarhan, Flaih, Hussein, Hussein, Novel coronavirus (COVID-19) Outbreak in Iraq: The First Wave and Future Scenario, medRxiv
Sultan, Sultan, Maded, Sultan, A descriptive study of COVID-19 infection among symptomatic patients in Al-Hawija district-Kirkuk-Iraq, International Journal of Psychosocial Rehabilitation
Tavakkoli, Mahdian, Razavi, Hosseinzadeh, Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone, J Pharmacopuncture
Thakkar, Arora, Kumar, Jaswaney, Faisaluddin et al., A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19
Toelzer, Gupta, Yadav, Borucu, Davidson et al., Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein, Science
Toelzer, Gupta, Yadav, Borucu, Davidson et al., Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein, Science
Topcagic, Zeljkovic, Karalija, Galijasevic, Sofic, Evaluation of phenolic profile, enzyme inhibitory and antimicrobial activities of Nigella sativa L. seed extracts, Bosnian Journal of Basic Medical Sciences
Walker, Whittaker, Watson, Baguelin, Winskill et al., The impact of COVID-19 and strategies for mitigation and suppression in low-and middle-income countries, Science
Wang, Zhang, Bai, An anti-oxidative therapy for ameliorating cardiac injuries of critically ill COVID-19-infected patients, Int J Cardiol